Public_2308W_annotation.xlsx
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Locus_tag in 2308WGene_synonymLocus_tag in 2308flagStartStopStrandProductNotesReference 1Reference 2Reference 3
4
BAW_10001dnaABAB1_00017842274chromosomal replication initiationproteinbinds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation ofchromosomal replication; can also affect transcription of multiple genes including itself.Chain et al. 2005. Infect Immun. 73:8353-61Brucella abortus 2308; accesion number NC_007618
5
BAW_10002dnaNBAB1_000225033696DNA polymerase III subunit betabinds the polymerase to DNA and acts as a sliding clampChain et al. 2005. Infect Immun. 73:8353-61Brucella abortus 2308; accesion number NC_007618
6
BAW_10003recFBAB1_000338785032recombination protein FRequired for DNA replication; binds preferentially to single-stranded; linear DNAChain et al. 2005. Infect Immun. 73:8353-61Brucella abortus 2308; accesion number NC_007618
7
BAW_10004moeBBAB1_000450705852molybdopterin biosynthesis proteinMoeBATP-dependent adenylate transferase; transfers adenyl moiety to the MoeD subunit of molybdopterin synthaseChain et al. 2005. Infect Immun. 73:8353-61Brucella abortus 2308; accesion number NC_007618
8
BAW_10005BAW_10005BAB1_000558696825cpyridine nucleotide-disulfide oxidoreductaseChain et al. 2005. Infect Immun. 73:8353-61Brucella abortus 2308; accesion number NC_007618
9
BAW_10006BAW_10006BAB1_000668228447cABC transporter ATPaseChain et al. 2005. Infect Immun. 73:8353-61Brucella abortus 2308; accesion number NC_007618
10
BAW_10007BAW_10007BAB1_000784719610cABC transporter permeaseChain et al. 2005. Infect Immun. 73:8353-61Brucella abortus 2308; accesion number NC_007618
11
BAW_10008BAW_10008BAB1_0008961010707cABC transporter permeaseChain et al. 2005. Infect Immun. 73:8353-61Brucella abortus 2308; accesion number NC_007618
12
BAW_10009BAW_10009BAB1_00091081912633csolute-binding family 5 proteinChain et al. 2005. Infect Immun. 73:8353-61Brucella abortus 2308; accesion number NC_007618
13
BAW_10010BAW_10010BAB1_00101268014548csolute-binding family 5 proteinChain et al. 2005. Infect Immun. 73:8353-61Brucella abortus 2308; accesion number NC_007618
14
BAW_10011BAW_10011BAB1_00111477915102cpredicted proteinChain et al. 2005. Infect Immun. 73:8353-61Brucella abortus 2308; accesion number NC_007618
15
BAW_10012BAW_10012BAB1_00121514815348cpredicted proteinChain et al. 2005. Infect Immun. 73:8353-61Brucella abortus 2308; accesion number NC_007618
16
BAW_10013BAW_10013BAB1_00131538815738cpredicted proteinChain et al. 2005. Infect Immun. 73:8353-61Brucella abortus 2308; accesion number NC_007618
17
BAW_10014BAW_10014BAB1_0014pseudo1600317171cFrame shift. Leu/Ile/Val-binding protein family:Extracellular ligand-binding receptor; similar to BMEI1930DelVecchio et al. 2002. Proc Natl Acad Sci U S A. 99(1):443-8.Brucella melitensis 16M genome; accession number NC_003317
18
BAW_10015BAW_10015BAB1_00151738017580predicted proteinChain et al. 2005. Infect Immun. 73:8353-61Brucella abortus 2308; accesion number NC_007618
19
BAW_10016BAW_10016BAB1_00161757718371cenoyl-CoA hydrataseCatalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoAChain et al. 2005. Infect Immun. 73:8353-61Brucella abortus 2308; accesion number NC_007618
20
BAW_10017BAW_10017BAB1_00171836819231chydroxymethylglutaryl-CoA lyasecatalyzes the formation of acetoacetate and acetyl-CoA from 3-hydroxy-3-methylglutaryl-CoAChain et al. 2005. Infect Immun. 73:8353-61Brucella abortus 2308; accesion number NC_007618
21
BAW_10018BAW_10018BAB1_00181922421245cmethylcrotonoyl-CoA carboxylaseChain et al. 2005. Infect Immun. 73:8353-61Brucella abortus 2308; accesion number NC_007618
22
BAW_10019BAW_10019BAB1_00192125722864ccarboxyl transferaseChain et al. 2005. Infect Immun. 73:8353-61Brucella abortus 2308; accesion number NC_007618
23
BAW_10020ivdBAB1_0020pseudo2286423694cDeletion at N-terminal; predicted protein; similar to BS1330_I0020Brucella suis 1330 genome; accesion number NC_004310Paulsen et al. 2002. Proc Natl Acad Sci U S A. 99(20):13148-53
24
BAW_10021BAW_10021BAB1_0021pseudo2330724356cTruncation; similar to 4'-mycarosyl isovaleryl-CoA transferase [Brucella abortus str. 2308 A] and to BS1330_I0023 (Brucella suis 1330)Brucella suis 1330 genome; accesion number NC_004310Brucella abortus 2308A accession number GCA_000182625.1
25
BAW_10022BAW_10022BAB1_00222487925262cpredicted proteinChain et al. 2005. Infect Immun. 73:8353-61Brucella abortus 2308; accesion number NC_007618
26
BAW_10023aroABAB1_002325647269993-phosphoshikimate 1-carboxyvinyltransferasecatalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvateand3-phosphoshikimate in tryptophan biosynthesisChain et al. 2005. Infect Immun. 73:8353-61Brucella abortus 2308; accesion number NC_007618
27
BAW_10024cmkBAB1_00242699627655cytidylate kinaseCatalyzes the formation of (d)CDP from ATP and (d)CMPChain et al. 2005. Infect Immun. 73:8353-61Brucella abortus 2308; accesion number NC_007618
28
BAW_10025rpsABAB1_0025278712957130S ribosomal protein S1in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs andisitselfbound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteinsChain et al. 2005. Infect Immun. 73:8353-61Brucella abortus 2308; accesion number NC_007618
29
BAW_10026BAW_10026BAB1_00262998930999cmembrane proteinChain et al. 2005. Infect Immun. 73:8353-61Brucella abortus 2308; accesion number NC_007618
30
BAW_10027lysR13BAB1_00273111532014transcriptional regulator LysRHaine et al; Infect Immun. 2005 Sep;73(9):5578-86.
31
BAW_10028BAW_10028BAB1_00283261933902clytic murein transglycosylaseChain et al. 2005. Infect Immun. 73:8353-61Brucella abortus 2308; accesion number NC_007618
32
BAW_10029recRBAB1_00293391834523crecombination protein RecRinvolved in a recombinational process of DNA repair; independent of the recBC complexChain et al. 2005. Infect Immun. 73:8353-61Brucella abortus 2308; accesion number NC_007618
33
BAW_10030BAW_10030BAB1_00303465434977cpredicted proteinChain et al. 2005. Infect Immun. 73:8353-61Brucella abortus 2308; accesion number NC_007618
34
BAW_10031BAW_10031BAB1_00313500236810cDNA polymerase III subunits gammaand taucatalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chainserves asa scaffold to help in the dimerizaton of the alpha;epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNAChain et al. 2005. Infect Immun. 73:8353-61Brucella abortus 2308; accesion number NC_007618
35
BAW_10032ffsffs3691637035ffsChain et al. 2005. Infect Immun. 73:8353-61Brucella abortus 2308; accesion number NC_007618
36
BAW_10033BAW_10033BAB1_00323709237496histidine triad proteinChain et al. 2005. Infect Immun. 73:8353-61Brucella abortus 2308; accesion number NC_007618
37
BAW_10034BAW_10034BAB1_00333752538472NUDIX hydrolaseChain et al. 2005. Infect Immun. 73:8353-61Brucella abortus 2308; accesion number NC_007618
38
BAW_10035pheABAB1_00343847339336cprephenate dehydratasecatalyzes the formation of phenylpyruvate from prephenate in phenylalanine biosynthesisChain et al. 2005. Infect Immun. 73:8353-61Brucella abortus 2308; accesion number NC_007618
39
BAW_10036kdsBBAB1_00353942540180c3-deoxy-manno-octulosonate cytidylyltransferaseCMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPSChain et al. 2005. Infect Immun. 73:8353-61Brucella abortus 2308; accesion number NC_007618
40
BAW_10037BAW_10037BAB1_00364055841166cysteine desulfuraseChain et al. 2005. Infect Immun. 73:8353-61Brucella abortus 2308; accesion number NC_007618
41
BAW_10038BAW_10038BAB1_00374121142176cmolybdopterin biosynthesis enzymeChain et al. 2005. Infect Immun. 73:8353-61Brucella abortus 2308; accesion number NC_007618
42
BAW_10039BAW_10039BAB1_00384270343728cytochrome o ubiquinol oxidase subunit IIChain et al. 2005. Infect Immun. 73:8353-61Brucella abortus 2308; accesion number NC_007618
43
BAW_10040qoxBBAB1_0039-0040pseudo4380845786Frame shift. Cytochrome c oxidase; subunit I; similar to BS1330_I0043 (Brucella suis 1330)Brucella suis 1330 genome; accesion number NC_004310Paulsen et al. 2002. Proc Natl Acad Sci U S A. 99(20):13148-53
44
BAW_10041BAW_10041BAB1_00414579046419cytochrome c oxidase subunit IIIChain et al. 2005. Infect Immun. 73:8353-61Brucella abortus 2308; accesion number NC_007618
45
BAW_10042qoxDBAB1_00424641946784cytochrome C oxidase subunit IVChain et al. 2005. Infect Immun. 73:8353-61Brucella abortus 2308; accesion number NC_007618
46
BAW_10043BAW_10043BAB1_00434678147059chistidine kinaseChain et al. 2005. Infect Immun. 73:8353-61Brucella abortus 2308; accesion number NC_007618
47
BAW_10044BAW_10044BAB1_00444741847747peptide-binding proteinno differences found to consider it a pseudogeneChain et al. 2005. Infect Immun. 73:8353-61Brucella abortus 2308; accesion number NC_007618
48
BAW_10045tamABAB1_00454823250151surface antigenBacterial surface antigen (D15)Chain et al. 2005. Infect Immun. 73:8353-61Brucella abortus 2308; accesion number NC_007618
49
BAW_10046tamBBAB1_00465034054887Autotransporter translocation and assembly factor TamBThis protein translocates adhesins and is essential for full virulence and intracelullar traffickingLamontagne et al. 2010. BMC Genomics. 11:300
50
BAW_10047BAW_10047BAB1_00475503255757predicted proteinChain et al. 2005. Infect Immun. 73:8353-61Brucella abortus 2308; accesion number NC_007618
51
BAW_10048BAW_10048BAB1_00485580856023cpredicted proteinChain et al. 2005. Infect Immun. 73:8353-61Brucella abortus 2308; accesion number NC_007618
52
BAW_10049BAW_10049BAB1_00495609356596cpredicted proteinChain et al. 2005. Infect Immun. 73:8353-61Brucella abortus 2308; accesion number NC_007618
53
BAW_10050BAW_10050BAB1_00505693457140cpredicted proteinChain et al. 2005. Infect Immun. 73:8353-61Brucella abortus 2308; accesion number NC_007618
54
BAW_10051BAW_10051BAB1_00515715158155cCopper binding proteinThis protein binds copper and is related to inorganic ion transport and metabolismLamontagne et al. 2010. BMC Genomics. 11:300
55
BAW_10052BAW_10052BAB1_00525829058688cpredicted proteinChain et al. 2005. Infect Immun. 73:8353-61Brucella abortus 2308; accesion number NC_007618
56
BAW_10053BAW_10053BAB1_00535890959304clactoylglutathione lyaseChain et al. 2005. Infect Immun. 73:8353-61Brucella abortus 2308; accesion number NC_007618
57
BAW_10054BAW_10054BAB1_00545950160664sodium:proton antiporterChain et al. 2005. Infect Immun. 73:8353-61Brucella abortus 2308; accesion number NC_007618
58
BAW_10055pgmBAB1_00556090162532cphosphoglucomutasecatalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphateChain et al. 2005. Infect Immun. 73:8353-61Brucella abortus 2308; accesion number NC_007618
59
BAW_10056BAW_10056BAB1_00566258862773cpredicted proteinChain et al. 2005. Infect Immun. 73:8353-61Brucella abortus 2308; accesion number NC_007618
60
BAW_10057BAW_10057BAB1_00576274863641ctranscriptional regulator LysRHaine et al; Infect Immun. 2005 Sep;73(9):5578-86.
61
BAW_10058BAW_10058BAB1_00586376664689esterase/lipase/thioesteraseChain et al. 2005. Infect Immun. 73:8353-61Brucella abortus 2308; accesion number NC_007618
62
BAW_10059frcKBAB1_00596476265460nucleoside triphosphate hydrolaseChain et al. 2005. Infect Immun. 73:8353-61Brucella abortus 2308; accesion number NC_007618
63
BAW_10060BAW_10060BAB1_00606556066249fumarylacetoacetate (FAA) hydrolaseChain et al. 2005. Infect Immun. 73:8353-61Brucella abortus 2308; accesion number NC_007618
64
BAW_10061BAW_10061BAB1_00616626966460predicted proteinChain et al. 2005. Infect Immun. 73:8353-61Brucella abortus 2308; accesion number NC_007618
65
BAW_10062BAW_10062BAB1_00626652266737predicted proteinChain et al. 2005. Infect Immun. 73:8353-61Brucella abortus 2308; accesion number NC_007618
66
BAW_10063BAW_10063BAB1_00636690367091Protein with unknown functionProtein with unknown functionLamontagne et al. 2010. BMC Genomics. 11:300
67
BAW_10064BAW_10064BAB1_00646710667969SLT domain-containing proteinChain et al. 2005. Infect Immun. 73:8353-61Brucella abortus 2308; accesion number NC_007618
68
BAW_10065BAW_10065BAB1_00656815168807Hly-III-like proteinChain et al. 2005. Infect Immun. 73:8353-61Brucella abortus 2308; accesion number NC_007618
69
BAW_10066dnaE2BAB1_00666894872181cerror-prone DNA polymeraseDNA polymerase involved in damage-induced mutagenesis and translesion synthesis. It is not the major replicative DNA polymerase.Chain et al. 2005. Infect Immun. 73:8353-61Brucella abortus 2308; accesion number NC_007618
70
BAW_10067BAW_10067BAB1_00677218173632cpredicted proteinChain et al. 2005. Infect Immun. 73:8353-61Brucella abortus 2308; accesion number NC_007618
71
BAW_10068BAW_10068BAB1_00687365874521cpredicted proteinChain et al. 2005. Infect Immun. 73:8353-61Brucella abortus 2308; accesion number NC_007618
72
BAW_10069btaEBAB1_00697574477942btaE; hyaluronate-binding autotransporter adhesin
An adhesin that belongs to the trimeric autotransporter family; is required for full virulence and defines a specific adhesive pole of Brucella suis. Infect Immun 81:996-1007 (2013). This autotransporter is one of the four predicted in Brucella genomes and it has been suggested that the combination present in each genome is related to host and tissue tropism. Other autotransporters with different degree of similarity are encoded in BOV_A0152; BOV_A1053; and BOV_1937 (pseudogene in B ovis; marine isolates and B abortus). All are pseudogenes in B melitensis 16M
Ruiz-Ranwez et al. 2013. Infect Immun. 81(3):996-1007
73
BAW_10070BAW_10070BAB1_00707815178699predicted proteinChain et al. 2005. Infect Immun. 73:8353-61Brucella abortus 2308; accesion number NC_007618
74
BAW_10071argGBAB1_00717877879998cargininosuccinate synthasecatalyzes the formation of 2-N(omega)-(L-arginino)succinate from L-citrulline and L-aspartate in arginine biosynthesis; AMP-formingChain et al. 2005. Infect Immun. 73:8353-61Brucella abortus 2308; accesion number NC_007618
75
BAW_10072BAW_10072BAB1_00728018580844lysine exporter protein LysE/YggAChain et al. 2005. Infect Immun. 73:8353-61Brucella abortus 2308; accesion number NC_007618
76
BAW_10073BAW_10073BAB1_00738084881351cpredicted proteinChain et al. 2005. Infect Immun. 73:8353-61Brucella abortus 2308; accesion number NC_007618
77
BAW_10074BAW_10074BAB1_00748138582620cpredicted proteinChain et al. 2005. Infect Immun. 73:8353-61Brucella abortus 2308; accesion number NC_007618
78
BAW_10075BAW_10075BAB1_00758288083383cpredicted proteinPutative uncharacterized proteinChain et al. 2005. Infect Immun. 73:8353-61Brucella abortus 2308; accesion number NC_007618
79
BAW_10076BAW_10076BAB1_00768383184214cpredicted proteinChain et al. 2005. Infect Immun. 73:8353-61Brucella abortus 2308; accesion number NC_007618
80
BAW_10077phhBBAB1_00778430284595cpterin-4-alpha-carbinolamine dehydratase4-alpha-hydroxytetrahydrobiopterin dehydratase activity; catalyzes the formation of (6R)-6-(L-erythro-1;2-dihydroxypropyl)-7; 8-dihydro-6H-pterin from (6R)-6-(L-erythro-1;2-dihydroxypropyl)-5;6;7; 8-tetrahydro-4a-hydroxypterin; functions in recycling tetrahydrobiopterin (BH4) in phenylalanine hydroxylase reactionChain et al. 2005. Infect Immun. 73:8353-61Brucella abortus 2308; accesion number NC_007618
81
BAW_10078BAW_10078BAB1_0078-0079pseudo8482285425Frame shift. Low molecular weight phosphotyrosine protein phosphatase. Similar to BS1330_I0083 (Brucella suis 1330)Brucella suis 1330 genome; accesion number NC_004310Paulsen et al. 2002. Proc Natl Acad Sci U S A. 99(20):13148-53
82
BAW_10079BAW_10079BAB1_00808533585925c2`-5` RNA ligaseChain et al. 2005. Infect Immun. 73:8353-61Brucella abortus 2308; accesion number NC_007618
83
BAW_10080BAW_10080BAB1_00818610686831cGDSL family lipaseLipolytic enzyme; G-D-S-L familyChain et al. 2005. Infect Immun. 73:8353-61Brucella abortus 2308; accesion number NC_007618
84
BAW_10081BAW_10081BAB1_00828697887706sugar ABC transporter ATPaseChain et al. 2005. Infect Immun. 73:8353-61Brucella abortus 2308; accesion number NC_007618
85
BAW_10082BAW_10082BAB1_00838770390252predicted proteinChain et al. 2005. Infect Immun. 73:8353-61Brucella abortus 2308; accesion number NC_007618
86
BAW_10083yccABAB1_00849048691223predicted proteinChain et al. 2005. Infect Immun. 73:8353-61Brucella abortus 2308; accesion number NC_007618
87
BAW_10084patBAB1_0085-0086pseudo9133891876Frame shift; phosphinothricin N-acetyltransferase; similar to BS1330_I0089 (Brucella suis 1330)Brucella suis 1330 genome; accesion number NC_004310Paulsen et al. 2002. Proc Natl Acad Sci U S A. 99(20):13148-53
88
BAW_10085BAW_10085BAB1_00879189692297cpredicted proteinChain et al. 2005. Infect Immun. 73:8353-61Brucella abortus 2308; accesion number NC_007618
89
BAW_10086BAW_10086BAB1_00889284793581cpredicted proteinChain et al. 2005. Infect Immun. 73:8353-61Brucella abortus 2308; accesion number NC_007618
90
BAW_10087BAW_10087BAB1_00899373493874cpredicted proteinChain et al. 2005. Infect Immun. 73:8353-61Brucella abortus 2308; accesion number NC_007618
91
BAW_10088acnABAB1_00909385896545caconitate hydrataseCatalyzes the conversion of citrate to isocitrateChain et al. 2005. Infect Immun. 73:8353-61Brucella abortus 2308; accesion number NC_007618
92
BAW_10089ccmABAB1_00919688997536cytochrome c biogenesis protein CcmAATP-binding protein; required for proper cytochrome c maturationChain et al. 2005. Infect Immun. 73:8353-61Brucella abortus 2308; accesion number NC_007618
93
BAW_10090ccmBBAB1_00929753698201cytochrome c-type biogenesis protein CcmBChain et al. 2005. Infect Immun. 73:8353-61Brucella abortus 2308; accesion number NC_007618
94
BAW_10091ccmCBAB1_00939825999044cytochrome c-type biogenesis protein CcmCChain et al. 2005. Infect Immun. 73:8353-61Brucella abortus 2308; accesion number NC_007618
95
BAW_10092BAW_10092BAB1_00949904199214heme exporter protein CcmDChain et al. 2005. Infect Immun. 73:8353-61Brucella abortus 2308; accesion number NC_007618
96
BAW_10093CycYBAB1_00959921199822thiol:disulfide oxidoreductase DsbEChain et al. 2005. Infect Immun. 73:8353-61Brucella abortus 2308; accesion number NC_007618
97
BAW_10094ilvDBAB1_0096100071101906cdihydroxy-acid dehydratasecatalyzes the dehydration of 2;3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate invaline andisoleucine biosynthesisChain et al. 2005. Infect Immun. 73:8353-61Brucella abortus 2308; accesion number NC_007618
98
BAW_10095BAW_10095BAB1_0097102087102224predicted proteinChain et al. 2005. Infect Immun. 73:8353-61Brucella abortus 2308; accesion number NC_007618
99
BAW_10096BAW_10096BAB1_0098102305102658cpredicted proteinChain et al. 2005. Infect Immun. 73:8353-61Brucella abortus 2308; accesion number NC_007618
100
BAW_10097BAW_10097BAB1_0099102763103140cresponse regulator receiverChain et al. 2005. Infect Immun. 73:8353-61Brucella abortus 2308; accesion number NC_007618
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