Pemphigus Vulgaris Research - Treatment
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DateProtocolSizeJournalTitleAuthorPubMedFull Text
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20161mg-1.5mg/kg per day prednisone up to 2mg. Tapering involves 7-14 days on decreasing dosage of prednisoneMedical extract from JesseInitial Management of pemphigus vulgaris and pemfigus foliaceusHertl, M et al
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2015Clinical remission at week 12 and 16 / intralesional rituximab plus oral prednisone3JAMA DermatologyIntralesional rituximab in the treatment of refactory oral pemphigus vulgarisVinay K et alhttps://www.ncbi.nlm.nih.gov/pubmed/25536513https://jamanetwork.com/journals/jamadermatology/fullarticle/2020880
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Sixteen studies with a total of 239 patients have evaluated the treatment of pemphigus vulgaris and pemphigus foliac;eus with MPA. The results of this review suggest that MPA, as MMF or EC-MPS, may be a promising adjuvant or alternative therapy for the treatment of pemphigus vulgaris and pemphigus foliaceus. It appears safe, at least in the medium term and its adverse events seem to be dose dependent239Journal Dematological TreatmentMycophenolate mofetil and enteric-coated mycophenolate sodium in the treatment of pemphigus vulgaris and pemphigus foliaceus.Doukaki S et alhttps://www.ncbi.nlm.nih.gov/pubmed/24521072
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2014Low dose rituximab and standard dose compared in 48 week trial; some also took prednisone. The 11 in low dose group achived complete remission.22British J of DermatologyClinical and immunological outcomes of high- and low-dose rituximab treatments in patients with pemphagisKanwar AJ et al
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2013Combo treatment prednisone and azathioprine had lower mean disease activity score compared to 100 percent prednisone. Mycophenolate mofetil was effective, lower relapse rate 94J European Academy of DermatologyRandomized double-blind trial of prednisone and azathioprine ... treatment of pemphigus vulgaris
Chams-Davatchi C et al
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Methotrexate in the treatment of pemphigus vulgaris: experience in 23 patients.Tran KD et alhttps://www.ncbi.nlm.nih.gov/pubmed/23772610
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2012Prednisone plus rituximab patients complete remission in six months (86%). Median time to remission was 70 days. Median time to relapse was 16 months.42J American Academy of DermatologyTherapy with rituximab for autoimmune pempfigusCianchini G
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2011azathioprine superior to mycophenolate mofetil. Also, mycophenolate mofetil was effectiveJ American Academy of DermatologyA systemic review of randomized controlled trials for pemphigus vulgaris and pemphigus foliaceusMartin LK et al
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2010Here mycophenolate mofetil had longer remissionJ Invest DermatologyTreating pemphigus vulgaris with prednisone and mycophenolate mofetil Beissert S et al
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2009375mg/m2, once per week for four weeks14Ann NY Academy SciencesRituximab in severe pemphigusSchmidt E et al
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20072mg/kg day - 23 patients, average time to stop blistering 18 days. Combo treatment prednisone and azathioprine had lower dose prednisone after one year and 80 percent remission compared to 100 percent prednisone (77 percent remission). Also, mycophenolate mofetil was effective.120 patients, four regiemesJ American Academy of DermatologyRandomized controlled open-label trial of four treatments for pemphigus vulgaris
Chams-Davatchi C et al
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2006rituximab infusions; duration of conventional therapy prior to this ranged from 20 to 132 months (mean, 55.7) - Complete clearance of lesions was achieved between the seventh and ninth infusions. Of the 11 patients, 9 received 10 infusions of rituximab and had a sustained remission.11New England Journal of MediciineTreatment of Pemphigus Vulgaris with Rituximab and Intravenous Immune GlobulinAhmed, et al
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