KIB - Antibiotics (public)
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Antibiotic abacusby Information is BeautifulAntibiotic family (group)PenicillinsPenicillinsAminoglycosidesAminoglycosidesOtherMacrolidesMacrolidesOtherGlycopeptidesTetracyclinesAminoglycosidesPenicillinsPenicillins (Aminopenicillins)PenicillinsNitroimidazolesPenicillins (Aminopenicillins)SulfonamidesCephalosporins (First generation)PCephalosporins (First generation)AminoglycosidesFluoroquinolonesFluroquinolonesRifamycinLincosamidesSulfonamides / other*AminoglycosidesPenicillinsCephalosporins (Third generation)Cephalosporins (Third generation)Cephalosporins (Third generation)CarbapenemsCarbapenemsPenicillins FluroquinolonesFluroquinolonesPenicillinsMulti-drugRemarksResistance scoreN antibiotics or classesAverage % resistanceSources
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Adding up drug resistancedata are % of bacteria that are resistant, US
x = resistance, but unquantified
Individual drugallPenicillinallStreptomycinChloramphenicolallErythromycinIsoniazidVancomycinTetracyclineKanamycinOxacillinallMethicillinMetronidazoleAmpicillin SulfamethoxazoleallCefalotinGentamicinallNalidixic acidRifampicinClindamycinTrimethoprim-sulfaAmikacinAmoxicillin-clavulanic acidallCeftriaxoneCeftazidimeallImipenemAmpicillin-sulbactam CeftiofurCiprofloxacinMoxifloxacinPiperacillin-tazobactam* TMP-SFX is a mixture of 1 part trimethoprim to 5 parts sulfamethoxazole1 least worrying - 4 most worryingat least some resistanceentries with numeric datahttp://www.cddep.org/resistancemap/overview
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Bacterium nameCausesGram negative?
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A. baumanii"Iraqibacter" - pneumonia, meningitisyesxx46%xxxx58%0%0%xxx52%41%x25%x51%increasing rapidly41831.71%
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K. pneumoniaepneumonia, bronchitis, urinary infectionsyes8%11%15%23%11%6%2513.60%
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E. faeciumurinary infections75%19%1247.00%
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N. gonorrhoeaegonorrhoeayes30%xx0.4%13%14%30%3614.35%
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Shigelladysentryyes56%14%45%0.9%78%47%6%0.2%2%1%46%0.06%2%0%0.06%0.06%x64%41618.64%
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M. tuberculosistuberculosis9%xxxxxx60%extremely drug-resistant variant379.00%
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P. mirabiliskidney stones, proteus9%22%28%27%2%0.6%resistance increasing steadily2517.60%
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CoNSfood poisoningxx0%16%63%x50%x33%34%x13%resistance decreasing steadily3932.67%
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C. difficilesevere diarrhoea, colitis11%3%0%x10%28%x39%3715.17%
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P. aeruginosalung, urinary, skin, wound & blood infectionsyes15%27%10%14%12%10%40% in Greece2515.60%
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S. pneumoniaepneumonia, meningitis & many other infections8%41%8%1224.50%
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E. colifood poisoningyes9%45%33%25%15%1.5%2525.40%
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S. aureusboils, sinusitis, food poisoning51%0.8%1125.90%
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After 1992: the development gap: no major new antibiotics developed for 20 years
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gram-negative bacteriastrong membrane, more resistant
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Date introduced19421944194919521952195519551958195919601960196119611964196419671967196819681976198119821983198519871987198719891992Substances separated by a dash e.g. Ampicillin-sulbactam are antibiotics administered with another agenthttp://apps.who.int/iris/bitstream/10665/112642/1/9789241564748_eng.pdf
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antibiotic resistance
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multi-drug-resistance
Consumption, US
Consumption, Eur.
Timeline 3 - MRSA