4DF indication table

	B	C	D	E	F	G	H
1
2
3	For internal use only
4
5	Discipline	Surgic procedure	Indication			Application instructions/notes	Contraindications
6	Discipline	Surgic procedure	Hemostasis	Adhesion prevention	other	Application instructions/notes	Contraindications

7	Gynecology	Endometriosis resection	x	x		Described in Korell Surgical Science 2014, 5(1), 533–539 & Korell et al. Biomed Research International 2016, Article ID 3029264, 1–9
8		Sectio caesarea	x	x		1g should be sufficient for adhesion prevention, for Hyalobarrier customers: 1:8-gel has similar consistency
9		Adhesiolysis		x		Described in Korell et al. Biomed Research International 2016, Article ID 3029264, 1–9
10		Myoma enucleation	(x)	x		Described in Korell Surgical Science 2014, 5(1), 533–539 & Korell et al. Biomed Research International 2016, Article ID 3029264, 1–9
11		Hysterectomy (e.g. LASH)	x	x		Described in Korell et al. Biomed Research International 2016, Article ID 3029264, 1–9
12		Resection of ovarian cysts	x	x		4DF for hemostasis reduces need for electrocautery and thereby conserves fertility
13		Axillary lymphadenectomy	x	x
14		Radical mastectomy	x
15		Lymphadenectomy (vulva carcinoma)	x	x
16		Wertheim operation	x	x
17		Intrauterine surgery (e.g. Asherman surgery)		x		For Hyalobarrier customers: 1:8-gel has similar consistency
18		Treatment of uterine perforation	x	x		Described in Ziegler et al. Journal of Medical Case Reports (2016) 10:243
19		Endometrium carcinoma	x	x		Described in Korell Surgical Science 2014, 5(1), 533–539 & Korell et al. Biomed Research International 2016, Article ID 3029264, 1–9
20		Uterus carcinoma	x	x		Described in Korell Surgical Science 2014, 5(1), 533–539
21
22
23	General surgery	Appendectomy	x	x
24		Tumor removal	x	x
25		Sleeve gastrectomy	x	x
26		Hernia surgery	x	x
27		Goitre surgery	x	x
28		Esophagus resection	x	x
29		Lymphadenectomy	x	x
30		B-I/ B-II, gastrectomy	x	x
31		Whipple procedure (right side of pancreas)	x	x
32		Left-sided pancreatic resection	x	x
33		Cholecystectomy (minimally invasive + open) for bleedings from the gal bladder bed (fossa)	x				Arterial bleedings
34		Partial liver resection	x	x			Arterial bleedings
35		Liver transplantation	x	x			Arterial bleedings
36		Atypical partial liver resection	x	x			Arterial bleedings
37		Adhesiolysis		x		Described in Blumhardt et al. Case Reports in Surgery 2018, Article ID 9628742, 1–6
38		General colorectal surgery		x
39		Seroma treatment	x		Healing/prevention of recurrence	Described in Kuthe International Journal of Surgery Case Reports 2016, 27, 48–50
40		Laparotomy with bowel involvement		x
41		Hartmann's operation		x
42		Hollow organ perforation (gall, stomach, bowel)	x	x
43		Intestinal fistula			Healing	Preparation of almost solid 4DF gel (5g 4DF + 20ml saline), scrape out fistula canal, apply 4DF gel within canal using a syringe, 4DF also promotes closure of fistula canal
44
45
46	Cardiac, thoracic & vascular surgery	LVAD/ RVAD/ bi-ventricular	x	x		Reported additional benefit is a reduction of scar tissue around the pump
47		Heart transplantation	x	x
48		Aortic dissection	x	x
49		Coronary artery bypass suregry	x	x
50		Aortic valve replacement	x	x
51		Bentall procedure	x	x
52		Ross procedure (pulmonary autograft)	x	x
53		Mitral valve replacement	x	x
54		Aortic aneurysm	x	x
55		Extracorporeal membrane oxygenation (ECMO)	x	x
56		Tetralogy of Fallot	x	x
57		Fontan procedure	x	x
58		Transposition of the great arteries (TGA)	x	x
59		Lobectomy	x	x
60		Segment resection	x	x
61		Wedge resection	x	x
62		Pneumectomy	x	x
63		Vascular implant	x	x
64		Thoracotomy	x	x
65		Coronary anastomosis	x	x
66		Aortic anastomosis	x	x
67		Mitral reconstruction	x	x
68		Sternotomy	x		Healing	Intrasternal application using a strip of Tabotamp directly under the sternum onto which the powder is given before closure (see video on PlantTec homepage)
69		Bidirectional Glenn procedure	x	x
70		Correction of anomalous pulmonary venous connection	x	x
71		AP shunt	x	x
72		Atrial septectomy	x	x
73		Norwood procedure	x	x
74		VSD closure with patch	x	x
75		Pulmonary artery banding	x	x
76		Blalock–Taussig shunt	x	x
77
78
79	Peripheral vascular surgery	Endarterectomy (Carotis)	x	x
80		Aneurysm of abdominal aorta	x	x
81		Aorto-femoral bypass (groin)	x	x
82
83
84	Orthopedic surgery	Total Knee Replacement (TKR)	x	x	Lubricant elastic layer	Lubricant elastic layer: usage as gel to enhance slippage of tissue upon the implant
85		Hip replacement	x		Lubricant elastic layer	Significant reduction of postoperative hematoma size (see Riebau et al. (2018) in the Compendium of Scientific Literature); Lubricant elastic layer: usage as gel to enhance slippage of tissue upon the implant
86		Tenolysis		x
87		Arthroscopic knee surgery		x
88		Kissing lesion		x
89		Iliac creast bleedings	x
90		Dupuytren's contracture	x
91
92
93	Laryngology	Functional endoscopic sinuses surgery (FESS)	x
94		Tonsillectomy	x
95		Endotracheal surgeries	x	x
96		Thyroidectomy	x	x		1 or 3 g 4DF, initially applied for hemostasis, remaining powder transformed into gel through dripping with saline, reduces postoperative pain and discomfort, reduces drainage volumes to a degree that drainages are not neccessary anymore
97
98
99	ENT	Neck dissection	x
100