iGEM Papers
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TopicNameLinkComments
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Paper shortlist
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A synthetic oscillatory network of transcriptional regulators.http://www.ncbi.nlm.nih.gov/pubmed/10659856
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Bacteria-mediated delivery of nanoparticles and cargo into cells.http://www.ncbi.nlm.nih.gov/pubmed/18654330
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Potential therapeutic applications of recombinant, invasive E. coli.http://www.ncbi.nlm.nih.gov/pubmed/15141160
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Computational design of receptor and sensor proteins with novel functions.http://www.ncbi.nlm.nih.gov/pubmed/12736688
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The tac promoter: a functional hybrid derived from the trp and lac promoters.http://www.ncbi.nlm.nih.gov/pubmed/6337371
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Design of therapeutic proteins with enhanced stability.http://www.ncbi.nlm.nih.gov/pubmed/19571001
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Wavelength mutations and posttranslational autoxidation of green fluorescent protein.http://www.ncbi.nlm.nih.gov/pubmed/7809066
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A chemical switch for inhibitor-sensitive alleles of any protein kinase.http://www.ncbi.nlm.nih.gov/pubmed/11014197chemical biology paper
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Engineering cottonseed for use in human nutrition by tissue-specific reduction of toxic gossypol.http://www.ncbi.nlm.nih.gov/pubmed/17110445
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Molecular breeding of carotenoid biosynthetic pathways.http://www.ncbi.nlm.nih.gov/pubmed/10888843
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Synthesis of methyl halides from biomass using engineered microbes.http://www.ncbi.nlm.nih.gov/pubmed/19378995
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A highly potent artificial transcription factor.http://www.ncbi.nlm.nih.gov/pubmed/12044151
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A fast, robust and tunable synthetic gene oscillator.http://www.ncbi.nlm.nih.gov/pubmed/18971928
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Construction of a genetic toggle switch in Escherichia coli.http://www.ncbi.nlm.nih.gov/pubmed/10659857
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Engineered riboregulators enable post-transcriptional control of gene expression.http://www.ncbi.nlm.nih.gov/pubmed/15208640
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Humanization of yeast to produce complex terminally sialylated glycoproteins.http://www.ncbi.nlm.nih.gov/pubmed/16960007
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Essential genes of a minimal bacterium.http://www.ncbi.nlm.nih.gov/pubmed/16407165
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Folding DNA to create nanoscale shapes and patterns.http://www.ncbi.nlm.nih.gov/pubmed/16541064DNA Origami
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A synthetic genetic edge detection program.http://www.ncbi.nlm.nih.gov/pubmed/19563759
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PARTS
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Controlling the enzymatic activity of a restriction enzyme by light.http://www.ncbi.nlm.nih.gov/pubmed/20080559intense protein engineering
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Controlling signaling with a specifically designed Gi-coupled receptor.http://www.ncbi.nlm.nih.gov/pubmed/9419379Original GPCR
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A universal RNAi-based logic evaluator that operates in mammalian cells.http://www.ncbi.nlm.nih.gov/pubmed/17515909
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Engineered riboregulators enable post-transcriptional control of gene expression.http://www.ncbi.nlm.nih.gov/pubmed/15208640Popular igem paper
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Spatiotemporal control of cell signalling using a light-switchable protein interaction.http://www.ncbi.nlm.nih.gov/pubmed/19749742
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Conditional control of protein function.http://www.ncbi.nlm.nih.gov/pubmed/16426967tough
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Monomeric fluorescent timers that change color from blue to red report on cellular trafficking.http://www.ncbi.nlm.nih.gov/pubmed/19136976nope
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A chemical switch for inhibitor-sensitive alleles of any protein kinasehttp://www.ncbi.nlm.nih.gov/pubmed/11014197Difficult read
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Analysis of combinatorial cis-regulation in synthetic and genomic promoters.http://www.ncbi.nlm.nih.gov/pubmed/19029883Very elegant readLets do this one!
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A bottom-up approach to gene regulation.http://www.ncbi.nlm.nih.gov/pubmed/16482159This one too!I second!
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Combinatorial promoter design for engineering noisy gene expressionhttp://www.ncbi.nlm.nih.gov/pubmed/17652177Looks good
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Automated design of synthetic ribosome binding sites to control protein expressionhttp://www.ncbi.nlm.nih.gov/pubmed/19801975Cool paper
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Higher-Order Cellular Information Processing with Synthetic RNA Deviceshttp://www.sciencemag.org/cgi/content/abstract/322/5900/456Win & Smolke
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DEVICES
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Combinatorial engineering of intergenic regions in operons tunes expression of multiple genes.http://www.ncbi.nlm.nih.gov/pubmed/16845378
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Rational design of allosteric ribozymes.http://www.ncbi.nlm.nih.gov/pubmed/9224568
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Guiding bacteria with small molecules and RNA.http://www.ncbi.nlm.nih.gov/pubmed/17480075
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Transgenic strategies for combinatorial expression of fluorescent proteins in the nervous system.http://www.ncbi.nlm.nih.gov/pubmed/17972876
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Reengineering orthogonally selective riboswitches.http://www.ncbi.nlm.nih.gov/pubmed/20133756Ok paper
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Reprogramming Control of an Allosteric Signaling Switch Through Modular Recombinationhttp://www.ncbi.nlm.nih.gov/pubmed/14512628?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_SingleItemSupl.Pubmed_Discovery_RA&linkpos=2&log$=relatedarticles&logdbfrom=pubmed
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Synthetic gene networks that count.http://www.ncbi.nlm.nih.gov/pubmed/19478183Good igem read
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A Synthetic Genetic Edge Detection Programhttp://www.ncbi.nlm.nih.gov/pubmed/19563759Should read
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Solving a Hamiltonian Path Problem with a bacterial computerhttp://www.jbioleng.org/content/3/1/11an igem published paperA good CS paper
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Engineered biological nanofactories trigger quorum sensing response in targeted bacteriahttp://www.nature.com/nnano/journal/vaop/ncurrent/full/nnano.2009.457.htmlFun paper
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An externally tunable bacterial band-pass filterhttp://www.ncbi.nlm.nih.gov/pubmed/19502423
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Diversity-based, model-guided construction of synthetic gene networks with predicted functionshttp://www.nature.com/nbt/journal/v27/n5/abs/nbt.1536.htmlFrom Jim Collins
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A Light-Driven DNA Nanomachine for the Efficient Photoswitching of RNA Digestionhttp://www.ncbi.nlm.nih.gov/pubmed/20175178?dopt=Abstract
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SYSTEMS
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Reconstitution of Rab- and SNARE-dependent membrane fusion by synthetic endosomes.http://www.ncbi.nlm.nih.gov/pubmed/19458617
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Next-generation synthetic gene networks.http://www.ncbi.nlm.nih.gov/pubmed/20010597Decent review
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Controlling the metabolic flux through the carotenoid pathway using directed mRNA processing and stabilization.http://www.ncbi.nlm.nih.gov/pubmed/11676567
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Engineering a mevalonate pathway in Escherichia coli for production of terpenoids.http://www.ncbi.nlm.nih.gov/pubmed/12778056A ClassicMedicine related
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Non-fermentative pathways for synthesis of branched-chain higher alcohols as biofuelshttp://www.nature.com/nature/journal/v451/n7174/full/nature06450.htmlGood biofuels paper
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A fast, robust and tunable synthetic gene oscillator.http://www.ncbi.nlm.nih.gov/pubmed/18971928Classicshould read
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Building biological memory by linking positive feedback loops.http://www.ncbi.nlm.nih.gov/pubmed/20018658
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A synthetic oscillatory network of transcriptional regulators.http://www.ncbi.nlm.nih.gov/pubmed/10659856The ClassicShould read this
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A synchronized quorum of genetic clockshttp://www.ncbi.nlm.nih.gov/pubmed/20090747
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Rewiring cellular morphology pathways with synthetic guanine nucleotide exchange factorshttp://www.ncbi.nlm.nih.gov/pubmed/17515921
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CHASSIS
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An integrated cell-free metabolic platform for protein production and synthetic biology.http://www.ncbi.nlm.nih.gov/pubmed/18854819
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Genome-minimized Streptomyces host for the heterologous expression of secondary metabolism.http://www.ncbi.nlm.nih.gov/pubmed/20133795
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Metabolic streamlining in an open-ocean nitrogen-fixing cyanobacteriumhttp://www.nature.com/doifinder/10.1038/nature08786
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Reviews
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Foundations for engineering biologyhttp://www.ncbi.nlm.nih.gov/pubmed/16306983Drew's review
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Genetic parts to program bacteriahttp://www.ncbi.nlm.nih.gov/pubmed/16978856Should read
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Synthetic biology: exploring and exploiting genetic modularity through the design of novel biological networkshttp://www.ncbi.nlm.nih.gov/pubmed/19562109?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_SingleItemSupl.Pubmed_Discovery_RA&linkpos=3&log$=relatedreviews&logdbfrom=pubmed
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Medicine
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Exogenous control of mammalian gene expression through modulation of RNA self-cleavage.http://www.ncbi.nlm.nih.gov/pubmed/15386015
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Bacteria-mediated delivery of nanoparticles and cargo into cells.http://www.ncbi.nlm.nih.gov/pubmed/18654330
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Toward a live microbial microbicide for HIV: commensal bacteria secreting an HIV fusion inhibitor peptide.http://www.ncbi.nlm.nih.gov/pubmed/16040799
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Computational Bio
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Genome-scale reconstruction and analysis of the Pseudomonas putida KT2440 metabolic network facilitates applications in biotechnology.http://www.ncbi.nlm.nih.gov/pubmed/18974823
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Manufacturing
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Recombinant protein expression in Escherichia colihttp://www.ncbi.nlm.nih.gov/pubmed/10508629We should do this first!
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Material Science
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Folding DNA to create nanoscale shapes and patterns.http://www.ncbi.nlm.nih.gov/pubmed/16541064
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Self-assembly of DNA into nanoscale three-dimensional shapes.http://www.ncbi.nlm.nih.gov/pubmed/19458720
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Ordering of Quantum Dots Using Genetically Engineered Viruseshttp://www.ncbi.nlm.nih.gov/pubmed/11988570
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Methods
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