Sales, by year, for certain drugs and cell therapies
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1
DrugINNDate first registered by US FDACompany or CompaniesIndicationUS FDA Orphan indications (23-10-2020)CurrencyYears since 1st US FDA approvalCumulative revenue (in millions)201920182017201620152014201320122011201020092008200720062005200420032002200120001999199819971996199519941993199219911990
2
Kyproliscarfilzomib2012-07-20A generalCancer: Multiple Myeloma1USD8.2$1,960$562$554$467$306$71$0
3
Humiraadalimumab2002-12-31AbbvieRheumatoid arthritis (initial indication, now many more)9USD17.5$148,214$15,222$19,936$18,427$16,078$14,012$12,543$10,659$9,265$7,932$6,508$5,500$4,500$3,000$2,000$1,500$852$280$0
4
Humira (US only)adalimumab2002-12-31AbbvieRheumatoid arthritis (initial indication, now many more)9USD17.5$13,685$12,361$10,432$8,405$6,524$5,236$4,377
5
Humira (USA Medicare part B)adalimumab2002-12-31AbbvieRheumatoid arthritis (initial indication, now many more)9USD17.5$0
6
Humira (USA Medicare part D)adalimumab2002-12-31AbbvieRheumatoid arthritis (initial indication, now many more)9USD17.5$2,198
7
Viekiradasabuvir sodium; ombitasvir; paritaprevir; ritonavir2014-12-19AbbvieHCV1USD5.8$178$784$1,522$1,639$48
8
Viekira (US only)dasabuvir sodium; ombitasvir; paritaprevir; ritonavir2014-12-19AbbvieHCV1USD5.8$6$61$342$804$48
9
Viekira (USA Medicare Part B)dasabuvir sodium; ombitasvir; paritaprevir; ritonavir2014-12-19AbbvieHCV1USD5.8$0
10
Viekira (USA Medicare Part D)dasabuvir sodium; ombitasvir; paritaprevir; ritonavir2014-12-19AbbvieHCV1USD5.8$90$220
11
Ampyradalfampridine2010-01-22Acorda TherapeuticsMS2USD10.6$3,207$455$543$493$437$366$303$266$211$133
12
Ampyra (USA Medicare Part B)dalfampridine2010-01-22Acorda TherapeuticsMS2USD10.6$0
13
Ampyra (USA Medicare Part D)dalfampridine2010-01-22Acorda TherapeuticsMS2USD10.6$206$176$136$99$72
14
Soliriseculizumab paroxysmal nocturnal hemoglobinuria2007-03-16AlexionPNH; aHUS8USD13.4$23,043$3,946$3,563$3,144$2,843$2,591$2,234$1,551$1,134$783$541$387$259$66$0
15
Soliris (US only)eculizumab paroxysmal nocturnal hemoglobinuria2007-03-16AlexionPNH; aHUS8USD13.4$7,305$1,588$1,235$1,059$944$730$561$400$263$206$160$113$46$0
16
Soliris (USA Medicare part B)eculizumab paroxysmal nocturnal hemoglobinuria2007-03-16AlexionPNH; aHUS8USD13.4$267$233$178$142$98
17
Soliris (USA Medicare part D)eculizumab paroxysmal nocturnal hemoglobinuria2007-03-16AlexionPNH; aHUS8USD13.4$21$13$10$8$7
18
Teflaroceftaroline fosamil for injection2010-10-29
Allergan Sales (acquired Cerexa)
Acute skin infections, community-acquired pneumonia0USD9.9$577$128$122$134$138$56$0
19
Teflaro (USA Medicare Part B)ceftaroline fosamil for injection2010-10-29
Allergan Sales (acquired Cerexa)
Acute skin infections, community-acquired pneumonia0USD9.9$1$0.3$0.1$0.5$0.2
20
Teflaro (USA Medicare Part D)ceftaroline fosamil for injection2010-10-29
Allergan Sales (acquired Cerexa)
Acute skin infections, community-acquired pneumonia0USD9.9$12$10$7$4$2
21
Viibryd/Fetzimavilazodone2011-01-21
Allergan Sales (acquired Cerexa)
Mental illness: MDD0USD9.7$1,496$350$336$342$328$140$0
22
Viibryd/Fetzima (US only)vilazodone2011-01-21
Allergan Sales (acquired Cerexa)
Mental illness: MDD0USD9.7$342$333$342$328$140
23
Viibryd/Fetzima (USA Medicare Part B)vilazodone2011-01-21
Allergan Sales (acquired Cerexa)
Mental illness: MDD0USD9.7$0$0$0$0$0
24
Viibryd/Fetzima (USA Medicare Part D)vilazodone2011-01-21
Allergan Sales (acquired Cerexa)
Mental illness: MDD0USD9.7$74$66$57$42$22
25
Vascepaisocapent ethyl2012-07-26
Amarin Pharms (Amarin parent based in Ireland)
hypertriglyceridemia0EUR8.2
26
Enbreletanercept1998-11-02AmgenRheumatoid Arthritics; Plaque Psoriasis; Psoriaric Arthritics; Ankylosing Spondylitisl Juvenile Idiopathic Arthritis2USD21.5$26,464$5,014$5,433$5,965$5,364$4,688
27
Enbrel (US only)etanercept1998-11-02AmgenRheumatoid Arthritics; Plaque Psoriasis; Psoriaric Arthritics; Ankylosing Spondylitisl Juvenile Idiopathic Arthritis2USD21.5$25,235$4,807$5,206$5,719$5,099$4,404
28
Enbrel (USA Medicare part B)etanercept1998-11-02AmgenRheumatoid Arthritics; Plaque Psoriasis; Psoriaric Arthritics; Ankylosing Spondylitisl Juvenile Idiopathic Arthritis2USD21.5$0
29
Enbrel (USA Medicare part D)etanercept1998-11-02AmgenRheumatoid Arthritics; Plaque Psoriasis; Psoriaric Arthritics; Ankylosing Spondylitisl Juvenile Idiopathic Arthritis2USD21.5$1,572$1,385$1,198$977$722
30
Proliadenosumab2010-06-01AmgenOsteoperosis2USD10.3$9,688$2,291$1,968$1,635$1,312$1,030$744$472$203$33$0
31
Prolia (US only)denosumab2010-06-01AmgenOsteoperosis2USD10.3$1,500$1,272$1,049$837
32
Prolia (USA Medicare Part B)denosumab2010-06-01AmgenOsteoperosis2USD10.3$1,087$917$727$631$484
33
Prolia (USA Medicare Part D)denosumab2010-06-01AmgenOsteoperosis2USD10.3$185$151$114$73$38
34
Xgevadenosumab2010-06-01AmgenOsteoperosis2USD10.3$9,642$1,786$1,575$1,529$1,405$1,221$1,019$748$351$8$0
35
Xgeva (US only)denosumab2010-06-01AmgenOsteoperosis2USD10.3$1,338$1,157$1,115$1,006$857$764$644$343
36
Xgeva (USA Medicare Part B)denosumab2010-06-01AmgenOsteoperosis2USD10.3$0$0$0$0$0
37
Xgeva (USA Medicare Part D)denosumab2010-06-01AmgenOsteoperosis2USD10.3$15$12$9$6$4
38
Edarbiazilsartan kamedoxomil2011-02-25
Arbor Pharmaceuticals LLC
HTNEUR9.6
39
Horizantgabapentin enacarbil2011-04-06
Arbor Pharmaceuticals LLC
Restless Legs SyndromeEUR9.5
40
Xtandienzalutamide2012-08-31AstellasProstate cancer0JPY¥1,003¥294¥252¥252¥137¥55¥12
41
Brilintaticagrelor2011-07-20AstraZenecaAcute coronary syndrome0USD9.2$4,727$1,321$1,079$839$619$476$283$89$21$0
42
Brilinta (US only)ticagrelor2011-07-20AstraZenecaAcute coronary syndrome0USD9.2$588$509$348$240$146$73$19$11
43
Brilinta (USA Medicare Part B)ticagrelor2011-07-20AstraZenecaAcute coronary syndrome0USD9.2$0$0$0$0$0
44
Brilinta (USA Medicare Part D)ticagrelor2011-07-20AstraZenecaAcute coronary syndrome0USD9.2$206$129$75$38$8
45
Tagrissoosimertinib2015-11-13AstraZenecaCancer: non-small-cell lung carcinomas 2USD5.0$3,257$1,860$955$423$19$0
46
Tagrisso (US only)osimertinib2015-11-13AstraZenecaCancer: non-small-cell lung carcinomas 2USD5.0$869$405$255
47
Tagrisso (USA Medicare part B)osimertinib2015-11-13AstraZenecaCancer: non-small-cell lung carcinomas 2USD5.0$0
48
Tagrisso (USA Medicare part D)osimertinib2015-11-13AstraZenecaCancer: non-small-cell lung carcinomas 2USD5.0$113
49
Xiaflexcollagenase clostridium histolyticum2010-02-02
Auxilium Pharmaceuticals (Acquired by Endo Pharmaceuticals)
Dupuytren's disease2USD10.6$826$265$213$190$158$0
50
Xiaflex (USA Medicare Part B)collagenase clostridium histolyticum2010-02-02
Auxilium Pharmaceuticals (Acquired by Endo Pharmaceuticals)
Dupuytren's disease2USD10.6$39$35$29$22$19.67
51
Xiaflex (USA Medicare Part D)collagenase clostridium histolyticum2010-02-02
Auxilium Pharmaceuticals (Acquired by Endo Pharmaceuticals)
Dupuytren's disease2USD10.6$3$2$2$1$0.80
52
Gadavistgadobutrol2011-03-14Bayer HealthcareCNS imagingEUR9.5€1,808€366€365€346€290€233€205€209€160€0
53
Gadavist (US only)gadobutrol2011-03-14Bayer HealthcareCNS imagingEUR9.5€112€116€104€86
54
Gadavist (USA Medicare Part B)gadobutrol2011-03-14Bayer HealthcareCNS imagingUSD9.5$5$4$3$2$2
55
Gadavist (USA Medicare Part D)gadobutrol2011-03-14Bayer HealthcareCNS imagingUSD9.5$0$0$0$0$0
56
Nataziaestradial valerate/dienogest tabs2010-05-06Bayer HealthcareFemale birth controlEUR10.3
57
Nexavarsorafenib2005-12-01Bayer HealthcareCancer: Hepatocellular carcinoma (HCC); renal cell carcinoma (RCC); thyroid carcinoma (DTC)5EUR14.7$8,540€712€834€870€892€773€771€792€725€705€604€462€270€130
58
Nexavar (US only)sorafenib2005-12-01Bayer HealthcareCancer: Hepatocellular carcinoma (HCC); renal cell carcinoma (RCC); thyroid carcinoma (DTC)5EUR14.7$1,146€216€294€312€324
59
Nexavar (USA Medicare part B)sorafenib2005-12-01Bayer HealthcareCancer: Hepatocellular carcinoma (HCC); renal cell carcinoma (RCC); thyroid carcinoma (DTC)5USD14.7$0$0$0$0$0$0
60
Nexavar (USA Medicare part D)sorafenib2005-12-01Bayer HealthcareCancer: Hepatocellular carcinoma (HCC); renal cell carcinoma (RCC); thyroid carcinoma (DTC)5USD14.7$844$214$206$169$138$117
61
Stivargaregorafenib2012-09-27Bayer HealthcareCancer: GISTEUR8.0€315€315€275€313€224€197
62
Stivarga (US only)regorafenib2012-09-27Bayer HealthcareCancer: GISTEUR8.0€149€166€142€181
63
Stivarga (USA Medicare Part B)regorafenib2012-09-27Bayer HealthcareCancer: GISTUSD8.0$0$0$0$0$0
64
Stivarga (USA Medicare Part D)regorafenib2012-09-27Bayer HealthcareCancer: GISTUSD8.0$76$100$87$84$12
65
Avonexinterferon beta-1a1996-05-17BiogenMSUSD23.9$34,350$1,916$2,152$2,314$2,630$3,013$3,006$2,913$2,687$2,518$2,323$2,203$1,868$1,707$1,543$1,417$143
66
Avonex (US only)interferon beta-1a1996-05-17BiogenMSUSD23.9$1,420$1,594$1,675$1,790$1,957$1,902$1,794
67
Avonex (USA Medicare Part B)interferon beta-1a1996-05-17BiogenMSUSD23.9$5$4$6
68
Avonex (USA Medicare Part D)interferon beta-1a1996-05-17BiogenMSUSD23.9$295$312$326$367$390
69
Spinrazanusinersen2016-12-23BiogenSpinal muscular atrophy (SMA)1USD3.9$4,710$2,097$1,724$884$5
70
Spinraza (US only)nusinersen2016-12-23BiogenSpinal muscular atrophy (SMA)1USD3.9$854$657$5
71
Spinraza (USA Medicare Part B)nusinersen2016-12-23BiogenSpinal muscular atrophy (SMA)1USD3.9$0
72
Spinraza (USA Medicare Part D)nusinersen2016-12-23BiogenSpinal muscular atrophy (SMA)1USD3.9$0
73
Tecfideradimethyl fumarate2013-03-27Biogen IDECMS0USD7.5$19,880$4,274$4,214$3,968$3,638$2,909$876
74
Tecfidera (US only)dimethyl fumarate2013-03-27Biogen IDECMS0USD7.5$3,294$3,169$2,908$2,427$864
75
Tecfidera (USA Medicare part B)dimethyl fumarate2013-03-27Biogen IDECMS0USD7.5$0$0$0$0
76
Tecfidera (USA Medicare part D)dimethyl fumarate2013-03-27Biogen IDECMS0USD7.5$932$876$599$159
77
Opdivonivolumab2014-12-22BMSCancer: NSCLC11USD5.8$23,609$7,204$6,735$4,948$3,774$942$6$0
78
Opdivo (US only)nivolumab2014-12-22BMSCancer: NSCLC11USD5.8$15,173$4,344$4,239$3,102$2,664$823$1
79
Opdivo (USA Medicare Part B)nivolumab2014-12-22BMSCancer: NSCLC11USD5.8$0$0
80
Opdivo (USA Medicare Part D)nivolumab2014-12-22BMSCancer: NSCLC11USD5.8$26$11
81
Pradaxadabigatran etexilate mesylate2010-10-19
Boehringer Ingelheim
Stroke0EUR9.9€6,8751,3851,2871,1981,2061,108$629$62$0
82
Pradaxa (USA Medicare Part B)dabigatran etexilate mesylate2010-10-19
Boehringer Ingelheim
Stroke0USD9.9$0$0$0$0$0
83
Pradaxa (USA Medicare Part D)dabigatran etexilate mesylate2010-10-19
Boehringer Ingelheim
Stroke0USD9.9$607$570$557$500$391
84
SpirivaTiotropium Bromide2004-01-30
Boehringer Ingelheim
COPD1EUR16.4€2,826€2,995€3,553€3,237€3,552€3,562€3,153
85
Spiriva (US only)Tiotropium Bromide2004-01-30
Boehringer Ingelheim
COPD1USD16.4$1,865
86
Spiriva (USA Medicare Part B)Tiotropium Bromide2004-01-30
Boehringer Ingelheim
COPD1USD16.4$0$0$0$0$0
87
Spiriva (USA Medicare Part D)Tiotropium Bromide2004-01-30
Boehringer Ingelheim
COPD1USD16.4$1,819$2,191$2,158$1,959$1,603
88
Tradjentalinagliptin2011-05-02
Boehringer Ingelheim
Diabetes0EUR9.4€4,0061,3331,128$909$636$0
89
Tradjenta (USA Medicare part B)linagliptin2011-05-02
Boehringer Ingelheim
Diabetes0USD$0
90
Tradjenta (USA Medicare part D)linagliptin2011-05-02
Boehringer Ingelheim
Diabetes0USD9.4$708$508$292$153$35
91
Daklinzadaclatasvir dihydrochloride2015-07-24
Bristol-Myers Squibb (BMS)
HCVUSD5.3$386$1,550$1,315
92
Daklinza (USA Medicare Part B)daclatasvir dihydrochloride2015-07-24
Bristol-Myers Squibb (BMS)
HCVUSD5.3$0
93
Daklinza (USA Medicare Part D)daclatasvir dihydrochloride2015-07-24
Bristol-Myers Squibb (BMS)
HCVUSD5.3$391$112
94
Eliquisapixaban2012-12-28
Bristol-Myers Squibb (BMS)
Heart Disease: Stroke0USD7.8$7,929$6,438
95
Spryceldasatinib2006-06-28
Bristol-Myers Squibb (BMS)
Cancer: Chronic Myeloid Leukemia (CML)4USD14.1$15,644$2,110$2,000$2,005$1,824$1,620$1,493$1,280$1,019$803$576$421$310$158$25$0
96
Sprycel (US only)dasatinib2006-06-28
Bristol-Myers Squibb (BMS)
Cancer: Chronic Myeloid Leukemia (CML)4USD14.1$1,091$1,105$969$829$671$541$404$294$188$123$92$58
97
Sprycel (USA Medicare Part B)dasatinib2006-06-28
Bristol-Myers Squibb (BMS)
Cancer: Chronic Myeloid Leukemia (CML)4USD14.1$0$0$0$0$0
98
Sprycel (USA Medicare Part D)dasatinib2006-06-28
Bristol-Myers Squibb (BMS)
Cancer: Chronic Myeloid Leukemia (CML)4USD14.1$322$280$215$158$105
99
Yervoyipilimumab2011-03-25
Bristol-Myers Squibb (BMS)
Cancer: Melanoma4USD9.5$9,576$1,489$1,330$1,244$1,053$1,126$1,308$960$706$360$0
100
Yervoy (US only)ipilimumab2011-03-25
Bristol-Myers Squibb (BMS)
Cancer: Melanoma4USD9.5$941$908$802$602
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