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Gene IDInfo (Summaries from Flybase.org)FBgn#
expression? (from https://dx.doi.org/10.1038%2Fs41598-020-74748-9, Supp 1, avg at 46 days)
Stock Available?
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AceAcetylcholine esterase (Ace) encodes an enzyme that catalyzes the hydrolysis of the neurotransmitter acetylcholine to acetate and choline; thus resetting the neurotransmission mechanism at neuromuscular junctionsFBgn0000024underexpressed in ADNo UAS overexpression
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PI4KIIIalphaPhosphatidylinositol 4-kinase III α (PI4KIIIα) encodes a lipid kinase that synthesizes phosphatidylinositol 4-phosphate from phosphatidylinositol. Its roles include localization of plasma membrane-associated cytoskeletal and membrane trafficking proteins, Hippo signaling regulation and polarization of developing oocytesFBgn0267350underexpressed in ADBDSC: 57112
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shrbshrub (shrb) encodes Shrub encodes Vps32/Snf7, a filament-forming subunit of the ESCRT-III complex involved in inward membrane budding. It regulates multiple cellular processes involving ESCRTs activity including multivesicular body biogenesis, cytokinesis, membrane repair and regulation of membrane associated signalingFBgn0086656underexpressed in AD
BDSC: 39635, BDSC: 39623, BDSC: 32559
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VhaM9.7-aPredicted to contribute to proton transmembrane transporter activity. Predicted to be involved in proton transmembrane transport. Predicted to be part of plasma membrane proton-transporting V-type ATPase complex and vacuolar proton-transporting V-type ATPase, V0 domain. Is expressed in adult head and ovariole. Orthologous to human ATP6V0E1 (ATPase H+ transporting V0 subunit e1) and ATP6V0E2 (ATPase H+ transporting V0 subunit e2)FBgn0035521underexpressed in ADFlyORF: F002524 (Switzerland)
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AP-2alphaAdaptor Protein complex 2- α subunit (AP-2α) encodes a subunit of the AP-2 adaptor complex. It is required for proper intracellular trafficking and secretion. It contributes to asymmetric cell division, Notch signalling, apico-basal polarity and neurogenesisFBgn0264855
underexpressed in AD (if at all)
BDSC: 64752
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AmphAmphiphysin (Amph) encodes a BAR and SH3 domain containing protein that regulates muscle transverse tubule formation. It exhibits post-synaptic localization at the neuromuscular junction and its mutants show locomotion defectsFBgn0027356
underexpressed in AD (if at all)
BDSC: 81608, VDRC: v7190 and BDSC: 6499
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faxTogether with Abl; involved in embryonic axonal developmentFBgn0014163
underexpressed in AD (if at all)
No UAS stocks
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Hsc70-3Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen. Involved in the correct folding of proteins and degradation of misfolded proteins (By similarity). Acts as a key repressor of the unfolded protein response (extracell.)FBgn0001218overexpressed in AD BDSC 32402, BDSC 80420
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MoeMoesin (Moe) encodes an Ezrin; Radixin; Moesin (ERM) protein involved in cortical cytoskeleton stability. It regulates the products of crb and Rho1. The product of Moe contributes to apical-basal polarity; mitotic spindle organisation and epithelial integrityFBgn0011661overexpressed in ADBDSC 31135, BDSC 31872
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FK506-bp2FK506-binding protein 12kD (Fkbp12) encodes a protein that binds the intracellular calcium channel encoded by RyR in an oxidation dependent manner. Loss of the binding between the products of Fkbp12 and RyR results in increased calcium leak and reduced muscle functionFBgn0013954overexpressed in ADBDSC 58245
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Rab4Rab4 (Rab4) encodes a member of the Rab family; which are small Ras-like GTPases involved in vesicle trafficking. The product of Rab4 controls endocytic recycling and regulates synapse organization and neurotransmission in the nervous system. It also contributes to the sorting of cell adhesion molecules during epithelial morphogenesis and immune-mediators during the innate immune responseFBgn0016701overexpressed in ADBDSC: 33757
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amonamontillado (amon) encodes a member of the Prohormone Convertase (PC) family of proteolytic enzymes. PCs generally recognize conserved basic amino acid sequences within protein precursors to direct catalysis of specific cleavage. amon product directly cleaves sli protein and may also target the propeptide encoded by Akh. It is also required for the production of bioactive neuropeptide hormones (e.g. those encoded by Hug, Crz, Ms, Capa and sNPF) (extracell.)FBgn0023179overexpressed in AD
BDSC: 28583, BDSC: 41635, BDSC: 44001
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GCS2alphaPredicted to enable glucan 1- 3-alpha-glucosidase activity. Predicted to be involved in N-glycan processing. Located in endomembrane system and extracellular region. Is expressed in several structures including adult heart; anterior endoderm anlage; excretory system; germ layer; and gut section. Human ortholog(s) of this gene implicated in polycystic kidney disease; polycystic kidney disease 3; and polycystic liver disease. Orthologous to several human genes including GANAB (glucosidase II alpha subunit) (extracell.)FBgn0027588overexpressed in ADBDSC: 34334
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DybPredicted to be a structural constituent of muscle. Involved in maintenance of presynaptic active zone structure and regulation of neurotransmitter secretion. Located in neuromuscular junction. Is expressed in several structures including embryonic/larval nervous system; embryonic/larval somatic muscle; labral sensory complex primordium; presumptive embryonic/larval system; and spermatozoon. Human ortholog(s) of this gene implicated in cardiomyopathy and left ventricular noncompaction. Orthologous to human DTNA (dystrobrevin alpha) and DTNB (dystrobrevin beta)FBgn0033739overexpressed in ADBDSC:36101 and BDSC: 32935
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SyndF-BAR-domain containing protein that regulates cellularization,membrane tubulation, Clathrin-mediated and bulk endocytosis, formation of subsynaptic reticulum and F-actin stability, contributes to coupling the plasma membrane and contractile ring in cytokinesisFBgn0053094overexpressed in ADBDSC: 27297
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GABA-B-R1metabotropic GABA-B receptor subtype 1 (GABA-B-R1) encodes a receptor involved in G protein-coupled receptor and gamma-aminobutyric acid signaling pathwaysFBgn0260446overexpressed in ADBDSC: 51817 and BDSC: 28353
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Vha26Vacuolar H[+]-ATPase 26kD subunit (Vha26) encodes the E subunit of the V1 domain of the vacuolar ATPase that is required for the morphology of tracheal cellsFBgn0283535overexpressed in ADBDSC: 38996
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Vha13Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase) (By similarity). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells (By similarity). In enterocytes, acts as part of a pHCl-2 sensory pathway which mediates Tor-dependent larval growth and metabolism in response to zinc availability (PubMed:32269334). Likely acts in maintaining enterocyte lysosomal acidification which consequently promotes Tor activation at the lysosome membraneFBgn0283536overexpressed in ADBDSC: 38233
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CG12163no phenotype data available (extracellular)FBgn0053293undetermined
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