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1 | Type | Date | Journal | Lead author | Study title | Abstract link | Publication link | Study findings | |||||||||||||||||||
2 | Publication | 7/7/2017 | PLOS One | Suosuo Yang, MD | Diagnostic Accuracy of Tablet-Based Software for the Detection of Concussion | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501428/pdf/pone.0179352.pdf | - This study examined the diagnostic accuracy of a BrainCheck battery of 6 neurocognitive tests for the detection of concussion. - Findings demonstrated consistent distributions of normative data and high test-restest reliability, sensitivity (83%) and specificity (87%) concluding that the BrainCheck testing application provides a rapid, portable testing method for TBI. | ||||||||||||||||||||
3 | Publication | 3/21/2019 | JMIR Publications | Samantha Groppell | A Rapid, Mobile Neurocognitive Screening Test to Aid in Identifying Cognitive Impairment and Dementia (BrainCheck): Cohort Study | https://aging.jmir.org/2019/1/e12615/ | - This study aimed to determine the accuracy and validity of BrainCheck Memory as a diagnostic aid for age-related cognitive impairment, as compared against physician diagnosis and other commonly used neurocognitive screening tests. - Findings demonstrated BrainCheck's concurrent validity to both the SLUMS exam and physician diagnossis with the BrainCheck composite score generating a high diagnostic sensitivity and specificity to both modalities. | ||||||||||||||||||||
4 | Publication | 5/16/2020 | medRxiv | Siao Ye | Validity of Computer Based Administration of Cognitive Assessments compared to Traditional Paper-Based Administration | https://www.medrxiv.org/content/10.1101/2020.05.12.20099507v1 | - A comparitive analysis of the BrainCheck assessment, a computer-based NPT battery, to traditional paper-based NPT’s, by evaluating individual tests as well as comparing composite scores to scores on traditional screening tools. - Analysis results showed that the BrainCheck composite score was correlated to the SLUMS exam, the MMSE, and the MoCA, concluding that BrainCheck may offer a computer-based avenue to address the gap between basic screening and formal neuropsychological testing. | ||||||||||||||||||||
5 | Publication | 5/29/2020 | medRxiv | Sanjeev Janarthanan | Use of Computerized Neurocognitive Assessment Software for the Detection of Alcohol Intoxication | https://www.medrxiv.org/content/10.1101/2020.05.12.20086868v2.full-text | - The purpose of this study was to explore the use of the BrainCheck battery to assess levels of alcohol impairment. - Using logistic regression models to classify intoxication, results from the best model demonstrated an 80.6% accuracy, 73.3% sensitivity, and 75.0% specificity for BrainCheck's ability to detect intoxication. - In conclusion, BrainCheck may provides another option to assess cognitive impairment due to alcohol, with the utility of being portable and available on a smartphone. | ||||||||||||||||||||
6 | Publication | 6/3/2020 | medRxiv | Siao Ye | Validation of Remote Testing using BrainCheck, a Computerized Neurocognitive Test | https://www.medrxiv.org/content/10.1101/2020.06.01.20119289v1 | - The primary aim of this analysis was to assess the BrainCheck battery across all administration platforms and interactions to observe any differences in assessment performance and establish the clinical efficacy of remote testing and self-administration. - In conclusion, the study results of 75 participants scores demonstrated that BrainCheck may be a robust, self-administered computerized neurocognitive testing solution with an appropriate adjustment for the platform used. | ||||||||||||||||||||
7 | Publication | 12/31/2020 | Exploration of Medicine | Siao Ye | Detection of Mild Traumatic Brain Injury in Pediatric Populations Using BrainCheck, a Tablet-Based Cognitive Testing Software: a Preliminary Study | https://www.explorationpub.com/Journals/em/Article/100127 | - This study explores the use of BrainCheck Sport, a computerized neurocognitive test that is available on iPad, iPhone, or computer desktop, for mTBI assessment. - BrainCheck Sport was able to detect significant differences in Coordination, Stroop, Immediate/Delayed Recognition between normal controls and mTBI patients. Receiver operating characteristic (ROC) analysis of our logistic regression model found a sensitivity of 84% and specificity of 81%. - BrainCheck Sport has potential in distinguishing mTBI from control participants, by providing a shorter, gamified test battery to assess cognitive function after brain injury, while also providing a method for tracking recovery with the opportunity to do so remotely from a patient’s home. | ||||||||||||||||||||
8 | Publication | 2/1/2021 | Journal of Functional Foods | Oluranti Mopelola Lawal | Consumption of Fresh Centella Asiatica Improves Short Term Alertness and Contentedness in Healthy Females | https://www.sciencedirect.com/science/article/pii/S1756464620305612#:~:text=Consumption%20of%20a%20smoothie%20containing,and%20contentedness%20after%20one%20hour.&text=No%20effect%20was%20observed%20on%20cognitive%20performance.&text=A%20dose–response%20effect%20for%20improving%20alertness%20was%20observed.&text=Clear%2Dheadedness%20was%20significantly%20enhanced%20even%20with%20a%20low%20dose%20smoothie. | - This study looks into the short-term effect of consuming fresh leaves of Centella asiatica on cognition and mood. Changes in different mood factors (alertness, calmness, contentedness) and cognitive functions, the latter of which were measured by the BrainCheck tests, were compared between three treatments (high dose vs. low dose vs. none of C. asiatica). - Results demonstrated significant improvements with higher concentration of C. asiatica for alertness and contentedness factors but not for cognitive functions. | ||||||||||||||||||||
9 | Publication | 2/16/2022 | Frontiers in Psychology | Ashley Henneghan | Cognitive Impairment in Non-Critical, Mild-to-Moderate COVID 19 Survivors | https://www.frontiersin.org/journals/psychology/articles/10.3389/fpsyg.2022.770459/full | - The aim of this study is to examine cognitive outcomes in cases of non-critical, mild-to-moderate COVID-19 by remotely administering cognitive-behavioral testing to determine the frequency of cognitive impairment and examine demographic, clinical, and psychosocial contributors to impairment. - Results found that the frequency of objective cognitive impairment was 40%. The largest number of participants (24%) showed impairment on a measure of executive functioning. Moderate COVID-19 severity was associated with attention/processing speed impairment (r = 0.27, p = 0.03), increased pain (r = 0.31, p = 0.01), and higher number of COVID-19 symptoms (r = 0.32, p = 0.01). | ||||||||||||||||||||
10 | Publication | 3/1/2022 | Journal of the American Association of Nurse Practitioners | Ashley Henneghan | Describing Cognitive Function and Psychosocial Outcomes of COVID-19 Survivors: A cross-sectional analysis | https://pubmed.ncbi.nlm.nih.gov/34469360/ | - The purpose of this study was to examine and characterize cognitive and related psychosocial symptoms in adults (21-75 years) who tested positive for or were treated as positive for COVID-19, with cognitive performance measured by the BrainCheck battery. - Findings demonstrated that cognitive dysfunction and psychological symptoms may be present in the weeks or months after COVID-19 diagnosis, even in those with mild to moderate illness severity. | ||||||||||||||||||||
11 | Publication | 4/15/2022 | JMIR Aging | Siao Ye | A Computerized Cognitive Test Battery for Detection of Dementia and Mild Cognitive Impairment: Instrument Validation Study | https://aging.jmir.org/2022/2/e36825 | - The aim of this study was to evaluate a computerized cognitive testing battery, BrainCheck, for its diagnostic accuracy and ability to distinguish the severity of cognitive impairment. - Analyses of the Overall BrainCheck Score show that classification between Normal Cognition, Mild Cognitive Impairment, and Dementia can be obtained with high accuracy (88% or higher sensitivity and specificity for separating dementia from NC, and 77% or higher sensitivity and specificity in separating the MCI group from the NC and dementia groups), suggesting BrainCheck can be used as a reliable tool for early detection of cognitive impairment. | ||||||||||||||||||||
12 | Publication | 10/11/2022 | Cancer Medicine | Oscar Franco-Rocha | Remote Assessment of Cognitive Dysfunction in Hematologic Malignancies Using Web-Based Neuropsychological Testing | https://onlinelibrary.wiley.com/doi/10.1002/cam4.5331 | - This research sought to examine cognitive functioning using BrainCheck, a web-based cognitive testing battery, to determine it's ability to detect differences between patients with cancer and healthy controls. - Findings showed that compared to controls, the cancer group demonstrated significantly lower scores in objective and subjective cognitive function, physical functioning, and social role performance and elevated fatigue scores. - Study results provide evidence for the BrainCheck battery's potential to detect differences in cognition between patients with cancer and healthy controls. | ||||||||||||||||||||
13 | Publication | 5/15/2023 | PLOS One | Heather Cuevas | The Role of Cognitive Rehabilitation in People with Type 2 Diabetes: A Study Protocol for a Randomized Controlled Trial | https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0285553 | - Diabetes is related to accelerated cognitive aging, cognitive deficits are related to poorer self-management, and improvements in cognitive performance as a result of cognitive rehabilitation can translate into improved performance in everyday life and, potentially, diabetes self-management. - The results of the proposed study will therefore potentially inform strategies to support cognitive function and diabetes self-management, as well as offer new mechanistic insights into cognitive function through the use of continuous glucose monitoring. | ||||||||||||||||||||
14 | Publication | 8/8/2023 | Surgery | William Lightle, MD, MPH | Objectively Measured Cognitive Dysfunction in Patients with Primary Hyperparathyroidism Improves After Parathyroidectomy | https://www.surgjournal.com/article/S0039-6060(23)00681-5/abstract# | - A relationship between primary hyperparathyroidism (PHPT) and decreased quality of life has been shown using patient-reported outcome measures, however, there remains a paucity of objectively measured data demonstrating cognitive dysfunction in patients with PHPT. - This research assessed whether parathyroidectomy resulted in quantifiable cognitive improvement. - Study results found that patients with PHPT experience objectively measurable cognitive changes associated with PHPT that can be reversed by parathyroidectomy, with improvements observed as early as 2 weeks after surgery. | ||||||||||||||||||||
15 | Publication | 8/13/2023 | Digit Health | Ashley Henneghan | Assessing Cancer-Related Cognitive Function in the Context of Everyday Life Using Ecological Mobile Cognitive Testing: A Protocol for a Prospective Quantitative Study | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10426293/ | - This publication presents the protocol for a study that aims to (1) establish the reliability and validity of ecological mobile cognitive testing to assess cancer-related cognitive impairment in breast cancer survivors, and (2) prospectively evaluate within-person processes (and interactions) among context, mood, and behavior that explain cognitive variability, everyday functioning, and quality of life of cancer survivors. | ||||||||||||||||||||
16 | Publication | 10/2023 | BrainCheck White Paper | Bin Huang, PhD | BrainCheck Screen Validation | https://braincheck.com/wp-content/uploads/2023/12/Screen-Validation-Whitepaper-VAL-SC10-001-Rev.-000.pdf | - Retrospective analysis of a clinical study involving 99 individuals, BrainCheck Screen correctly identified patients with cognitive impairment with 92% sensitivity and 74% specificity. - BrainCheck Screen's high sensitivity ensures minimal missed impaired cases, making it an effective pre-screening tool. | ||||||||||||||||||||
17 | Publication | 1/1/2024 | Geriatric Nursing | Jeeyon Kim | The Impact of Musical Reward Responses on Cognitive Function in Older Adults with Type 2 Diabetes | https://www.sciencedirect.com/science/article/abs/pii/S0197457223003087 | - This study investigated which factors of musical reward impact cognitive function in older adults with Type 2 Diabetes. A secondary data analysis was conducted with 185 older adults with Type 2 Diabetes and subjective cognitive decline. - The findings suggest that music interventions for older adults with Type 2 Diabetes may need to focus on managing their psychological states for the intervention to have beneficial effects on cognitive function. | ||||||||||||||||||||
18 | Publication | 2/2/2024 | Journal of Homosexuality | Oscar Franco-Rocha | An Exploratory Analysis of Contributors to Cognitive Functioning Among Sexual and Gender Minority Individuals Who Had COVID-19 | https://pubmed.ncbi.nlm.nih.gov/38305820/ | - In this secondary analysis of a remote study, researchers examined associations between cognitive and psychosocial health and explored differences between these health outcomes among sexual and gender minority (SGM) individuals and heterosexual cisgender adults who had COVID-19. - Findings demonstated that objective cognition was associated with age, SGM classification, racial or ethnic minority classification, income, comorbidities, COVID-19 severity, number of symptoms, and pain. Furthermore, subjective cognition was associated with comorbidities, number of symptoms, depression, anxiety, sleep disturbance, pain, and stress. | ||||||||||||||||||||
19 | Publication | 4/30/2024 | Journal of Audiology & Otology | Fawen Zhang, PhD | Cognitive Functions and Subjective Hearing in Cochlear Implant Users | https://www.ejao.org/journal/view.php?number=866 | - This study examined cognitive function among cochlear implant (CI) users by utilizing BrainCheck to investigate the relationship between cognitive performance and subjective evaluation of hearing. - Compared to controls, CI users exhibited poorer cognitive function in all domains except immediate and delayed recognition. - This study concludes that BrainCheck online cognitive testing is a convenient and effective tool to self-evaluate cognitive function in CI users. | ||||||||||||||||||||
20 | Publication | 4/1/2024 | Computer Informatics Nursing | Shennell Wood, BSN, RN | Development and Use of a Tech-Based Data Management System for a Cognitive Rehabilitation Randomized Controlled Trial for People With Type 2 Diabetes | https://journals.lww.com/cinjournal/abstract/2024/04000/development_and_use_of_a_tech_based_data.3.aspx | - This article describes the electronic process used to design and implement a technology-based data management system to implement a randomized controlled trial of a comprehensive cognitive rehabilitation intervention to improve cognitive function and diabetes self-management in people with type 2 diabetes. - The resulting framework offers a template to support the development of technology-based inter ventions. Initial development may be time-consuming, but the benefits of the technology-based format surpass any drawbacks. | ||||||||||||||||||||
21 | Publication | 8/2024 | American Journal of Physical Medicine & Rehabilitation | Mohanakrishnan Sathyamoorthy, MD, | Enhanced External Counterpulsation Improves Cognitive Function of Persons With Long COVID | https://pubmed.ncbi.nlm.nih.gov/38206585/ | - The study involved participants with persistent cognitive symptoms following COVID-19 infection. - They underwent a series of EECP sessions, and their cognitive functions were assessed before and after the treatment. - The results indicated significant improvements in cognitive performance post-EECP, suggesting that this therapy may be beneficial in alleviating cognitive deficits associated with Long COVID. | ||||||||||||||||||||
22 | Publication | 8/2024 | Science Diabetes Self-Management and Care | Heather Cuevas | Perceived Cognitive Function and Glycemic Variability: Baseline Results From a Cognitive Rehabilitation Intervention | https://pubmed.ncbi.nlm.nih.gov/39044609/ | - The researchers found that individuals with higher glycemic variability reported lower perceived cognitive function. This suggests that fluctuations in blood glucose levels may negatively impact cognitive perceptions in this population. - These findings highlight the importance of maintaining stable blood glucose levels to potentially preserve cognitive function in adults with type 2 diabetes. | ||||||||||||||||||||
23 | Publication | 9/2024 | Fronteirs in Psychology | Duong Huynh, PhD | Comparing Psychometric Characteristics of a Computerized Cognitive Test (BrainCheck-Assess) against the Montreal Cognitive Assessment (MoCA) | https://www.frontiersin.org/journals/psychology/articles/10.3389/fpsyg.2024.1428560/full | - In this study, researchers examined: (1) the linear relationship between BC-Assess and MoCA and their equivalent cut-off scores, and (2) the extent to which they agree on their impressions of an individual's cognitive status. - Study findings demonstrated that the BrainCheck-Assess battery and the MoCA show a high degree of agreement in their impressions based on their recommended cut-offs: (i) for differentiating dementia from MCI/NC; (ii) and for differentiating dementia/MCI from NC. - This study provides further validation of BrainCheck-Assess in a sample of older adults by showing its high correlation and agreement in impression with the widely used MoCA. | ||||||||||||||||||||
24 | Publication | 01/03/2025 | Digital Health | Ashley Henneghan | Feasibility and psychometric quality of smartphone administered cognitive ecological momentary assessments in women with metastatic breast cancer | https://pubmed.ncbi.nlm.nih.gov/39758254/ | - This study examined the feasibility and psychometric quality of smartphone-administered cognitive ecological momentary assessments (EMAs) in women with metastatic breast cancer. - The researchers found that using smartphones to deliver cognitive EMAs in this population is both feasible and reliable. Participants were able to complete the assessments with minimal technical issues, and the data collected demonstrated strong psychometric properties. - These findings suggest that smartphone-based cognitive EMAs can be a valuable tool for real-time monitoring of cognitive function in women with metastatic breast cancer, potentially aiding in personalized treatment approaches. | ||||||||||||||||||||
25 | Publication | 01/29/2025 | Ethnicity and Health | Heather Cuevas | Adaptation of the Florida Cognitive Activities Scale for Latinx adults with chronic diseases | https://www.tandfonline.com/doi/abs/10.1080/13557858.2025.2458306 | - Instrumentation study in three phases to adapt the Florida Cognitive Activities Scale (FCAS) - The FACS-L was administered to 70 participants (mean age 62.17 years; 57% female; 51% Mexican American) with BrainCheck used to measure cognitive functioning. - Spanish-speaking participants successfully completed BrainCheck Assess with appropriate language localization. - Completion rates were similar across ethnic and language groups, supporting accessibility. - 92% of participants completed the BrainCheck assessment via telehealth. | ||||||||||||||||||||
26 | Publication | 02/26/2025 | Fatigue: Biomedicine, Health, and Behavior | Deborah Duricka | Stellate Ganglion Block reduces symptoms of SARS-CoV-2-induced ME/CFS: A prospective cohort pilot study | https://www.tandfonline.com/doi/full/10.1080/21641846.2025.2455876#abstract | - Objective: Determine the effect of stellate ganglion block (SGB) on symptoms of ME/CFS. - BrainCheck Assess was the primary digital assessment tool used in the telehealth workflow and was used to administer cognitive testing remotely by trained facilitators with support from community partners. - BrainCheck scores were used to guide clinical recommendations (e.g., no follow-up, re-screening, or referral for further evaluation). - Results aligned with clinical judgment and follow-up decisions made by neurologists and social workers. | ||||||||||||||||||||
27 | Publication | 02/26/2025 | JMIR Aging | Duong Huynh, PhD | Performance of a Digital Cognitive Assessment in Predicting Dementia Stages Delineated by the Dementia Severity Rating Scale: Retrospective Study | https://aging.jmir.org/2025/1/e65292 | - Objective: Evaluate how well the BrainCheck digital cognitive assessment predicts dementia severity stages, using the Dementia Severity Rating Scale (DSRS) as a reference. - Design: Retrospective analysis using real-world clinical data from 646 patients across the U.S. - Findings: BrainCheck’s composite cognitive scores were significantly associated with DSRS scores. - It successfully differentiated between normal cognition, mild cognitive impairment (MCI), and dementia. | ||||||||||||||||||||
28 | Publication | 03/18/2025 | Geriatric Nursing | Jeeyon Kim, PhD | Associations between physical activity, glucose variability, and cognitive function in older adults with type 2 diabetes | https://www.sciencedirect.com/science/article/abs/pii/S0197457225001181 | - This study aimed to examine the relationships among PA, glucose variability, and cognitive function in older adults with T2DM and explore whether glucose variability mediates this relationship. - Physical activity is associated with better cognitive function only in the low cognitive function group. - Glucose variability was not associated with physical activity and cognitive function. - Physical activity may be beneficial for older adults with type 2 diabetes who already exhibit some cognitive decline. | ||||||||||||||||||||
29 | Publication | 07/02/2025 | Frontiers in Digital Health | Duong Huynh, PhD | Reliability of remote self-administered digital cognitive assessments: preliminary validation study | https://www.frontiersin.org/journals/digital-health/articles/10.3389/fdgth.2025.1571053/full | - BrainCheck Assess is a reliable and feasible tool for remote cognitive testing: self-administration produces results statistically indistinguishable from in-person, coordinator-led sessions. - It maintains strong consistency across devices and demographics. - Age-related cognitive patterns emerge as expected, supporting cognitive validity. - These findings support BC‑Assess as a strong option for unsupervised tele-neuropsychological screening, especially useful for remote or underserved populations. | ||||||||||||||||||||
30 | Publication | 08/08/2025 | International Journal of Molecular Sciences | Ghazaleh Azimi | Circulating FGF-21 as a Disease-Modifying Factor Associated with Distinct Symptoms and Cognitive Profiles in Myalgic Encephalomyelitis and Fibromyalgia | https://www.mdpi.com/1422-0067/26/16/7670 | - BrainCheck can effectively monitor cognitive improvements or side effects over time in response to interventions - BrainCheck can serve as a robust tool to further explore how FGF-21 levels correlate with specific cognitive domains (e.g., processing speed, memory, executive function) - Given the correspondence between high FGF-21 and improved cognition (in ME) and poor mental health/PEM (in low FGF-21), BrainCheck could help delineate cognitive subprofiles within these disorders—especially when paired with FGF-21 measurement. | ||||||||||||||||||||
31 | Publication | 08/28/2025 | Journal of Translational Medicine | Atefeh Moezzi | Haptoglobin phenotypes and structural variants associate with post-exertional malaise and cognitive dysfunction in myalgic encephalomyelitis | https://link.springer.com/article/10.1186/s12967-025-07006-z | - This study uses BrainCheck in a provocation (stress) paradigm (pre/post exertion) to capture cognitive fluctuations. BrainCheck may be well-suited for dynamic cognitive assessments (not just static screening) — e.g., baseline → stress → follow-up changes. - BrainCheck can serve as a functional outcome tool linked to molecular/physiologic pathways. - Findings show ME patients showed a significant reduction in plasma Hp levels after exertional stress (T90) compared to baseline; healthy controls did not. | ||||||||||||||||||||
32 | Publication | 09/24/2025 | Oxford Academic’s Public Policy & Aging Report. | Shaoqing Ge, PhD, MPH, RN | Exploring neurologists’ perspectives: barriers and facilitators in implementing cognitive care planning | https://academic.oup.com/ppar/advance-article-abstract/doi/10.1093/ppar/praf014/8263163?redirectedFrom=fulltext#no-access-message | - Neurologists identified clear implementation barriers—including limited post-diagnostic resources, time constraints, and EHR workflow gaps—highlighting the need for integrated, efficient tools to support Cognitive Care Planning (CCP). - BrainCheck’s CCP directly addresses these needs through pre-visit digital assessments, templated EMR workflows, and collaborative care models that streamline documentation and enhance patient engagement. - Findings reinforce BrainCheck’s leadership in Collaborative Care for Cognition, positioning the platform as a scalable, multidisciplinary solution for improving cognitive care delivery across both specialty and primary care settings. | ||||||||||||||||||||
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