ABCDEFGHIJKLMNOPQRSTUVWXYZ
1
Dog Common Finding List for Toxicity Study　（イヌ一般毒性試験用常用所見集）
2
Organ systemOrgan Findings
　　紫字: SEND&INHAND共通用語
　　橙色字: INHAND用語
　　緑字: SEND term
　　黒字：毒性病理組織学/委員会提案		　　　　　　　Modifier　
　　
　
　　橙色字: INHAND用語　　
　　黒字：　委員会提案		Remarks


備考
3
Cardio-vascularAortamineralizationmedia; wall; etc.
4
Cardio-vascularHeartarteritis (necrosis/inflammation, media or wall, artery)
5
Cardio-vascularHeartpolyarteritis (necrosis/inflammation, media or wall, artery)
6
Cardio-vascularHeartdegeneration, cardiomyocytehyaline; vacuolar; fatty; etc.
7
Cardio-vascularHeartdegeneration/necrosis, cardiomyocyte
8
Cardio-vascularHeartedema, myocardiuminterstitial
9
Cardio-vascularHeartfibrosis, myocardium
10
Cardio-vascularHearthemorrhagesubendocardial; epicardial; myocardial; valve; etc.
11
Cardio-vascularHearthyperplasia, mesotheliumepicardium or pericardium
12
Cardio-vascularHearthypertrophy, cardiomyocyte
13
Cardio-vascularHeartinfiltrate, + cell type(s)mononuclear cell; lymphocyte; neutrophil; eosinophil; mixed cell; etc.
14
Cardio-vascularHeartmineralization, cardiomyocyte (myocardium)
15
Cardio-vascularHeartmineralization, medial or mural artery
16
Cardio-vascularHeartnecrosis/infiltratecell type(s); cardiomyocyte
17
Cardio-vascularHeartpigment, cardiomyocyte (myocardium)
18
Cardio-vascularHeartthrombusatrium
19
Cardio-vascularHeartvacuolation, cardiomyocyte
20
DigestiveTongueapoptosis/single cell necrosissquamous epitheliumApoptosis, necrosisの区別がつく場合は単独で記載
21
DigestiveTongueatrophy, squamous epithelium
22
DigestiveTonguedegeneration/necrosis, muscle fiber
23
DigestiveTongueedema
24
DigestiveTongueerosion/ulcer明らかな区別がつく場合は単独で記載
25
DigestiveTonguehyperkeratosis
26
DigestiveTonguehyperplasia, squamous cell
27
DigestiveTongueinfiltrate, + cell type(s)mononuclear cell; lymphocyte; neutrophil; eosinophil; mixed cell; etc.
28
DigestiveEsophagusapoptosis/single cell necrosissquamous epitheliumApoptosis, necrosisの区別がつく場合は単独で記載
29
DigestiveEsophagusatrophy, squamous epithelium
30
DigestiveEsophagusdegeneration/necrosis, muscle fiber
31
DigestiveEsophagusedema
32
DigestiveEsophaguserosion/ulcer明らかな区別がつく場合は単独で記載
33
DigestiveEsophagushyperplasia, squamous cell
34
DigestiveEsophagusinfiltrate, + cell type(s)mononuclear cell; lymphocyte; neutrophil; eosinophil; mixed cell; etc.
35
DigestiveStomachapoptosis/single cell necrosisApoptosis, necrosisの区別がつく場合は単独で記載
36
DigestiveStomachatrophymucosa
37
DigestiveStomachcellularity Increased, lymphocyte
38
DigestiveStomachcyst, glandular
39
DigestiveStomachedemamucosa; submucosa; etc.
40
DigestiveStomacherosion/ulcer明らかな区別がつく場合は単独で記載
41
DigestiveStomachhemorrhage
42
DigestiveStomachhyperplasia, + cell types(s)mucosa; chief cell; parietal cell; mucous cells; etc. + focal; diffuse + regenerative; etc.
43
DigestiveStomachhyperplasia, neuroendocrine cell
44
DigestiveStomachhypertrophy, mucous cell
45
DigestiveStomachinfiltrate, + cell type(s)mononuclear cell; lymphocyte; neutrophil; eosinophil; mixed cell; etc.
46
DigestiveStomachmineralization
47
DigestiveStomachregeneration, glandular epithelium
48
DigestiveStomachsingle cell necrosisglandular epithelium
49
DigestiveStomachvacuolation, + cell type(s)mucosa; chief cell; parietal cell; mucous cells; etc.
50
DigestiveSmall intestine; duodenum, jejunum, ileumapoptosis/single cell necrosismucosa; Brunner's glandApoptosis, necrosisの区別がつく場合は単独で記載
51
DigestiveSmall intestine; duodenum, jejunum, ileumatrophyvillus; mucosa; Brunner's gland
52
DigestiveSmall intestine; duodenum, jejunum, ileumdilatationcrypt; lumen; etc.
53
DigestiveSmall intestine; duodenum, jejunum, ileumectopic tissuefundic gland; pancreas
54
DigestiveSmall intestine; duodenum, jejunum, ileumerosion/ulcer明らかな区別がつく場合は単独で記載
55
DigestiveSmall intestine; duodenum, jejunum, ileumhyperplasiavillus; mucosa; atypical; goblet cell etc.
56
DigestiveSmall intestine; duodenum, jejunum, ileumhypertrophyvillus; mucosa; etc.
57
DigestiveSmall intestine; duodenum, jejunum, ileuminfiltrate, + cell type(s)mononuclear cell; lymphocyte; neutrophil; eosinophil; mixed cell; etc.
58
DigestiveSmall intestine; duodenum, jejunum, ileummineralization
59
DigestiveSmall intestine; duodenum, jejunum, ileumnecrosismucosa; Brunner's gland
60
DigestiveSmall intestine; duodenum, jejunum, ileumregenerationmucosa; Brunner's gland
61
DigestiveSmall intestine; duodenum, jejunum, ileumsingle cell necrosismucosa; Brunner's gland
62
DigestiveSmall intestine; duodenum, jejunum, ileumvacuolationmucosa
63
DigestiveLarge intestine; cecum, colon, rectumapoptosis/single cell necrosismucosaApoptosis, necrosisの区別がつく場合は単独で記載
64
DigestiveLarge intestine; cecum, colon, rectumatrophymucosa
65
DigestiveLarge intestine; cecum, colon, rectumdilatationlumen, etc.
66
DigestiveLarge intestine; cecum, colon, rectumerosion/ulcer明らかな区別がつく場合は単独で記載
67
DigestiveLarge intestine; cecum, colon, rectumhyperplasiamucosa
68
DigestiveLarge intestine; cecum, colon, rectumhypertrophymucosa
69
DigestiveLarge intestine; cecum, colon, rectuminfiltrate, + cell type(s)mononuclear cell; lymphocyte; neutrophil; eosinophil; mixed cell; etc.
70
DigestiveLarge intestine; cecum, colon, rectummineralization
71
DigestiveLarge intestine; cecum, colon, rectumnecrosismucosa
72
DigestiveLarge intestine; cecum, colon, rectumregenerationmucosa
73
DigestiveLarge intestine; cecum, colon, rectumsingle cell necrosismucosa
74
DigestiveLarge intestine; cecum, colon, rectumvacuolationmucosa
75
DigestiveLiveraccumulation, glycogen (rarefaction)hepatocyte
76
DigestiveLiveratrophyhepatocyte
77
DigestiveLiverbasophilic granuleshepatocyte; Kupffer cellOligonucleotide treatment
78
DigestiveLiverbile plug
79
DigestiveLiverextramedullary hematopoiesis
80
DigestiveLiverfatty changehepatocyte
81
DigestiveLiverfibrosis
82
DigestiveLiverhyperplasia, + cell type(s)bile duct; Ito cell; oval cell; etc.
83
DigestiveLiverhypertrophy, hepatocytecentrilobular; periportal; midzonal; diffuse
84
DigestiveLiverhypertrophy/hyperplasia, Kupffer cell
85
DigestiveLiverinclusionintranuclear and cytoplasmic; intranuclear brick; intranuclear; cytoplasmic
86
DigestiveLiverinfiltrate, + cell type(s)mononuclear cell; lymphocyte; neutrophil; eosinophil; mixed cell; etc. + Glisson sheath; perivascular; peribiliary; etc.
87
DigestiveLiverkaryomegaly/multinucleated hepatocytes
88
DigestiveLivermicrogranuloma (granuloma)
89
DigestiveLivermitotic figures, increasedhepatocyte
90
DigestiveLivernecrosis, +zonecentrilobular; periportal; midzonal
91
DigestiveLivernecrosis, focal/multifocal
92
DigestiveLiverpigmentlipofuscin; hemosiderin; etc. + hepatocyte; Kupffer cell
93
DigestiveLiversingle cell necrosishepatocyte
94
DigestiveLivervacuolationhepatocyte
95
DigestiveGallbladderarteritis (necrosis/inflammation, media or wall, artery)
96
DigestiveGallbladdercalculus
97
DigestiveGallbladderhemorrhage
98
DigestiveGallbladderhyperplasia
99
DigestiveGallbladderhyperplasia, cystic mucinous
100
DigestiveGallbladderinfiltrate, + cell type(s)mononuclear cell; lymphocyte; neutrophil; eosinophil; mixed cell; etc.