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TimestampTopic Focus
Publication Date
Publication Type
Article Title
https://pediatrics.aappublications.org/content/early/2020/05/12/peds.2020-1567?cct=2287
Summarize up to 3 key pointsSource Hyperlink
Email Address
2
6/25/2020 8:54:59
Consensus Statement / General Review
6/25/0020
Expert Opinion / Letter to Editor / Commentary
The Ethics of Creating a Resource Allocation Strategy During the COVID-19 PandemicLaventhal, Ncommentary on research allocation during covid
https://pediatrics.aappublications.org/content/early/2020/06/23/peds.2020-1243?cct=2287
laura.sherlock@cuanschutz.edu
3
6/25/2020 8:35:11
Consensus Statement / General Review
7/23/0020
Expert Opinion / Letter to Editor / Commentary
Mitigating the Impacts of the COVID-19 Pandemic Response on At-Risk ChildrenWong, C
discusses 3 at risk groups: 1- children w behavioral/therapy needs who are not receiving the same degree of support/therapy (1/6 kids), 2- foster children/children at risk for maltreatment (>400,000 kids), 3- children w medical complexity who may not be accessing health care as they were prior
https://pediatrics.aappublications.org/content/early/2020/06/20/peds.2020-0973?cct=2287
laura.sherlock@cuanschut.edu
4
6/25/2020 8:40:41
Consensus Statement / General Review
7/24/0020
Expert Opinion / Letter to Editor / Commentary
Sheltering in Place in a Xenophobic Climate: COVID-19 and Children in Immigrant FamiliesCholera, R
perspective piece about the unique challenges and needs for children of immigrant families (1/4 children, >18 million US children)
https://pediatrics.aappublications.org/content/early/2020/06/22/peds.2020-1094?cct=2287
laura.sherlock@cuanschutz.edu
5
6/25/2020 8:49:08
NICU-specific guidelines (PPE, DR practices, etc.)
7/24/0020
Expert Opinion / Letter to Editor / Commentary
COVID-19 and Keeping Clean: A Narrative Review To Ascertain the Efficacy of Personal Protective Equipment To Safeguard Health Care Workers Against SARS-CoV-2
Sud, S
challenges of decreasing transmission- reviews
1- what is know about contact and COVID staying on surfaces for hours to days but uncertainty about transfer efficiency
2-respiratory and where the 6 ft guideline is from "The Centers for Disease Control and Prevention’s historical radius for droplet transmission was loosely defined as 3 ft, but after the SARS-CoV-1 outbreak, this distance was extended to 6 feet on the basis of data suggesting that medical students in Hong Kong were infected at greater rates when adjacent to (∼6 ft away from) an index patient with SARS with whom they had no direct physical contact."
3- airborne, discussing they think this is less likely with covid but recognizing studies find PCR positive in air ducts etc

discusses mask safety and reuse, states that most virus gets trapped in the middle of the n95 and inactivates w time
https://hosppeds.aappublications.org/content/early/2020/06/22/hpeds.2020-0135?cct=2287
laura.sherlock@cuanschutz.edu
6
6/25/2020 9:02:01
Management & Therapeutics
7/25/0020
Peer-Reviewed Article
https://pediatrics.aappublications.org/content/early/2020/06/23/peds.2020-1437?cct=2287Patel, P
case report of a 12 yo (previously healthy) w severe covid and ITP thrombocytopenia. treated w steroids and IVIG for platelet count. no response to hydroxychloroquione or azithro, resp improvement after IL-6 antibody and remdesivir
https://pediatrics.aappublications.org/content/early/2020/06/23/peds.2020-1437?cct=2287
laura.sherlock@cuanschutz.edu
7
6/25/2020 8:58:16
Consensus Statement / General Review
7/25/0020
Expert Opinion / Letter to Editor / Commentary
Sillimon Cohen R
stay at home presents challenges for: LGBTQ children and those none gender conforming (up to 16%), children at risk for maltreatment/abuse ( 678 000 children and adolescents experiencing maltreatment in 2018), and children struggling w substance abuse disorders.
https://pediatrics.aappublications.org/content/early/2020/06/23/peds.2020-1306?cct=2287
laura.sherlock@cuanschutz.edu
8
4/1/2020 23:31:09
NICU-specific guidelines (PPE, DR practices, etc.)
6/26/2019
Peer-Reviewed Article
Optical microscopic study of surface morphology and filetering efficiency of face masks
Low-cost cloth face masks may decrease transmission among the population. Washing and drying affect the filtering efficiency as do pore size, shape, clearance, and density.
https://doi.org/10.7717/peerj.7142
susan.niermeyer@cuanschutz.edu
9
3/31/2020 18:12:41
Clinical Features (of neonatal infection)
2/6/2020
Peer-Reviewed Article
Clinical analysis of 10 neonates born to mothers with 2019-nCoV pneumonia
Among the 10 neonates, 6 were premature and 4 term.
Neonates manifested shortness of breath, fever, thrombocytopenia and abnormal liver function as well as tachycardia, vomiting, pneumothorax.
Pharyngeal swabs collected from 9 neonates were all negative.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7036645/pdf/tp-09-01-51.pdf
susan.niermeyer@cuanschutz.edu
10
4/1/2020 11:45:11
Clinical Features (of neonatal infection)
2/10/2020
Expert Opinion / Letter to Editor
Potential Maternal and Infant Outcomes from Coronavirus 2019-nCoV (SARS-CoV-2) Infecting Pregnant Women: Lessons from SARS, MERS, and Other Human Coronavirus Infections
Review from early Febhttps://www.mdpi.com/1999-4915/12/2/194
CLYDE.WRIGHT@UCDENVER.EDU
11
4/1/2020 11:53:57
Perinatal/Neonatal Transmission
2/12/2020
Peer-Reviewed Article
Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records
No evidence of intrauterine transmission
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30360-3/fulltext
CLYDE.WRIGHT@UCDENVER.EDU
12
4/2/2020 12:10:02
Clinical Features (of neonatal infection)
2/14/2020
Peer-Reviewed Article
Novel Coronavirus Infection in Hospitalized Infants Under 1 Year of Age in China
1. Retrospective case series of hospitalized infants with presumed community acquired COVID-19
2. Ages range from 56 days old to 11 months old
3. None of the infants required mechanical ventilation or intensive care
https://jamanetwork.com/journals/jama/fullarticle/2761659
robert.dietz@cuanschutz.edu
13
4/1/2020 12:03:51
Perinatal/Neonatal Transmission
2/18/2020
Expert Opinion / Letter to Editor
Coronavirus Disease 2019 (COVID-19) and Pregnancy: What obstetricians need to know
Brief tips on managing COVID during pregnancy with recommendations on what to do after birth
https://www.ajog.org/article/S0002-9378(20)30197-6/fulltext
CLYDE.WRIGHT@UCDENVER.EDU
14
4/21/2020 18:56:35
Perinatal/Neonatal Transmission
2/27/2020
Expert Opinion / Letter to Editor
Positive RT-PCR test results in patients recovered from COVID-19Lan, L.
Four patients with COVID-19 who had resolved symptoms and 2 negative RT-PCR results again had positive RT-PCR test results 5-13 days later. These findings are consistent with those reported from Korea, suggesting persistent viral shedding, reactivation, or reinfection.
https://jamanetwork.com/journals/jama/fullarticle/2762452?guestAccessKey=aa589170-647b-4af6-83b6-c53601aa46f6&utm_source=silverchair&utm_medium=email&utm_campaign=article_alert-jama&utm_content=etoc&utm_term=042120
susan.niermeyer@cuanschutz.edu
15
4/24/2020 9:20:49
Perinatal/Neonatal Transmission
2/28/2020
Peer-Reviewed Article
A well infant with Coronavirus disease 2019 with high viral loadKam, K-q.
An asymptomatic 6-mo-old infant with COVID-19 had persistently positive nasopharyngeal swabs for 16 days. Infants may also play a role in asymptomatic transmission in the community.
https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciaa201/5766416
susan.niermeyer@cuanschutz.edu
16
4/1/2020 10:18:30
Consensus Statement / General Review
2/28/2020
Expert Opinion / Letter to Editor
Q&A: The novel coronavirus outbreak causing COVID-19Some general questions answered in the early stages of the pandemic
https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-020-01533-w?utm_source=sn&utm_medium=referral&utm_content=null&utm_campaign=BSLB_4_CA01_GL_BSLB_USG_CA01_GL_LSGR_PubH_Coronavirus_LandingPage
clyde.wright@cuanschutz.edu
17
4/1/2020 11:57:51
Consensus Statement / General Review
3/1/2020
Expert Opinion / Letter to Editor
Coronavirus disease (COVID‐19) and neonate: What neonatologist need to knowLu, Q.Short review on topics relevant to neonatologist
https://onlinelibrary.wiley.com/doi/full/10.1002/jmv.25740
CLYDE.WRIGHT@UCDENVER.EDU
18
4/1/2020 11:05:34
Clinical Features (of neonatal infection)
3/1/2020
Peer-Reviewed Article
Epidemiological Characteristics of 2143 Pediatric Patients With 2019 Coronavirus Disease in China
Characterizes clinical manifestations of COVID+ pediatric patients. Letter to authors asks about whether routine vaccine schedule provides some protection and explains why children are protected (https://pediatrics.aappublications.org/content/early/2020/03/16/peds.2020-0702/tab-e-letters), authors reply they have no information on that issue.
https://pediatrics.aappublications.org/content/early/2020/03/16/peds.2020-0702/tab-article-info
CLYDE.WRIGHT@UCDENVER.EDU
19
4/1/2020 11:08:25
Consensus Statement / General Review
3/1/2020
Expert Opinion / Letter to Editor
COVID-19 in Children: Initial Characterization of the Pediatric DiseaseEditorial review of Dong et al manuscript describing 2143 pediatric patients
https://pediatrics.aappublications.org/content/early/2020/03/16/peds.2020-0834
CLYDE.WRIGHT@UCDENVER.EDU
20
4/28/2020 21:10:25
Perinatal/Neonatal Transmission
3/4/2020
Expert Opinion / Letter to Editor
Air, surface environmental, and personal protective equipment contamination by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) from a symptomatic patient
Ong, S.W.X.
Environmental sampling from 3 symptomatic COVID-19 patients showed extensive environmental contamination before room cleaning in the bed and bath area as well as air outlet fan, supporting respiratory and fecal shedding. Only one of 5 PPE sites (top of shoes) was positive. All swabs were negative post room cleaning, supporting the effectiveness of standard routines.
https://jamanetwork.com/journals/jama/fullarticle/2762692
susan.niermeyer@cuanschutz.edu
21
4/1/2020 22:53:45
NICU-specific guidelines (PPE, DR practices, etc.)
3/4/2020
Expert Opinion / Letter to Editor
Proposal for prevention and control of the 2019 novel coronavirus disease in newborn infants
1.) suggested delivery room managment: neg pressure room, PPE
2.) suggests universal screening of all infants and Respiratory/GI/CV/temp issues could be presenting sign
3.) suggested for symptomatic babies: neg pressure room, full PPE from head to toe, discharge when afebrile x72hrs, PCR neg from NP swab x2
https://fn.bmj.com/content/early/2020/03/04/archdischild-2020-318996
satya.houin@childrenscolorado.org
22
3/31/2020 18:26:19
Perinatal/Neonatal Transmission
3/5/2020
Peer-Reviewed Article
Lack of vertical transmission of severe acute respiratory syndrome Coronavirus 2, China
Woman at 35 weeks gestation with positive sputum, but negative serum, urine, feces, amniotic fluid umbilical cord blood, placenta and breast milk.
Baby was delivered by C-section for FHR 110, sent to a negative-pressure ward, and oropharyngeal swab at birth negative for SARS-CoV-2.
https://doi.org/10.3201/eid2606.200287
susan.niermeyer@cuanschutz.edu
23
4/1/2020 12:01:23
Perinatal/Neonatal Transmission
3/6/2020
Peer-Reviewed Article
Pregnancy and Perinatal Outcomes of Women With Coronavirus Disease (COVID-19) Pneumonia: A Preliminary Analysis
Brief report of pregnancy and COVID
https://www.ajronline.org/doi/full/10.2214/AJR.20.23072
CLYDE.WRIGHT@UCDENVER.EDU
24
3/31/2020 19:20:58
Perinatal/Neonatal Transmission
3/8/2020
Peer-Reviewed Article
[Analysis of the pregnancy outcomes in pregnant women with COVID-19 in Hubei Province]
Comparison of pregnancy outcomes of 16 women with COVID-19 and 45 women without.
Mean gestational ages 38.7 and 37.9 wks and all deliveries were by Caesarean section.
There was no different in fetal distress, meconium-stained amniotic fluid, preterm birth, asphyxia; however, only 1 mother had severe disease.
https://doi.org/10.3760/cma.j.cn112141-20200218-00111
susan.niermeyer@cuanschutz.edu
25
4/6/2020 11:46:31
NICU-specific guidelines (PPE, DR practices, etc.)
3/10/2020Webpage ABM STATEMENT ON CORONAVIRUS 2019 (COVID-19)
Academy of Breastfeeding Medicine
ABM recommendations for breastfeeding and expressing breastmilk
https://www.bfmed.org/abm-statement-coronavirus
stephanie.bourque@childrenscolorado.org
26
4/1/2020 12:59:21
Consensus Statement / General Review
3/10/2020
Expert Opinion / Letter to Editor
Chinese expert consensus on the perinatal and neonatal management for the prevention and control of the 2019 novel coronavirus infection (First edition)
Old, but flow diagram on page 4 is nice outline of one option for managing positive mom, positive baby, or positive dyad.
http://atm.amegroups.com/article/view/35751/html
meganjkirkley@gmail.com
27
4/1/2020 11:11:30
Perinatal/Neonatal Transmission
3/13/2020
Peer-Reviewed Article
Characteristics of pediatric SARS-CoV-2 infection and potential evidence for persistent fecal viral shedding
1) case series of 10 patients (2mo-15 yrs) and all diagnosed based on exposure history
2) Pediatric patients had limited respiratory symptoms, but had persistent fecal shedding (lasting longer than respiratory symptoms, and often without GI sx)
3) all patient treated with alpha-interferon tid; one tx with azithro and IVIG and kept in hospital until swabs negative!!
https://www.nature.com/articles/s41591-020-0817-4?utm_source=sn&utm_medium=referral&utm_content=RMarketing&utm_campaign=BSLB_4_CA01_GL_BSLB_USG_CA01_GL_LSGR_PubH_Coronavirus_LandingPage
CLYDE.WRIGHT@UCDENVER.EDU
28
4/24/2020 9:51:42
Perinatal/Neonatal Transmission
3/16/2020
Peer-Reviewed Article
Infants born to mothers with a new Coronavirus (COVID-19)Chen, Y.
This early report of infants born to COVID-19 positive mothers in China showed no positive viral testing. Two of 4 infants had rashes at birth and one had tachypnea requiring non-invasive mechanical ventilation.
https://www.frontiersin.org/articles/10.3389/fped.2020.00104/full
susan.niermeyer@cuanschutz.edu
29
4/5/2020 17:38:47
Management & Therapeutics
3/16/2020WebpageNIH clinical trial of investigational vaccine for COVID-19 beginsN/A
1) Phase 1 trial of mrna-1273 developed by Moderna Inc (Cambridge, MA)
2) Enrolled 45 healthy adults at KP Seattle who will receive varying doses 28-days apart and be followed for 1 year.
https://www.nih.gov/news-events/news-releases/nih-clinical-trial-investigational-vaccine-covid-19-begins
meganjkirkley@gmail.com
30
4/24/2020 9:27:35
Clinical Features (of neonatal infection)
3/17/2020
Peer-Reviewed Article
A 55-day-old female infant infected with 2019 novel Coronavirus disease: presenting with pneumonia, liver injury, and heart damage
Cui, Y.
Although disease is usually mild, young infants with COVID-19 can present with multiple organ damage and severe disease.
https://academic.oup.com/jid/advance-article/doi/10.1093/infdis/jiaa113/5807961
susan.niermeyer@cuanschutz.edu
31
4/15/2020 17:50:01
Consensus Statement / General Review
3/17/2020
Expert Opinion / Letter to Editor
Aerosol and surface stability of SARS-CoV-2 as compared with SARS-CoV-1van Doremalen, N.
This review summarizes laboratory investigation of the 2 viruses in aerosol and on different surfaces. Aerosol and fomite transmission of SARS-CoV-2 is plausible, since the virus is viable and infectious in aerosols for hours and on surfaces up to days.
https://www.nejm.org/doi/full/10.1056/NEJMc2004973?query=TOC
susan.niermeyer@cuanschutz.edu
32
4/1/2020 11:59:58
Perinatal/Neonatal Transmission
3/17/2020
Peer-Reviewed Article
An Analysis of 38 Pregnant Women with COVID-19, Their Newborn Infants, and Maternal-Fetal Transmission of SARS-CoV-2: Maternal Coronavirus Infections and Pregnancy Outcomes.
No evidence of perinatal transmission
https://www.archivesofpathology.org/doi/pdf/10.5858/arpa.2020-0901-SA
CLYDE.WRIGHT@UCDENVER.EDU
33
4/1/2020 12:43:07
NICU-specific guidelines (PPE, DR practices, etc.)
3/17/2020WebpageNew coronavirus stable for hours on surfaces
virus detectable in aerosols for up to three hours, up to 24 hours on cardboard and up to two to three days on plastic and stainless steel
https://www.nih.gov/news-events/news-releases/new-coronavirus-stable-hours-surfaces
meganjkirkley@gmail.com
34
4/1/2020 23:45:49
NICU-specific guidelines (PPE, DR practices, etc.)
3/17/2020Webpage
COVID-19 Recommendations for Management of Pregnant Women an Neonates with Suspected or Confirmed COVID-19
Ontario Health Guidelines/Protocols for management (linked from EBNEO)
https://www.obgyn.utoronto.ca/sites/default/files/toronto_region_covid_19_management_of_pregnant_women_and_neonates_with_suspected_or_confirmed_covid_march_17_2020.pdf
stephanie.bourque@childrenscolorado.org
35
4/1/2020 11:55:22
Clinical Features (of neonatal infection)
3/18/2020
Peer-Reviewed Article
Clinical characteristics of novel coronavirus disease 2019 (COVID-19) in newborns, infants and children
Short report on clinical characteristics including neonatal patients
https://www.pediatr-neonatol.com/article/S1875-9572(20)30026-7/fulltext
CLYDE.WRIGHT@UCDENVER.EDU
36
4/4/2020 17:44:13
Perinatal/Neonatal Transmission
3/23/2020
Peer-Reviewed Article
Risks of Novel Coronavirus Disease in PregnancyPanahi, L.
Review article (note published March 23)
1) Covid-19 in pregnant women associated with PTB, fetal distress, miscarriage but no evidence of infection in newborns.
2) Unlike SARS/MERS pregnant women do NOT seem to be at risk for more severe respiratory symptoms than non-pregnant adults.
https://www.ncbi.nlm.nih.gov/pubmed/32232217
meganjkirkley@gmail.com
37
4/21/2020 23:35:27
Consensus Statement / General Review
3/23/2020
Peer-Reviewed Article
Using social and behavioural science to support COVID-19 pandemic responseVan Bavel, J.J.
Insights from social and behavioural sciences can help align human behavior with the recommendations of epidemiologists and public health experts.
https://doi.org/10.31234/osf.io/y38m9
susan.niermeyer@cuanschutz.edu
38
4/1/2020 23:31:41
Consensus Statement / General Review
3/23/2020
Peer-Reviewed Article
Systematic review of COVID‐19 in children shows milder cases and a better prognosis than adults
1) pediatric cases account for 1-5% of total cases; 2) common symptoms of fever/respiratory symptoms with decreased rates of severe pneumonia compared to adults; 3) pediatric cases less likely to have elevated inflammatory markers and leukopenia compared to adults
https://onlinelibrary.wiley.com/doi/abs/10.1111/apa.15270
stephanie.bourque@childrenscolorado.org
39
4/1/2020 11:49:26
Clinical Features (of neonatal infection)
3/24/2020
Peer-Reviewed Article
Clinical features and obstetric and neonatal outcomes of pregnant patients with COVID-19 in Wuhan, China: a retrospective, single-centre, descriptive study
One of the initial reports on maternal/neonatal infection
https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(20)30176-6/fulltext
CLYDE.WRIGHT@UCDENVER.EDU
40
4/1/2020 23:40:50
NICU-specific guidelines (PPE, DR practices, etc.)
3/24/2020WebpagePreparing your Maternal and Neonatal Units to Respond to COVID-19CMQCC Webinar (linked from EBNEO)
https://www.youtube.com/watch?v=O45ZuFrBE9g&feature=youtu.be
stephanie.bourque@childrenscolorado.org
41
4/3/2020 13:32:15
NICU-specific guidelines (PPE, DR practices, etc.)
3/25/2020
Expert Opinion / Letter to Editor
Labor and Delivery Guidance for COVID-19Boelig, R.C.MFM/OBGYN recommendations for screening, antenatal steroids and labor/delivery precautions
https://www.sciencedirect.com/science/article/pii/S2589933320300409
stephanie.bourque@childrenscolorado.org
42
4/27/2020 21:27:14
Diagnosis & Testing
3/25/2020
Expert Opinion / Letter to Editor
A pregnant woman and the SARS-CoV-2 infection: how are barriers easily crossed?Indraccolo, U.
An Italian obstetrician describes how easily the fear of pregnancy complications (such as preeclampsia) can cross the barriers for preventing contagion and introduce SARS-CoV-2 into the hospital.
https://www.recentiprogressi.it/articoli.php?archivio=yes&vol_id=3347&id=33190
susan.niermeyer@cuanschutz.edu
43
4/6/2020 17:14:45
Management & Therapeutics
3/25/2020
Expert Opinion / Letter to Editor
COVID-19 and chloroquine/hydroxychloroquine- is there ophthalmologic concernMarmor M
1- doses being used/proposed are about 4-5 times higher (China) or 2x higher (France) than what is used for lupus. with prolonged use in SLE, retinal toxicity can develop. it is unknown if the higher doses will increase short term risk. This ophthalmologist doesn't think routine exams post use are needed at this point but suggests being aware
2- completely unknown what the impact on the developing retina would be, important in our population
https://www.ajo.com/article/S0002-9394(20)30132-X/pdf
laura.sherlock@cuanschutz.edu
44
4/3/2020 11:18:59
Clinical Features (of neonatal infection)
3/25/2020
Peer-Reviewed Article
Clinical and epidemiological features of 36 children with coronavirus disease 2019 (COVID-19) in Zhejiang, China: an observational cohort study
Qiu, H.
Review of 36 children (mean age 3.5 years) with COVID-19. About half had moderate sx with evidence of PNA; the rest had mild symptoms or were asymptomatic. Leukopenia, fever, and elevated inflammatory markers were associated with more severe disease. All survived.
https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(20)30198-5/fulltext
meganjkirkley@gmail.com
45
4/1/2020 23:26:13
Consensus Statement / General Review
3/25/2020
Expert Opinion / Letter to Editor
Why is COVID-19 so mild in children?
1) immune system differences, transfer of maternal Abs; 2) expression of ACE-2 receptor needed for SARS-Cov2 is different in children; 3) fecal evidence of disease/carrier state persists much longer than nasopharyngeal secretions
https://onlinelibrary.wiley.com/doi/epdf/10.1111/apa.15271
stephanie.bourque@childrenscolorado.org
46
4/2/2020 15:47:54
Management & Therapeutics
3/26/2020WebpageCOVID-19 Research in Brief: 20 March to 27 March, 2020Carvalho, TBrief summary of a weeks worth of research regarding COVID19
https://www.nature.com/articles/d41591-020-00006-0
CLYDE.WRIGHT@UCDENVER.EDU
47
5/8/2020 12:43:27
Management & Therapeutics
3/26/2020
Expert Opinion / Letter to Editor
Safe delivery for pregnancies affected by COVID-19Qi, H.
This commentary from Chinese obstetricians outlines the rationale behind recommendations for early delivery, C-section delivery, and separation of COVID-19 positive mothers and their infants as well as monitoring and testing of health professionals.
https://obgyn.onlinelibrary.wiley.com/doi/full/10.1111/1471-0528.16231
susan.niermeyer@cuanschutz.edu
48
4/5/2020 11:14:57
Perinatal/Neonatal Transmission
3/26/2020Webpage
Transmission potential of SARS-CoV-2 in viral shedding observed at the University of Nebraska Medical Center
Santarpia, J.L.
[Release pre-peer-review] There is evidence that SARS-CoV-2 is shed into the environment as expired particles, during toileting (stool), and through contact with fomites. This supports disease spread through both direct (droplet and person-to-person) and indirect (contaminated objects and airborne) contact.
https://www.medrxiv.org/content/10.1101/2020.03.23.20039446v2
susan.niermeyer@cuanschutz.edu
49
3/31/2020 13:45:21
Clinical Features (of neonatal infection)
3/26/2020WebpageBurden of COVID-19 and epidemiologic risk factors in children
Based on the China experience, asymptomatic or minimally symptomatic infection in children appears to be common and is probably responsible for community spread. Children are less likely to present with fever. Co-infection with other respiratory virus is well documented. Children have similar findings on CXR/Chest CT but have milder illness overall.
https://www.cdc.gov/coronavirus/2019-ncov/hcp/pediatric-hcp.html
meganjkirkley@gmail.com
50
3/31/2020 17:52:53
Perinatal/Neonatal Transmission
3/26/2020
Peer-Reviewed Article
Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia
Among the first confirmed cases, median age was 59 years and 56% were male.
The mean incubation period was 5.2 days with the 95th percentile at 12.5 days.
In early stages, the epidemic doubled in size every 7.4 days for a basic reproductive number estimated at 2.2.
https://www.nejm.org/doi/full/10.1056/NEJMoa2001316
susan.niermeyer@cuanschutz.edu
51
3/31/2020 18:01:11
Perinatal/Neonatal Transmission
3/26/2020
Expert Opinion / Letter to Editor
Defining the epidemiology of Covid-19 - studies needed
Counting the number of cases is necessary to calibrate the epidemic response.
Surveillance and cohort studies in well-defined settings/populations can help in describing the overall burden and the household and community attack rate.
https://www.nejm.org/doi/full/10.1056/NEJMp2002125
susan.niermeyer@cuanschutz.edu
52
4/1/2020 10:30:15
Clinical Features (of neonatal infection)
3/26/2020
Peer-Reviewed Article
Neonatal Early-Onset Infection With SARS-CoV-2 in 33 Neonates Born to Mothers With COVID-19 in Wuhan, China
Case series from Wuhan Children's Hospital discussing 33 neonates born to COVID19 positive mothers. Of these, 3 patients were found to be COVID19 positive by day of 2 of life and all presented with lethargy and pneumonia; and 2 of the 3 presented with fever. These symptoms were mild and supportable and all 3 had "favorable" outcomes. Perhaps importantly, this data suggests that perinatal transmission is possible.
https://jamanetwork.com/journals/jamapediatrics/fullarticle/2763787?guestAccessKey=dc607cc9-7197-4cc2-8d64-25a5f3f3132b&utm_source=silverchair&utm_medium=email&utm_campaign=article_alert-jamapediatrics&utm_term=mostread&utm_content=olf-widget_03302020
clyde.wright@cuanchutz.edu
53
4/1/2020 10:32:55
Consensus Statement / General Review
3/26/2020
Expert Opinion / Letter to Editor
Management of Critically Ill Adults With COVID-19
Consensus guidelines from 36 experts in 12 countries on management of adults with COVID. Guidelines on infection control, respiratory, cardiovascular, antibiotic/antiviral therapies are offered. Most to nearly all are of weak evidence level - and extrapolated from general sepsis/ARDS literature. Notably, steroids if intubated are recommended and convalescent plasma is NOT recommended at this point.
https://jamanetwork.com/journals/jama/fullarticle/2763879
CLYDE.WRIGHT@UCDENVER.EDU
54
4/1/2020 10:37:30
Perinatal/Neonatal Transmission
3/26/2020
Peer-Reviewed Article
Antibodies in Infants Born to Mothers With COVID-19 Pneumonia
Case series of 6 mother-infant dyads of infant antibody levels (IgG and IgM) born to COVID+mothers with pneumonia
Editorial of interest: https://jamanetwork.com/journals/jama/fullarticle/2763851
https://jamanetwork.com/journals/jama/fullarticle/2763854
CLYDE.WRIGHT@UCDENVER.EDU
55
4/1/2020 11:21:26
Management & Therapeutics
3/26/2020
Expert Opinion / Letter to Editor
Covid-19: what treatments are being investigated?Reviews potential therapies for COVID in adultshttps://www.bmj.com/content/368/bmj.m1252
CLYDE.WRIGHT@UCDENVER.EDU
56
4/1/2020 11:22:47
Management & Therapeutics
3/26/2020
Expert Opinion / Letter to Editor
Covid-19: FDA approves use of convalescent plasma to treat critically ill patientsUpdate on use of convalescent plasma to treat severe diseasehttps://www.bmj.com/content/368/bmj.m1256
CLYDE.WRIGHT@UCDENVER.EDU
57
4/1/2020 23:19:18
Management & Therapeutics
3/26/2020
Expert Opinion / Letter to Editor
ACOG Q&A on antenatal corticosteroids and COVID
1.) no data currently to discourage use of betamethasone. Therefore RECOMMENDS betamethasone in <34 weeks gestation
2.) discourages use of betamethasone in late preterm gestation 34+0 to 36+6 weeks
https://www.acog.org/clinical-information/physician-faqs/covid-19-faqs-for-ob-gyns-obstetrics
satya.houin@childrenscolorado.org
58
4/1/2020 23:24:21
Perinatal/Neonatal Transmission
3/26/2020
Peer-Reviewed Article
Turbulent gas clouds and respiratory pathogen emissions: potential implications for reducing transmission of COVID-19
The dichotomy of droplet vs. aerosol transmission may actually be a continuum of droplet sizes. Outstanding videos show the dynamics of cough and sneeze "semiballistic emission trajectories".
https://jamanetwork.com/journals/jama/article-abstract/2763852
susan.niermeyer@cuanschutz.edu
59
4/2/2020 10:45:12
Perinatal/Neonatal Transmission
3/26/2020
Peer-Reviewed Article
Possible Vertical Transmission of SARS-CoV-2 From an Infected Mother to Her Newborn
An 34wk infant born in Wuhan, China was SARS-CoV-2 positive on RT-PCR and had IgG and IgM to SARS-CoV-2 were elevated in the infant. Vaginal secretions of the mother were negative for the virus, indicating likely in utero transmission.
https://jamanetwork.com/journals/jama/fullarticle/2763853
robert.dietz@cuanschutz.edu
60
4/2/2020 11:31:57
Perinatal/Neonatal Transmission
3/26/2020
Expert Opinion / Letter to Editor
Can SARS-CoV-2 Infection Be Acquired In Utero? More Definitive Evidence Is Needed
Editorial preaching caution on proclaiming vertical transmission is possible based on first generation ELISA testing of SARS-CoV-2 IgG and IgM testing with relatively low specificity and sensitivity. As testing improves in quality and quantity, more evidence is needed when counseling expectant mothers who are positive for COVID-19.
https://jamanetwork.com/journals/jama/fullarticle/2763851
robert.dietz@cuanschutz.edu
61
4/9/2020 12:04:06
Perinatal/Neonatal Transmission
3/27/2020
Peer-Reviewed Article
COVID-19 in pregnancy: early lessonsBreslin, NEarly experience with COVID19 in pregnancy in New York
https://www.sciencedirect.com/science/article/pii/S2589933320300410
CLYDE.WRIGHT@UCDENVER.EDU
62
4/9/2020 17:11:32
Management & Therapeutics
3/27/2020
Expert Opinion / Letter to Editor
Treatment of 5 Critically Ill Patients with COVID-19 with Convalescent PlasmaChen, S
1- unblinded, not randomized, only 5 patients (2 women, 3 men)- MV with severe PNA, already had received methylpred and antivirals
2- treated w plasma that had specific antibody titer >1:1000 between hospital days 10-22
3- all patients improved by temp, PaO2/FiO2, 3 discharged, 2 stable and improved by time paper submitted
https://jamanetwork.com/journals/jama/fullarticle/2763983
laura.sherlock@cuanschutz.edu
63
4/4/2020 16:41:25
Management & Therapeutics
3/27/2020
Expert Opinion / Letter to Editor
Non-steroidal anti-inflammatory drugs and covid-19Little, PEditorial on the potential harms associated with NSAIDS in the setting of COVID19 infectionhttps://www.bmj.com/content/368/bmj.m1185
CLYDE.WRIGHT@UCDENVER.EDU
64
4/27/2020 15:41:51
Diagnosis & Testing
3/27/2020
Peer-Reviewed Article
A mild type of childhood Covid-19 - A case reportYin, X.
A 9-yo child was hospitalized with fever to 38.9C for 3 days. He had no other symptoms and no clear exposure; chest CT was essentially normal and remained so despite confirm positive RT-PCR for SARS-CoV-2."COVID-19 has strong transmission and high concealment" and must be suspected even when symptoms are mild and imaging negative if disease spread is to be contained.
https://www.sciencedirect.com/science/article/pii/S2352621120300164?via%3Dihub
susan.niermeyer@cuanschutz.edu
65
4/2/2020 16:41:17
NICU-specific guidelines (PPE, DR practices, etc.)
3/29/2020
Peer-Reviewed Article
Preparing an obstetric unit in the heart of the epidemic strike of COVID-19: quick reorganization tips
Capanna, F.
Obstetricians from across Europe offer suggestions on the rapid reorganization of physical spaces, workflow, and patient care (outpatient, imaging, antenatal, labor and delivery, postnatal units) in the face of the novel Coronavirus pandemic.
https://doi.org/10.1080/14767058.2020.1749258
susan.niermeyer@cuanschutz.edu
66
4/1/2020 12:35:16
Perinatal/Neonatal Transmission
3/29/2020
Peer-Reviewed Article
Detectable SARS‐CoV‐2 Viral RNA in Feces of Three Children during Recovery Period of COVID‐19 Pneumonia
Children with mild COVID infection all had positive throat swabs within 7 days, and positive viral RNA in stool by 10 days. Positive viral RNA in stool seems to persist at least a week after throat swabs negative.
https://onlinelibrary.wiley.com/doi/10.1002/jmv.25795
meganjkirkley@gmail.com
67
4/8/2020 20:30:58
Clinical Features (of neonatal infection)
3/30/2020
Peer-Reviewed Article
Maternal and neonatal outcomes of pregnant women with COVID-19 pneumonia: a case-control study
Li, N.
Pregnant women with COVID-19 presented with mild or absent respiratory symptoms. There were no severe respiratory outcomes; newborns were negative on early testing.
https://doi.org/10.1093/cid/ciaa352
susan.niermeyer@cuanschutz.edu
68
4/2/2020 17:10:18
NICU-specific guidelines (PPE, DR practices, etc.)
3/30/2020
Peer-Reviewed Article
International perspectives concerning donor milk banking during the SARS-CoV-2 (COVID-19) pandemic
Marinelli, K.A.
https://journals.sagepub.com/doi/full/10.1177/0890334420917661
susan.niermeyer@cuanschutz.edu
69
4/20/2020 22:40:08
Consensus Statement / General Review
3/30/2020
Peer-Reviewed Article
Presence of SARS-Coronavirus-2 in sewageMedema, G.
This pre-peer review report documents the presence of SARS-CoV-2 in sewage during the emergence of COVID-19 in the Netherlands. The identification preceded reported cases and may serve as a sensitive tool to monitor virus circulation in the population.
https://www.medrxiv.org/content/10.1101/2020.03.29.20045880v1
susan.niermeyer@cuanschutz.edu
70
4/9/2020 20:53:13
Diagnosis & Testing
3/30/2020
Peer-Reviewed Article
Proposal for international standardization of the use of lung ultrasound for COVID-19 pateients; a simple, quantitative, reproducible method
Soldati, G.
Lung ultrasound offers a point-of-care tool for diagnosis of the extent of lung involvement with COVID-19, avoiding need for CT scan and improving severity estimation over chest x-ray. Details of acquisition, scoring, and classification, and data-sharing are presented.
https://doi.org/10.1002/jum.15285
susan.niermeyer@cuanschutz.edu
71
4/1/2020 17:46:41
Management & Therapeutics
3/30/2020
Expert Opinion / Letter to Editor
Novel Coronavirus Treatment with Ribavirin - Groundwork for Evaluation for COVID-19
1- ribavirin shows direct antiviral effects on covid in vitro (Vero-RML6 and LLC-MK2 cells). Prior studied in SARS (2003- Canada and Hong Kong)- equivocal results even when in combo w steroids
2- ribavirin can be given aerosolized (has been used in RSV) or orally- for Covid has been suggested IV or oral (S/E hemolysis, anemia, hyperbili)
3- cost for manufacturing in the US is reportedly $0.2-2.1 per gram
https://onlinelibrary.wiley.com/doi/epdf/10.1002/jmv.25798
laura.sherlock@cuanschutz.edu
72
4/23/2020 16:45:39
Management & Therapeutics
3/31/2020
Expert Opinion / Letter to Editor
Utility of Substandard Face Mask Options for Health Care Workers During the COVID-19 Pandemic
Abd-Elsayed, A
1. Fit and seal-test respirators remain the gold standard PPE against droplet-transmitted infections.
2. Cloth masks have variable reports of benefit against viral transmission, though they are likely worse than surgical masks.
3. The benefit of any mask is significantly dependent on adherence of facemark use.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7172555/
robert.dietz@cuanschutz.edu
73
4/5/2020 11:43:46
Perinatal/Neonatal Transmission
3/31/2020
Peer-Reviewed Article
Quantifying SARS-CoV-2 transmission suggests epidemic control with digital contact tracing
Ferretti, L
Manual contact tracing cannot keep up with pandemic spread, could an APP help us do this in real time?
https://science.sciencemag.org/content/early/2020/03/30/science.abb6936
CLYDE.WRIGHT@UCDENVER.EDU
74
4/2/2020 15:39:19
Diagnosis & Testing
3/31/2020
Expert Opinion / Letter to Editor
Diagnosis and Management of COVID-19 DiseaseKrishnan, V
Public Health information series from ATS; great bullet points on what has been learned about disease in adults. Helpful reference list.
https://www.atsjournals.org/doi/pdf/10.1164/rccm.2020C1
CLYDE.WRIGHT@UCDENVER.EDU
75
4/2/2020 16:29:20
NICU-specific guidelines (PPE, DR practices, etc.)
3/31/2020
Peer-Reviewed Article
Emergency cesarean section performed in a patient with confirmed severe acute respiratory syndrome Coronavirus-2: a case report
Lee, D. H.
Cesarean section at term in a woman with COVID-19 and obstructed labor utilized a dedicated operating room, spinal anesthesia, and enhanced PPE for personnel. Mother and infant were cared for separately postnatally.
https://doi.org/10.4097/kja.20116
susan.niermeyer@cuanschutz.edu
76
4/1/2020 11:17:33
Management & Therapeutics
3/31/2020
Expert Opinion / Letter to Editor
EMA advice on the use of NSAIDs for Covid-19Opinion paper on adults and use of NSAIDs: No reason to stop taking
https://dtb.bmj.com/content/early/2020/03/31/dtb.2020.000021
CLYDE.WRIGHT@UCDENVER.EDU
77
4/1/2020 11:28:12
Management & Therapeutics
3/31/2020
Expert Opinion / Letter to Editor
Routine childhood immunization may protect against COVID-19HYPOTHESIS only: role of routine vaccines in increasing resistance to COVID
https://www.sciencedirect.com/science/article/pii/S0306987720304837
CLYDE.WRIGHT@UCDENVER.EDU
78
4/1/2020 11:30:23
Clinical Features (of neonatal infection)
3/31/2020
Expert Opinion / Letter to Editor
Renin-angiotensin system: The unexpected flaw inside the human immune system revealed by SARS-CoV-2
HYPOTHESIS ONLY: consideration of how ACE inhibitor therapy may increase susceptibility to COVID
https://www.sciencedirect.com/science/article/pii/S0306987720304370
CLYDE.WRIGHT@UCDENVER.EDU
79
4/1/2020 11:32:06
Perinatal/Neonatal Transmission
3/31/2020
Expert Opinion / Letter to Editor
Why are pregnant women susceptible to COVID-19? An immunological viewpointProvides some guidelines on managing pregnant women with active COVID
https://www.sciencedirect.com/science/article/pii/S0165037820300437
CLYDE.WRIGHT@UCDENVER.EDU
80
4/1/2020 11:36:19
Management & Therapeutics
3/31/2020
Expert Opinion / Letter to Editor
The use of anti-inflammatory drugs in the treatment of people with severe coronavirus disease 2019 (COVID-19): The Perspectives of clinical immunologists from China
Pertinent discussion on use of anti-inflammatories during COVID (logical extension to use during pregnancy for fetal lung maturity)
https://www.sciencedirect.com/science/article/pii/S1521661620301984
CLYDE.WRIGHT@UCDENVER.EDU
81
4/1/2020 16:56:35
Management & Therapeutics
3/31/2020
Expert Opinion / Letter to Editor
Corticosteroids in Allergic Rhinitis in COVID-19 Infected Patients- an ARIA-EAACI Statement
1- patients (including children) with allergic rhinitis/atopy do not appear to have increased risk of morbidity/mortality, as opposed to adults with COPD/asthma
2- 40 pediatric patients with allergic rhinitis treated in Wuhan, 2/3 on intranasal steroids and 1/3 not- no difference in outcomes
3- recommendation: do not stop intranasal corticosteroids in patients at this time. While neonates infrequently are on intranasal CS, limited retrospective pediatric data supports the use of them will not worsen outcomes
https://onlinelibrary.wiley.com/doi/epdf/10.1111/all.14302
laura.sherlock@cuanschutz.edu
82
4/2/2020 16:30:03
Clinical Features (of neonatal infection)
4/1/2020
Expert Opinion / Letter to Editor
Why the immune system fails to mount an adaptive immune response to a Covid ‐19 infection
Ahmadpoor, PHypothesis paper about the innate/adaptive immune response to COVID19
https://onlinelibrary.wiley.com/doi/pdf/10.1111/tri.13611
CLYDE.WRIGHT@UCDENVER.EDU
83
4/2/2020 17:03:50
NICU-specific guidelines (PPE, DR practices, etc.)
4/1/2020
Expert Opinion / Letter to Editor
COVID-19 and breastfeeding: not that simpleBerveiller, P.
Temporary separation of a newborn from a symptomatic mother may be prudent, but the feeding of expressed breast milk should be encouraged.
https://journals.sagepub.com/doi/full/10.1177/0890334420917102
susan.niermeyer@cuanschutz.edu
84
4/2/2020 13:42:58
NICU-specific guidelines (PPE, DR practices, etc.)
4/1/2020
Expert Opinion / Letter to Editor
U.S. NICUs and donor milk banks brace for COVID-19Furlow, B.
Need to consider 1)how to get around limitations on milk donors bringing milk, 2)implications of decreased touch/skin-to-skin time for NICU babies while restrictions on visitation and volunteers are in place.
https://www.thelancet.com/journals/lanchi/article/PIIS2352-4642(20)30103-6/fulltext
meganjkirkley@gmail.com
85
4/2/2020 16:20:15
Clinical Features (of neonatal infection)
4/1/2020
Expert Opinion / Letter to Editor
A New Symptom of COVID‐19: Loss of Taste and SmellGautier, JFAnosmia as a symptom in adults
https://onlinelibrary.wiley.com/doi/10.1002/oby.22809
CLYDE.WRIGHT@UCDENVER.EDU
86
4/2/2020 16:49:40
Clinical Features (of neonatal infection)
4/1/2020
Peer-Reviewed Article
Novel coronavirus in a 15-day-old neonate with clinical signs of sepsis, a case reportKamali Aghdam, M.
A 15 do neonate was admitted with fever, lethargy, cutaneous mottling, and respiratory distress without cough. Mother had symptoms of COVID-19. The baby recovered with supportive care.
https://doi.org/10.1080/23744235.2020.1747634
susan.niermeyer@cuanschutz.edu
87
4/23/2020 13:05:32
Consensus Statement / General Review
4/1/2020
Expert Opinion / Letter to Editor
Let us not forget the mask in our attempts to stall the spread of COVID-19Leung, C.C.
The author summarizes experience from Hong Kong and China with mass mask wearing as part of non-pharmacologic measures to interrupt transmission. Variance with WHO recommendations is highlighted.
https://doi.org/10.5588/ijtld.20.0124
susan.niermeyer@cuanschutz.edu
88
4/9/2020 12:32:00
NICU-specific guidelines (PPE, DR practices, etc.)
4/1/2020
Expert Opinion / Letter to Editor
A contingency plan for the management of the 2019 novel coronavirus outbreak in neonatal intensive care units
Wang, J. et al
Plan proposed includes recommendations for diagnostic and discharge criteria, treatment, prevention, and control strategies specific to management of neonates in NICU. Proposal made by pediatric committee of Medical Association of Chinese People's Liberation Army.
https://www.sciencedirect.com/science/article/pii/S2352464220300407
stephanie.chassen@cuanschutz.edu
89
4/3/2020 20:30:19
Perinatal/Neonatal Transmission
4/1/2020
Peer-Reviewed Article
Presymptomatic transmission of SARS-CoV-2 - Singapore, January 23-March16, 2020Wei, W.E.
Viral shedding can occur in the absence of symptoms and before symptom onset. Containment measures should account for presymptomatic transmission in contact tracing and prevention measures should address this potential.
https://www.cdc.gov/mmwr/volumes/69/wr/mm6914e1.htm?s_cid=mm6914e1_w
susan.niermeyer@cuanschutz.edu
90
4/10/2020 14:21:38
Perinatal/Neonatal Transmission
4/1/2020
Expert Opinion / Letter to Editor
Environment and personal protective equipment tests for SARS-CoV-2 in the isolation room of an infant with infection
Yung, C. F.
A largely asymptomatic 6 mo old infant with COVID-19 demonstrated high viral shedding and testing of environmental surfaces revealed presence of virus, likely carried by caregivers' hands (in isolation environment). Caregiver face shield and gown tested negative.
https://doi.org/10.7326/M20-0942
susan.niermeyer@cuanschutz.edu
91
4/1/2020 23:15:19
Management & Therapeutics
4/1/2020
Expert Opinion / Letter to Editor
An uncomplicated delivery in a patient with COVID-19 in the United States
Case description of vaginal delivery of COVID-19 positive mother, managed with mask on the patient, droplet and contact precautions, separation from the infant, feeding with pumped milk and formula, and discharge on day 6 (no re-testing of mother, no testing of infant) with both mother and baby clinically well.
https://www.nejm.org/doi/full/10.1056/NEJMc2007605?query=TOC
susan.niermeyer@cuanschutz.edu
92
4/2/2020 10:06:24
Clinical Features (of neonatal infection)
4/1/2020
Expert Opinion / Letter to Editor
First case of neonatal infection due to SARS-CoV-2 in Spain
First neonatal case in SPAIN. Appears postpartum trasmission, 1st RT-PCR test negative on day 7th in asymptomatic phase, turned positive on day 9th
https://www.analesdepediatria.org/es-pdf-S1695403320301302
CLYDE.WRIGHT@UCDENVER.EDU
93
4/2/2020 19:08:21
Consensus Statement / General Review
4/2/2020WebpageFAQs: Management of Infants Born to Mothers with Suspected or Confirmed COVID-19AAP
Brief FAQs from AAP regarding delivery room PPE, neonatal testing, isolation from mothers and hospital discharge critiera
https://services.aap.org/en/pages/2019-novel-coronavirus-covid-19-infections/faqs-management-of-infants-born-to-covid-19-mothers/
stephanie.bourque@childrenscolorado.org
94
4/5/2020 11:35:57
Perinatal/Neonatal Transmission
4/2/2020
Expert Opinion / Letter to Editor
Rapid expert consultation on the possibility of bioaerosol spread of SARS-CoV-2 for the COVID-19 pandemic
Fineberg, H.V.
There is evidence for bioaerosol spread of SARS-CoV-2 with speaking, as well as aerosolization with nasal cannula use. Patient toilet facilities and PPE doffing sites also returned high yield of viral RNA. Infectivity of these isolates has not been well established.
https://www.nap.edu/catalog/25769/rapid-expert-consultation-on-the-possibility-of-bioaerosol-spread-of-sars-cov-2-for-the-covid-19-pandemic-april-1-2020
susan.niermeyer@cuanschutz.edu
95
4/2/2020 17:00:46
Perinatal/Neonatal Transmission
4/2/2020
Expert Opinion / Letter to Editor
Vertical Transmission of Coronavirus Disease 19 (COVID-19) from Infected Pregnant Mothers to Neonates: A Review
Karimi-Zarchi, M
Review of published work on pregnant mothers with COVID19 and neo outcomes; conclusion that
https://www.tandfonline.com/doi/full/10.1080/15513815.2020.1747120
CLYDE.WRIGHT@UCDENVER.EDU
96
4/2/2020 19:05:35
NICU-specific guidelines (PPE, DR practices, etc.)
4/2/2020
Expert Opinion / Letter to Editor
INITIAL GUIDANCE: Management of Infants Born to Mothers with COVID-19Puopolo, K.M.4/2/20 Updated Guidelines from AAP-COFN, SONPM and Committee on Infectious Diseases
https://downloads.aap.org/AAP/PDF/COVID%2019%20Initial%20Newborn%20Guidance.pdf
stephanie.bourque@childrenscolorado.org
97
4/18/2020 11:40:05
Perinatal/Neonatal Transmission
4/2/2020
Peer-Reviewed Article
SARS-CoV-2 is not detectable in the vaginal fluid of women with severe COVID-19 infectionQiu, LNo SARS-CoV-2 in vaginal fluid, implications for peri-delivery transmission?
https://academic.oup.com/cid/article/doi/10.1093/cid/ciaa375/5815295?searchresult=1
CLYDE.WRIGHT@UCDENVER.EDU
98
4/6/2020 16:53:05
Management & Therapeutics
4/2/2020
Expert Opinion / Letter to Editor
3CLpro inhibitors as a potential therapeutic option for COVID-19: available evidence and ongoing clinical trials
Sisay, M
1- Protease inhibitors are considered a treatment option for Covid. the main covid19 proteinase is 3-chymotrypsin like protease. Therapeutics that inhibit the cleavage function of 3CLpro may inhibit viral replication
2- lopinavir and ritonavir show promising binding affinity to SARS-CoV by molecular dynamic simulation analysis
3- as of 4/2/20 there were 11 RCT and 1 non randomized trials for LPV/r in the US NLM
https://reader.elsevier.com/reader/sd/pii/S1043661820309798?token=20A0E8135A33FFDE573D74122AE3BB2FBC3343F5301B5126F19F383458C2EB549FC2EDC8F3D3094429892E8E5B08CF7F
laura.sherlock@cuanschutz.edu
99
4/2/2020 19:12:27
NICU-specific guidelines (PPE, DR practices, etc.)
4/2/2020WebpageCanadian COVID-19 Resources
Online resources including Canadian provincial approaches to neonatal care, literature review and simulation videos for teams preparing to manage PUI/COVID+ patients
https://www.allthingsneonatal.com/canadian-covid-19-resources/
stephanie.bourque@childrenscolorado.org
100
4/5/2020 12:08:32
Management & Therapeutics
4/2/2020
Expert Opinion / Letter to Editor
Drugs and the renin-angiotensin system in covid-19editorial/review on interaction b/w renin-angiotensin system and COVID19https://www.bmj.com/content/369/bmj.m1313
CLYDE.WRIGHT@UCDENVER.EDU