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|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | Biomarker | Preferred Term | HGNC_ID | Biomolecule | Tissue | Cell | Context | Organism | Senescence Hallmark | Citation | Experimental Evidence | ||||||||||||||||||||
2 | BAX | BCL2 associated X, apoptosis regulator | HGNC:959 | mRNA | Adipose tissue | Obesity | Human | DDR | 25682741 | rt-qPCR | |||||||||||||||||||||
3 | BDNF | brain derived neurotrophic factor | HGNC:1033 | Protein | Adipose tissue | progenitors | Aging | Mouse | SASP/Inflammation | 32489703 | IHC, Immunoblot, rt-qPCR | ||||||||||||||||||||
4 | CCAR2 | cell cycle and apoptosis regulator 2 | HGNC:23360 | mRNA | Adipose tissue | Obesity | Human | DDR | 25682741 | rt-qPCR | |||||||||||||||||||||
5 | CCL2 | C-C motif chemokine ligand 2 | HGNC:10618 | Protein | Adipose tissue | Aging | Human | SASP/Inflammation | 29988130 | rt-qPCR, Immunoassay | |||||||||||||||||||||
6 | CD38 | CD38 molecule | HGNC:1667 | Protein | Adipose tissue | immune cells | Aging | Mouse | Metabolic adaptations | 33199925 | IHC, IF | ||||||||||||||||||||
7 | CDKN1A | cyclin dependent kinase inhibitor 1A | HGNC:1784 | mRNA, Protein | Adipose tissue | endothelial cells, mesenchymal stem cells, myeloid cells, macrophages | Aging, Obesity | Human, Mouse | Cell cycle arrest | 35024619, 34813734, 30131393, 35417665, 24397850, 31971661 | scSeq, rt-qPCR, Immunoblot, Mouse model | ||||||||||||||||||||
8 | CDKN1C | cyclin dependent kinase inhibitor 1C | HGNC:1786 | mRNA, Protein | Adipose tissue | stem cells | Aging | Human | Cell cycle arrest | 32224418 | rt-qPCR, RNAseq, IF | ||||||||||||||||||||
9 | CDKN2A | cyclin dependent kinase inhibitor 2A | HGNC:1787 | mRNA, | Adipose tissue | Aging, Obesity | Human, Mouse | Cell cycle arrest | 35024619, 31199925, 26578790, 29988130, 30907060, 35417665, 24397850, 31971661, 34813734 | scSeq, rt-qPCR, Immunoblot, Mouse model | |||||||||||||||||||||
10 | CXCL8 | C-X-C motif chemokine ligand 8 | HGNC:6025 | Protein | Adipose tissue | Aging | Human | SASP/Inflammation | 29988130 | rt-qPCR, Immunoassay | |||||||||||||||||||||
11 | GDF15 | growth differentiation factor 15 | HGNC:30142 | Protein | Adipose tissue | Aging | Human, Mouse | SASP/Inflammation | 32691494 | RNAseq | |||||||||||||||||||||
12 | H2AX | H2A.X variant histone | HGNC:4739 | Protein | Adipose tissue | progenitors | Aging, Obesity | Human, Mouse | DDR | 26578790, 35417665 | IF | ||||||||||||||||||||
13 | IL1B | interleukin 1 beta | HGNC:5992 | Protein | Adipose tissue | Aging | Human | SASP/Inflammation | 30907060 | Immunoassay | |||||||||||||||||||||
14 | IL6 | interleukin 6 | HGNC:6018 | mRNA, Protein | Adipose tissue | Aging, Obesity | Mouse | SASP/Inflammation | 35024619, 26578790, 29988130, 30131393, 35417665 | rt-qPCR, Immunoassay, Immunoblot | |||||||||||||||||||||
15 | LMNB1 | lamin B1 | HGNC:6637 | Protein | Adipose tissue | immune cells | Aging | Mouse | Nuclear changes | 31199925 | IF | ||||||||||||||||||||
16 | MDM2 | MDM2 proto-oncogene | HGNC:6973 | Protein | Adipose tissue | Aging | Mouse | Cell cycle arrest | 30131393 | rt-qPCR, Immunoblot | |||||||||||||||||||||
17 | MMP12 | matrix metallopeptidase 12 | HGNC:7158 | mRNA | Adipose tissue | progenitors | Aging | Mouse | SASP/Inflammation | 26578790 | rt-qPCR, Immunoassay | ||||||||||||||||||||
18 | MMP3 | matrix metallopeptidase 3 | HGNC:7173 | mRNA | Adipose tissue | progenitors | Aging | Mouse | SASP/Inflammation | 26578790 | rt-qPCR, Immunoassay | ||||||||||||||||||||
19 | NAD+ | Nicotinamide adenine dinucleotide | Adipose tissue | immune cells | Aging | Mouse | Metabolic adaptations | 33199925 | HPLC-Mass Spectroscopy | ||||||||||||||||||||||
20 | RRAD | RRAD, Ras related glycolysis inhibitor and calcium channel regulator | HGNC:10446 | mRNA | Adipose tissue | Aging | Human | Metabolic adaptations | 30391675 | RNAseq, rt-qPCR, Immunoblot | |||||||||||||||||||||
21 | SA-β-Gal | senescence associated beta galactosidase | Adipose tissue | Aging, Obesity | Human, Mouse | Increased lysosomal content | 35024619, 29346516, 24397850, 36617688, 29988130, 30907060, 30131393, 35417665 | Colorimetric and Fluorescent staining and microscopy | |||||||||||||||||||||||
22 | SERPINE1 | serpin family E member 1 | HGNC:8583 | Protein | Adipose tissue | Aging | Human | SASP/Inflammation | 29988130 | rt-qPCR, Immunoassay | |||||||||||||||||||||
23 | SIRT1 | sirtuin 1 | HGNC:14929 | Protein | Adipose tissue | mesenchymal stem cells | Aging | Human | Nuclear changes | 29678576 | rt-qPCR, Immunoblot | ||||||||||||||||||||
24 | TNF | tumor necrosis factor | HGNC:11892 | mRNA | Adipose tissue | progenitors | Aging | Mouse | SASP/Inflammation | 26578790, 30131393 | rt-qPCR, Immunoassay | ||||||||||||||||||||
25 | TP53 | tumor protein p53 | HGNC:11998 | mRNA | Adipose tissue | Obesity | Human | Cell cycle arrest | 25682741 | rt-qPCR | |||||||||||||||||||||
26 | ATM | ATM serine/threonine kinase | HGNC:795 | Protein | Bone marrow | Bone marrow mesenchyme | Aging | Mouse | Cell cycle arrest | 37524694 | CyTOF | ||||||||||||||||||||
27 | BCL2 | BCL2 apoptosis regulator | HGNC:990 | Protein | Bone marrow | Bone marrow mesenchyme | Aging | Mouse | Cell cycle arrest | 37524694 | CyTOF | ||||||||||||||||||||
28 | CCL2 | C-C motif chemokine ligand 2 | HGNC:10618 | mRNA | Bone marrow | Osteocyte, Bone, Needle biopsies of Bone - Marrow | Aging | Human, Mouse | SASP/Inflammation | 27341653, 35974106 | rt-qPCR | ||||||||||||||||||||
29 | CCL20 | C-C motif chemokine ligand 20 | HGNC:10619 | mRNA | Bone marrow | Bone marrow stroma | Oncogene induced senescence | Mouse | SASP/Inflammation | 30401703 | rt-qPCR | ||||||||||||||||||||
30 | CCL24 | C-C motif chemokine ligand 24 | HGNC:10623 | mRNA | Bone marrow | Bone and bone marrow biopses | Aging | Human | SASP/Inflammation | 35974106 | rt-qPCR, scRNA-seq | ||||||||||||||||||||
31 | CCL3 | C-C motif chemokine ligand 3 | HGNC:10627 | mRNA | Bone marrow | Needle biopsies of Bone - Marrow | Aging | Human | SASP/Inflammation | 27341653 | scRNA-seq | ||||||||||||||||||||
32 | CCL5 | C-C motif chemokine ligand 5 | HGNC:10632 | mRNA | Bone marrow | Osteocyte, Bone marrow stroma | Aging, Irradiation Induced senescence | Mouse | SASP/Inflammation | 27341653, 26657143 | rt-qPCR | ||||||||||||||||||||
33 | CCL7 | C-C motif chemokine ligand 7 | HGNC:10634 | mRNA | Bone marrow | Osteocytes | Aging | Mouse | SASP/Inflammation | 27341653 | rt-qPCR | ||||||||||||||||||||
34 | CCL8 | C-C motif chemokine ligand 8 | HGNC:10635 | mRNA | Bone marrow | Osteoblast progenitor, Osteocyte, Needle biopsies of Bone - Marrow | Aging | Human, Mouse | SASP/Inflammation | 27341653 | rt-qPCR | ||||||||||||||||||||
35 | CDKN1A | cyclin dependent kinase inhibitor 1A | HGNC:1784 | mRNA, Protein | Bone marrow | Osteocytes, Bone marrow mesenchyme and stroma, bone, Needle biopsies of Bone - Marrow | Aging, Oncogene induced senescence, Irradiation Induced senescence | Human, Mouse | Cell cycle arrest | 27341653, 37524694, 30401703, 26657143, 35974106 | rt-qPCR, scRNA-seq, CyTOF | ||||||||||||||||||||
36 | CDKN2A | cyclin dependent kinase inhibitor 2A | HGNC:1787 | mRNA, Protein | Bone marrow | Osteoblast progenitor, Osteoblast, Osteocyte, Bone, Bone marrow mesenchyme and stroma, Needle biopsies of Bone - Marrow, Needle biopsies of Bone - Marrow | Aging, Oncogene induced senescence, Irradiation Induced senescence | Human, Mouse | Cell cycle arrest | 27341653, 36711531, 30401703, 26657143 | rt-qPCR, scRNA-seq, CyTOF | ||||||||||||||||||||
37 | CEBPB | CCAAT enhancer binding protein beta | HGNC:1834 | Protein | Bone marrow | Bone marrow mesenchyme | Aging | Mouse | SASP/Inflammation | 37524694 | CyTOF | ||||||||||||||||||||
38 | CSF1 | colony stimulating factor 1 | HGNC:2432 | mRNA | Bone marrow | Osteocyte, Needle biopsies of Bone - Marrow | Aging | Human, Mouse | SASP/Inflammation | 27341653 | rt-qPCR | ||||||||||||||||||||
39 | CSF2 | colony stimulating factor 2 | HGNC:2434 | mRNA | Bone marrow | Osteoblast progenitor, Osteocyte, Needle biopsies of Bone - Marrow | Aging | Human, Mouse | SASP/Inflammation | 27341653 | rt-qPCR | ||||||||||||||||||||
40 | CSF3 | colony stimulating factor 3 | HGNC:2438 | mRNA | Bone marrow | Needle biopsies of Bone - Marrow | Aging | Human | SASP/Inflammation | 27341653 | rt-qPCR | ||||||||||||||||||||
41 | CXCL1 | C-X-C motif chemokine ligand 1 | HGNC:4602 | Protein | Bone marrow | Bone marrow mesenchyme | Aging | Mouse | SASP/Inflammation | 37524694 | CyTOF | ||||||||||||||||||||
42 | CXCL15 | Cxcl15 C-X-C motif chemokine 15, no homolog in humans | mRNA | Bone marrow | Osteocyte, Bone marrow mesenchyme and stroma | Aging | Mouse | SASP/Inflammation | 27341653, 37524694 | rt-qPCR, CyTOF | |||||||||||||||||||||
43 | CXCL2 | C-X-C motif chemokine ligand 2 | HGNC:4603 | mRNA | Bone marrow | Osteoblast progenitor | Aging | Mouse | SASP/Inflammation | 27341653 | rt-qPCR | ||||||||||||||||||||
44 | FAS | Fas cell surface death receptor | HGNC:11920 | mRNA | Bone marrow | Osteoblast progenitor, Osteoblast, Osteocyte, Needle biopsies of Bone - Marrow | Aging | Human, Mouse | SASP/Inflammation | 27341653 | rt-qPCR | ||||||||||||||||||||
45 | FGF13 | fibroblast growth factor 13 | HGNC:3670 | mRNA | Bone marrow | Bone and bone marrow biopses | Aging | Human | SASP/Inflammation | 35974106 | scRNA-seq | ||||||||||||||||||||
46 | HMGB1 | high mobility group box 1 | HGNC:4983 | mRNA | Bone marrow | Osteocytes | Aging | Mouse | Nuclear changes | 27341653 | rt-qPCR | ||||||||||||||||||||
47 | ICAM1 | intercellular adhesion molecule 1 | HGNC:5344 | mRNA | Bone marrow | Osteocyte, Needle biopsies of Bone - Marrow | Aging | Human, Mouse | SASP/Inflammation | 27341653 | rt-qPCR | ||||||||||||||||||||
48 | IFNG | interferon gamma | HGNC:5438 | mRNA | Bone marrow | Osteoblast progenitor | Aging | Mouse | SASP/Inflammation | 27341653 | rt-qPCR | ||||||||||||||||||||
49 | IGFBP3 | insulin like growth factor binding protein 3 | HGNC:5472 | mRNA | Bone marrow | Osteocytes | Aging | Mouse | SASP/Inflammation | 27341653 | rt-qPCR | ||||||||||||||||||||
50 | IGFBP4 | insulin like growth factor binding protein 4 | HGNC:5473 | mRNA | Bone marrow | Osteocytes, Needle biopsies of Bone - Marrow | Aging | Human, Mouse | SASP/Inflammation | 27341653 | rt-qPCR | ||||||||||||||||||||
51 | IGFBP7 | insulin like growth factor binding protein 7 | HGNC:5476 | mRNA | Bone marrow | Bone and bone marrow biopses | Aging | Human | SASP/Inflammation | 35974106 | rt-qPCR | ||||||||||||||||||||
52 | IL17A | interleukin 17A | HGNC:5981 | mRNA | Bone marrow | Osteocyte | Aging | Mouse | SASP/Inflammation | 27341653 | scRNA-seq | ||||||||||||||||||||
53 | IL1A | interleukin 1 alpha | HGNC:5991 | mRNA, Protein | Bone marrow | Osteocyte, Bone marrow mesenchyme and stroma | Aging, Irradiation Induced senescence | Mouse | SASP/Inflammation | 27341653, 37524694, 26657143 | rt-qPCR, CyTOF | ||||||||||||||||||||
54 | IL1B | interleukin 1 beta | HGNC:5992 | mRNA, Protein | Bone marrow | Bone marrow mesenchyme and stroma | Aging, Irradiation Induced senescence | Mouse | SASP/Inflammation | 37524694, 26657143 | rt-qPCR, CyTOF | ||||||||||||||||||||
55 | IL6 | interleukin 6 | HGNC:6018 | mRNA, Protein | Bone marrow | Osteocyte, Bone marrow mesenchyme and stroma | Aging, Oncogene induced senescence, Irradiation Induced senescence | Mouse | SASP/Inflammation | 27341653, 36711531, 30401703, 26657143 | rt-qPCR, scRNA-seq, CyTOF | ||||||||||||||||||||
56 | INHBA | inhibin subunit beta A | HGNC:6066 | mRNA | Bone marrow | Osteoblast | Aging | Mouse | SASP/Inflammation | 27341653 | rt-qPCR | ||||||||||||||||||||
57 | IRF1 | interferon regulatory factor 1 | HGNC:6116 | mRNA | Bone marrow | Osteocytes, Needle biopsies of Bone - Marrow | Aging | Human, Mouse | SASP/Inflammation | 27341653 | rt-qPCR | ||||||||||||||||||||
58 | LMNB1 | lamin B1 | HGNC:6637 | mRNA | Bone marrow | Bone marrow stroma | Oncogene induced senescence | Mouse | Nuclear changes | 30401703 | rt-qPCR | ||||||||||||||||||||
59 | MKI67 | marker of proliferation Ki-67 | HGNC:7107 | Protein | Bone marrow | Bone marrow mesenchyme | Aging | Mouse | Cell cycle arrest | 37524694 | CyTOF | ||||||||||||||||||||
60 | MMP12 | matrix metallopeptidase 12 | HGNC:7158 | mRNA | Bone marrow | Osteocytes | Aging | Mouse | SASP/Inflammation | 27341653 | rt-qPCR | ||||||||||||||||||||
61 | MMP13 | matrix metallopeptidase 13 | HGNC:7159 | mRNA | Bone marrow | Osteocytes | Aging | Mouse | SASP/Inflammation | 27341653 | rt-qPCR | ||||||||||||||||||||
62 | MMP9 | matrix metallopeptidase 9 | HGNC:7176 | mRNA | Bone marrow | Osteocytes | Aging | Mouse | SASP/Inflammation | 27341653 | rt-qPCR | ||||||||||||||||||||
63 | NFKB1 | nuclear factor kappa B subunit 1 | HGNC:7794 | Protein | Bone marrow | Bone marrow mesenchyme | Aging | Mouse | SASP/Inflammation | 37524694 | CyTOF | ||||||||||||||||||||
64 | NFKB1 | nuclear factor kappa B subunit 1 | HGNC:7794 | mRNA | Bone marrow | Osteocytes | Aging | Mouse | SASP/Inflammation | 27341653 | rt-qPCR | ||||||||||||||||||||
65 | PAPPA | pappalysin 1 | HGNC:8602 | mRNA | Bone marrow | Needle biopsies of Bone - Marrow | Aging | Human | SASP/Inflammation | 27341653 | rt-qPCR | ||||||||||||||||||||
66 | SA-β-Gal | senescence associated beta galactosidase | Protein, | Bone marrow | Bone marrow stroma | Irradiation Induced senescence | Mouse | Increased lysosomal content | 26657143 | Staining | |||||||||||||||||||||
67 | SEMA3F | semaphorin 3F | HGNC:10728 | mRNA | Bone marrow | Bone and bone marrow biopses | Aging | Human | SASP/Inflammation | 35974106 | scRNA-seq | ||||||||||||||||||||
68 | SERPINB2 | serpin family B member 2 | HGNC:8584 | mRNA | Bone marrow | Osteocytes | Aging | Mouse | SASP/Inflammation | 27341653 | rt-qPCR | ||||||||||||||||||||
69 | SERPINE1 | serpin family E member 1 | HGNC:8583 | mRNA | Bone marrow | Osteocytes | Aging | Mouse | SASP/Inflammation | 27341653 | rt-qPCR | ||||||||||||||||||||
70 | TGFB1 | transforming growth factor beta 1 | HGNC:11766 | mRNA | Bone marrow | Bone marrow stroma | Aging, Irradiation Induced senescence | Human, Mouse | SASP/Inflammation | 26657143, 35974106 | rt-qPCR, scRNA-seq | ||||||||||||||||||||
71 | TNF | tumor necrosis factor | HGNC:11892 | mRNA, Protein | Bone marrow | Osteoblast progenitor, Osteocyte, Needle biopsies of Bone - Marrow , Bone marrow mesenchyme and stroma | Aging | Human, Mouse | SASP/Inflammation | 27341653, 37524694 | rt-qPCR, CyTOF | ||||||||||||||||||||
72 | TP53 | tumor protein p53 | HGNC:11998 | mRNA, Protein | Bone marrow | Osteocyte, Bone marrow mesenchyme | Aging | Mouse | Cell cycle arrest | 27341653, 37524694 | CyTOF | ||||||||||||||||||||
73 | VCAM1 | vascular cell adhesion molecule 1 | HGNC:12663 | mRNA | Bone marrow | Osteocytes | Aging | Mouse | SASP/Inflammation | 27341653 | rt-qPCR | ||||||||||||||||||||
74 | VEGFA | vascular endothelial growth factor A | HGNC:12680 | mRNA | Bone marrow | Osteoblast progenitor | Aging | Mouse | SASP/Inflammation | 27341653 | rt-qPCR | ||||||||||||||||||||
75 | 4-HNE | 4-Hydroxy-2-nonenal | Cardiovascular system | Cardiomyocytes | Aging | Mouse | Metabolic adaptations | 30737259 | IF | ||||||||||||||||||||||
76 | 8-OHdG | 8-hydroxy-2'-deoxyguanosine | Cardiovascular system | Cardiomyocytes, VSMC, aorta | Atheroscelortic plaque, Aging, AgII induce AAA | Human, Mouse | DDR | 27650558, 30737259, 16794190 | IF, IHC | ||||||||||||||||||||||
77 | ACTA1 | actin alpha 1, skeletal muscle | HGNC:129 | mRNA | Cardiovascular system | Cardiomyocytes | Aging, MI | Mouse | Changes in morphology | 30737259, 36150603 | rt-qPCR | ||||||||||||||||||||
78 | BMP1 | bone morphogenetic protein 1 | HGNC:1067 | mRNA | Cardiovascular system | cadriomyocytes, cardiac fibroblasts | Heart failure | Mouse | SASP/Inflammation | 35672400 | rt-qPCR | ||||||||||||||||||||
79 | CAPN3 | calpain 3 | HGNC:1480 | mRNA | Cardiovascular system | Cardiomyocytes | MI | Mouse | Changes in morphology | 36150603 | rt-qPCR | ||||||||||||||||||||
80 | CCL11 | C-C motif chemokine ligand 11 | HGNC:10610 | mRNA, Protein | Cardiovascular system | aorta, stromal cells, cardiac fibroblasts | Aging, MI, ischemia–reperfusion injury | Mouse | SASP/Inflammation | 32805724, 36150603, 32996233 | RNA-seq, rt-qPCR, LC-MS/MS | ||||||||||||||||||||
81 | CCL2 | C-C motif chemokine ligand 2 | HGNC:10618 | mRNA, protein | Cardiovascular system | Aorta, total tissue, cMSCs, cardiac stromal cells | AAA AngII, Aging, Heart failure, MI | Mouse, Human | SASP/Inflammation | 27650558, 32805724, 31353772, 36150603, 33668142, 36150603 | RNA-seq, WB, rt-qPCR, WB, Microarray | ||||||||||||||||||||
82 | CCL7 | C-C motif chemokine ligand 7 | HGNC:10634 | mRNA | Cardiovascular system | aorta | Aging | Mouse | SASP/Inflammation | 32805724 | RNA-seq | ||||||||||||||||||||
83 | CCL8 | C-C motif chemokine ligand 8 | HGNC:10635 | mRNA | Cardiovascular system | Total tissu, cardiac stromal cells, CMSCs, Aorta | Aging, Heart failure | Mouse | SASP/Inflammation | 32805724, 31353772, 33668142 | RNA-seq, rt-qPCR, Microarray | ||||||||||||||||||||
84 | CCN1 | cellular communication network factor 1 | HGNC:2654 | mRNA, Protein | Cardiovascular system | cardiac fibroblasts | Heart failure | Mouse | SASP/Inflammation | 27126529 | rt-qPCR, WB | ||||||||||||||||||||
85 | CCND1 | cyclin D1 | HGNC:1582 | protein | Cardiovascular system | VSMC, aorta | Atheroscelortic plaque | Human | Cell cycle arrest | 16794190 | WB | ||||||||||||||||||||
86 | CCNE1 | cyclin E1 | HGNC:1589 | protein | Cardiovascular system | VSMC, aorta | Atheroscelortic plaque | Human | Cell cycle arrest | 16794190 | WB | ||||||||||||||||||||
87 | CDKN1A | cyclin dependent kinase inhibitor 1A | HGNC:1784 | mRNA, protein | Cardiovascular system | whole tissue, Endothelial Cells, aorta, vSMC, Cardiomyocytes, cMSCs, cardiac stromal cells, cardiac fibroblasts | Aging, Atheroscelortic plaque, AngII induce AAA, TAA, Heart failure, ischemia, pressure overload, atrial fibrillation | Mouse | Cell cycle arrest | 25735595, 32805724, 36465181, 27650558 | rt-qPCR, RNA-seq, WB, IHC, IF | ||||||||||||||||||||
88 | CDKN2A | cyclin dependent kinase inhibitor 2A | HGNC:1787 | mRNA, Protein | Cardiovascular system | VSMC, aorta, Cardiomyocytes, cardiac stromal cells, macrophages, CPCs (=cMSCs), cardiac fibroblasts | Aging, Atherosclerosis, Atheroscelortic plaque, atrial fibrillation, TAC, Heart failure, MI | Human, Mouse | Cell cycle arrest | 25735595, 32805724, 27789842, 36465181, 16794190, 30737259, 31353772, 33668142, 36150603, 30854802, 33668142, 36150603,28938531,27126529,33668142, 36150603, 30920115 | rt-qPCR, RNA-seq, WB, IHC, IF | ||||||||||||||||||||
89 | CDKN2B | cyclin dependent kinase inhibitor 2B | HGNC:1788 | mRNA | Cardiovascular system | cMSCs, cardiomyocytesm cardiac stromal cells | Heart failure, Aging | Mouse | Cell cycle arrest | 30737259, 36150603, 31353772, 33668142 | rt-qPCR | ||||||||||||||||||||
90 | CDKN2C | cyclin dependent kinase inhibitor 2C | HGNC:1789 | mRNA | Cardiovascular system | cMSCs, cardiac stromal cells | Aging, Heart failure | Mouse | Cell cycle arrest | 31353772, 33668142 | rt-qPCR | ||||||||||||||||||||
91 | cGAS | cyclic GMP-AMP synthase | HGNC:21367 | protein | Cardiovascular system | aorta | Aging | Human, Mouse | SASP/Inflammation | 36465181 | WB | ||||||||||||||||||||
92 | CSF2 | colony stimulating factor 2 | HGNC:2434 | mRNA | Cardiovascular system | Stromal cells | Aging, MI | Mouse | SASP/Inflammation | 36150603 | rt-qPCR | ||||||||||||||||||||
93 | CX3CL1 | C-X3-C motif chemokine ligand 1 | HGNC:10647 | mRNA | Cardiovascular system | Total tissu, cardiac stromal cells, cMSCs | Aging, Heart failure, IRI | Mouse | SASP/Inflammation | 31353772, 33668142, 32996233 | rt-qPCR, Microarray | ||||||||||||||||||||
94 | CXCL1 | C-X-C motif chemokine ligand 1 | HGNC:4602 | mRNA | Cardiovascular system | Cardiac fibroblasts | Heart failure, chemOtherapy induced cardiotoxicity, myocardial infarction | Mouse | SASP/Inflammation | 24040275 | |||||||||||||||||||||
95 | CXCL10 | C-X-C motif chemokine ligand 10 | HGNC:10637 | Protein | Cardiovascular system | cardiac fibroblasts | ischemia–reperfusion injury | Mouse | SASP/Inflammation | 32996233 | LC-MS/MS | ||||||||||||||||||||
96 | CXCL12 | C-X-C motif chemokine ligand 12 | HGNC:10672 | mRNA | Cardiovascular system | Total tissu, cardiac stromal cells | Heart failure | Mouse | SASP/Inflammation | 33668142 | rt-qPCR | ||||||||||||||||||||
97 | CXCL2 | C-X-C motif chemokine ligand 2 | HGNC:4603 | mRNA | Cardiovascular system | Cardiac fibroblasts | Heart failure, chemOtherapy induced cardiotoxicity | Mouse | SASP/Inflammation | 24040275 | |||||||||||||||||||||
98 | DHE | Dehydrolactone | Cardiovascular system | Total heart, aorta | Aging | Mouse | Metabolic adaptations | 36150603, 25735595 | IF | ||||||||||||||||||||||
99 | EDN3 | endothelin 3 | HGNC:3178 | mRNA | Cardiovascular system | Cardiomyocytes | Aging | Mouse | SASP/Inflammation | 30737259 | rt-qPCR, RNA seq | ||||||||||||||||||||
100 | EdU | 5-ethynyl-2'-deoxyuridine | Cardiovascular system | CPCs (=cMSCs) | Aging | Human | Cell cycle arrest | 30854802 | IF |