ABCDEFGHIJKLMNOPQRSTUVWXYZAAABACADAEAFAGAHAIAJAKALAMANAOAPAQARASATAUAVAWAXAYAZ
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BRAIN/CNS PATH
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AuthorTitleCountryDate PublishedN (Brains)Autopsy
Deceased Path
Living PathCSFCells In VivoOrganoids
Animal Studies
Neurological Symptoms
ImagingJournalDOILinkContactEmail
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1Soloman IH, et alNeuropathological Features of Covid-19USA (MA)12-Jun-2018xxN Engl J Med.
DOI: 10.1056/NEJMc2019373
https://www.nejm.org/doi/full/10.1056/NEJMc2019373
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2Schurink B, et al
Viral presence and immunopathology in patients with lethal COVID-19: a prospective autopsy cohort study
Netherlands25-Sep-20xx
The Lancet Microbe
https://doi.org/10.1016/S2666-5247(20)30144-0
https://www.thelancet.com/journals/lanmic/article/PIIS2666-5247(20)30144-0/fulltext
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3Dolhnikoff M, et al
SARS-CoV-2 in cardiac tissue of a child with COVID-19-related multisystem inflammatory syndrome
Brazil20-Aug-201xx
Lancet Child Adolesc Health
https://doi.org/10.1016/S2352-4642(20)30257-1
https://www.thelancet.com/journals/lanchi/article/PIIS2352-4642(20)30257-1/fulltext
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4Puelles VG, et alMultiorgan and renal tropism of SARS‐CoV‐2Germany13-May-2021xN Engl J Med.
https://doi.org/10.1056/NEJMc2011400
https://www.nejm.org/doi/full/10.1056/NEJMc2011400?query=featured_coronavirus
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5Li Z, et al
The brain, another potential target organ, needs early protection from SARS‐CoV‐2 neuroinvasion
China31-Mar-201x
Sci China Life Sci
https://doi.org/10.1007/s11427-020-1690-y
https://link.springer.com/article/10.1007/s11427-020-1690-y
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6Moriguchi T, et al
A first case of meningitis/encephalitis associated with SARS‐coronavirus‐2
Japan3-Apr-201xInt J Infect Dis
https://doi.org/10.1016/j.ijid.2020.03.062
https://www.ijidonline.com/article/S1201-9712(20)30195-8/fulltext
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7Bulfamonte G, et al.
First ultrastructural autoptic findings of SARS-CoV-2 in olfactory pathways and brainstem
Italy20-Jun1x
Minerva Medica
DOI: 10.23736/S0375-9393.20.14432-8
https://www.minervamedica.it/en/getfreepdf/a1NVK0pSd1h1WU5nY0FlQnhXZ25uajByS2dyM3BCdVprZWErbzk5RXJPN0VIK3MyL0xVa0hZcjFPdEVDa013WQ%253D%253D/R02Y2020N06A0678.pdf
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8Song E, et alNeuroinvasion of SARS-CoV-2 in human and mouse brainUSA (CT)8-Sep-203xxxxx
PREPRINT: BioRxIv
PREPRINT: bioRxiv
https://doi.org/10.1101/2020.06.25.169946.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7491522/pdf/nihpp-2020.06.25.169946.pdf
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9Huang YH, et al
SARS-CoV-2 Detected in Cerebrospinal Fluid by PCR in a Case of COVID-19 Encephalitis
USA (CA)06 May 20201 CSF samplex1Seizures
Brain Behav Immun.
https://dx.doi.org/10.1016%2Fj.bbi.2020.05.012
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202824/
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10Lee MH, et alMicrovascular Injury in the Brains of Patients with COVID-19
USA (MD/NY/IA)
30 December 202013xxN Engl J Med.
DOI: 10.1056/NEJMc2033369
https://www.nejm.org/doi/full/10.1056/NEJMc2033369#.X-z9hxRCh2s.twitter
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11Vivanti AJ et alTransplacental transmission of SARS-CoV-2 infectionFrance14 July 20201 CSFxxx1xxx
Infant irritability, poor feeding, axial hypertonia and opisthotonos
irritability, poor feeding, axial hypertonia and opisthotonos
Nature Comms
https://doi.org/10.1038/s41467-020-17436-6
https://www.nature.com/articles/s41467-020-17436-6/figures/3
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12Lorenz N, et al
Neonatal Early-Onset Infection With SARS-CoV-2 in a Newborn Presenting With Encephalitic Symptoms
GermanyAugust 20201 CSFxxx1xxx
CSF: RT-PCR, RIDAGENE SARS-CoV-2 RUO (R-Biopharm, Darmstadt, Germany)].
Infant encephalitic symptoms (lethargic but severely hyperexcitable, high pitched crying)
cerebral sonography
The Pediatric Infectious Disease Journal
doi: 10.1097/INF.0000000000002735
https://journals.lww.com/pidj/Fulltext/2020/08000/Neonatal_Early_Onset_Infection_With_SARS_CoV_2_in.36.aspx
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13Meinhardt J, et al
Olfactory transmucosal SARS-CoV-2 invasion as a port of central nervous system entry in individuals with COVID-19
Germany30 November 202033Nature
https://doi.org/10.1038/s41586-021-03710-0
https://www.nature.com/articles/s41586-021-03710-0
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14Yang AC, et al
Dysregulation of brain and choroid plexus cell types in severe COVID-19
USA21 June 202122x
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COVID-19 NEUROLOGY PROTOCOLS BMC
https://covidneurology.org/about
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Thank you for checking out this project! This is a living document and a work in progress!
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HELP make this data better! Don't see a study?! PLEASE LET ME KNOW: either "Add Comment," find me on Twitter @ErinSandersNP, or connect via my website erinsandersnp.org
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Functional Imaging
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Guedj E, et al18F-FDG brain PET hypometabolism in patients with long COVIDFrance26 Jan 202135 (44 controls)PET
Eur J Nucl Med Mol Imaging
https://doi.org/10.1007/s00259-021-05215-4
https://link.springer.com/article/10.1007/s00259-021-05215-4#citeas
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Guedj E, et al
18F-FDG brain PET hypometabolism in post-SARS-CoV-2 infection: substrate for persistent/delayed disorders?
France2020PET
Eur J Nucl Med Mol Imaging
https://doi.org/10.1007/s00259-020-04973-x.
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Guedj E, et alPET imaging of COVID-19: the target and the numberFrance2020PET
Eur J Nucl Med Mol Imaging
https://doi.org/10.1007/s00259-020-04820-z.
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Morbelli S, et alCOVID-19 and the brain: impact on nuclear medicine in neurology.2020
Eur J Nucl Med Mol Imaging
https://doi.org/10.1007/s00259-020-04965-x.
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Clinical Trials/Registries
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National Institutes of Health (NIH) COVID-19 Neuro Databank-BioBank
https://med.nyu.edu/departments-institutes/population-health/divisions-sections-centers/biostatistics/research/nih-neurodatabank-neurobiobank
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Continuous Monitoring of Pooled International Trials of Convalescent Plasma for COVID-19 Hospitalized Patients (COMPILE)
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https://med.nyu.edu/departments-institutes/population-health/divisions-sections-centers/biostatistics/research/continuous-monitoring-pooled-international-trials-convalescent-plasma-covid19-hospitalized-patients
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Clinical and Neuroimaging Correlation in Patients with COVID-19
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http://www.ajnr.org/content/41/10/1791.abstract
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Electroencephalographic Abnormalities are Common in COVID‐19 and are Associated with Outcomes
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https://onlinelibrary.wiley.com/doi/10.1002/ana.26060
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