Drug Sales, by year (updated June 5, 2018)
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1
DrugINNDate first registered by US FDACompany or CompaniesIndicationCurrencyYears since 1st US FDA approvalCumulative revenue (in millions)2018:Q22017201620152014201320122011201020092008200720062005200420032002200120001999199819971996199519941993199219911990
2
Brilintaticagrelor2011-07-20AstraZenecaAcute coronary syndromeUSD6.9$3,406$1,079$839$619$476$283$89$21$0
3
Brilinta (US only)ticagrelor2011-07-20AstraZenecaAcute coronary syndromeUSD6.9$509$348$240$146$73$19$11
4
Brilinta (USA Medicare Part B)ticagrelor2011-07-20AstraZenecaAcute coronary syndromeUSD6.9$0$0$0$0$0
5
Brilinta (USA Medicare Part D)ticagrelor2011-07-20AstraZenecaAcute coronary syndromeUSD6.9$206$129$75$38$8
6
Teflaro
ceftaroline fosamil for injection
2010-10-29
Allergan Sales (acquired Cerexa)
Acute skin infections, community-acquired pneumonia
USD7.6$449$122$134$138$56$0
7
Teflaro (USA Medicare Part B)
ceftaroline fosamil for injection
2010-10-29
Allergan Sales (acquired Cerexa)
Acute skin infections, community-acquired pneumonia
USD7.6$1$0.3$0.1$0.5$0.2
8
Teflaro (USA Medicare Part D)
ceftaroline fosamil for injection
2010-10-29
Allergan Sales (acquired Cerexa)
Acute skin infections, community-acquired pneumonia
USD7.6$12$10$7$4$2
9
Eyleaaflibercept2011-11-18
Regeneron Pharmaceuticals
AMDUSD6.5$5,929$5,195
10
Eylea (US only)aflibercept2011-11-18
Regeneron Pharmaceuticals
AMDUSD6.5$13,709$3,702$3,323$2,676$1,736$1,409$838$25$0
11
Eylea (USA Medicare Part B)aflibercept2011-11-18
Regeneron Pharmaceuticals
AMDUSD6.5$2,209$1,814$1,295$1,080
12
Eylea (USA Medicare Part D)aflibercept2011-11-18
Regeneron Pharmaceuticals
AMDUSD6.5$10$6$3$2$1
13
Advair
fluticasone propionate; salmeterol xinafoate
2000-08-24GSKAsthmaGBP17.5£61,296£3,130£3,485£3,681£4,229£5,274£5,046£5,061£5,139£4,977£4,137£3,499£3,313£3,003£2,441£2,192£1,631£850£208
14
Advair (US only)
fluticasone propionate; salmeterol xinafoate
2000-08-24GSKAsthmaGBP17.5£1,610£1,829£1,865£1,972£2,769£2,533£2,475£2,604£2,592£2,161£1,891£1,870£1,687£1,330£1,235£876£328
15
Advair (USA Medicare Part B)
fluticasone propionate; salmeterol xinafoate
2000-08-24GSKAsthmaUSD17.5$0$0$0$0$0
16
Advair (USA Medicare Part D)
fluticasone propionate; salmeterol xinafoate
2000-08-24GSKAsthmaUSD17.5$2,320.13$2,270.02$2,276.38$2,263.00$1,886
17
Xolairomalizumab2003-06-20Genentech/Roche
Asthma and chronic idiopathic urticaria
CHF14.71,742CHF1,498CHF
18
Xolair (US only)omalizumab2003-06-20Genentech/Roche
Asthma and chronic idiopathic urticaria
CHF14.71,742CHF1,498CHF
19
Xolair (US only)omalizumab2003-06-20Genentech/Roche
Asthma and chronic idiopathic urticaria
USD14.71521
20
Xolair (USA Medicare Part B)omalizumab2003-06-20Genentech/Roche
Asthma and chronic idiopathic urticaria
USD14.7$328
21
Xolair (USA Medicare Part D)omalizumab2003-06-20Genentech/Roche
Asthma and chronic idiopathic urticaria
USD14.7$79
22
Herceptintrastuzumab1998-09-25RocheBreast cancerCHF19.375,807CHF7,014CHF6,782CHF6,538CHF6,275CHF6,079CHF5,889CHF5,253CHF5,429CHF5,266CHF5,092CHF4,852CHF3,927CHF2,146CHF1,435CHF1,177CHF1,007CHF806CHF540CHF300CHF
23
Herceptin (US only)trastuzumab1998-09-25RocheBreast cancerCHF19.32,697CHF2,509CHF2,384CHF1,967CHF
24
Herceptin (USA Medicare part B)trastuzumab1998-09-25RocheBreast cancerUSD19.3$704$646$561$503$467
25
Herceptin (USA Medicare Part D)trastuzumab1998-09-25RocheBreast cancerUSD19.3$15$15$11$8$7
26
Kadcyla
ado-trastuzumab emtansine
2/22/2013RocheBreast cancerCHF5.3$3,284CHF914CHF831CHF769CHF536CHF234
27
Kadcyla
ado-trastuzumab emtansine
2/22/2013RocheBreast cancerCHF5.33,284CHF914CHF831CHF769CHF536CHF234CHF
28
Kadcyla (US only)
ado-trastuzumab emtansine
2/22/2013RocheBreast cancerCHF5.3CHF343.00CHF316.00CHF308.00CHF282.00CHF222.00
29
Kadcyla (USA Medicare part B)
ado-trastuzumab emtansine
2/22/2013RocheBreast cancerUSD5.3$113$106$101
30
Kadcyla (USA Medicare part D)
ado-trastuzumab emtansine
2/22/2013RocheBreast cancerUSD5.3$2$2$3$2
31
Pomalyst/Imnovidpomalidomide2013-02-08CelgeneCancerUSD5.3$4,906$1,614$1,311$983$680$305$12$1$0
32
Pomalyst/Imnovid (US only)pomalidomide2013-02-08CelgeneCancerUSD5.3$1,008$778$592$443
33
Pomalyst/Imnovid (USA Medicare Part B)pomalidomide2013-02-08CelgeneCancerUSD5.3$0$0$0$0
34
Pomalyst/Imnovid (USA Medicare Part D)pomalidomide2013-02-08CelgeneCancerUSD5.3$477$359$260$128
35
Revlimidlenalidomide2005-12-27CelgeneCancerUSD12.3$43,794$8,187$6,974$5,801$4,980$4,280$3,767$3,208$2,469$1,706$1,325$774$321$3$0
36
Revlimid (US only)lenalidomide2005-12-27CelgeneCancerUSD12.3$5,426$4,417$3,535$2,916
37
Revlimid (USA Medicare Part B)lenalidomide2005-12-27CelgeneCancerUSD12.3$0$0$0$0$0
38
Revlimid (USA Medicare Part D)lenalidomide2005-12-27CelgeneCancerUSD12.3$2,662$2,077$1,672$1,350$1,017
39
Keytrudapembrolizumab2014-09-04MerckCancerUSD3.8$5,832$3,809$1,402$566$55$0
40
Keytruda (Medicare)pembrolizumab2014-09-04MerckCancerUSD3.8$4
41
Keytruda (US only)pembrolizumab2014-09-04MerckCancerUSD3.8$2,309$792$393
42
Keytruda (USA Medicare part B)pembrolizumab2014-09-04MerckCancerUSD3.8$0
43
Keytruda (USA Medicare part D)pembrolizumab2014-09-04MerckCancerUSD3.8$4$2
44
Zaltrapziv-aflibercept2012-08-03Sanofi Aventis USCancerEUR5.8€364$75$65$77$69$53$25$0
45
Zaltrap (US only)ziv-aflibercept2012-08-03Sanofi Aventis USCancerEUR5.8$9$14$21$27$36
46
Zaltrap (USA Medicare Part B)ziv-aflibercept2012-08-03Sanofi Aventis USCancerUSD5.8$6$10$13$0$0
47
Zaltrap (USA Medicare Part D)ziv-aflibercept2012-08-03Sanofi Aventis USCancerUSD5.8$0$0$0$0$0
48
Granixtbo-filgrastim2012-08-29Sicor BiotechCancerEUR5.8
49
Erivedgevismodegib2012-01-30Genentech/Roche
Cancer: advanced basal cell carcinoma
CHF6.3203CHF167CHF128CHF75CHF29CHF
50
Erivedge (US only)vismodegib2012-01-30Genentech/Roche
Cancer: advanced basal cell carcinoma
CHF6.3134CHF117CHF83CHF66CHF29CHF
51
Erivedge (USA Medicare Part B)vismodegib2012-01-30Genentech/Roche
Cancer: advanced basal cell carcinoma
USD6.3$0$0$0$0$0
52
Erivedge (USA Medicare Part D)vismodegib2012-01-30Genentech/Roche
Cancer: advanced basal cell carcinoma
USD6.3$85$68$49$35$12
53
Alimtapemetrexed2004-02-04Eli Lilly
Cancer: Advanced nonsquamous non-small Cell Lung Cancer (NSCLC)
USD14.1$24,530$2,063$2,283$2,493$2,792$2,703$2,594$2,461$2,209$1,706$1,155$854$612$463$143
54
Alimta (US only)pemetrexed2004-02-04Eli Lilly
Cancer: Advanced nonsquamous non-small Cell Lung Cancer (NSCLC)
USD14.1$11,404$1,034$1,101$1,162$1,230$1,209$1,122$995$957$816$562$448$350$296$122
55
Alimta (USA Medicare Part B)pemetrexed2004-02-04Eli Lilly
Cancer: Advanced nonsquamous non-small Cell Lung Cancer (NSCLC)
USD14.1$512$548$559$548$508
56
Alimta (USA Medicare Part D)pemetrexed2004-02-04Eli Lilly
Cancer: Advanced nonsquamous non-small Cell Lung Cancer (NSCLC)
USD14.1$8$7$8$8$6
57
Votrient
pazopanib hydrochloride
2009-10-19Novartis
Cancer: advanced renal carcinoma, advanced soft tissue sarcoma
USD8.6$808$729$565
58
Votrient (US only)
pazopanib hydrochloride
2009-10-19Novartis
Cancer: advanced renal carcinoma, advanced soft tissue sarcoma
USD8.6$407$357$287
59
Votrient (USA Medicare Part B)
pazopanib hydrochloride
2009-10-19Novartis
Cancer: advanced renal carcinoma, advanced soft tissue sarcoma
USD8.6$0$0$0$0$0
60
Votrient (USA Medicare Part D)
pazopanib hydrochloride
2009-10-19Novartis
Cancer: advanced renal carcinoma, advanced soft tissue sarcoma
USD8.6$105$127$112$82$41
61
Erwinaze
asparaginase ewinia chrysanthemi
2011-11-18
Jazz Pharmaceuticals
Cancer: ALLUSD6.5$1,047$197$201$203$200$174$72$0
62
Halaven, Americas (North, Central and South America)
eribulin mesylate
2010-11-15Eisai Inc.Cancer: breast JPY7.5¥92,111¥15,725¥16,619¥18,285¥16,488¥13,351¥11,643
63
Halaven, EMEA (Europe, Middle East, Africa, Russia and Oceania)
eribulin mesylate
2010-11-15Eisai Inc.Cancer: breast JPY7.5¥61,856¥12,114¥10,948¥13,166¥11,569¥8,674¥5,385
64
Halaven, Japan
eribulin mesylate
2010-11-15Eisai Inc.Cancer: breast JPY7.5¥44,860¥9,270¥7,763¥6,799¥6,063¥6,424¥5,469¥3,072
65
Ibrancepalbociclib2015-02-03PfizerCancer: Breast cancerUSD3.4$5,984$3,126$2,135$723$0
66
Ibrance (US only)palbociclib2015-02-03PfizerCancer: Breast cancerUSD3.4$2,068$718
67
Ibrance (USA Medicare Par B)palbociclib2015-02-03PfizerCancer: Breast cancerUSD3.4$0$0
68
Ibrance (USA Medicare part D)palbociclib2015-02-03PfizerCancer: Breast cancerUSD3.4$995$306
69
Afinitoreverolimus2009-03-30Novartis
Cancer: Breast/Kidney/Pancreatic; Advanced GI/Lung NET; Renal Angiomyolipoma With Tuberous Sclerosis Complex; SEGA With Tuberous Sclerosis Complex
USD9.1$9,086$1,525$1,516$1,607$1,575$1,309$797$443$243$70$1$0
70
Afinitor (US only)everolimus2009-03-30Novartis
Cancer: Breast/Kidney/Pancreatic; Advanced GI/Lung NET; Renal Angiomyolipoma With Tuberous Sclerosis Complex; SEGA With Tuberous Sclerosis Complex
USD9.1$775$892$805$691
71
Afinitor (USA Medicare part B)everolimus2009-03-30Novartis
Cancer: Breast/Kidney/Pancreatic; Advanced GI/Lung NET; Renal Angiomyolipoma With Tuberous Sclerosis Complex; SEGA With Tuberous Sclerosis Complex
USD9.1$0
72
Afinitor (USA Medicare part D)everolimus2009-03-30Novartis
Cancer: Breast/Kidney/Pancreatic; Advanced GI/Lung NET; Renal Angiomyolipoma With Tuberous Sclerosis Complex; SEGA With Tuberous Sclerosis Complex
USD9.1$347$393$353$274$125
73
Imbruvicaibrutinib2013-11-13
Pharmacyclics Inc,/Johnson and Johnson
Cancer: Chronic Lymphocytic Leukemia (CLL); Mantle Cell Lymphoma (MCL); Waldenström’s Macroglobulinemia (WM); Marginal zone lymphoma; chronic graft versus host disease (cGVHD)
USD4.6$4,033$1,893$1,251$689$200$0
74
Spryceldasatinib2006-06-28
Bristol-Myers Squibb (BMS)
Cancer: Chronic Myeloid Leukemia (CML)
USD11.8$11,534$2,005$1,824$1,620$1,493$1,280$1,019$803$576$421$310$158$25$0
75
Sprycel (US only)dasatinib2006-06-28
Bristol-Myers Squibb (BMS)
Cancer: Chronic Myeloid Leukemia (CML)
USD11.8$1,105$969$829$671$541$404$294$188$123$92$58
76
Sprycel (USA Medicare Part B)dasatinib2006-06-28
Bristol-Myers Squibb (BMS)
Cancer: Chronic Myeloid Leukemia (CML)
USD11.8$0$0$0$0$0
77
Sprycel (USA Medicare Part D)dasatinib2006-06-28
Bristol-Myers Squibb (BMS)
Cancer: Chronic Myeloid Leukemia (CML)
USD11.8$322$280$215$158$105
78
Istodaxromidepsin2009-11-05Celgene
Cancer: Cutaneous T-Cell Lymphoma
USD8.5$441$76$79$69$66$54$50$31$16
79
Istodax (US only)romidepsin2009-11-05Celgene
Cancer: Cutaneous T-Cell Lymphoma
USD8.5$67$72$65$61$50
80
Istodax (USA Medicare Part B)romidepsin2009-11-05Celgene
Cancer: Cutaneous T-Cell Lymphoma
USD8.5$34$31$29$20$21
81
Istodax (USA Medicare Part D)romidepsin2009-11-05Celgene
Cancer: Cutaneous T-Cell Lymphoma
USD8.5$0$0$0$0
82
Rituxan;or Gazyva
rituximab; obinutuzumab
1997-11-26; 2013/01/11
Genentech/Biogen IDEC; Roche
Cancer: Follicular Lymphoma; Chronic Lymphocytic Lymphoma
USD$45,431$4,207$3,942$3,848$3,557$3,426$3,132$2,925$2,759$2,666$2,587$2,849$2,071$1,832$1,573$1,361$1,080$779$424$263$152$0
83
Stivargaregorafenib2012-09-27Bayer HealthcareCancer: GISTEUR5.7€315€275€313€224€197
84
Stivarga (US only)regorafenib2012-09-27Bayer HealthcareCancer: GISTEUR5.7€166€142€181
85
Stivarga (USA Medicare Part B)regorafenib2012-09-27Bayer HealthcareCancer: GISTUSD5.7$0$0$0$0$0
86
Stivarga (USA Medicare Part D)regorafenib2012-09-27Bayer HealthcareCancer: GISTUSD5.7$76$100$87$84$12
87
Nexavarsorafenib2005-12-01Bayer Healthcare
Cancer: Hepatocellular carcinoma (HCC); renal cell carcinoma (RCC); thyroid carcinoma (DTC)
EUR12.3€7,828€834€870€892€773€771€792€725€705€604€462€270€130
88
Nexavar (US only)sorafenib2005-12-01Bayer Healthcare
Cancer: Hepatocellular carcinoma (HCC); renal cell carcinoma (RCC); thyroid carcinoma (DTC)
EUR12.3€930€294€312€324
89
Nexavar (USA Medicare part B)sorafenib2005-12-01Bayer Healthcare
Cancer: Hepatocellular carcinoma (HCC); renal cell carcinoma (RCC); thyroid carcinoma (DTC)
USD12.3$0$0$0$0$0$0
90
Nexavar (USA Medicare part D)sorafenib2005-12-01Bayer Healthcare
Cancer: Hepatocellular carcinoma (HCC); renal cell carcinoma (RCC); thyroid carcinoma (DTC)
USD12.3$844$214$206$169$138$117
91
Perjetapertuzumab2012-06-08Genentech
Cancer: HER2-positive breast cancer
CHF6.06,787CHF2,196CHF1,846CHF1,445CHF918CHF326CHF56CHF0CHF
92
Perjeta (Europe)pertuzumab2012-06-08Genentech
Cancer: HER2-positive breast cancer
CHF6.0767CHF628CHF432CHF238CHF
93
Perjeta (US only)pertuzumab2012-06-08Genentech
Cancer: HER2-positive breast cancer
CHF6.01,013CHF905CHF804CHF540CHF
94
Perjeta (USA Medicare Part B)pertuzumab2012-06-08Genentech
Cancer: HER2-positive breast cancer
USD6.0$201$169$110$0$0.0
95
Perjeta (USA Medicare Part D)pertuzumab2012-06-08Genentech
Cancer: HER2-positive breast cancer
USD6.0$4$4$2$1$0.3
96
Inlytaaxitinib2012-01-27P.F. Prism C.V.Cancer: Kidney USD6.3$1,999$339$401$430$410$319$100$0
97
Sutentsunitinib2006-01-26Pfizer
Cancer: Kidney; Gastrointestinal Stromal Tumor; Advanced Pancreatic NET
USD12.2$11,774$1,081$1,095$1,120$1,174$1,204$1,236$1,187$1,066$964$847$581$219$0
98
Sutent (US only)sunitinib2006-01-26Pfizer
Cancer: Kidney; Gastrointestinal Stromal Tumor; Advanced Pancreatic NET
USD12.2$391$368$354$351
99
Sutent (USA Medicare part B)sunitinib2006-01-26Pfizer
Cancer: Kidney; Gastrointestinal Stromal Tumor; Advanced Pancreatic NET
USD12.2$0$0$0$0$0
100
Sutent (USA Medicare part D)sunitinib2006-01-26Pfizer
Cancer: Kidney; Gastrointestinal Stromal Tumor; Advanced Pancreatic NET
USD12.2$183$161$158$146$104
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