Malaria Molecules, Click on "OSM Number" to see visualisation
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ABCDEFGHIJKLMNOPQRSTUVWXYZAAABACADAEAFAGAHAIAJAKALAMANAOAPAQARASATAUAVAWAXAYAZBABBBCBDBEBFBGBHBIBJBKBLBMBNBOBPBQBRBSBTBUBVBW
1
OSM NumberInternal IDPubChem CIDMMV IDSMILESInChIIChI Key
Series
AssaysPfaI EC50 (Inh)Pfal IC50 (GSK)Pfal IC50 (Syngene)Pfal IC50 (Dundee)Pfal IC50 (Avery)Pfal (K1) IC50 (Avery)Pfal IC50 (Ralph)Pfal IC50 (Guy)Pfal (K1) IC50 (Guy)Pfal IC50 (Batra)Pfal (K1) IC50 (Batra)Pfal (3D7) IC50 (Broad)Pfal (Dd2) IC50 (Broad)PfaI EC50 uMol (Mean) QualifierPfaI EC50 uMol (Mean)Single Shot Inhibition %PRR (Rate of Killing)PfATP4 'Test Set'
Ion Regulation (ANU)
DHODHLate Stage Gametocyte (Avery)Pb Liver StageHepG2
Cytotox HEK293 (120)
Cytotox HEK293 (40)Cytotox Vero MTTCytotox THP1hERG pIC50t1/2 HLM (Monash)t1/2 HLM (Inh)t1/2 MLM (Monash)t1/2 RLM (Inh)t1/2 HCH (Monash)t1/2 RCH (Monash)t1/2 plasma Humant1/2 plasma MouseCLint HLM (Monash)
%remain plasma Human
%remain plasma Mouse
CLint HLM (Inh)CLint MLM (Monash)CLint RLM (Inh)CLint HCH (Monash)CLint RCH (Monash)
EH H M'some (Monash)
EH M M'some (Monash)
EH H H'cyte (Monash)
EH R H'cyte (Monash)
LogD 3.0 (Monash)LogD 7.4 (Monash)
Sol 2.0 ug/mL (Monash)
Sol 6.5 ug/mL (Monash)
Sol 6.8 uM (Inh)Sol 7.4 uM (Inh)cPPB % (Monash)CL Rat (Inh)Vss Rat (Inh)T1/2 Rat (Inh)Tmax Rat (Inh)Oral F Rat (Inh)Dofetilide (Inh)Cerep (Inh)Vivo NOD/SCID ED90
Vivo Berghei %activity
Vivo Parasit Cl
Aldehyde Oxidase
CLint,app (µL/min/mg)
2
OSM-A-11233035
O=C(/C(S/1)=C/C2=C(C)N(C(C)=C2)C3=CC=C(S(=O)(N)=O)C=C3)NC1=N\C4=CC=CC=C4
InChI=1S/C22H20N4O3S2/c1-14-12-16(15(2)26(14)18-8-10-19(11-9-18)31(23,28)29)13-20-21(27)25-22(30-20)24-17-6-4-3-5-7-17/h3-13H,1-2H3,(H2,23,28,29)(H,24,25,27)/b20-13-
ODRSSOQWOHNABY-MOSHPQCFSA-N
13.054.3793.7145
3
OSM-A-10O=C([H])C1=C(C)N(C(C)=C1)C2=CC(OC)=CC=C2
InChI=1S/C14H15NO2/c1-10-7-12(9-16)11(2)15(10)13-5-4-6-14(8-13)17-3/h4-9H,1-3H3
XTPVHYRCFNPCRL-UHFFFAOYSA-N
1#DIV/0!
4
OSM-A-11IC1=CC=C(N2C(C)=CC=C2C)C=C1
InChI=1S/C12H12IN/c1-9-3-4-10(2)14(9)12-7-5-11(13)6-8-12/h3-8H,1-2H3
CLGKGHWNVMDYQB-UHFFFAOYSA-N
1#DIV/0!
5
OSM-A-12IC1=CC=C(N2C(C)=CC(C([H])=O)=C2C)C=C1
InChI=1S/C13H12INO/c1-9-7-11(8-16)10(2)15(9)13-5-3-12(14)4-6-13/h3-8H,1-2H3
SSNYMKCLPCTDEB-UHFFFAOYSA-N
1#DIV/0!
6
OSM-A-2O=C(/C(S/1)=C/C2=C(C)N(C(C)=C2)C3=CC=C(C#N)C=C3)NC1=N\C4=CC=CC=C4
InChI=1S/C23H18N4OS/c1-15-12-18(16(2)27(15)20-10-8-17(14-24)9-11-20)13-21-22(28)26-23(29-21)25-19-6-4-3-5-7-19/h3-13H,1-2H3,(H,25,26,28)/b21-13-
LXPLFPVISCVJSC-BKUYFWCQSA-N
10.5741.8291.2015
7
OSM-A-3O=C(/C(S/1)=C/C2=C(C)N(C(C)=C2)C3=CC(OC)=CC=C3)NC1=N\C4=CC=CC=C4
InChI=1S/C23H21N3O2S/c1-15-12-17(16(2)26(15)19-10-7-11-20(14-19)28-3)13-21-22(27)25-23(29-21)24-18-8-5-4-6-9-18/h4-14H,1-3H3,(H,24,25,27)/b21-13-
QRGVMORNNJFJKZ-BKUYFWCQSA-N
10.0980.140.119
8
OSM-A-4O=C(/C(S/1)=C/C2=C(C)N(C(C)=C2)C3=CC=C(I)C=C3)NC1=N\C4=CC=CC=C4
InChI=1S/C22H18IN3OS/c1-14-12-16(15(2)26(14)19-10-8-17(23)9-11-19)13-20-21(27)25-22(28-20)24-18-6-4-3-5-7-18/h3-13H,1-2H3,(H,24,25,27)/b20-13-
LZWDTKNFRNEIKZ-MOSHPQCFSA-N
11.7453.1622.4535
9
OSM-A-5CC1=CC=C(C)N1C2=CC=C(S(=O)(N)=O)C=C2
InChI=1S/C12H14N2O2S/c1-9-3-4-10(2)14(9)11-5-7-12(8-6-11)17(13,15)16/h3-8H,1-2H3,(H2,13,15,16)
STHWURXTZRCILS-UHFFFAOYSA-N
1#DIV/0!
10
OSM-A-6O=C([H])C1=C(C)N(C(C)=C1)C2=CC=C(S(N)=O)C=C2
InChI=1S/C13H14N2O2S/c1-9-7-11(8-16)10(2)15(9)12-3-5-13(6-4-12)18(14)17/h3-8H,14H2,1-2H3
JYZXFZAZSQBBQH-UHFFFAOYSA-N
1#DIV/0!
11
OSM-A-7CC1=CC=C(C)N1C2=CC=C(C#N)C=C2
InChI=1S/C13H12N2/c1-10-3-4-11(2)15(10)13-7-5-12(9-14)6-8-13/h3-8H,1-2H3
FNDFKQYZEDOHRC-UHFFFAOYSA-N
1#DIV/0!
12
OSM-A-8O=C([H])C1=C(C)N(C(C)=C1)C2=CC=C(C#N)C=C2
InChI=1S/C14H12N2O/c1-10-7-13(9-17)11(2)16(10)14-5-3-12(8-15)4-6-14/h3-7,9H,1-2H3
AZYQCNIOZJETFM-UHFFFAOYSA-N
1#DIV/0!
13
OSM-A-9CC1=CC=C(C)N1C2=CC(OC)=CC=C2
InChI=1S/C13H15NO/c1-10-7-8-11(2)14(10)12-5-4-6-13(9-12)15-3/h4-9H,1-3H3
GVGRVGMGPYDHOB-UHFFFAOYSA-N
1#DIV/0!
14
OSM-E-1PT-1-1057519183FC1=CC=C(N2C(C)=CC(S(N(C)CC(N)=O)(=O)=O)=C2C)C=C1
InChI=1S/C15H18FN3O3S/c1-10-8-14(23(21,22)18(3)9-15(17)20)11(2)19(10)13-6-4-12(16)5-7-13/h4-8H,9H2,1-3H3,(H2,17,20)
KRDORFFFZGUMFF-UHFFFAOYSA-N
1>50#DIV/0!
15
OSM-E-10PT-1-6; PT-1-7; PT-1-8; PT-1-9FC1=CC=C(N2C(C)=CC(S(N(C)CC(OC)=O)(=O)=O)=C2C)C=C1
InChI=1S/C16H19FN2O4S/c1-11-9-15(24(21,22)18(3)10-16(20)23-4)12(2)19(11)14-7-5-13(17)6-8-14/h5-9H,10H2,1-4H3
LIADENKDGVSTCO-UHFFFAOYSA-N
1#DIV/0!
16
OSM-E-11PT-1-11FC1=CC=C(N2C(C)=CC(S(N([H])CC(OC)=O)(=O)=O)=C2C)C=C1
InChI=1S/C15H17FN2O4S/c1-10-8-14(23(20,21)17-9-15(19)22-3)11(2)18(10)13-6-4-12(16)5-7-13/h4-8,17H,9H2,1-3H3
MAMSLIRHTVGOCI-UHFFFAOYSA-N
1#DIV/0!
17
OSM-E-12PT-1-4FC1=CC=C(N2C(C)=CC(S([O-])(=O)=O)=C2C)C=C1.[H][N+]3=CC=CC=C3
InChI=1S/C12H12FNO3S.C5H5N/c1-8-7-12(18(15,16)17)9(2)14(8)11-5-3-10(13)4-6-11;1-2-4-6-5-3-1/h3-7H,1-2H3,(H,15,16,17);1-5H
GVWFBFKDWILLTG-UHFFFAOYSA-N
1#DIV/0!
18
OSM-E-13PT-1-3
FC1=CC=C(N2C(C)=C(S(N(CC(OC)=O)C)(=O)=O)C(S(N(C)CC(OC)=O)(=O)=O)=C2C)C=C1
InChI=1S/C20H26FN3O8S2/c1-13-19(33(27,28)22(3)11-17(25)31-5)20(34(29,30)23(4)12-18(26)32-6)14(2)24(13)16-9-7-15(21)8-10-16/h7-10H,11-12H2,1-6H3
HLULFYCSKNZRBP-UHFFFAOYSA-N
1#DIV/0!
19
OSM-E-14PT-1-1310877131O=C(OC)COCC#C
InChI=1S/C6H8O3/c1-3-4-9-5-6(7)8-2/h1H,4-5H2,2H3
AIQJXQPQNMKDGJ-UHFFFAOYSA-N
1#DIV/0!
20
OSM-E-2PT-1-12FC1=CC=C(N2C(C)=CC(S(NCC(N)=O)(=O)=O)=C2C)C=C1
InChI=1S/C14H16FN3O3S/c1-9-7-13(22(20,21)17-8-14(16)19)10(2)18(9)12-5-3-11(15)4-6-12/h3-7,17H,8H2,1-2H3,(H2,16,19)
RMHRPTFDPMUFGU-UHFFFAOYSA-N
1>50#DIV/0!
21
OSM-E-3PT-1-5
FC1=CC=C(N2C(C)=C(S(N(CC(N)=O)C)(=O)=O)C(S(N(C)CC(N)=O)(=O)=O)=C2C)C=C1
InChI=1S/C18H24FN5O6S2/c1-11-17(31(27,28)22(3)9-15(20)25)18(32(29,30)23(4)10-16(21)26)12(2)24(11)14-7-5-13(19)6-8-14/h5-8H,9-10H2,1-4H3,(H2,20,25)(H2,21,26)
TZMPVBDMPWKREJ-UHFFFAOYSA-N
1>50#DIV/0!
22
OSM-E-4PT-1-14-C1FC1=CC=C(N2N=NC(COC(CBr)=O)=C2)C=C1
InChI=1S/C11H9BrFN3O2/c12-5-11(17)18-7-9-6-16(15-14-9)10-3-1-8(13)2-4-10/h1-4,6H,5,7H2
UNGOTBWYUGGCJU-UHFFFAOYSA-N
1>50#DIV/0!
23
OSM-E-5PT-1-14-C2FC1=CC=C(N2N=NC(COCC(OCC)=O)=C2)C=C1
InChI=1S/C13H14FN3O3/c1-2-20-13(18)9-19-8-11-7-17(16-15-11)12-5-3-10(14)4-6-12/h3-7H,2,8-9H2,1H3
OAQNGCWJHOFYIG-UHFFFAOYSA-N
1>50#DIV/0!
24
OSM-E-6PT-1-14-C3FC1=CC=C(N2N=NC(COCC(OC)=O)=C2)C=C1
InChI=1S/C12H12FN3O3/c1-18-12(17)8-19-7-10-6-16(15-14-10)11-4-2-9(13)3-5-11/h2-6H,7-8H2,1H3
MXCBYXCXBDMCMO-UHFFFAOYSA-N
1>50#DIV/0!
25
OSM-E-7PT-1-14-C4FC1=CC=C(N2N=NC(COCC(OCC3=CN(C4=CC=C(F)C=C4)N=N3)=O)=C2)C=C1
InChI=1S/C20H16F2N6O3/c21-14-1-5-18(6-2-14)27-9-16(23-25-27)11-30-13-20(29)31-12-17-10-28(26-24-17)19-7-3-15(22)4-8-19/h1-10H,11-13H2
CWJPLXSSRWVEAF-UHFFFAOYSA-N
1>50#DIV/0!
26
OSM-E-8PT-1-15FC1=CC=C(N2N=NC(COCC(N)=O)=C2)C=C1
InChI=1S/C11H11FN4O2/c12-8-1-3-10(4-2-8)16-5-9(14-15-16)6-18-7-11(13)17/h1-5H,6-7H2,(H2,13,17)
XMSVYANCVZPQJL-UHFFFAOYSA-N
1>50#DIV/0!
27
OSM-E-9PT-1-9; PMY54FC1=CC=C(N2C(C)=CC(S(Cl)(=O)=O)=C2C)C=C1
InChI=1S/C12H11ClFNO2S/c1-8-7-12(18(13,16)17)9(2)15(8)11-5-3-10(14)4-6-11/h3-7H,1-2H3
MZWDVJVLEJEILM-UHFFFAOYSA-N
1#DIV/0!
28
OSM-L-1SBBH-1-9
CC(N1C2=CC(F)=CC=C2)=CC(/C=C(C(N/3C4=CC=CC=C4)=O)\SC3=N/C5=CC=CC=C5)=C1C
InChI=1S/C28H22FN3OS/c1-19-16-21(20(2)31(19)25-15-9-10-22(29)18-25)17-26-27(33)32(24-13-7-4-8-14-24)28(34-26)30-23-11-5-3-6-12-23/h3-18H,1-2H3/b26-17-,30-28-
URZLHIHAUACTCO-DUPRQXJUSA-N
13.2>53.292
29
OSM-L-2SBHK-516O=C(OCC#N)C1=C(C)N(N=C1)C2=CC=CC=C2
InChI=1S/C13H11N3O2/c1-10-12(13(17)18-8-7-14)9-15-16(10)11-5-3-2-4-6-11/h2-6,9H,8H2,1H3
LVOFSOINGBOZCK-UHFFFAOYSA-N
1#DIV/0!
30
OSM-S-1PMY1; AEW1; PT1; MD223145454FC1=CC=C(N2C(C)=CC=C2C)C=C1
InChI=1S/C12H12FN/c1-9-3-4-10(2)14(9)12-7-5-11(13)6-8-12/h3-8H,1-2H3
AIWFQKZWZOYVMK-UHFFFAOYSA-N
1#DIV/0!
31
OSM-S-10
PMY14-3-A; AEW80
1228983MMV689017FC1=CC=C(N2C(C)=CC(/C=C3S/C(NC\3=O)=N\C4=CC=CC=C4)=C2C)C=C1
InChI=1S/C22H18FN3OS/c1-14-12-16(15(2)26(14)19-10-8-17(23)9-11-19)13-20-21(27)25-22(28-20)24-18-6-4-3-5-7-18/h3-13H,1-2H3,(H,24,25,27)/b20-13-
IMCPBTMVWRMBHR-MOSHPQCFSA-N
10.0320.1760.3610.2010.1925slow2510317<1.6<1.6
32
OSM-S-100AEW73; MD1871450943FC1=CC=C(N2C(C)=CC(C(OC(C)C(O)=O)=O)=C2C)C=C1
InChI=1S/C16H16FNO4/c1-9-8-14(16(21)22-11(3)15(19)20)10(2)18(9)13-6-4-12(17)5-7-13/h4-8,11H,1-3H3,(H,19,20)
CLQCMRDHQCCPEN-UHFFFAOYSA-N
100
33
OSM-S-101PMY5971459966FC1=CC=C(N2C(C)=CC(C3=NC(C(O)=O)=CO3)=C2C)C=C1
InChI=1S/C16H13FN2O3/c1-9-7-13(15-18-14(8-22-15)16(20)21)10(2)19(9)12-5-3-11(17)4-6-12/h3-8H,1-2H3,(H,20,21)
PZPDUGQJGPKVEM-UHFFFAOYSA-N
100
34
OSM-S-102MNR5371461679FC1=CC=C(N2C(C)=CC(C(CCC(NC)=O)=O)=C2C)C=C1
InChI=1S/C17H19FN2O2/c1-11-10-15(16(21)8-9-17(22)19-3)12(2)20(11)14-6-4-13(18)5-7-14/h4-7,10H,8-9H2,1-3H3,(H,19,22)
NTSUYUWERKMXIY-UHFFFAOYSA-N
100
35
OSM-S-103MNR5471452751CC(N1C2=CC=C(F)C=C2)=C(C(CCC(N)=O)=O)C=C1C
InChI=1S/C16H17FN2O2/c1-10-9-14(15(20)7-8-16(18)21)11(2)19(10)13-5-3-12(17)4-6-13/h3-6,9H,7-8H2,1-2H3,(H2,18,21)
IUFWRPRMBNNROV-UHFFFAOYSA-N
1
61% at 40 micromolar
#DIV/0!
36
OSM-S-104MNR5571450944FC1=CC=C(N2N=CC(C3=NC(C(O)=O)=CO3)=C2C)C=C1
InChI=1S/C14H10FN3O3/c1-8-11(13-17-12(7-21-13)14(19)20)6-16-18(8)10-4-2-9(15)3-5-10/h2-7H,1H3,(H,19,20)
WPAXFMQFJQZBFD-UHFFFAOYSA-N
100
37
OSM-S-105MNR5657519185FC1=CC=C(N2N=CC(C3=NC(C(N)=O)=CO3)=C2C)C=C1
InChI=1S/C14H11FN4O2/c1-8-11(14-18-12(7-21-14)13(16)20)6-17-19(8)10-4-2-9(15)3-5-10/h2-7H,1H3,(H2,16,20)
JODCOGVLCRBBMU-UHFFFAOYSA-N
100
38
OSM-S-10644528665NC1=C2C(C=C(C3=CC(S(N)(=O)=O)=CC=C3)S2)=NC=N1
InChI=1S/C12H10N4O2S2/c13-12-11-9(15-6-16-12)5-10(19-11)7-2-1-3-8(4-7)20(14,17)18/h1-6H,(H2,13,15,16)(H2,14,17,18)
MQMXDJVOZKMSNT-UHFFFAOYSA-N
30.0880.088102
39
OSM-S-107FC(C=C1)=CC=C1CN(CC2)CCN2C3=C4C(C=CS4)=NC=N3
InChI=1S/C17H17FN4S/c18-14-3-1-13(2-4-14)11-21-6-8-22(9-7-21)17-16-15(5-10-23-16)19-12-20-17/h1-5,10,12H,6-9,11H2
HYCIFMXWGMZZSB-UHFFFAOYSA-N
3#DIV/0!
40
OSM-S-108AEW34O=C(/C(S/1)=C/C2=C(C)NC(C)=C2)NC1=N\C3=CC=CC=C3
InChI=1S/C16H15N3OS/c1-10-8-12(11(2)17-10)9-14-15(20)19-16(21-14)18-13-6-4-3-5-7-13/h3-9,17H,1-2H3,(H,18,19,20)/b14-9-
RARJKBCELXYZBB-ZROIWOOFSA-N
11.21.244
41
OSM-S-109MNR82
O=C(/C(S/1)=C/C2=C(C)N(C3=CC=C([N+]([O-])=O)C=C3)C(C)=C2)NC1=N\C4=CC=CC=C4
InChI=1S/C22H18N4O3S/c1-14-12-16(15(2)25(14)18-8-10-19(11-9-18)26(28)29)13-20-21(27)24-22(30-20)23-17-6-4-3-5-7-17/h3-13H,1-2H3,(H,23,24,27)/b20-13-
CHHZBZWZMLCOEW-MOSHPQCFSA-N
10.2620.2620
42
OSM-S-11PMY15; PMY18; AEW3; MNR97894104FC1=CC=C(N2C(C)=C(CO)C=C2C)C=C1
InChI=1S/C13H14FNO/c1-9-7-11(8-16)10(2)15(9)13-5-3-12(14)4-6-13/h3-7,16H,8H2,1-2H3
RXDPKDMALDFFCU-UHFFFAOYSA-N
1#DIV/0!
43
OSM-S-110MNR83
O=C(/C(S/1)=C/C2=C(C)N(C3=CC=C([N+]([O-])=O)C=C3)C(C)=C2)NC1=N\C4=CC(O)=CC=C4
InChI=1S/C22H18N4O4S/c1-13-10-15(14(2)25(13)17-6-8-18(9-7-17)26(29)30)11-20-21(28)24-22(31-20)23-16-4-3-5-19(27)12-16/h3-12,27H,1-2H3,(H,23,24,28)/b20-11-
NAHYEQMJTBIJRP-JAIQZWGSSA-N
12.32.326
44
OSM-S-111MNR84O=C(/C(S/1)=C/C2=C(C)N(C3=CC=C(OC)C=C3)C(C)=C2)NC1=N\C4=CC=CC=C4
InChI=1S/C23H21N3O2S/c1-15-13-17(16(2)26(15)19-9-11-20(28-3)12-10-19)14-21-22(27)25-23(29-21)24-18-7-5-4-6-8-18/h4-14H,1-3H3,(H,24,25,27)/b21-14-
KXIVXNPEYYNDHE-STZFKDTASA-N
10.1460.1470.2040.1656666667ANo0.6860.34544.3863220781.6-3.11.6-3.1
45
OSM-S-112MNR85O=C(/C(S/1)=C/C2=C(C)N(C3=CC=C(OC)C=C3)C(C)=C2)NC1=N\C4=CC(O)=CC=C4
InChI=1S/C23H21N3O3S/c1-14-11-16(15(2)26(14)18-7-9-20(29-3)10-8-18)12-21-22(28)25-23(30-21)24-17-5-4-6-19(27)13-17/h4-13,27H,1-3H3,(H,24,25,28)/b21-12-
RTYHWQWUZGEAOW-MTJSOVHGSA-N
11.61.638
46
OSM-S-113MNR92O=C(/C(S/1)=C/C2=C(C)N(C3=CC=CC=N3)C(C)=C2)NC1=N\C4=CC=C(O)C=C4
InChI=1S/C21H18N4O2S/c1-13-11-15(14(2)25(13)19-5-3-4-10-22-19)12-18-20(27)24-21(28-18)23-16-6-8-17(26)9-7-16/h3-12,26H,1-2H3,(H,23,24,27)/b18-12-
QZBWTSAVUQHJPY-PDGQHHTCSA-N
100
47
OSM-S-114MNR94O=C(/C(S/1)=C/C2=C(C)N(C3=CC=CC=C3)C(C)=C2)NC1=N\C4=CC(O)=CC=C4
InChI=1S/C22H19N3O2S/c1-14-11-16(15(2)25(14)18-8-4-3-5-9-18)12-20-21(27)24-22(28-20)23-17-7-6-10-19(26)13-17/h3-13,26H,1-2H3,(H,23,24,27)/b20-12-
ASANPQFHMMSZFH-NDENLUEZSA-N
11.21.242
48
OSM-S-115MNR95O=C(/C(S/1)=C/C2=C(C)N(C3=CC=CC=C3)C(C)=C2)NC1=N\C4=CC=C(O)C=C4
InChI=1S/C22H19N3O2S/c1-14-12-16(15(2)25(14)18-6-4-3-5-7-18)13-20-21(27)24-22(28-20)23-17-8-10-19(26)11-9-17/h3-13,26H,1-2H3,(H,23,24,27)/b20-13-
OIEJMTDGFAFKDZ-MOSHPQCFSA-N
11.81.835
49
OSM-S-116AEW776915212CC(N1C2=CC=C(F)C=C2)=C(C(OC(C)C(N)=O)=O)C=C1C
InChI=1S/C16H17FN2O3/c1-9-8-14(16(21)22-11(3)15(18)20)10(2)19(9)13-6-4-12(17)5-7-13/h4-8,11H,1-3H3,(H2,18,20)
JKLVGXNSTVWIID-UHFFFAOYSA-N
11111
50
OSM-S-117 (DUPLICATE OF OSM-S-64)
#DIV/0!
51
OSM-S-118C12=NC=NC(C3=CC=CC=C3)=C1SC=C2
InChI=1S/C12H8N2S/c1-2-4-9(5-3-1)11-12-10(6-7-15-12)13-8-14-11/h1-8H
ROUKINVYJAEUCD-UHFFFAOYSA-N
3#DIV/0!
52
OSM-S-119BrC1=C(Br)C2=NC=NC(C3=CC=CC=C3)=C2S1
InChI=1S/C12H6Br2N2S/c13-8-10-11(17-12(8)14)9(15-6-16-10)7-4-2-1-3-5-7/h1-6H
MHSGERTZTNZZKP-UHFFFAOYSA-N
3#DIV/0!
53
OSM-S-12PMY20292955CC(N1C2=CC=CC=C2)=CC(C(O)=O)=C1C
InChI=1S/C13H13NO2/c1-9-8-12(13(15)16)10(2)14(9)11-6-4-3-5-7-11/h3-8H,1-2H3,(H,15,16)
CIRVCSCFJALBOH-UHFFFAOYSA-N
1
70% at 120 micromolar
50% at 120 micromolar
000
54
OSM-S-120BrC1=CC2=NC=NC(C3=CC=CC=C3)=C2S1
InChI=1S/C12H7BrN2S/c13-10-6-9-12(16-10)11(15-7-14-9)8-4-2-1-3-5-8/h1-7H
TUFQXFIDQNLCGQ-UHFFFAOYSA-N
3#DIV/0!
55
OSM-S-121ClC1=C2C(C=C(Br)S2)=NC=N1
InChI=1S/C6H2BrClN2S/c7-4-1-3-5(11-4)6(8)10-2-9-3/h1-2H
RJKAKJGOZXERRE-UHFFFAOYSA-N
3#DIV/0!
56
OSM-S-122C12=NC=NC(C3=CC=CC=C3)=C1SC(C4=CC=CC=C4)=C2
InChI=1S/C18H12N2S/c1-3-7-13(8-4-1)16-11-15-18(21-16)17(20-12-19-15)14-9-5-2-6-10-14/h1-12H
QDXZKUSOZDDGPU-UHFFFAOYSA-N
3#DIV/0!
57
OSM-S-123NC1=C2C(C=C(C3=CC=CC=C3)S2)=NC=N1
InChI=1S/C12H9N3S/c13-12-11-9(14-7-15-12)6-10(16-11)8-4-2-1-3-5-8/h1-7H,(H2,13,14,15)
WQVHTLKGGYMXIO-UHFFFAOYSA-N
3#DIV/0!
58
OSM-S-124COC(C=C1)=CC=C1C2=CC3=NC=NC(N4CCOCC4)=C3S2
InChI=1S/C17H17N3O2S/c1-21-13-4-2-12(3-5-13)15-10-14-16(23-15)17(19-11-18-14)20-6-8-22-9-7-20/h2-5,10-11H,6-9H2,1H3
LPCKDTSEWUTBJN-UHFFFAOYSA-N
3#DIV/0!
59
OSM-S-125BrC1=CC2=NC=NC(N3CCOCC3)=C2S1
InChI=1S/C10H10BrN3OS/c11-8-5-7-9(16-8)10(13-6-12-7)14-1-3-15-4-2-14/h5-6H,1-4H2
WUXPEHRGQLOSNM-UHFFFAOYSA-N
3#DIV/0!
60
OSM-S-126C12=NC=NC(N3CCOCC3)=C1SC(C4=CC=CC=C4)=C2
InChI=1S/C16H15N3OS/c1-2-4-12(5-3-1)14-10-13-15(21-14)16(18-11-17-13)19-6-8-20-9-7-19/h1-5,10-11H,6-9H2
LBOQIBFHJGJRTG-UHFFFAOYSA-N
3#DIV/0!
61
OSM-S-127NS(C1=CC(C2=CC3=NC=NC(N4CCOCC4)=C3S2)=CC=C1)(=O)=O
InChI=1S/C16H16N4O3S2/c17-25(21,22)12-3-1-2-11(8-12)14-9-13-15(24-14)16(19-10-18-13)20-4-6-23-7-5-20/h1-3,8-10H,4-7H2,(H2,17,21,22)
MDGVTZLJAVLGJP-UHFFFAOYSA-N
3#DIV/0!
62
OSM-S-128NC1=C2C(C=C(C3=CC=C(C(C)(C)C)C=C3)S2)=NC=N1
InChI=1S/C16H17N3S/c1-16(2,3)11-6-4-10(5-7-11)13-8-12-14(20-13)15(17)19-9-18-12/h4-9H,1-3H3,(H2,17,18,19)
KLCMSKCOVXKOMY-UHFFFAOYSA-N
3#DIV/0!
63
OSM-S-129NC1=C2C(C=C(C3=CC=C(S(N)(=O)=O)C=C3)S2)=NC=N1
InChI=1S/C12H10N4O2S2/c13-12-11-9(15-6-16-12)5-10(19-11)7-1-3-8(4-2-7)20(14,17)18/h1-6H,(H2,13,15,16)(H2,14,17,18)
NPCFGALHIPAZAV-UHFFFAOYSA-N
3#DIV/0!
64
OSM-S-13PMY21757547CC1=CC=C(N2C(C)=C(C(O)=O)C=C2C)C=C1
InChI=1S/C14H15NO2/c1-9-4-6-12(7-5-9)15-10(2)8-13(11(15)3)14(16)17/h4-8H,1-3H3,(H,16,17)
YNFCEUIZSXIFCE-UHFFFAOYSA-N
1
70% at 120 micromolar
0000
65
OSM-S-130NC1=C2C(C=C(C3=CC=C(C(N(C)C)=O)C=C3)S2)=NC=N1
InChI=1S/C15H14N4OS/c1-19(2)15(20)10-5-3-9(4-6-10)12-7-11-13(21-12)14(16)18-8-17-11/h3-8H,1-2H3,(H2,16,17,18)
XJSSUNQWKKUSSC-UHFFFAOYSA-N
3#DIV/0!
66
OSM-S-131NC1=C2C(C=C(C3=CC=C(OC)C=C3)S2)=NC=N1
InChI=1S/C13H11N3OS/c1-17-9-4-2-8(3-5-9)11-6-10-12(18-11)13(14)16-7-15-10/h2-7H,1H3,(H2,14,15,16)
DRUQZXVTFOTIEO-UHFFFAOYSA-N
3#DIV/0!
67
OSM-S-132NC1=C2C(C=C(C3=CC=C(C(N4CCOCC4)=O)C=C3)S2)=NC=N1
InChI=1S/C17H16N4O2S/c18-16-15-13(19-10-20-16)9-14(24-15)11-1-3-12(4-2-11)17(22)21-5-7-23-8-6-21/h1-4,9-10H,5-8H2,(H2,18,19,20)
KOSDTDDFEYEHDU-UHFFFAOYSA-N
3#DIV/0!
68
OSM-S-133NC1=C2C(C=C(C3=CC=CC(C(N(C)C)=O)=C3)S2)=NC=N1
InChI=1S/C15H14N4OS/c1-19(2)15(20)10-5-3-4-9(6-10)12-7-11-13(21-12)14(16)18-8-17-11/h3-8H,1-2H3,(H2,16,17,18)
UZIAJWZVDQPKFB-UHFFFAOYSA-N
3#DIV/0!
69
OSM-S-134NC1=C2C(C=C(C3=CC=C(C(N4CCN(C)CC4)=O)C=C3)S2)=NC=N1
InChI=1S/C18H19N5OS/c1-22-6-8-23(9-7-22)18(24)13-4-2-12(3-5-13)15-10-14-16(25-15)17(19)21-11-20-14/h2-5,10-11H,6-9H2,1H3,(H2,19,20,21)
OUPUOWHKLRDGOE-UHFFFAOYSA-N
3#DIV/0!
70
OSM-S-135NC1=C2C(C=C(C3=CC=CC(C(N)=O)=C3)S2)=NC=N1
InChI=1S/C13H10N4OS/c14-12-11-9(16-6-17-12)5-10(19-11)7-2-1-3-8(4-7)13(15)18/h1-6H,(H2,15,18)(H2,14,16,17)
YWVZUIYPEKTRTJ-UHFFFAOYSA-N
3#DIV/0!
71
OSM-S-136BrC1=CC2=NC=NC(N3CCN(CC4=CC=C(F)C=C4)CC3)=C2S1
InChI=1S/C17H16BrFN4S/c18-15-9-14-16(24-15)17(21-11-20-14)23-7-5-22(6-8-23)10-12-1-3-13(19)4-2-12/h1-4,9,11H,5-8,10H2
DQEWYYDIDSUSJB-UHFFFAOYSA-N
3#DIV/0!
72
OSM-S-137
FC(C=C1)=CC=C1CN(CC2)CCN2C3=C4C(C=C(C5=CC=CC(S(N)(=O)=O)=C5)S4)=NC=N3
InChI=1S/C23H22FN5O2S2/c24-18-6-4-16(5-7-18)14-28-8-10-29(11-9-28)23-22-20(26-15-27-23)13-21(32-22)17-2-1-3-19(12-17)33(25,30)31/h1-7,12-13,15H,8-11,14H2,(H2,25,30,31)
OWXZZWFFXSEZNL-UHFFFAOYSA-N
3#DIV/0!
73
OSM-S-138MNR121CC1=CC(/C=C(S/2)/C(NC2=N\C3=CC=CC=C3)=O)=C(C)N1C4=CC=C(N)C=C4
InChI=1S/C22H20N4OS/c1-14-12-16(15(2)26(14)19-10-8-17(23)9-11-19)13-20-21(27)25-22(28-20)24-18-6-4-3-5-7-18/h3-13H,23H2,1-2H3,(H,24,25,27)/b20-13-
HRLJSVOIZGABSH-MOSHPQCFSA-N
12.32.3
74
OSM-S-139BrC1=CC2=NC=NC(N)=C2S1
InChI=1S/C6H4BrN3S/c7-4-1-3-5(11-4)6(8)10-2-9-3/h1-2H,(H2,8,9,10)
VKZWSZNMIMJBJX-UHFFFAOYSA-N
3#DIV/0!22
75
OSM-S-14PMY2218179364CC(N1C2=CC=C(C(F)(F)F)C=C2)=CC(C(O)=O)=C1C
InChI=1S/C14H12F3NO2/c1-8-7-12(13(19)20)9(2)18(8)11-5-3-10(4-6-11)14(15,16)17/h3-7H,1-2H3,(H,19,20)
LVAKCYJWXASSHB-UHFFFAOYSA-N
1
25% at 120 micromolar
0000
76
OSM-S-140BrC1=CC2=NC=NC(NN)=C2S1
InChI=1S/C6H5BrN4S/c7-4-1-3-5(12-4)6(11-8)10-2-9-3/h1-2H,8H2,(H,9,10,11)
KWCMTNUZOMHMJQ-UHFFFAOYSA-N
3#DIV/0!14
77
OSM-S-141CN(C)C1=C2C(C=CS2)=NC=N1
InChI=1S/C8H9N3S/c1-11(2)8-7-6(3-4-12-7)9-5-10-8/h3-5H,1-2H3
AXPZJYARDJLZHH-UHFFFAOYSA-N
3#DIV/0!18
78
OSM-S-142NC1=C2C(C=C(C3=CC(C(N4CCN(C)CC4)=O)=CC=C3)S2)=NC=N1
InChI=1S/C18H19N5OS/c1-22-5-7-23(8-6-22)18(24)13-4-2-3-12(9-13)15-10-14-16(25-15)17(19)21-11-20-14/h2-4,9-11H,5-8H2,1H3,(H2,19,20,21)
USHWEAINWXCOHP-UHFFFAOYSA-N
3>5#DIV/0!52
79
OSM-S-143ClC1=C2C(C=C(C3=CC(S(N)(=O)=O)=CC=C3)S2)=NC=N1
InChI=1S/C12H8ClN3O2S2/c13-12-11-9(15-6-16-12)5-10(19-11)7-2-1-3-8(4-7)20(14,17)18/h1-6H,(H2,14,17,18)
WDYQLTAMDQFUGG-UHFFFAOYSA-N
3#DIV/0!33
80
OSM-S-144NS(C1=CC=CC(C2=CC3=NC=NC(OCCN(C)C)=C3S2)=C1)(=O)=O
InChI=1S/C16H18N4O3S2/c1-20(2)6-7-23-16-15-13(18-10-19-16)9-14(24-15)11-4-3-5-12(8-11)25(17,21)22/h3-5,8-10H,6-7H2,1-2H3,(H2,17,21,22)
WBVWEEAUMTUSGX-UHFFFAOYSA-N
3#DIV/0!
81
OSM-S-145NS(C1=CC=CC(C2=CC3=NC=NC(N(C)C)=C3S2)=C1)(=O)=O
InChI=1S/C14H14N4O2S2/c1-18(2)14-13-11(16-8-17-14)7-12(21-13)9-4-3-5-10(6-9)22(15,19)20/h3-8H,1-2H3,(H2,15,19,20)
CGTVWFYTOADSRO-UHFFFAOYSA-N
3#DIV/0!23
82
OSM-S-146CC(C(C)(C)O1)(C)OB1C2=CC(S(NC(OC(C)(C)C)=O)(=O)=O)=CC=C2
InChI=1S/C17H26BNO6S/c1-15(2,3)23-14(20)19-26(21,22)13-10-8-9-12(11-13)18-24-16(4,5)17(6,7)25-18/h8-11H,1-7H3,(H,19,20)
MSQKEIBBVCULRN-UHFFFAOYSA-N
3#DIV/0!
83
OSM-S-147O=C(OC)C1=NC=CN=C1
InChI=1S/C6H6N2O2/c1-10-6(9)5-4-7-2-3-8-5/h2-4H,1H3
TWIIRMSFZNYMQE-UHFFFAOYSA-N
4#DIV/0!
84
OSM-S-148O=C(OC)C1=NC=C[N+]([O-])=C1
InChI=1S/C6H6N2O3/c1-11-6(9)5-4-8(10)3-2-7-5/h2-4H,1H3
ZTAQCRRTNOJVIU-UHFFFAOYSA-N
4#DIV/0!
85
OSM-S-149O=C(OC)C1=NC(Cl)=CN=C1
InChI=1S/C6H5ClN2O2/c1-11-6(10)4-2-8-3-5(7)9-4/h2-3H,1H3
MVVYUJFEXRODQA-UHFFFAOYSA-N
4#DIV/0!
86
OSM-S-15PMY26464O=C(C1=CC=CC=C1)NCC(O)=O
InChI=1S/C9H9NO3/c11-8(12)6-10-9(13)7-4-2-1-3-5-7/h1-5H,6H2,(H,10,13)(H,11,12)
QIAFMBKCNZACKA-UHFFFAOYSA-N
1#DIV/0!
87
OSM-S-150OC(C1=NC(Cl)=CN=C1)=O
InChI=1S/C5H3ClN2O2/c6-4-2-7-1-3(8-4)5(9)10/h1-2H,(H,9,10)
KGGYMBKTQCLOTE-UHFFFAOYSA-N
4#DIV/0!
88
OSM-S-151CC(C(C)(C)O1)(C)OB1C2=CC(S(N)(=O)=O)=CC=C2
InChI=1S/C12H18BNO4S/c1-11(2)12(3,4)18-13(17-11)9-6-5-7-10(8-9)19(14,15)16/h5-8H,1-4H3,(H2,14,15,16)
OHKKUZJVWWPUNY-UHFFFAOYSA-N
3#DIV/0!
89
OSM-S-152CC(C(C)(C)O1)(C)OB1C2=CC(S(NC)(=O)=O)=CC=C2
InChI=1S/C13H20BNO4S/c1-12(2)13(3,4)19-14(18-12)10-7-6-8-11(9-10)20(16,17)15-5/h6-9,15H,1-5H3
YIIPTCFKYOTDME-UHFFFAOYSA-N
3#DIV/0!
90
OSM-S-153CC(C(C)(C)O1)(C)OB1C2=CC(S(N(C)C)(=O)=O)=CC=C2
InChI=1S/C14H22BNO4S/c1-13(2)14(3,4)20-15(19-13)11-8-7-9-12(10-11)21(17,18)16(5)6/h7-10H,1-6H3
YFEWVSRTWWHXFP-UHFFFAOYSA-N
3#DIV/0!
91
OSM-S-154BrC1=CC(S(NC)(=O)=O)=CC=C1
InChI=1S/C7H8BrNO2S/c1-9-12(10,11)7-4-2-3-6(8)5-7/h2-5,9H,1H3
UVSNSICXRVZAJR-UHFFFAOYSA-N
3#DIV/0!
92
OSM-S-155BrC1=CC(S(N(C)C)(=O)=O)=CC=C1
InChI=1S/C8H10BrNO2S/c1-10(2)13(11,12)8-5-3-4-7(9)6-8/h3-6H,1-2H3
RHBJVOGENJVLGT-UHFFFAOYSA-N
3#DIV/0!
93
OSM-S-156CCOC(CCSCC(OCC)=O)=O
InChI=1S/C9H16O4S/c1-3-12-8(10)5-6-14-7-9(11)13-4-2/h3-7H2,1-2H3
VKVGPGWOHFRXIG-UHFFFAOYSA-N
3#DIV/0!
94
OSM-S-157O=C(OCC)C1SCCC1
InChI=1S/C7H12O2S/c1-2-9-7(8)6-4-3-5-10-6/h6H,2-5H2,1H3
VHDROBMEJHQSNW-UHFFFAOYSA-N
3#DIV/0!
95
OSM-S-158O=C(OC)C1=C(NC(C(F)(F)F)=O)C=CS1
InChI=1S/C8H6F3NO3S/c1-15-6(13)5-4(2-3-16-5)12-7(14)8(9,10)11/h2-3H,1H3,(H,12,14)
CJNCTQZMIQZVQQ-UHFFFAOYSA-N
3#DIV/0!
96
OSM-S-159IC1=CC2=NC=NC(N3CCOCC3)=C2S1
InChI=1S/C10H10IN3OS/c11-8-5-7-9(16-8)10(13-6-12-7)14-1-3-15-4-2-14/h5-6H,1-4H2
UZWIPNXYAJRTAG-UHFFFAOYSA-N
3#DIV/0!
97
OSM-S-16PMY2754704O=C(NC1=C(C)N(C)N(C2=CC=CC=C2)C1=O)CNC(C3=CC=CC=C3)=O
InChI=1S/C20H20N4O3/c1-14-18(20(27)24(23(14)2)16-11-7-4-8-12-16)22-17(25)13-21-19(26)15-9-5-3-6-10-15/h3-12H,13H2,1-2H3,(H,21,26)(H,22,25)
URWSDMBJVGVIQC-UHFFFAOYSA-N
1>5000>50
98
OSM-S-167BrC1=CC2=NC=NC(NC)=C2S1
InChI=1S/C7H6BrN3S/c1-9-7-6-4(10-3-11-7)2-5(8)12-6/h2-3H,1H3,(H,9,10,11)
ICKALLHQGIOSOG-UHFFFAOYSA-N
3#DIV/0!
99
OSM-S-168CNC1=C2C(C=CS2)=NC=N1
InChI=1S/C7H7N3S/c1-8-7-6-5(2-3-11-6)9-4-10-7/h2-4H,1H3,(H,8,9,10)
AZPMALJVBUIZFS-UHFFFAOYSA-N
3#DIV/0!
100
OSM-S-169CN(C)C1=C2C(C=C(Br)S2)=NC=N1
InChI=1S/C8H8BrN3S/c1-12(2)8-7-5(10-4-11-8)3-6(9)13-7/h3-4H,1-2H3
QWNQRCLDQDDVBK-UHFFFAOYSA-N
3#DIV/0!
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Malaria Molecules