Senescence GO Terms

	A	B	C	D	E	F	H	I	J	K	M	N	O	P
1	Functional Enrichment of GO Terms in CellAge genes (for comparison)						ElasticNet CellAge vs non-CellAge Classifier				ElasticNet Senescense Promoter vs. Inhibitor Classifier
2							AUC 0.82				AUC 0.66
3	Background geneset: All human protein-coding genes from NCBI (18,400)						Label: Is gene in CellAge?				Label: does gene promote senescence?
4	Study genes: All genes in CellAge (279)						Features: length 17,506 binary vector encoding GO terms for gene				Features: length 17,506 binary vector encoding GO terms for gene
5							Included genes: all human genes from NCBI gene2go (19,238)				Included genes: all CellAge genes that either promote or inhibit senescence (272)
6	Grouped by GO namespace, sorted by FDR-adjusted p-value within each group						Grouped by GO namespace, GO Term coefficients in model sorted by abs(coefficient)				Grouped by GO namespace, GO Term coefficients in model sorted by abs(coefficient)
7	id	p-value	enrichment	cellage_count	ns	name	id	coefficient	ns	name	id	coefficient	ns	name
8	GO:0000122	4.57E-24	5.69791	58	BP	negative regulation of transcription from RNA polymerase II promoter	GO:0008285	0.731192	BP	negative regulation of cell proliferation	GO:0051301	-0.658073	BP	cell division
9	GO:0045944	1.30E-23	4.779866	66	BP	positive regulation of transcription from RNA polymerase II promoter	GO:0000122	0.587924	BP	negative regulation of transcription from RNA polymerase II promoter	GO:0008285	0.526409	BP	negative regulation of cell proliferation
10	GO:0006468	1.49E-21	7.375631	43	BP	protein phosphorylation	GO:0006468	0.483493	BP	protein phosphorylation	GO:0006355	0.451376	BP	regulation of transcription, DNA-templated
11	GO:0008285	1.47E-19	7.457456	39	BP	negative regulation of cell proliferation	GO:0045944	0.412141	BP	positive regulation of transcription from RNA polymerase II promoter	GO:0016310	0.44867	BP	phosphorylation
12	GO:0045893	8.64E-18	6.031022	42	BP	positive regulation of transcription, DNA-templated	GO:0045892	0.283067	BP	negative regulation of transcription, DNA-templated	GO:0007265	0.435431	BP	Ras protein signal transduction
13	GO:0045892	1.73E-16	6.077594	39	BP	negative regulation of transcription, DNA-templated	GO:0007165	0.242178	BP	signal transduction	GO:0055114	-0.398245	BP	oxidation-reduction process
14	GO:0007050	2.78E-12	10.863332	20	BP	cell cycle arrest	GO:0016055	0.224283	BP	Wnt signaling pathway	GO:0007050	0.396757	BP	cell cycle arrest
15	GO:0018105	7.95E-12	10.268081	20	BP	peptidyl-serine phosphorylation	GO:0007050	0.219356	BP	cell cycle arrest	GO:0006950	-0.393269	BP	response to stress
16	GO:0006366	1.04E-10	4.484606	35	BP	transcription from RNA polymerase II promoter	GO:0007568	0.217997	BP	aging	GO:0009314	-0.382655	BP	response to radiation
17	GO:0090398	1.30E-10	32.589995	10	BP	cellular senescence	GO:0006351	-0.207884	BP	transcription, DNA-templated	GO:0006936	-0.378022	BP	muscle contraction
18	GO:0090399	3.56E-10	49.971326	8	BP	replicative senescence	GO:0006355	-0.204351	BP	regulation of transcription, DNA-templated	GO:0050790	-0.372019	BP	regulation of catalytic activity
19	GO:0042981	1.12E-09	6.871057	22	BP	regulation of apoptotic process	GO:0090399	0.195589	BP	replicative senescence	GO:0007186	0.362351	BP	G-protein coupled receptor signaling pathway
20	GO:0007346	2.54E-09	12.955529	14	BP	regulation of mitotic cell cycle	GO:0045893	0.186276	BP	positive regulation of transcription, DNA-templated	GO:0006508	-0.358778	BP	proteolysis
21	GO:0006974	5.00E-09	7.172918	20	BP	cellular response to DNA damage stimulus	GO:0006695	0.176047	BP	cholesterol biosynthetic process	GO:0008284	-0.34835	BP	positive regulation of cell proliferation
22	GO:0043066	5.27E-09	4.634867	29	BP	negative regulation of apoptotic process	GO:0007155	0.164915	BP	cell adhesion	GO:0006457	-0.345861	BP	protein folding
23	GO:0010628	2.85E-08	5.786154	22	BP	positive regulation of gene expression	GO:0010628	0.16448	BP	positive regulation of gene expression	GO:0006468	0.336667	BP	protein phosphorylation
24	GO:0048146	3.49E-08	16.167194	11	BP	positive regulation of fibroblast proliferation	GO:0043066	0.163954	BP	negative regulation of apoptotic process	GO:0000086	-0.330245	BP	G2/M transition of mitotic cell cycle
25	GO:1901796	1.73E-07	8.453796	15	BP	regulation of signal transduction by p53 class mediator	GO:0045766	0.159395	BP	positive regulation of angiogenesis	GO:0045892	-0.327497	BP	negative regulation of transcription, DNA-templated
26	GO:0006338	3.57E-07	11.243548	12	BP	chromatin remodeling	GO:0043547	-0.154076	BP	positive regulation of GTPase activity	GO:0060337	0.307964	BP	type I interferon signaling pathway
27	GO:0006978	3.69E-07	32.793683	7	BP	DNA damage response, signal transduction by p53 class mediator resulting in ...	GO:0000209	0.148077	BP	protein polyubiquitination	GO:0048146	-0.29871	BP	positive regulation of fibroblast proliferation
28	GO:0007569	3.91E-07	23.986237	8	BP	cell aging	GO:0008283	0.137105	BP	cell proliferation	GO:0006357	-0.297354	BP	regulation of transcription from RNA polymerase II promoter
29	GO:2000772	4.80E-07	44.974194	6	BP	regulation of cellular senescence	GO:0048146	0.133367	BP	positive regulation of fibroblast proliferation	GO:0034220	-0.295278	BP	ion transmembrane transport
30	GO:0071456	6.23E-07	9.280389	13	BP	cellular response to hypoxia	GO:0006928	0.127235	BP	movement of cell or subcellular component	GO:0043687	0.292479	BP	post-translational protein modification
31	GO:0035897	9.59E-07	62.464158	5	BP	proteolysis in other organism	GO:0001558	0.124158	BP	regulation of cell growth	GO:0046777	-0.291612	BP	protein autophosphorylation
32	GO:0008283	1.06E-06	4.645222	22	BP	cell proliferation	GO:0018105	0.121789	BP	peptidyl-serine phosphorylation	GO:0045893	0.290134	BP	positive regulation of transcription, DNA-templated
33	GO:0070301	2.04E-06	12.704574	10	BP	cellular response to hydrogen peroxide	GO:0001649	0.117478	BP	osteoblast differentiation	GO:0006351	0.289748	BP	transcription, DNA-templated
34	GO:0010629	2.59E-06	7.390126	14	BP	negative regulation of gene expression	GO:2000772	0.116986	BP	regulation of cellular senescence	GO:0007420	-0.285442	BP	brain development
35	GO:0043065	2.67E-06	4.835935	20	BP	positive regulation of apoptotic process	GO:0071456	0.112651	BP	cellular response to hypoxia	GO:0042981	-0.279535	BP	regulation of apoptotic process
36	GO:0006977	3.09E-06	12.089837	10	BP	DNA damage response, signal transduction by p53 class mediator resulting in ...	GO:0016569	0.103492	BP	covalent chromatin modification	GO:0051607	0.278614	BP	defense response to virus
37	GO:0000165	6.81E-06	5.072277	18	BP	MAPK cascade	GO:0016021	-0.824735	CC	integral component of membrane	GO:0031648	-0.267268	BP	protein destabilization
38	GO:0090400	1.00E-05	74.956989	4	BP	stress-induced premature senescence	GO:0005654	0.465936	CC	nucleoplasm	GO:0016020	-0.851689	CC	membrane
39	GO:0071480	1.17E-05	20.180728	7	BP	cellular response to gamma radiation	GO:0005634	0.340402	CC	nucleus	GO:0005654	-0.770552	CC	nucleoplasm
40	GO:0045766	1.17E-05	7.960034	12	BP	positive regulation of angiogenesis	GO:0005622	0.334649	CC	intracellular	GO:0000139	0.457541	CC	Golgi membrane
41	GO:0006915	1.68E-05	3.529048	25	BP	apoptotic process	GO:0005887	-0.230329	CC	integral component of plasma membrane	GO:0005622	0.402078	CC	intracellular
42	GO:0005654	1.56E-35	3.270941	131	CC	nucleoplasm	GO:0005743	-0.146594	CC	mitochondrial inner membrane	GO:0016363	0.370372	CC	nuclear matrix
43	GO:0000790	3.16E-06	6.118938	16	CC	nuclear chromatin	GO:0005829	0.132199	CC	cytosol	GO:0005737	0.363262	CC	cytoplasm
44	GO:0004674	4.13E-25	9.156678	43	MF	protein serine/threonine kinase activity	GO:0005874	-0.120571	CC	microtubule	GO:0005813	-0.341483	CC	centrosome
45	GO:0005524	4.81E-21	3.807012	74	MF	ATP binding	GO:1904813	0.116227	CC	ficolin-1-rich granule lumen	GO:0043234	0.333034	CC	protein complex
46	GO:0003682	5.29E-13	6.246416	31	MF	chromatin binding	GO:0004674	0.491604	MF	protein serine/threonine kinase activity	GO:0000922	-0.312119	CC	spindle pole
47	GO:0019901	1.84E-11	5.664256	30	MF	protein kinase binding	GO:0005524	0.417341	MF	ATP binding	GO:0005524	0.659829	MF	ATP binding
48	GO:0004672	9.29E-11	8.372855	21	MF	protein kinase activity	GO:0003682	0.271371	MF	chromatin binding	GO:0003700	0.447218	MF	transcription factor activity, sequence-specific DNA binding
49	GO:0008134	3.15E-08	5.745832	22	MF	transcription factor binding	GO:0005525	-0.243392	MF	GTP binding	GO:0001085	0.385389	MF	RNA polymerase II transcription factor binding
50	GO:0044212	3.49E-08	6.814272	19	MF	transcription regulatory region DNA binding	GO:0045296	0.237482	MF	cadherin binding	GO:0003677	0.37678	MF	DNA binding
51	GO:0004708	2.23E-07	34.979928	7	MF	MAP kinase kinase activity	GO:0019901	0.235988	MF	protein kinase binding	GO:0019901	0.343389	MF	protein kinase binding
52	GO:0003700	4.71E-07	3.234889	35	MF	transcription factor activity, sequence-specific DNA binding	GO:0046872	-0.219303	MF	metal ion binding	GO:0042803	-0.343368	MF	protein homodimerization activity
53	GO:0019899	4.78E-07	4.893335	22	MF	enzyme binding	GO:0031994	0.172835	MF	insulin-like growth factor I binding	GO:0002039	0.327408	MF	p53 binding
54	GO:0003714	5.87E-07	6.46837	17	MF	transcription corepressor activity	GO:0004930	-0.136012	MF	G-protein coupled receptor activity	GO:0005515	-0.308268	MF	protein binding
55	GO:0002039	8.55E-07	11.778955	11	MF	p53 binding	GO:0003779	-0.123382	MF	actin binding	GO:0031490	-0.287917	MF	chromatin DNA binding
56	GO:0001077	2.06E-06	5.197747	19	MF	transcriptional activator activity, RNA polymerase II core promoter proximal...	GO:0005509	-0.118694	MF	calcium ion binding	GO:0004674	0.283053	MF	protein serine/threonine kinase activity
57	GO:0004713	3.23E-06	7.98722	13	MF	protein tyrosine kinase activity	GO:0004713	0.116005	MF	protein tyrosine kinase activity	GO:0045296	-0.273407	MF	cadherin binding
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