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NOTE: This CEA was modeled based on our CEA for Fortify Health's iron fortification program. We have not yet adjusted the cell descriptions and notes in column A to refer specifically to Evidence Action's IFA supplementation program.
We have specifically highlighted inputs in red where we've made updates to our previous inputs to account for differences between Evidence Action's IFA supplementation program and Fortify Health's iron fortification program (explanations in "Notes" column).
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Evidence Action's IFA supplementation program
India
(10 year timeline)
Notes
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Anemia morbidity averted
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Annual YLDs per person attributed to dietary iron deficiency in India0.0137
See "Counterfactual burden" tab. This input includes upward adjustments to account for: 1) higher burden among children not receiving supplementation (since we model the benefits of Evidence Action's program as coming from an increase in the number of children receiving supplementation who would not have received it otherwise), and 2) higher burden in the 5 Indian states where EvAc is working relative to the national average.
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Relative risk of iron deficiency with iron fortification from academic literature21%
See results for the effect of iron supplementation on iron deficiency among children 5-12 years on Table 3 of the Low et al. 2013 meta-analysis (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3832580/).
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Internal validity adjustment for iron deficiency90%
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External validity adjustment for iron deficiency80%
Adding 20% discount to account for weekly/biweekly vs daily supplementation and time children spend out of school/AWCs.
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Discount for partial supplementation85%
We roughly assume that trials included in Low et al. 2013 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3832580/) measure the effect of moving from no supplementation to full coverage (i.e. that treatment groups received full coverage and control groups received no coverage). The discount here accounts for our best guess that some of the increase in coverage from IFA will come from going from partial coverage to full coverage, rather than no coverage to full coverage.

Based on Evidence Action's coverage survey results in Uttarakhand, Jharkhand, and Haryana, we calculate ~50% of children have received any IFA supplementation, and of those ~30% with partial coverage and ~70% with full coverage. Very roughly guessing that partial coverage provides about half the effect on dietary iron deficiency as full coverage, we calculate an ~85% discount. This is a very rough guess. See calculations here.
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Anemia YLDs per person 0-14 years averted by iron fortification0.0066
Calc. We assume the effect size reported in Low et al. 2013 for children 5-12 years is equivalent to the effect size for children 0-14 years.
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Value assigned to 1 YLD averted2.3
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Units of value per beneficiary0.0152Calc
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Cognitive benefits in children
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Percent of population that's 0-14 years old83.4%
Adjusted for program-specific age structure (6 months to 19 years)
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Proportion of children 0-14 with dietary iron deficiency34.7%
See "Counterfactual burden" tab. This input includes upward adjustments to account for: 1) higher burden among children not receiving supplementation (since we model the benefits of Evidence Action's program as coming from an increase in the number of children receiving supplementation who would not have received it otherwise), and 2) higher burden in the 5 Indian states where EvAc is working relative to the national average.
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Increase in IQ from iron supplementation in children with anemia (standard deviations)0.3
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Internal validity adjustment for IQ in children70%
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External validity adjustment for IQ in children28.7%
Adding 40% discount to account for weekly/biweekly vs daily supplementation and time children spend out of school/AWCs, and children under 3 likely not benefitting from cognitive improvements.
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IQ points per standard deviation15
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Increase in IQ from iron fortification in children with iron deficiency (points)0.77Calc
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Percentage increase in wages/consumption for every 1 point increase in IQ0.7%
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Adjustment to amortize benefits10.0%
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Percent of cognitive benefit that is retained into adulthood33%
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Multiplier for resource sharing2
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Percent increase in consumption from one year of iron fortification (cohort mean)0.010%Calc
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Mean increase in annual ln(consumption)0.00010Calc
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Mean number of years between supplementation and initial consumption benefits11
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Median duration of consumption benefits40
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Discount rate4%
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Present value of lifetime benefits0.0013Calc
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Value assigned to increasing ln(consumption) by one unit for one person for one year1.44
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Units of value per beneficiary0.00182Calc
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Cognitive benefits in adults
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Proportion of cohort of income-earning age17%
Adjusted for program-specific age structure (6 months to 19 years)
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Proportion of working-age adults that have dietary iron deficiency 30.3%
See "Counterfactual burden" tab. This input includes upward adjustments to account for: 1) higher burden among children not receiving supplementation (which we assume to be the primary IFA program beneficiaries), and 2) higher burden in the 5 Indian states where EvAc is working.
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Increase in IQ from iron supplementation in adults with anemia (standard deviations)0.35
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Internal validity adjustment for IQ in adults85%
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External validity adjustment for IQ in adults40.0%
Adding 20% discount to account for weekly/biweekly vs daily supplementation and time children spend out of school/AWCs.
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IQ points per standard deviation15
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Increase in IQ from iron fortification in average adult (points)0.08Calc
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Percentage increase in wages/consumption for every 1 point increase in IQ0.7%
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Multiplier for resource sharing2
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Percentage increase in consumption from iron fortification in average adult0.10%Calc
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Increase in annual ln(consumption) 0.0010Calc
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Value assigned to increasing ln(consumption) by one unit for one person for one year1.44
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Units of value per beneficiary0.001Calc
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Intervention cost
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Annual cost per person (nominal USD), with adjustment$0.81Calc
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Downside adjustments
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Total downside adjustment factor-10%
This is a rough guess. It is intended to capture risk of wastage, quality of monitoring and evaluation, and confidence in funds being used for the intended purpose.
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Inclusion/exclusion
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Concern that the supplementation is less effective against severe anemia-15%
Based on our conversation with an expert in iron interventions, our understanding is that supplementation and fortification are relatively less effective against severe anemia. In India, we estimate roughly 20% of anemia burden is due to severe anemia (calculations are internal). Because we're unsure about how important this adjustment is, we apply a lower adjustment.
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Effect being smaller when we model using anemia rather than iron deficiency-5%
We've also tried modeling supplementation programs as reduction in anemia (as opposed to iron deficiency). We find results are slightly lower using this approach so apply a small downward adjustment.
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Benefits from folic acid10%
In addition to iron, supplements also provide folic acid. We have not modeled additional benefits of folic acid but apply a small upward adjustment.
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Increased beneficiaries due to private school participation10%
The target population only includes children in private schools; however, states might decide to scale the program to all private schools, depending on the result of the pilot (see associated grant page for more information). We’d guess this would increase the target population by ~30% (see "Source: Targeted children" tab). We guess this is fairly unlikely (<50% chance) so the positive adjustment is less than 30%.
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Total adjustment for additional benefits and negative or offsetting impacts0%Calc
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Results
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Units of value per dollar donated, initial0.02Calc
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Cost-effectiveness, multiples of cash transfers from GiveDirectly, initial6.8Calc
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Units of value per dollar donated, after downside adjustments and inclusion/exclusion0.02Calc
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Cost-effectiveness, multiples of cash transfers from GiveDirectly, after downside adjustments and inclusion/exclusion
6.1Calc
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Cost-effectiveness, multiples of cash transfers from GiveDirectly, after accounting for leverage/funging
11.5
Calc. We add a leverage/funging adjustment since this IFA is a technical assistance intervention.
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Contribution of each outcome to overall cost-effectiveness
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Percent of value coming from anemia morbidity averted82%Calc
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Percent of value coming from cognitive benefits in children 10%Calc
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Percent of value coming from cognitive benefits in adults 8%Calc
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