QTc Prolongation.xlsx

	B	C	D	E	F	I	J
1	Source: Beach et al. 2018, Psychosomatics
2	Sheet created by Nils Wendel, MD. nilskwendel@gmail.com			Base Rate Of Arrhthymic Syncopy/Probable Long QT-Related Death @ 400ms
3		Hazard Ratio = 1.052^(QTc-400)/10
4				High: 1 in 16000 Low: 1 in 50000
5				High: 1 in 16000 Low: 1 in 50000
6
7			Average Expected Incidence at Given QTc			Source
8			Average Expected Incidence at Given QTc			SJS/TEN Phenobarb	1 in 5000
9	QTc (ms)	Hazard Ratio	Frequency	Percentage	Comparable Freq.
10	400	1.00	1 in 33000	0.0030%	Risk of SJS/TEN w/ Bactrim	Source
11	420	1.11	29,818	0.0034%		Phenytoin	1 in 2800
12	430	1.16	28,344	0.0035%		Carbamazepine	1 in 3900
13	460	1.36	24,346	0.0041%
14	480	1.50	21,998	0.0045%
15	500	1.66	19,877	0.0050%
16	520	1.84	17,961	0.0056%
17	540	2.03	16,229	0.0062%
18	560	2.25	14,664	0.0068%
19	580	2.49	13,250	0.0075%
20	640	3.38	9,775	0.0102%	Low estimate of NMS w/ antidopamergics
21	910	13.27	2,487	0.0402%	Risk of SJS/TEN w/lamotrigine
22
23			Preferred QTc Forumulas
24		Children:	Bazett
25		Adults:	Hodges
26		Rate Correction:	Fridericia	Framingham
27		Afib:	Fridericia
28		BBB:	QTc - (QRS-100)*
29			*No clearly agreed upon formula
30
31	Citalopram (60mg)	18.5ms	Quetiapine	3.4 (0.9 to 6)
32	TCAs	13ms	Olanzapine	4.3 (1.9 to 6.7)
33	Lurasidone	-2.2 (-4.5 to 0.2)	Risperidone	4.8 (2.7 to 6.9)
34	Paliperidone	1.2 (-2.9 to 5.3)	Ziprasidone	9.7 (7.4 to 12)
35	Haloperidol	1.7 (-0.23 to 3.6)	Aripiprazole	-0.4 (-3.6 to 2.8)
36	Huhn et al. 2019	All PO medications	Mean Difference (95% CI)
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