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1 | Lab Name | Test Name(s) | # Gene(s) on Panel | # DPYD Variants Tested | Type of Sequencing | DYPD Variants Included | Sample Type | TAT | Cost | Physician or Patient Initiated | How to Order | Other notes | |||||||||||||||||
2 | LabCorp | DPD 5-Fluorouracil Toxicity (Test 512275) | 1 | 1 | PCR genotyping | c.1905+1G>A (previously *2A, rs3918290), c.1679T>G (previously *13, rs55886062), c.2846A>T (rs67376798), c.1236G>A (in HapB3 with c.1129-5923C>G, rs56038477), c.557A>G (rs115232898) | Whole blood or buccal swab | 6-10 days from specimen pickup | Unclear on website; billing phone number: 800-845-6167 | Physician initiated | Physicians log into LabCorp portal to place orders | CLIA certified, CAP accredited | https://oncology.labcorp.com/tests/512275/i-dpyd-i-genotyping | ||||||||||||||||
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4 | Quest | Dihydropyrimidine Dehydrogenase (DPD) Gene Mutation Analysis | 1 | 1 | PCR genotyping | Test not currently offered. | Whole blood | 6-10 days from receipt at lab | Unclear on website | Physician initiated | Not as clear from website; provider login likely necessary | CLIA certified, CAP accredited | |||||||||||||||||
5 | Pharmacogenomics Panel | 44 | Not specified | Microarray | Whole blood (preferred), saliva, buccal swab | Need to contact customer service for estimate | Unclear on website | Physician initiated | Not as clear from website; provider login likely necessary | CLIA certified, CAP accredited | https://testdirectory.questdiagnostics.com/test/test-detail/36943/pharmacogenomics-panel?p=r&cc=PHP&q=dpyd | ||||||||||||||||||
6 | Color | Extended and Standard panels | 73 and 24, respectively | 21 | *1, *2A, *3, *4, *5, *6, *7, *8, *9A, *9B, *10, *11, *12, *13, HapB3, rs3918290, rs55886062.1, rs75017182, rs56038477, rs67376798, rs115232898 | Blood or saliva | 2-4 weeks after receipt at lab | $249 self-pay; insurance billing available; $50 testing for first-degree relatives of patients who tested positive on a Color test | Physician or patient initiated | Providers order online or on paper; patients can order online and get physician approval via independent network | CLIA certified, CAP accredited | https://www.color.com/learn/color-genes | |||||||||||||||||
7 | ARUP | Dihydropyrimidine Dehydrogenase (DPYD), 3 Variants | 1 | 3 | PCR genotyping | *2A *13 c.2846A>T | Whole blood | 5-10 days from receipt at lab | Must be an ARUP client to access pricing information; CPT code 81232 | Physician initiated | Unclear from site; apears physicians enroll as clients and then can access ordering information | CLIA certified, CAP accredited | https://ltd.aruplab.com/Tests/Pub/2012166 | ||||||||||||||||
8 | OneOme | RightMed | 27 | 5 https://oneome.com/rightmed-test/#genes-covered | PCR genotyping | *2A, Asp949Val, *13, HapB3, Tyr186Cys | Blood or buccal swab | 7-10 business days after receipt at lab | OOP total is $349; financial assistance program offers aid based on family size and income; beneficiaries of federal programs (Medicaid, Medicare, etc.) typically owe $0 | Physician or patient initiated | Physicians can fill out requisition form on website or paper OR patient can request test online and get physician approval via independent network | CLIA certified, CAP accredited | https://oneome.com/rightmed-test/ | ||||||||||||||||
9 | Indiana University Genetic Testing Laboratories | PGx Pharmacogenomics Genotyping Panel | 14 | 4 | PCR genotyping | *2A, 2846 A>T, *13, 557A>G | Blood or saliva | 7-10 days after receipt | Physician initiated | This link describes how physicians may order IU genetic testing via their EMR software; not seeing other methods on site https://geneticslab.medicine.iu.edu/Files/Cerner%20postcard.pdf | CLIA certified, CAP accredited | https://geneticslab.medicine.iu.edu/generic.html?id=145 https://geneticslab.medicine.iu.edu/Files/FINAL_MMGE%20clinics%20and%20IUGTL%2011.12.2020.pdf | |||||||||||||||||
10 | PGx DPYD Genotyping | 1 | 4 | Microarray genotyping | *2A, 2846 A>T, *13, 557A>G | Blood or saliva | 7-10 days after receipt | Physician initiated | This link describes how physicians may order IU genetic testing via their EMR software; not seeing other methods on site https://geneticslab.medicine.iu.edu/Files/Cerner%20postcard.pdf | CLIA certified, CAP accredited | https://geneticslab.medicine.iu.edu/generic.html?id=140 | ||||||||||||||||||
11 | Mayo | DPYD Full Gene Sequencing | 1 | 1 | Sequencing | Blood or saliva | 5-10 days after receipt | Authorized users can sign in to view test prices; those unauthorized can call customer service https://www.mayocliniclabs.com/test-catalog/Overview/65213#Fees-and-Codes | Physician initiated | Must have an account with MayoAccess, which requires pre-approval | CLIA certified, CAP accredited | https://www.mayocliniclabs.com/test-catalog/Overview/65213 | |||||||||||||||||
12 | Dihydropyrimidine Dehydrogenase Genotype | 1 | 8 | PCR genotyping | *2A, *7, *8, *10, *13, 2846A>T, 1129-5923C>G, and 557A>G | Blood or saliva | 3-10 days after receipt | Authorized users can sign in to view test prices; those unauthorized can call customer service https://www.mayocliniclabs.com/test-catalog/Overview/65213#Fees-and-Codes | Physician initiated | Must have an account with MayoAccess, which requires pre-approval | CLIA certified, CAP accredited | https://www.mayocliniclabs.com/test-catalog/Overview/610052#Overview | |||||||||||||||||
13 | RPRD | Whole Pharmacogenomics Scan (WPS) | 38 | 22 | Genotpying | 61C>T, *7, 557A>G, *8, 1129-5923C>G, *12, *13, *3, *2, 2846A>T, *10, 62G>A, *9, 496A>G, 775A>G, *11, *4, *5, 1905C>G, *6, 2656C>T, *9B | Blood or saliva | 4-6 weeks after receipt | Site asks patients to contact them to ask about self pay; insurance pay option also available https://www.rprdx.com/testing/billing/billing-information/ | Physician initiated | Fill out and send in test requsition form https://www.rprdx.com/testing/how-it-works/ | CLIA certified | https://www.rprdx.com/testing/whole-pharmacogenomics-scan-wps/ | ||||||||||||||||
14 | Precision Health PGx Panel | 25 | 22 | Genotyping | 61C>T, *7, 557A>G, *8, 1129-5923C>G, *12, *13, *3, *2, 2846A>T, *10, 62G>A, *9, 496A>G, 775A>G, *11, *4, *5, 1905C>G, *6, 2656C>T, *9B | Blood, saliva, or buccal swab | 2 weeks after receipt | Site asks patients to contact them to ask about self pay; insurance pay option also available https://www.rprdx.com/testing/billing/billing-information/ | Physician initiated | Fill out and send in test requsition form https://www.rprdx.com/testing/how-it-works/ | CLIA certified | https://www.rprdx.com/testing/precision/ | |||||||||||||||||
15 | Sinochips Diagnostics | Comprehensive Panel | 9? | Genotyping | Buccal swab | 5-7 days after receipt | Insurance billing available; self-pay costs "no more than $399" | Physician initiated | Site directs patients to contact providers to order | CLIA certified, CAP accredited | https://sinochipsdiagnostics.com/benefits-pgx-testing/comprehensive/ | ||||||||||||||||||
16 | DPYD Genotyping | 1 | 9 | Genotyping | DPYD *2A, *7, *8, *10, *12, *13, c.2846A>T, HapB3, c. 557A>G | Buccal swab | 5-7 days after receipt | Insurance billing available; self-pay costs "no more than $399" | Patient or physician initiated | Site directs patients to contact providers to order | CLIA certified, CAP accredited | https://sinochipsdiagnostics.com/benefits-pgx-testing/dpyd/ | |||||||||||||||||
17 | Tempus | Tempus xT Solid Tumor + Normal Test; has optional DPYD genotyping add-on (though DPYD is included on the sequencing test) | 648 | 5 (with DPYD add-on) | Sequencing (with option for DPYD genotyping) | Blood or saliva, or tumor tissue | 7-10 days after receipt | Insurance billing available; site also offers financial assistance program with which they say most patients pay less than $100 https://www.tempus.com/resources/faqs-billing/ | Physician initiated | Physicians fill out online requisition https://www.tempus.com/order/ | CLIA certified, CAP accredited | https://www.tempus.com/oncology/genomic-profiling/ https://www.tempus.com/oncology/ai-algorithms/ | |||||||||||||||||
18 | Levine Cancer Institute | 5 | |||||||||||||||||||||||||||
19 | Prevention Genetics | Dihydropyrimidine Dehydrogenase Deficiency via the DPYD Gene | 1 | Sequencing (NGS) | Blood preferred; salvia, buccal swab, amniotic fluid, or dried blood spots accepted | 18 days after receipt | $640 | "Must be ordered by a qualified healthcare provider" according to requisition form | Provider uses myPrevent portal online or fills out requisition form https://www.preventiongenetics.com/forms | Candidates for this test are patients with dihydropyrimidine dehydrogenase deficiency. Testing is also indicated for family members of patients who have known DPYD mutations. It should be noted that this testing is NOT for complete risk evaluation of DPYD-associated fluoropyrimidine toxicities. This test may also be considered for the reproductive partners of individuals who carry pathogenic variants in DPYD. | https://www.preventiongenetics.com/testInfo?val=Dihydropyrimidine-Dehydrogenase-Deficiency-via-the-DPYD-Gene | ||||||||||||||||||
20 | Fulgent Genetics | DPYD Single Gene Test | 1 | Sequencing (NGS) | Blood, saliva, or buccal swab | 3-5 weeks after receipt | Fulgent has insurance billing options and financial aid available based on need https://www.fulgentgenetics.com/company/billing | Physician initiated | Physician can order online or fill out requisition form | CLIA certified, CAP accredited | https://www.fulgentgenetics.com/Dihydropyrimidine-Dehydrogenase-Deficiency | ||||||||||||||||||
21 | PGx Comprehensive NGS Panel | 44 | Sequencing (NGS) | Blood, saliva, or buccal swab | 10-14 days after receipt | Fulgent has insurance billing options and financial aid available based on need https://www.fulgentgenetics.com/company/billing | Physician initiated | Physician can order online or fill out requisition form | CLIA certified, CAP accredited | https://www.fulgentgenetics.com/PGx-Comprehensive | |||||||||||||||||||
22 | Picture PGx | 18 | 4 | Genotyping (uses NGS though) | *1, *2A, *13, rs67376798 | Saliva | 3-5 weeks after receipt | $295 (no insurance billing) | Patient initiated | Patient can order online and collect sample at home | CLIA certified, CAP accredited | https://www.picturegenetics.com/PGx | |||||||||||||||||
23 | Baylor Genetics | DPYD Prenatal Sequence Analysis (GeneAware) (Prenatal Sequence Analysis) | Disorder-specific testing available for ~700 conditions listed on requisition form | Sequencing | Options on requisition are amniotic fluid, CVS, fetal blood, cultured amniocytes, or cultured CVS | 21 days after receipt | Insurance and institution billing available; OOP price not listed | Physician initiated | Physician fills out requisition form: https://www.baylorgenetics.com/wp-content/uploads/2022/02/baylor-genetics-prenatal-comprehensive-req.pdf | We require that the referring center consult with our laboratory genetic counselors regarding prenatal cases prior to submitting any samples. Please call 1-800-411-4363. | https://www.bcm.edu/research/medical-genetics-labs/test_detail.cfm?testcode=60322&show=1 | ||||||||||||||||||
24 | DPYD Sequence Analysis (Familial Mutation/Variant Analysis) | 1 | Sequencing | Blood or saliva | 21 days after receipt | Insurance and institution billing available; OOP price not listed | Physician initiated | Physicians can add this test and others to a custom requsition form and place order | This test can only be performed if there is a previously identified familial mutation. A laboratory report containing the relative's mutation information, the specific biological relationship of this patient and the tested relative and the clinical status of this patient (symptomatic or asymptomatic) must be submitted with the specimen. If the original familial mutation was identified in another laboratory, this testing must be discussed with one of our genetic counselors prior to sending a specimen. | https://www.bcm.edu/research/medical-genetics-labs/test_detail.cfm?testcode=29341&show=1 | |||||||||||||||||||
28 | Admera Health | PGxOne Plus | 62 | Sequencing (NGS) | Buccal swab, mouth wash/oral rince, saliva, blood | 7-10 business days after receipt | Insurance billing available; no other specific info | Physician initiated | Physicians can order the test directly from Admera Health. Orders can be placed by the following methods: 1. Online using the "Order Now" option on our website at https://www.admerahealth.com/ordernow/ or by 2) By emailing or calling Admera Health at clientcare@admerahealth.com or (908)-222-0533 | CLIA certified, CAP accredited | https://www.admerahealth.com/pgxone-plus/ | ||||||||||||||||||
29 | Variantyx | Genomic Inform | (WGS) | Whole genome sequencing | Blood, saliva, gDNA | ~4 weeks after receipt | Insurance and institution billing available; OOP price not listed | Physician initiated | Providers order testing via provider portal | CLIA certified, CAP accredited | https://www.variantyx.com/products-services/genomic-inform/ | ||||||||||||||||||
30 | Sanford Imagenetics | Basic PharmGx panel | 11 | Genotyping | Whole blood preferred | 5-7 days after receipt | Patient or physician initiated | Note: patients must have existing relationship with a Sanford Health PCP. Patients can either ask provider to order or send request via patient portal to be considered for eligibility | CLIA certified, CAP accredited | https://imagenetics.sanfordhealth.org/preemptive-genetic-screening/ https://sanfordlaboratories.testcatalog.org/catalogs/455/files/10301 | |||||||||||||||||||
31 | DPYD Genotyping | 1 | Genotyping | Whole blood preferred | 5-7 days after receipt | Patient or physician initiated | Note: patients must have existing relationship with a Sanford Health PCP. Patients can either ask provider to order or send request via patient portal to be considered for eligibility | CLIA certified, CAP accredited | https://imagenetics.sanfordhealth.org/medical-genetics-lab/ Option listed under "Available Genetic Tests" | ||||||||||||||||||||
32 | https://www.ncbi.nlm.nih.gov/gtr/all/tests/?term=1806[geneid] | ||||||||||||||||||||||||||||
33 | AccessDx Lab | PGx Profile | 38 | 5 | PCR genotyping | rs115232898, rs3918290, rs55886062, rs67376798, rs75017182 (HapB3) | buccal swab | 7-10 days | OOP total is $249; financial assistance program offers aid based on family size and income; beneficiaries of federal programs (Medicaid, Medicare, etc.) typically owe $0 | Physician initiated | Physicians log into portal or send paper requisition with sample | CLIA certified, CAP accredited | https://www.accessdxlab.com/solutions/accessdx-pgx-profile/ | ||||||||||||||||
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