生化所105-2專題討論
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A cationic tetrapyrrole inhibits toxic activities of the cellular prion protein.
Sci Rep. 2016 Mar 15;6:23180.
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A common glycan structure on immunoglobulin G for enhancement of effector functions.
Proc Natl Acad Sci U S A. 2015 Aug 25;112(34):10611-6.
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A Critical SUMO1 Modification of LKB1 Regulates AMPK Activity during Energy Stress.Cell Rep. 2015 Aug 4;12(5):734-42.104-1
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A dual AAV system enables the Cas9-mediated correction of a metabolic liver disease in newborn mice.
Nat Biotechnol. 2016 Mar;34(3):334-8.
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5
A Dynamic Search Process Underlies MicroRNA Targeting.Cell. 2015 Jul 2;162(1):96-107.104-1
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A Eukaryote without a Mitochondrial Organelle.
Curr Biol. 2016 May 23;26(10):1274-84.
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A G-protein activation cascade from Arl13B to Arl3 and implications for ciliary targeting of lipidated proteins.
Elife. 2015 Nov 9;4. pii: e11859.
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8
A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation.Cell. 2015 Aug 27;162(5):1066-77.104-1
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A PGC1α-mediated transcriptional axis suppresses melanoma metastasis.
Nature. 2016 Aug 31;537(7620):422-426.
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10
A recellularized human colon model identifies cancer driver genes.
Nat Biotechnol. 2016 Aug;34(8):845-51.
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11
A red meat-derived glycan promotes inflammation and cancer progression.
Proc Natl Acad Sci U S A. 2015 Jan 13;112(2):542-7.
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12
A thiamin-utilizing ribozyme decarboxylates a pyruvate-like substrate.
Nat Chem. 2013 Nov;5(11):971-7.
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A two-photon fluorescent sensor revealing drug-induced liver injury via tracking γ-glutamyltranspeptidase (GGT) level in vivo.
Biomaterials. 2016 Feb;80:46-56. doi: 10.1016/j.biomaterials.2015.11.047. Epub 2015 Dec 2.
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14
Acetylation-regulated interaction between p53 and SET reveals a widespread regulatory mode.
Nature. 2016 Sep 14;538(7623):118-122.
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Acidosis Drives the Reprogramming of Fatty Acid Metabolism in Cancer Cells through Changes in Mitochondrial and Histone Acetylation.
Cell Metab. 2016 Aug 9;24(2):311-23.
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Adiponectin Enhances Cold-Induced Browning of Subcutaneous Adipose Tissue via Promoting M2 Macrophage Proliferation.Cell Metab. 2015 Aug 4;22(2):279-90.104-1
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ALS-Causing Mutations Significantly Perturb the Self-Assembly and Interaction with Nucleic Acid of the Intrinsically Disordered Prion-Like Domain of TDP-43.
PLoS Biol. 2016 Jan 6;14(1):e1002338.
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18
Alzheimer's disease-associated mutations increase amyloid precursor protein resistance to γ-secretase cleavage and the Aβ42/Aβ40 ratio.
Cell Discov. 2016 Aug 23;2:16026.
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Amplified in breast cancer 1 promotes colorectal cancer progression through enhancing notch signaling Oncogene (2015) 34, 3935–3945104-1
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Amyloid-b Peptide Induces Mitochondrial Dysfunction by Inhibition of Preprotein Maturation.
Cell Metabolism 20, 662–669, October 7, 2014
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Amyloid-like Self-Assembly of a Cellular Compartment.
Cell. 2016 Jul 28;166(3):637-50.
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An atomic structure of human γ-secretase. Nature. 2015 Sep 10;525(7568):212-7.104-1
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An ERK/Cdk5 axis controls the diabetogenic actions of PPARγ. Nature. 2015 Jan 15;517(7534):391-5.104-1
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An ID2-dependent mechanism for VHL inactivation in cancer.
Nature. 2016 Jan 14;529(7585):172-7.
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25
An in-tumor genetic screen reveals that the BET bromodomain
protein, BRD4, is a potential therapeutic target in ovarian carcinoma.
P Natl Acad Sci USA 112(1): 232-237, 2015.
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26
An obligatory role for neurotensin in high-fat-diet-induced obesity.
Nature. 2016 May 11;533(7603):411-5.
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ATM Couples Replication Stress and Metabolic Reprogramming during Cellular Senescence.Cell Report.2015.04.014104-1
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Atypical Transcriptional Activation by TCF via a Zic Transcription Factor in C. elegans Neuronal Precursors. Dev Cell. 2015 Jun 22;33(6):737-45. doi: 10.1016/j.devcel.2015.04.018. Epub 2015 Jun 11104-1
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Autophagic clearance of polyQ proteins mediated by ubiquitin-Atg8 adaptors of the conserved CUET protein family.Cell. 2014 Jul 31;158(3):549-63.104-1
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Autophagy Promotes Focal Adhesion Disassembly and Cell Motility of Metastatic Tumor Cells through the Direct Interaction of Paxillin with LC3.
Cell Rep. 2016 May 24;15(8):1660-72.
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Backbone NMR reveals allosteric signal transduction networks in the β1-adrenergic receptor.
Nature. 2016 Feb 11;530(7589):237-41.
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Balancing between affinity and speed in target DNA
search by zinc-finger proteins via modulation of
dynamic conformational ensemble.Proc Natl Acad Sci U S A. 2015 Sep 15
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Balancing between affinity and speed in target DNA search by zinc-finger proteins via modulation of dynamic conformational ensemble. Proc Natl Acad Sci U S A, 112(37), E5142-5149. 104-1
34
Bile Acids Protect Expanding Hematopoietic Stem Cells from Unfolded Protein Stress in Fetal Liver.
Cell Stem Cell. 2016 Apr 7;18(4):522-32.
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Broad Anti-tumor Activity of a Small Molecule that Selectively Targets the Warburg Effect and Lipogenesis.
Cancer Cell. 2015 Jul 13;28(1):42-56.
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C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector.
Science. 2016 Aug 5;353(6299):aaf5573.
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Carbohydrate-Neuroactive Hybrid Strategy for Metabolic Glycan Engineering of the Central Nervous System in Vivo.
J Am Chem Soc. 2017 Jan 18;139(2):693-700.
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Caspase-3 promotes genetic instability and carcinogenesis.
Mol Cell. 2015 Apr 16;58(2):284-96.
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CDA directs metabolism of epigenetic nucleosides
revealing a therapeutic window in cancer.Nature 524, 114–118
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Cellular Cholesterol Directly Activates Smoothened in Hedgehog Signaling.
Cell. 2016 Aug 25;166(5):1176-1187.e14.
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Centrosome Amplification Is Sufficient to Promote Spontaneous Tumorigenesis in Mammals.
Dev Cell. 2017 Feb 6;40(3):313-322.e5.
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Characterization of a Steroid Receptor Coactivator Small Molecule Stimulator that Overstimulates Cancer Cells and Leads to Cell Stress and Death.Cancer Cell. 2015 Aug 10;28(2):240-52.104-1
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Chemically modified guide RNAs enhance CRISPR-Cas genome editing in human primary cells.Nat Biotechnol. 2015 Sep;33(9):985-9.104-1
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Clearance of persistent hepatitis C virus infection
in humanized mice using a claudin-1-targeting
monoclonal antibody. Nat Biotechnol. 2015 May;33(5):549-54.
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Coincident Phosphatidic Acid Interaction Restrains Drp1 in Mitochondrial Division.
Mol Cell. 2016 Sep 15;63(6):1034-43.
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Combined EGFR/MEK Inhibition Prevents the Emergence of Resistance in EGFR-Mutant Lung Cancer. 2015 June 2; 10.1158/2159-8290104-1
47
Compounds Triggering ER Stress Exert Anti-Melanoma Effects and Overcome BRAF Inhibitor Resistance.
Cancer Cell. 2016 Jul 11;30(1):183.
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Confinement and low adhesion induce fast amoeboid migration of slow mesenchymal cells.
Cell. 2015 Feb 12;160(4):659-72.
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Conformational propensities of intrinsically disordered proteins influence the mechanism of binding and folding. Proc. Nat. Acad. Sci. USA. 2015 Aug 4;112(31):9614-9.104-1
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Creating small transcription activating RNAs. Nature Chemical Biology 2015 Mar;11(3):214-20. doi: 10.1038/nchembio.1737. Epub 2015 Feb 2.104-1
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CRISPR-Cas9 delivery to hard-to-transfect cells via membrane deformation.
Sci Adv. 2015 Aug 14;1(7):e1500454.
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Cytoplasmic protein aggregates interfere with nucleocytoplasmic transport of protein and RNA.
Science. 2016 Jan 8;351(6269):173-6.
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Deficiency of Parkinson's disease-related gene Fbxo7 is associated with impaired mitochondrial metabolism by PARP activation.
Cell Death Differ. 2016 Sep 30.
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Defining roles of PARKIN and ubiquitin phosphorylation by PINK1 in mitochondrial quality control using a ubiquitin replacement strategy. Proceedings of the National Academy of Sciences 112.21 (2015): 6637-6642.104-1
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Degradation of AMPK by a cancer-specific ubiquitin ligase.
Cell. 2015 Feb 12;160(4):715-28.
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Deposition of 5-Methylcytosine on Enhancer RNAs Enables the Coactivator Function of PGC-1α.
Cell Rep. 2016 Jan 26;14(3):479-92.
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Differential Requirements for eIF4E Dose in Normal Development and Cancer.
Cell. 2015 Jul 2;162(1):59-71.
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Discovery of cancer drug targets by CRISPR-Cas9 screening of protein domains.
Nat Biotechnol. 2015 Jun;33(6):661-7.
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Disorder and residual helicity alter p53-Mdm2 binding affinity and signaling in cells. Nat Chem Biol. 2014 Dec;10(12):1000-2. 104-1
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Distinct EMT programs control normal mammary stem cells and tumour-initiating cells Nature. 2015 Sep 10;525(7568):256-60.104-1
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DNA Methylation on N6-Adenine in C. elegans. Greer et al., 2015, Cell 161: 868-878.104-1
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DNMT3b Modulates Melanoma Growth by Controlling Levels of mTORC2 Component RICTOR.
Cell Rep. 2016 Mar 8;14(9):2180-92.
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Drug sensitivity of single cancer cells is predicted by changes in mass accumulation rate.
Nat Biotechnol. 2016 Nov;34(11):1161-1167.
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Dub3 inhibition suppresses breast cancer invasion and metastasis by promoting Snail1 degradation.
Nat Commun. 2017 Feb 15;8:14228.
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Dynein Binding of Competitive Regulators Dynactin and NudE Involves Novel Interplay Between Phosphorylation Site and Disordered Spliced Linkers.
Structure. 2017 Jan 31.
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Efficient introduction of specific homozygous and heterozygous mutations using CRISPR/Cas9.
Nature. 2016 May 5;533(7601):125-9.
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EglN2 associates with the NRF1-PGC1α complex and controls mitochondrial function in breast cancer.
EMBO J. 2015 Dec 2;34(23):2953-70.
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eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation.
Nature. 2016 Aug 4;536(7614):96-9.
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Electron Transport Chain Remodeling by GSK3 during Oogenesis Connects Nutrient State to Reproduction.
Cell. 2016 Jan 28;164(3):420-32.
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Endogenous formaldehyde is a hematopoietic stem cell genotoxin and metabolic carcinogen. Molecular Cell. (2015) 60, 177–188.104-1
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Epigenetic gene regulation by Janus kinase 1 in diffuse large B-cell lymphoma.
Proc Natl Acad Sci U S A. 2016 Nov 15;113(46):E7260-E7267.
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Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers.
Nat Biotechnol. 2015 May;33(5):510-7.
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Estrogen Receptor α Promotes Breast Cancer by Reprogramming Choline Metabolism.
Cancer Res. 2016 Oct 1;76(19):5634-5646.
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Extracellular metabolic energetics can promote cancer progression.Cell. 2015 Jan 29;160(3):393-406.104-1
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Fascin Regulates Nuclear Movement and Deformation in Migrating Cells.
Dev Cell. 2016 Aug 22;38(4):371-83.
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Fast-response and highly selective fluorescent probes for biological signaling molecule NO based on N-nitrosation of electron-rich aromatic secondary amines.
Biomaterials. 2016 Feb;78:11-9.
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Fatty acid synthesis configures the plasma membrane for inflammation in diabetes.
Nature. 2016 Nov 10;539(7628):294-298.
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Fatty acid trafficking in starved cells: regulation by lipid droplet lipolysis, autophagy, and mitochondrial fusion dynamics.
Dev Cell. 2015 Mar 23;32(6):678-92.
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Feedback modulation of cholesterol metabolism by the lipid-responsive non-coding RNA LeXis.
Nature. 2016 May 11;534(7605):124-8.
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FGF21 Mediates Endocrine Control of Simple Sugar Intake and Sweet Taste Preference by the Liver.
Cell Metab. 2016 Feb 9;23(2):335-43.
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Genomic analysis identifies new drivers and progression pathways in skin basal cell carcinoma.
Nat Genet. 2016 Apr;48(4):398-406.
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Global analysis of protein structral changes in complex proteomes.Nat Biotechnol. 2014 Oct;32(10):1036-44104-1
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Global Oct4 target gene analysis reveals novel downstream PTEN and TNC genes required for drug-resistance and metastasis in lung cancer. Tang, Chen et al., 2015, Nucleic Acids Res 43(3): 1593-1608104-1
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Glucose Uptake and Runx2 Synergize to Orchestrate Osteoblast Differentiation and Bone Formation Wei et al., 2015, Cell 161, 1576–1591104-1
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Glycosylation-Dependent IFN-γR Partitioning in Lipid and Actin Nanodomains Is Critical for JAK Activation.
Cell. 2016 Aug 11;166(4):920-34.
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Hepatic B cell leukemia-3 promotes hepatic steatosis and inflammation through insulin-sensitive metabolic transcription factors.
J Hepatol. 2016 Dec;65(6):1188-1197.
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High-Density Lipoproteins Exert Pro-inflammatory Effects on Macrophages via Passive Cholesterol Depletion and PKC-NF-κB/STAT1-IRF1 Signaling.
Cell Metab. 2017 Jan 10;25(1):197-207.
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High-fat diet enhances stemness and tumorigenicity of intestinal progenitors.
Nature. 2016 Mar 3;531(7592):53-8.
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Histone Degradation in Response to DNA Damage Enhances Chromatin Dynamics and Recombination Rates.
Nat Struct Mol Biol 24 (2), 99-107. 2017 Jan 09.
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HP1 Is Involved in Regulating the Global Impact of DNA Methylation
on Alternative Splicing. Cell Rep. 2015 Feb 24;10(7):1122-34.
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Human BRCA1-BARD1 ubiquitin ligase activity counteracts chromatin barriers to DNA resection.
Nat Struct Mol Biol. 2016 Jul;23(7):647-55.
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Hybrid Periportal Hepatocytes Regenerate the Injured Liver without Giving Rise to Cancer.
AbstractSend to:
Cell. 2015 Aug 13;162(4):766-79.
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Id2 and E Proteins Orchestrate the Initiation and Maintenance of MLL-Rearranged Acute Myeloid Leukemia.
Cancer Cell. 2016 Jul 11;30(1):59-74.
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Indigenous Bacteria from the Gut Microbiota Regulate Host Serotonin Biosynthesis. Cell. 2015 Apr 9;161(2):264-76104-1
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Inhibiting Drivers of Non-mutational Drug Tolerance Is a Salvage Strategy for Targeted Melanoma Therapy.
Cancer Cell. 2016 Mar 14;29(3):270-84.
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Insulin post-transcriptionally modulates Bmal1 protein to affect the hepatic circadian clock.
Nat Commun. 2016 Aug 31;7:12696.
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Integrin alpha1beta1 expression is controlled by c-MYC in colorectal cancer cells.
Oncogene. 2015 Jun 22. doi: 10.1038/onc.2015.231.
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Integrins Form an Expanding Diffusional Barrier that Coordinates Phagocytosis.
Cell. 2016 Jan 14;164(1-2):128-40.
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Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration.
Nature. 2015 Dec 24;528(7583):560-4.
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Intestinal Autophagy Improves Healthspan and Longevity in C. elegans during Dietary Restriction.
PLoS Genet. 2016 Jul 14;12(7):e1006135.
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