Unit/Skill Choice

Use Red Hood (Or the Laser Red Hood - think the regular is better, but the laser is also fine)

Grab all POW, then Att Spd when it's not a choice against POW

Don't bother trying to clear Challenge mode without maxing skill tree - final upgrade is huge and challenge mode is not good for farming. Get enough currency to max out the skill tree, and then reset skill tree to Red Hood

Boomerang, Landmine, Reflector, Tactical Rifle (last weapon is typically energy field/sword but this is the least important weapon)

All should be maxed at level 5 except you don't need to level 5 the starter weapon, but upgrade it if other options are bad (some people also say sword gets worse at 5 than 4)

Modules in order of priority from highest to lowest

Extra Life (only need 1 point in this which is nice)

Purple Triple stat module 1

Purple Triple stat module 2

Increase ATK SPD

Movement Speed

Keep in mind that you will end up level 37-40 by the time you reach 15 minutes when exp/hp/charge/bomb drops stop, so there is a limited amount of levels to put in modules.

Modules scale very differently, and have breakpoints in power (e.g., purple triple stat goes from 5% -> 7% -> 10% -> 15% -> 20%) so may be better to reach breakpoint than putting in a "better" module but not hitting a final breakpoint

Early game, use your initial bursts to clear out mobs

Grab Boomerang and level that as soon as possible - there is periodic spawns of ranged mobs near mid-game that you are forced to pay attention and dodge red lasers unless you have a leveled boomerang to clear them before they shoot

If you don't have all your weapon slots filled out, avoid taking the random drop box so you aren't stuck with a garbage weapon. Similarly, if you're 5/6 slots for modules, you might not want to take the random drop box as you might get stuck with a useless module

Try to stick to one area and stack as many pick ups as possible and avoid picking them up - you need Liliweiss bombs to clear the invincible ranged mobs, and multiple bombs will let you clear out the ranged mobs as they continue to spawn in during the boss fight

For less effort - once you are strong enough, you can stand still near a magnet and grab every so often instead of walking around

After 15 minutes, drops do not spawn anymore, so pick a spot next to a bomb, and AFK until 30 minutes

In terms of module priority see above - getting 30 minutes is easy if you grab modules/weapons accordingly, but for clearing boss, a leveled up HP regen is close to necessary (Level 5 is 3 hp regen every 2 seconds compared to level 1's 1 hp regen every 5 seconds)

Getting "rare" modules like hp regen, purple triple stat, res, seems to be more common once possible options are eliminated by leveling a module to 5

If you are going for the boss kill, then you can reset early if your are forced to pick a bad weapon, or if you don't get key modules

At 30 minutes, use the bomb next to you to clear all the invincible ranged mobs

Stand diagonally of the boss as it shoots in all cardinal directions, then when it shoots in the intercardinal/diagonal directions, use the burst

Grab the lightning/burst charger to regen on burst quickly, grab hearts if low, and once invincible ranged mobs are starting to trinkle in and become unmanageable, clear with bombs

Boss will do a spiral shot after a few rotations, play safe and run away so you have more space to dodge + gap between bullets become larger

Boss shots do far more damage than random bullets from the ranged mobs or colliding with the mob spawns, focus on dodging the boss bullets more than other attacks

If you don't have any bombs, you can ESC -> End -> Confirm and start at the beginning of the boss fight which will reset the mobs. This however seems to reset all pickups, so you will have to play without any pickups. (You also will always start at the beginning of the boss fight at 30:00 no matter when you reset after 30)

https://www.youtube.com/watch?v=JBy681FFxoU

If you die during the boss fight, you can ALT F4 Nikke and restart the game to retry the boss from the beginning of the fight (without pickups on the ground)