A2M KhanM Table1

	A	C	F	H	I	K
1	Table 1. Involvement of Protease In Diseases
2	Route of entry	Mode of transmission	Pathogen	Disease	Type of pathogen	Proteases
3	Mucosal surfaces Mouth and respiratory tracts	Inhalation or ingestion of infective material (e.g. saliva droplets, spores)	Measles virus	Measles	Paramyxovirus	serine protease
4			Influenza virus	Influenza	Orthomyxovirus	serine proteases
5			Varicella-zoster	Chickenpox	Harpesvirus	serine protease
6			Epstein-Barr virus	Mononucleosis	Harpesvirus	serine protease
7			Streptococcus pyogenes	Tonsilitis	Gram-positive bacteria	serine, metallo- protease
8			Haemophilus influenzae	Pneumonia,meningitis	Gram-negative bacteria	serine, metallo- protease
9			Neisseria Meningitidis	Meningococcal meningitis	Gram-negative bacteria	IgA specific serine endopeptidase
10						IgA specific metallo endopeptidase
11
12	Gastrointestinal tract	Contaminated water or food	Rotavirus	Diarrhea	Rotavirus	protease native to the host gut
13			Hepatitis A	Jaundice	Picornavirus	trypsin-like serine proteases
14			Salmonella enteritidis	Food poisoning	Gram-negative bacterium	PgtE-outer membrane protease
15			S. typhimurium
16			Vibrio cholerae	Cholera	Gram-negative bacterium	haemagglutinin/protease
17			Salmonella typhi	Typhoid fever	Gram-negative bacterium	cystein proteases caspase-1
18
19	Reproductive tract and other routs	Sexual transmission / infected blood	Hepatitis B virus	Hepatitis B	Hepadnavirus	V8 protease
20			Human immunodeficiency	Acquired immunodeficiency
21			virus (HIV)	syndrome (AIDS) Retrovirus	Retrovirus	Retroviral aspartyl protease
22
23		Sexual transmission	Neisseria gonorrhoeae	Gonorrhea	Gram-negative bacterium	IgA specific serine endopeptidase
24		Sexual transmission	Treponema pallidum	Syphilis	Bacterium (spirochete)	Metalloprotease
25
26	Oppurtunistic Pathogens	Resident microbiota	Candida albicans	Candidiasis, thrush	Fungus	Aspartyl Proteinases
27		Resident microbiota	Candida albicans	Candidiasis, thrush		Aspartyl Proteinases
28		Resident lung microbiota	Pneumocystis jirovecii	Pneumonia		serine protease
29		Resident lung microbiota	Pneumocystis jirovecii	Pneumonia		serine protease
30
31	External surface	Physical contact	Trichophyton	Athlete’s foot	Fungus	serine-protease
32	External surface	Physical contact	Trichophyton	Athlete’s foot	Fungus	serine-protease
33	Wounds and abrasions	Minor skin abrasions	Bacillus anthracis	Cutaneous anthrax	Gram-positive bacteria	Immune Inhibitor A1 protease
34		Puncture wounds	Clostridium tetani	Tetanus	Gram-positive bacteria	Metalloendopeptidase
35		Handling infected animals	Francisella tularensis	Tularemia	Gram-negative bacterium	serine protease
36
37	Insect bites	Mosquito bites	Flavivirus	Yellow fever	Virus	flavivirus protease NS3
38		(Aedes aegypti)
39		Deer tick bites	Borrelia burgdorferi	Lyme disease	Bacterium (spirochete)	HtrA protease
40		Mosquito bites (Anopheles)	Plasmodium spp.	Malaria	Protozoan	Serine Proteases
41
42	Skin penetration	Skin contact	Strongyloides stercoralis	strongyloidiasis	parasite	Serine Proteases
43			Streptococcus pyogenes	rheumatic fever, sepsis,		streptococcal dehydrogenase
44				severe soft-tissue invasion	Gram-positive bacteria	streptokinase
45			Yersinia pestis	plague	Gram-negetive bacteria	transmembrane proteases,
46						plasminogen activator protease
47			Borrelia burgdorferi	Lyme disease	spirochete	serine protease
48
49	Corneal penetration		Pseudomonas aeruginosa	Corneal Keratitis	Gram-negetive bacteria	metalloprotease, alkaline protease
50	Corneal penetration		Serratia marcescens	Corneal Keratitis	Gram-negetive bacteria	56-kilodalton (kDa) protease
51
52	Dental inflammation		Porphyromonas gingivalis	Peridontal Disease	Gram-negetive bacteria	cysteine proteinases
53
54	Intestinal dysentry		Entamoeba histolytica	amebic dysentery	anaerobic parasitic protozoan	cysteine proteinases
55
56	Inactivation of Complement protein system		Streptococcus, Serratia,	multiple diseases	Gram-positive bacteria	Streptococcal C5a protease,
57	Inactivation of immunoglobulin g (IgG)		Pseudomonas, Entamoeba	multiple diseases	Gram-negetive bacteria	Candida acid protease, Entamoeba
58			histolytica, Porphyromonas	multiple diseases	fungus, amoeba	cysteine protease complement
59			Candida albicans	Candidiasis		protein - C3, immunoglobulin g (IgG)
60						IgA1 protease, Serratia
61						Marcescens 56K protease,
62						Candida protease
63
64	Cleavage of kininogen		Pseudomonas aeruginosa	multiple diseases	Gram-negetive bacteria	Elastase, Lys-gingivain
65	Cleavage of kininogen		Porphyromonas gingivalis	Peridontal Disease
66
67	Depletion of protease inhibitor		Serratia, Pseudomonas,	multiple diseases		Elastase, Serratia 56K protease,
68			Candida, Aeromonas		fungus	Serine protease
69			Salmonicida	control gene expression	Gram-negetive bacteria
70
71	Bradykinin cascade activation		Serratia, Pseudomonas,	diarrheal disease, cholera	Gram-positive bacteria	Metalloproteases, aspartyl
72			Candida, Entamoeba	multiple diseases	Gram-negative bacterium	proteases, cysteine protease
73			histolytica,Vibrio cholerae		fungus
74
75	Plasmin-catalyzed plasmin generation		Streptococcus pyogenes,	fibrinolysis	Gram-positive bacteria	Streptokinase-activated
76	Plasmin-catalyzed plasmin generation		Staphylococcus aureus			autoproteolytic conversion
77
78	Plasminogen activator- catalyzed plasmin generation		Yersinia pestis	bloody diarrhea	Gram-negative bacterium	Microbial plasminogen activators
79	Plasminogen activator- catalyzed plasmin generation		Escherichia coli	severe anemia,	Gram-negative bacterium	Microbial plasminogen activators
80
81	Activation of host matrix metalloproteinases(MMPs)		Porphyromonas gingivalis	Peridontal Disease	Gram-negetive bacteria	Microbial plasminogen activators
82	Activation of host matrix metalloproteinases(MMPs)
83
84	Proteases those activates microbial toxins		Bacillus anthracis,	Cutaneous anthrax	Gram-positive bacteria	Immune Inhibitor A1 protease
85			Pseudomonas aeruginosa	multiple diseases	Gram-negetive bacteria	Elastase, Lys-gingivain
86
87	Microbial toxin itself a protease		Clostridium botulinum	botulism	Gram-positive bacteria	Botulinus toxin, Tetanus toxin
88			Clostridium tetani	Tetanus	Gram-positive bacteria
89
90	Diabetes					Matrix metalloproteinases [MMPs],
91						plasmin, and elastase
92
93	Hypertension					Aspartyl Protease Renin
94
95	Hepatitis C		Hepatitis C virus	Hepatitis C	Virus	NS3/4A
96
97	Alzheimer's disease					Memapsin
98
99	Rheumatoid arthritis and osteoarthritis					Cysteine,
100