MCR Labs - Cannabinoids
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FULL NAMEEFFECTS/USESSOURCE (STUDY)SENTENCE CONFIRMING THE EFFECT (Include Cannabinoid)TREATMENT FORSOURCE (STUDY)SENTENCE CONFIRMING THE EFFECT (Include Cannabinoid)
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THCTetrahydrocannabinolanti-inflammatory
http://www.sciencedirect.com/science/article/pii/0014299973901076
The oral anti-inflammatory efficacy of Δ9-THC was compared to phenylbutazone and acetylsalicylic acid.Alzheimer's Disease
https://www.ncbi.nlm.nih.gov/pubmed/25024327
These sets of data strongly suggest that THC could be a potential therapeutic treatment option for Alzheimer's disease through multiple functions and pathways
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reduction of tumor
http://www.jimmunol.org/content/165/1/373.short
Our findings suggest the THC promotes tumor growth by inhibiting antitumor immunity by a CB2 receptor-mediated, cytokine-dependent pathway.Neuropathic Pain
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2950205/
A single inhalation of 25 mg of 9.4% tetrahydrocannabinol herbal cannabis three times daily for five days reduced the intensity of pain, improved sleep and was well tolerated.
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increase appetite
http://www.sciencedirect.com/science/article/pii/S0163725802002577
The same effect is observed in animals and in humans with the psychotropic plant cannabinoid Δ9-tetrahydrocannabinol, which is an approved appetite-enhancing drug.Multiple Sclerosis
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3394820/
In a trial of a sublingual spray containing delta-9-THC alone or combined with cannabinol, Rog and colleagues reported a 41% reduction in pain, compared with a 22% reduction with placebo.18 Literature on cannabinoids for pain conditions other than multiple sclerosis is limited, although three recent randomized placebo-controlled trials of smoked cannabis found significant reductions in neuropathic pain.
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anti obesityhttp://www.sciencedirect.com/science/article/pii/S0163725802002577In obese humans, it causes weight reduction. Very little is known about the physiological and biochemical mechanisms involved in the effects of Δ9-tetrahydrocannabinol and the cannabinoids in feeding and appetite.Parkinson's Disease
http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2990.2011.01248.x/full
Δ9-tetrahydrocannabinol (Δ9-THC) exerts a direct neuroprotective effect in a human cell culture model of Parkinson's disease
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https://www.ncbi.nlm.nih.gov/pubmed/22236282
Δ⁹-tetrahydrocannabinol (Δ⁹-THC) is neuroprotective in models of Parkinson's disease (PD).
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reduce nausea
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3165951/
Cannabinoid agonists (Δ9-THC, HU-210) and the fatty acid amide hydrolase (FAAH) inhibitor, URB-597, suppress conditioned gaping reactions (nausea) in rats as they suppress vomiting in emetic species.Cancer
https://www.ncbi.nlm.nih.gov/pubmed/6985702?dopt=Abstract
We conclude that THC is an effective antiemetic in many patients who receive chemotherapy for cancer and for whom other antiemetics are ineffective.
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memory impairment
https://link.springer.com/article/10.1007/BF02246347
Moreover, these results suggest that scopolamine and Δ9-THC do not impair spatial memory in a common serial pathway, though they may converge on a third neurochemical system.Crohn's Disease
https://www.ncbi.nlm.nih.gov/pubmed/23648372
Although the primary end point of the study (induction of remission) was not achieved, a short course (8 weeks) of THC-rich cannabis produced significant clinical, steroid-free benefits to 10 of 11 patients with active Crohn's disease, compared with placebo, without side effects
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antioxidant
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC20965/
Cannabidiol and THC also were shown to prevent hydroperoxide-induced oxidative damage as well as or better than other antioxidants in a chemical (Fenton reaction) system and neuronal cultures.Anorexia
http://psycnet.apa.org/record/1994-46417-001
THC is an effective appetite stimulant in patients with advanced cancer
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Anti-spasmodic
https://link.springer.com/article/10.2165/00023210-199911050-00001
The clinical data derive from 7 clinical trials, albeit involving small numbers of patients, which indicate that cannabis itself, the cannabinoid Δ9-tetrahydrocannabinol (Δ9-THC) and the synthetic analogue of Δ9-THC nabilone can reduce the intensity of several symptoms in patients with MS or spinal cord injury, including spasticity, pain, tremor and nocturiacachexia
http://europepmc.org/abstract/med/9208884
Use of progestogens (megesterol acetate, medroxyprogesterone), corticosteroids (decadron, prednisone), metoclopramide, tetrahydrocannabinol (dronabinol), and possibly anabolic steroids (nandrolone decanoate, oxandrolone), melatonin, and eicosapentaenoic acid, may yield therapeutic benefit.
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Analgesic
http://www.pnas.org/content/96/10/5780.short
In contrast, we still found Δ9-THC-induced analgesia in the tail-flick test and other behavioral (licking of the abdomen) and physiological (diarrhea) responses after Δ9-THC administration. gastrointestinal disorder
http://onlinelibrary.wiley.com/doi/10.1046/j.1365-2036.1999.00441.x/full
It has been reported that THC inhibits gastrointestinal motility in mice.11, 12 Our present findings in humans would also suggest this and support the concept that one of THC’s peripheral effects is to inhibit gastrointestinal smooth muscle actio
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crohn's disease
https://www.karger.com/Article/PDF/356512
Although the primary end point of induction of remission was statistically not achieved, they were able to demonstrate that an 8-week treatment with tetrahydrocannabinol (THC)- rich cannabis caused a decrease in the Crohn’s disease activity index in 90% of patients without producing significant side effects.
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stress-relieving
http://www.sciencedirect.com/science/article/pii/S037687161730220X
Our findings suggest that a low dose of THC produces subjective stress-relieving effects in line with those commonly reported among cannabis users, but that higher doses may non-specifically increase negative mood.
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ADHD
http://mcforadhd.free.fr/ARTICLE%20ADHD%20DRIVING%20GERMANY.pdf
Thus, it has to be considered, that in the case of ADHD, THC can have atypical effects
and can even lead to an enhanced driving related performance.
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Bipolar
http://journals.sagepub.com/doi/abs/10.1177/0269881105051541
The cannabinoids Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD) may exert sedative, hypnotic, anxiolytic, antidepressant, antipsychotic and anticonvulsant effects. Pure synthetic cannabinoids, such as dronabinol and nabilone and specific plant extracts containing THC, CBD, or amixture of the two in known concentrations, are available and can be delivered sublingually. Controlled trials of these cannabinoids as adjunctive medication in bipolar disorder are now indicated.
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OCD
http://www.sciencedirect.com/science/article/pii/S0278584610004586
Additionally, an “add-on” effect of dronabinol, a synthetic form of Δ9-THC, improving OCD treatment has been observed (Schindler et al., 2008).
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PTSD
https://link.springer.com/article/10.1007/s40261-014-0212-3
Orally absorbable Δ9-THC was safe and well tolerated by patients with chronic PTSD.
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CBDCannabidiolanti-inflammatory
http://www.sciencedirect.com/science/article/pii/S0168365903004152
In conclusion, ethosomes enable CBD's skin permeation and its accumulation in a depot at levels that demonstrate the potential of transdermal CBD to be used as an anti-inflammatory treatment.Epilepsy
https://www.ncbi.nlm.nih.gov/pubmed/25282526
Further data from well-designed studies are needed regarding short- and long-term efficacy and side effects of CBD or high-CBD/low-THC products for the treatment of seizures and epilepsy in children and adults.
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antioxidant
http://jpet.aspetjournals.org/content/314/2/780.short
This study provides the first demonstration of CBD as an in vivo neuroprotectant and shows the efficacy of lipophilic antioxidants in preventing binge ethanol-induced brain injury.Cancer
http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2125.2012.04298.x/full
On the basis of these results, evidence is emerging to suggest that CBD is a potent inhibitor of both cancer growth and spread.
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neuroprotectant
https://www.researchgate.net/profile/Jose_Martinez-Orgado/publication/23148432_Neuroprotective_Effects_of_the_Nonpsychoactive_Cannabinoid_Cannabidiol_in_Hypoxic-Ischemic_Newborn_Piglets/links/00b7d538c6d0f32527000000.pdf
In conclusion, administration of CBD after a HI insult in newborn piglets reduced short-term brain damage, in a manner that can be attributed to a CBD-induced reduction of cerebral hemodynamic impairment, improvement of brain metabolic activity postinsult, reduction of brain edema, and reduction of seizures. These neuroprotective effects were not only free from side effects but also associated with some cardiac, hemodynamic, and ventilatory benefits.Depression
https://www.ncbi.nlm.nih.gov/pubmed/27010632
These results suggest that CBD may be beneficial for the treatment of clinical depression and other states with prominent anhedonia.
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anxiolytic
https://www.ncbi.nlm.nih.gov/pubmed/28553229
The results confirmed that the acute administration of CBD induced anxiolytic effects with a dose-dependent inverted U-shaped curve in healthy subjectsAnxiety
https://www.nature.com/npp/journal/v36/n6/full/npp20116a.html
The increase in anxiety induced by the SPST on subjects with SAD was reduced with the use of CBD, resulting in a similar response as the HC.
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antidepressant
http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2009.00521.x/full
BD (30 mg·kg−1) treatment reduced immobility time in the forced swimming test, as did the prototype antidepressant imipramine, without changing exploratory behaviour in the open field arena.Psychotic Disorders
http://www.sciencedirect.com/science/article/pii/S0920996411002246
Although the observed effects are subtle, using high cannabidiol content cannabis was associated with significantly lower degrees of psychotic symptoms providing further support for the antipsychotic potential of cannabidio
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analgesic
http://www.sciencedirect.com/science/article/pii/S0014299904012348
We conclude that centrally inactive (+)-cannabidiol analogues should be further developed as antidiarrheal, antiinflammatory and analgesic drugs for gastrointestinal and other peripheral conditions.Chronic Pain
http://www.sciencedirect.com/science/article/pii/S0149291807002949
THC/CBD was effective, with no evidence of tolerance, in these select patients with CNP and MS who completed ∼2 years of treatment (n = 28).
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anti-tumoral agent
http://jpet.aspetjournals.org/content/308/3/838.short
In conclusion, the nonpsychoactive CBD was able to produce a significant antitumor activity both in vitro and in vivo, thus suggesting a possible application of CBD as an antineoplastic agent.Diabetes
https://www.ncbi.nlm.nih.gov/pubmed/27767974
Cannabidiol (CBD), a phytocannabinoid, derived from the plant, Cannabis sativa, was shown to lower the incidence of diabetes in non-obese diabetic (NOD) mice, an animal model of spontaneous T1D development.
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Anti-emetic
http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2011.01621.x/full
These results suggest that CBD produced its anti-emetic/anti-nausea effects by indirect activation of the somatodendritic 5-HT1A autoreceptors in the DRN.Anorexia
http://www.neurology.org/content/84/14_Supplement/P6.039.short
These patients illustrate the potential therapeutic use of cannabis in seizure disorders or anorexia. The route of administration (inhaled or buccal) avoids the first-pass effect associated with pill formulations and presents higher levels of cannabinoids such as cannabidiol (CBD) to the endocannabinoid system in the frontal and insular cortex.
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Anti-bacterial
https://link.springer.com/article/10.1007%2FBF00399444?LI=true
The minimum inhibiting concentrations (MIC) of Ag-tetrahydrocannabinol (THC) and cannabidiol (CBD) for staphylococci and streptococci in broth are in the range of 1-5 pg/ml. In the same range, both compounds are also bactericidal. Cachexia
http://europepmc.org/articles/pmc4718203
Findings presented at the 2015 International Cannabinoid Research Society at their 25th Annual Symposium in Nova Scotia, Canada, reported that use of CBD was beneficial for treatment of liver fibrosis and inflammation, metabolic syndrome, overweight and obesity, anorexia/cachexia syndrome, and osteoarthritic and other musculoskeletal conditions.15
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Anti-proliferative
https://link.springer.com/article/10.1007/s11626-013-9719-9
In addition, these cells were more sensitive to cannabidiol-induced antiproliferative actions through changes in cellular energetics: from a drop of oxygen consumption rate and loss of mitochondrial membrane integrity in cells treated under atmospheric conditions to an increase in reactive oxygen species in intact mitochondria in cells treated under low-oxygen conditions. gastrointestinal disorder
http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2982.2008.01114.x/full
Cannabidiol further reduced gastrointestinal motility in septic mice but did not affect gastrointestinal motility in control mice.
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Anti-spasmodic
http://www.mdpi.com/1424-8247/3/7/2197/htm
Moreover, CBD has anti-spasmodic, anxiolytic, antinausea and anti-rheumatoid arthritis properties [11]. nausea
http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2011.01621.x/full
These results suggest that CBD produced its anti-emetic/anti-nausea effects by indirect activation of the somatodendritic 5-HT1A autoreceptors in the DRN.
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Anti-psychotic
https://www.researchgate.net/profile/Francisco_Guimaraes2/publication/227707576_A_Critical_Review_of_the_Antipsychotic_Effects_of_Cannabidiol_30_Years_of_a_Translational_Investigation/links/543d11510cf20af5cfbfa362.pdf
The first evidence that cannabidiol (CBD), a non-psychoactive component of Cannabis sativa, could have antipsychotic properties was published in 1982 [1]stress
http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2125.2012.04341.x/full
CBD has also been reported to be neuroprotective, to reduce signs of oxidative stress, to modulate cytokine release and to increase calcium release from neuronal and glial intracellular stores (reviewed in [44]), and at 15 µM to induce mRNA expression of several phosphatases in prostate and colon cancer cells
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Immunosuppressive
http://www.sciencedirect.com/science/article/pii/S0014299912000052
Cannabidiol has been shown to have potent immunosuppressive and anti-inflammatory properties in several rodent models of inflammation (Mechoulam et al., 2002).Bipolar
http://www.sciencedirect.com/science/article/pii/S2090536X14000525
The third constituent is cannabidiol. It is one of the major constituents of the cannabis plant. It is supposed to have a wider scope than THC because it is less psychoactive. Its molecular formula is C21H30O2. It is used in the treatment of nausea, convulsions, bipolar disorders, etc.
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Anti-psoriatichttp://scholarsarchive.jwu.edu/student_scholarship/8/CBD, in repeated studies, has been determined to exhibit a profound number of therapeutic effects acting as an antipsychotic, antiepileptic, neuroprotective, vasorelaxant, antispasmodic, anti-ischemic, anti-proliferative, antiemetic, antibacterial, antipsoriatic, intestinal anti-prokinetic, analgesic, bone stimulant, and anti-inflammatory (Bostwick 172).
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Intestinal Anti-prokinetic
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Bone stimulant
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CBCCannabichromeneAnti-Inflammatory
http://www.sciencedirect.com/science/article/pii/0024320580906311
It was not known if Cannabichromene (CBC), which is a major constituent of drug types of Cannabis, has anti-inflammatory properties as do other cannabinoids.Inflammation
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3417459/
CBC selectively reduces inflammation-induced hypermotility in vivo in a manner that is not dependent on cannabinoid receptors or TRPA1
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Anti-Fungal
http://onlinelibrary.wiley.com/doi/10.1002/j.1552-4604.1981.tb02606.x/full
In both tests, CBC was superior to phenylbutazone. Antibacterial activity of CBC and its isomers and homologs was evaluated using gram-positive, gram-negative, and acid-fast bacteria. Antifungal activity was evaluated using yeastlike and filamentous fungi and a dermatophyte. Antibacterial activity was strong, and the antifungal activity was mild to moderate.Fungal
http://onlinelibrary.wiley.com/doi/10.1002/j.1552-4604.1981.tb02606.x/full
Antibacterial activity of CBC and its isomers and homologs was evaluated using gram-positive, gram-negative, and acid-fast bacteria. Antifungal activity was evaluated using yeastlike and filamentous fungi and a dermatophyte. Antibacterial activity was strong, and the antifungal activity was mild to moderate.
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Anti-epileptic
https://www.researchgate.net/profile/Mariana_Babayeva2/publication/271443312_Marijuana_Compounds_A_Non-Conventional_Therapeutic_Approach_to_Epilepsy_in_Children/links/551c13e80cf2909047b9c14d/Marijuana-Compounds-A-Non-Conventional-Therapeutic-Approach-to-Epilepsy-in-Children.pdf
CBD has proven beneficial in experimental models of several neurologic disorders, including those of seizure and epilepsy [97], as have other cannabinoids such as Cannabichromene (CBC) and the propyl homologs of THC and CBD
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Analgesic
http://onlinelibrary.wiley.com/doi/10.1111/bph.12120/full
CBC was found to exerts analgesic actions in a CGS 15943 (adenosine receptors antagonist)-sensitive way (Maione et al., 2011).
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Anti-proliferative
http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2011.01327.x/full
Cannabigerol, cannabichromene, cannabidiol acid and THC acid (Ligresti et al., 2006) as well as desacetyllevonantradol (Ruh et al., 1997) also inhibit cell proliferation in different breast cancer cell lines
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CBNCannabinolAppetite Stimulant
https://www.ncbi.nlm.nih.gov/pubmed/22543671
Cannabinol induced a CB(1)R-mediated increase in appetitive behaviors via significant reductions in the latency to feed and increases in consummatory behaviors via increases in meal 1 size and duration.
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Antibiotic
https://www.ncbi.nlm.nih.gov/pubmed/18681481
Marijuana (Cannabis sativa) has long been known to contain antibacterial cannabinoids, whose potential to address antibiotic resistance has not yet been investigated. All five major cannabinoids (cannabidiol (1b), cannabichromene (2), cannabigerol (3b), Delta (9)-tetrahydrocannabinol (4b), and cannabinol (5)) showed potent activity against a variety of methicillin-resistant Staphylococcus aureus (MRSA) strains of current clinical relevance.
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Potential Medication for ALS
http://www.tandfonline.com/doi/full/10.1080/14660820510030149?scroll=top&needAccess=true
CBN was delivered via subcutaneously implanted osmotic mini‐pumps (5 mg/kg/day) over a period of up to 12 weeks. We found that this treatment significantly delays disease onset by more than two weeks while survival was not affected. Further research is necessary to determine whether non‐psychotropic cannabinoids might be useful in ameliorating symptoms in ALS.
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5270417/
Moreover, treatment with cannabinol (CBN), a non-psychotropic cannabinoid, through its residual affinity to CB1 receptors, is able to delay significantly disease onset in ALS hSOD(G93A) mice subcutaneously implanted with osmotic mini-pumps.
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Potential Medication for Glaucoma
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1772142/
Cannabinoids have the potential of becoming a useful treatment for glaucoma, as they seem to have neuroprotective properties and effectively reduce intraocular pressure.
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Analgesic
https://link.springer.com/article/10.1007/BF00421466
The results of this investigation seem to suggest that both THC and CME possess narcotic-like analgesic activity similar to morphine, while CBN appears to be a non-narcotic type analgesic like aspirin.
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CBGCannabigerolAntibiotic
http://pubs.acs.org/doi/full/10.1021/np8002673?src=recsys
Evidence that pre-cannabidiol (1a) is a powerful plant antibiotic was, nevertheless, obtained,(4) and more recent investigations have demonstrated, to various degrees, antibacterial activity for the nonpsychotropic cannabinoids cannabichromene (CBC, 2),(5) cannabigerol (CBG, 3b),(6) and cannabidiol (1b),(7) as well as for the psychotropic agent Δ9-tetrahydrocannabinol (THC, 4b).Huntington’s Disease
https://www.nature.com/articles/srep29789?WT.feed_name=subjects_neuroscience
a novel cannabigerol derivative, enhances neuronal progenitor cell survival and alleviates symptomatology in murine models of Huntington’s disease.
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Anti-Tumor
https://link.springer.com/article/10.1007%2FBF02976895?LI=true
Cannabigerol(3) was synthesized and evaluated for its inhibitory activity against mouse skin melanoma cells. Cannabigerol displayed significant antitumor activity [inhibitory concentration (IC50)=31.3l μ/mL]in vitro assay. glaucoma
http://online.liebertpub.com/doi/abs/10.1089/jop.1990.6.259
These results suggest that cannabigerol and related cannabinoids may have therapeutic potential for the treatment of glaucoma.
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Anti-Oxidant
https://www.ncbi.nlm.nih.gov/pubmed/28348416
Based on its antioxidant activities, CBG may hold great promise as an anti-oxidant agent and therefore used in clinical practice as a new approach in oxidative-stress related disorders.
Cancer
https://link.springer.com/article/10.1007/BF02975301
Cannabigerol (3) exhibited the highest growth-inhibitory activity against the cancer cell lines.
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Antidepressant & Mood-Stabilizer
https://docs.google.com/viewer?url=patentimages.storage.googleapis.com/pdfs/US20140039043.pdf
Surprisingly the applicants have found that cannabigerol (CBG) and cannabigerol type compounds (including cannabigerol propyl analogue (CBGV)) and derivatives thereof, are useful in the treatment of mood disorders, particularly depression.Irritable bowel syndrome
http://www.sciencedirect.com/science/article/pii/S0006295213000543
In conclusion, CBG attenuated murine colitis, reduced nitric oxide production in macrophages (effect being modulated by the CB2 receptor) and reduced ROS formation in intestinal epithelial cells. CBG could be considered for clinical experimentation in IBD patients.
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Anti-proliferative
http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2011.01327.x/full
Cannabigerol, cannabichromene, cannabidiol acid and THC acid (Ligresti et al., 2006) as well as desacetyllevonantradol (Ruh et al., 1997) also inhibit cell proliferation in different breast cancer cell lines (Table 1).
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Anti-inflammatory
https://link.springer.com/article/10.1007/s11481-012-9399-3
As part of a study on the SAR of phytocannabinoids, we have investigated the effect of the oxidation modification in the resorcinol moiety of cannabigerol (CBG) on CB1, CB2 and PPARγ binding affinities, identifying cannabigerol quinone (VCE-003) as a potent anti-inflammatory agent
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THCvTetrahydrocannabivarinAnticonvulsant
http://onlinelibrary.wiley.com/doi/10.1111/j.1528-1167.2010.02523.x/full
These data demonstrate that Δ9-THCV exerts antiepileptiform and anticonvulsant properties, actions that are consistent with a CB1 receptor–mediated mechanism and suggest possible therapeutic application in the treatment of pathophysiologic hyperexcitability states. Diabetes
http://care.diabetesjournals.org/content/39/10/1777
THCV could represent a new therapeutic agent in glycemic control in subjects with type 2 diabetes.
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Promotes weightloss
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3671751/
THCV is a new potential treatment against obesity-associated glucose intolerance with pharmacology different from that of CB1 inverse agonists/antagonists.anti-acne agents
http://onlinelibrary.wiley.com/doi/10.1111/exd.13042/full
Our data suggest that CBG and CBGV may have potential in the treatment of dry-skin syndrome, whereas CBC, CBDV and especially THCV show promise to become highly efficient, novel anti-acne agents
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Anti-Nausea
http://onlinelibrary.wiley.com/doi/10.1111/bph.12322/full
The pattern of findings indicates that neither THCV nor CBDV produced a behavioural profile characteristic of CB1 receptor inverse agonists. As well, these compounds may have therapeutic potential in reducing nausea. Parkinson’s Disease
http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2011.01278.x/full
Given its antioxidant properties and its ability to activate CB2 but to block CB1 receptors, Δ9-THCV has a promising pharmacological profile for delaying disease progression in PD and also for ameliorating parkinsonian symptoms.
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CBDvCannabidivarinAnti-Epileptic
https://peerj.com/articles/214/#fig-5
These results provide the first molecular confirmation of behaviourally observed effects of the non-psychoactive, anticonvulsant cannabinoid, CBDV, upon chemically-induced seizures and serve to underscore its suitability for clinical development.Epilepsy
https://peerj.com/articles/214/#fig-5
These results provide the first molecular confirmation of behaviourally observed effects of the non-psychoactive, anticonvulsant cannabinoid, CBDV, upon chemically-induced seizures and serve to underscore its suitability for clinical development.
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Anti-Nausea
http://onlinelibrary.wiley.com/doi/10.1111/bph.12322/full
The pattern of findings indicates that neither THCV nor CBDV produced a behavioural profile characteristic of CB1 receptor inverse agonists. As well, these compounds may have therapeutic potential in reducing nausea.Convulsion
https://www.ncbi.nlm.nih.gov/pubmed/22970845
These results indicate that CBDV is an effective anticonvulsant in a broad range of seizure models.
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Anti-Inflammatory
http://onlinelibrary.wiley.com/doi/10.1111/bph.12322/full
Recent in vivo work has highlighted CBDV's anti-inflammatory effects in mice (Tubaro et al., 2010). Acne Vulgaris
http://onlinelibrary.wiley.com/doi/10.1111/exd.13042/full
Our data suggest that CBG and CBGV may have potential in the treatment of dry-skin syndrome, whereas CBC, CBDV and especially THCV show promise to become highly efficient, novel anti-acne agents
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Delta (8)-THCDelta-8-tetrahydrocannabinolboost appetite
https://www.ncbi.nlm.nih.gov/pubmed/15099912
Thus, delta(8)-THC (0.001 mg/kg) caused increased food consumption and tendency to improve cognitive function, without cannabimimetic side effects. Hence, a low dose of THC might be a potential therapeutic agent in the treatment of weight disorders.
58
CBGACannabigerolic Acid Antimicrobial
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4887452/
Phytochemical investigation of a high potency variety of Cannabis sativa L. resulted in the isolation of six new metabolites, (±)-6,7-trans-epoxycannabigerolic acid (2), (±)-6,7-cis-epoxycannabigerolic acid (3), (±)-6,7-cis-epoxycannabigerol (4), (±)-6,7-trans-epoxycannabigerol (5), 5′-methyl-4-pentylbiphenyl-2,2′,6-triol (7), and 7-methoxycannabispirone (8), along with seven known compounds namely, cannabigerolic acid (1), 5′-methoxycannabigerolic acid (6), cannabispirone (9), β-cannabispiranol (10), dehydrocannabifuran (11), cannflavin B (12) and cannabigerol (13). The antimicrobial as well as the antileishmanial activities were investigated.
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Antibiotic
https://books.google.com.ph/books?id=7eVUAQAAQBAJ&pg=PA191&lpg=PA191&dq=Cannabigerolic+Acid+Antibiotic&source=bl&ots=O6VzIEgnuA&sig=viVyOoAzlKz8IOlGXDIWHwr7vbw&hl=en&sa=X&ved=0ahUKEwjlvN_UpvHVAhUJErwKHZtGCaAQ6AEIazAG#v=onepage&q=Cannabigerolic%20Acid%20Antibiotic&f=false
Cannabidol, cannabigerol, cannabidiolic, acid and cannabigerolic acidhave shown antibiotic properties (ElSohly 1982). A 1960 report stated: 'Noreworthy is the effect upon Staphylococcus aureus strainwhich are resistant to penicillin and to other antibiotics.
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Anti-inflammatory
https://www.jstage.jst.go.jp/article/bpb/34/5/34_5_774/_pdf
Anti-inflammatory activity (i.e., inhibition of COX-2) is proposed to play an important role in the development of colon cancer, which makes this subject interesting to study further. In the present work, the six cannabinoids tetrahydrocannabinol (D9 -THC), tetrahydrocannabinolic acid (D9 -THC-A), cannabidiol (CBD), cannabidiolic acid (CBDA), cannabigerol (CBG) and cannabigerolic acid (CBGA), isolated from Cannabis sativa, were evaluated for their effects on prostaglandin production.
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CBGAMCannabigerolic Acid Monomethylether
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CBGMCannabigerol Monomethylether
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CBGVA
Cannabigerovarinic Acid
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CBGVCannabigerovarin
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CBCACannabichromenic Acidanti-fungal
http://pdf.easechem.com/pdf/32/08869bca-3cf4-4b35-a897-3d6731d90462.pdf
Cannabichromene (1) and cannabichromenic acid (2) were isolated from Cannabis sativa L (Figure 1).1 The resin of this plant has shown a variety of interesting pharmacological activities such as anti-inflammatory, anti-fungal, and anti-microbial effects.2anti-fungal
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Reduces Inflammation
http://pdf.easechem.com/pdf/32/08869bca-3cf4-4b35-a897-3d6731d90462.pdf
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CBCVACannabichromevarinic Acid
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CBCVCannabichromevarin
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CBDACannabidiolic Acidanti-inflammatory
http://dmd.aspetjournals.org/content/36/9/1917.short
Nonsteroidal anti-inflammatory drugs containing a carboxyl group in their chemical structures such as salicylic acid are known to inhibit nonselectively both COX-1 and COX-2. CBDA and Δ9-THCA have a salicylic acid moiety in their structures. Thus, the structural requirements for the CBDA-mediated COX-2 inhibition were next studied. There is a structural difference between CBDA and Δ9-THCA; phenolic hydroxyl groups of CBDA are freed from the ring formation with the terpene moiety, although Δ9-THCA has dibenzopyran ring structure.cancer
http://www.sciencedirect.com/science/article/pii/S0378427412012854
The data presented in this report suggest for the first time that as an active component in the cannabis plant, CBDA offers potential therapeutic modality in the abrogation of cancer cell migration, including aggressive breast cancers.
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anti-nausea
http://onlinelibrary.wiley.com/doi/10.1111/bph.12043/full
Consequently, CBDA shows promise as a treatment for nausea and vomiting, including anticipatory nausea for which no specific therapy is currently available.
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anti-cancer
https://www.ncbi.nlm.nih.gov/pubmed/22963825
The data presented in this report suggest for the first time that as an active component in the cannabis plant, CBDA offers potential therapeutic modality in the abrogation of cancer cell migration, including aggressive breast cancers.
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CBDMCannabidiol Monomethylether
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CBD-C4Cannabidiol-C4
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CBDVACannabidivarinic Acid
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CBD-C1Cannabidiorcol
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THCA-ATetrahydrocannabinolic Acid A
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THCA-BTetrahydrocannabinolic Acid B
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THCA-C4Tetrahydrocannabinolic Acid-C4
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THCVATetrahydrocannabinolic Acid
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THCVTetrahydrocannabivarinanti-convulsive
https://www.ncbi.nlm.nih.gov/pubmed/20196794
These data demonstrate that Δ⁹-THCV exerts antiepileptiform and anticonvulsant properties, actions that are consistent with a CB1 receptor-mediated mechanism and suggest possible therapeutic application in the treatment of pathophysiologic hyperexcitability states.diabetes/obesity
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3671751/
Based on these data, it can be suggested that THCV may be useful for the treatment of the metabolic syndrome and/or type 2 diabetes, either alone or in combination with existing treatments.
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appetite suppressant
http://www.cannabis-med.org/meeting/Cologne2007/reader.pdf
THCV can behave as a CB1 receptor antagonist both in vivo and in vitro (reviewed in Pertwee, 2007), raising the possibility that THCV might (i) share the ability of other CB1 receptor antagonists to suppress feeding and body weight in animals and manParkinson’s disease
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3165958/
Given its antioxidant properties and its ability to activate CB2 but to block CB1 receptors, Δ9-THCV has a promising pharmacological profile for delaying disease progression in PD and also for ameliorating parkinsonian symptoms.
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reduce panic attack
https://books.google.com.ph/books?id=tCzdCwAAQBAJ&pg=PT182&lpg=PT182&dq=Tetrahydrocannabivarin+for+panic+attack&source=bl&ots=zUPOJe35z5&sig=mABMZJFW2ghuthjoltk3TzZc9I4&hl=en&sa=X&ved=0ahUKEwi3k8SCvvHVAhWLyLwKHTQfCsI4ChDoAQg3MAE#v=onepage&q=Tetrahydrocannabivarin%20for%20panic%20attack&f=false
It is noted that THCV has greater psychoactiveeffects than THC, but its effects are of shorter duration and more energizing. For this reason, THCV has been called the "sports car" of the cannabinoids. THCV may block panic attacks without suppression of emotions.epilepsy
http://onlinelibrary.wiley.com/doi/10.1111/bph.12321/full
Initially, we investigated the effects of modified CBDV BDS (containing no Δ9-THCV or Δ9-THC; Table 1) on PTZ-induced seizures in Experiments 1.1–1.4.
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stimulate bone growth
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3499879/
Several phytocannabinoids including cannabidiol, cannabinol, cannabidivarin, THC, and tetrahydrocannabivarin (THCV) have been reported to stimulate bone nodule formation, collagen production, and alkaline phosphatase activity in cultures of bone marrow stromal cells
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THCA-C1Tetrahydrocannabiorcolic Acid
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THC-C1Tetrahydrocannabiorcol
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THCATetrahydrocannabinolic Acidantispasmodic
http://www.amchro.com/uct/Potency_and_Pesticide_Content_in_Medical_vs._Recreational_Marijuana_0_6101-02-01.pdf
Cannabis researchers have begun further research into THCA-A’s potential therapeutic properties, such as anti-inflammatory capabilities, antispasmodic treatments and as use as an analgesic5 .cancer
https://www.ncbi.nlm.nih.gov/pubmed/17513301
Based on these results, we conclude that CBCA and THCA have the ability to induce necrotic cell death via mitochondrial dysfunction in the leaf cells of C. sativa.
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https://www.ncbi.nlm.nih.gov/pubmed/21175579
CBD was the only compound to inhibit FAAH, whereas the BDS of CBC > CBG > CBGV inhibited NAAA. CBC = CBG > CBD inhibited ACU, as did the BDS of THCVA, CBGV, CBDA and THCA, but the latter extracts were more potent inhibitors.

These results are relevant to the analgesic, anti-inflammatory and anti-cancer effects of cannabinoids and Cannabis extracts.
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nausea
http://onlinelibrary.wiley.com/doi/10.1111/bph.12316/full
These data suggest that THCA may be a more potent alternative to THC in the treatment of nausea and vomiting.
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CBECannabielsoinpentobarbital-induced sleep.
http://www.sciencedirect.com/science/article/pii/009130579190360E
The results suggest that CBD and CBDM are biotransformed by P-450 to CBE-type metabolites via 1S,2R-epoxides. In pharmacological studies using mice, CBDD and 1S, 2R-epoxy-CBD-2′,6′-diacetate produced hypothermia, and CBD, CBDM and CBEM prolonged pentobarbital-induced sleep.
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CBTCannabitriol
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CBLCannabicyclol
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CBLACannabicyclolic acid
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CBLVCannabicyclolvarin
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Anandamide or AEAArachidonoylethanolamineimpair memory
http://journals.lww.com/behaviouralpharm/pages/articleviewer.aspx?year=1996&issue=05000&article=00008&type=abstract
This is the first report that anandamide impairs memory; results suggest that endogenous cannabinoids may be involved in cognitive processes influencing memory.
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biomarker of infertility
https://academic.oup.com/humupd/article/20/4/501/832531/Endocannabinoids-as-biomarkers-of-human
Among the various candidates, endocannabinoids (eCBs), and in particular anandamide (AEA), represent potential biomarkers of human fertility disturbances.
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anti-proliferative
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0026823
The most cytotoxic treatment was achieved by the co-incubation of AEA with the selective FAAH inhibitor URB597, which drastically reduced cell viability partly by inhibiting AEA hydrolysis and consequently increasing AEA levels. This combination of molecules synergistically decreased cell proliferation without inducing cell apoptosis or necrosis.
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Noladin ether2-Arachidonyl glyceryl ether
100
NADAN-Arachidonoyl dopamineAnti-inflammatory
http://www.jimmunol.org/content/172/4/2341.short
These findings provide new mechanistic insights into the anti-inflammatory activities of NADA and highlight their potential to design novel therapeutic strategies to manage inflammatory diseases.
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Cannabinoid Studies