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1 | two | Claimed Research Topic/Idea | Person(s) who claimed the topic/idea | Institution Affiliation | Role (first author) | Contact Info | Project Proposal | Date of Approval of Data Request | DOI | Abstract/Summary | |||||||||||||
2 | 1 | Elevated threat-sensitivity and reduced reward-sensitivity associated with increased peripheral inflammation among young adults | Iris Ka-Yi Chat, Chan, M., Vinograd, M., Craske, M. G., Roth, M., Miller, G. E., Zinbarg, R., & Nusslock, R. | Northwestern University | BrainMAPD Research Coordinators | kychat@northwestern.edu | Presentation | ||||||||||||||||
3 | 2 | Establishing adaptive social capital in the face of risk: Subjective social status, emotion processing, and CVD risk in young adults. | Meanne Chan, Chat, I. K., Vinograd, M., Craske, M. G., Roth, M., Miller, G. E., Zinbarg, R., & Nusslock, R. | University of Hong Kong | BrainMAPD immune consultant/Research Assistant Professor | meanne.chan@gmail.com | Symposium | ||||||||||||||||
4 | 3 | Early life adversity predicts amygdala activation during fear acquisition | Meghan Vinograd, Young, K. S., Staples-Bradley, L. K., Sun, M., Damme, K. S. F., Bookheimer, S. Y., Zinbarg, R. E., Craske, M. G., Nusslock, R. | UCLA | Graduate student (PI: Michelle Craske) | mvinograd@ucla.edu | Poster | ||||||||||||||||
5 | 4 | The impact of early life adversity on working memory for negative and neutral information among young adults. | Meghan Vinograd, Kelley, N. J., Young, K. S., Zinbarg, R. E., Nusslock, R. | UCLA | Graduate student (PI: Michelle Craske) | mvinograd@ucla.edu | Poster | ||||||||||||||||
6 | 5 | Social Feedback Learning Reduces Negative Bias and Impaired Motivation in Anxiety and Depression | Katie Young, Hasratian, A., Zinbarg, R. E., Nusslock, R., & Craske, M. G. | UCLA | Post-doc on BrainMAPD | ksy296@gmail.com | Presentation | ||||||||||||||||
7 | 6 | Associations Among Purposeful Exercise, Cognitive Reappraisal Tendency, and Internalizing Symptoms | Alexandra Tanner, Young, K. S., Nusslock, R., Zinbarg, R. E., Bookheimer, S. Y., & Craske, M. G. | UCLA | Graduate student (PI: Michelle Craske) | tannera@ucla.edu | Poster; Publication | 2/15/2018 | |||||||||||||||
8 | 7 | Evidence for a general factor of behavioral activation system sensitivity. | Nicholas J. Kelley, Kramer, A. M., Young, K. S., Echiverri-Cohen, A. M., Chat, I. K.-Y., Bookheimer, S. Y., Nusslock, R., Craske, M. G., & Zinbarg, R. E. | Northwestern University | Post-doc on BrainMAPD | nicholasjkelley@gmail.com | Publication | https://doi.org/10.1016/j.jrp.2019.01.002 | Individual differences in one’s propensity to engage the behavioral activation system (BAS) and behavioral inhibition system (BIS) have primarily been studied with Caver and White’s (1994) BIS/BAS scale. Whereas, Carver and White identified the BIS as a unidimensional scale, they identified three separable BAS group factors - drive, fun seeking, and reward responsiveness -which Carver urged against combining into a BAS total score. Despite this, a BAS total score has been used extensively although researchers have yet to test whether a BAS general factor exists and, if so, whether a BAS total score can be interpreted as primarily being a measure of the general factor. The current study observed that the best fitting BAS factor model of those we tested was a hierarchical model with three group facets and a general factor. This model was largely invariant across both sex and race/ethnicity. We show, for the first time, that a general factor accounts for the majority of the variance in BAS total scores. Due to the superior fit of the hierarchical model and variance accounted for by the general factor, we conclude that researchers are psychometrically justified in using a BAS total score. | https://drive.google.com/file/d/1-2Jev0YzfgaEgIazp89APfEPQM7Ja7yr/view?usp=sharing | |||||||||||||
9 | 8 | General Distress in Anxiety and Depression Associated with Increased Systemic Inflammation | Iris Ka-Yi Chat, Kelley, N. J., Vinograd, M., Perez, M., Zinbarg, R. E., Young, K. S., Echiverri, A., Craske, M. G., Miller, G. E., & Nusslock, R. | Northwestern University | BrainMAPD Research Coordinators | kychat@northwestern.edu | Poster | 3/23/2018 | |||||||||||||||
10 | 9 | Emotional content impacts how executive function ability relates to willingness to wait and to work for reward | Kate Damme, & Kelley, N. J., Quinn, M. E., Glazer, J., Chat, I. K., Young, K. S., Nusslock, R., Zinbarg, R. E., Bookheimer, S., & Craske, M. E. | Northwestern University | Graduate student (PI: Robin Nusslock) | kate.damme@u.northwestern.edu | Publication | 2/15/2018 | https://doi.org/10.3758/s13415-019-00712-4 | Research has demonstrated that better value-based decision making (e.g., waiting or working for rewards) relates to greater executive function (EF) ability. However, EF is not a static ability, but is influenced by the emotional content of the task. As such, EF ability in emotional contexts may have unique associations with value-based decision making, in which costs and benefits are explicit. Participants (N = 229) completed an EF task (with both negative and neutral task conditions) and two value-based decision-making tasks. Willingness to wait and to work were evaluated in separate path models relating the waiting and working conditions to the EF conditions. Willingness to wait and willingness to work showed distinct relationships with EF ability: Greater EF ability on a negative, but not on a neutral, EF task was related to a willingness to wait for a reward, whereas greater EF ability across both EF tasks was related to a greater willingness to work for a reward. EF ability on a negative EF task showed an inverted-U relationship to willingness to wait for reward, and was most related to willingness to wait at a 6-month delay. Greater EF, regardless of whether the task was negative or neutral, was related to a greater willingness to work when reward was uncertain (50%) or was likely (88%), but not when reward was unlikely (12%). This study suggests that the emotional content of value-based decisions impacts the relationship between EF ability and willingness to wait or to work for reward. | https://drive.google.com/file/d/1-5Eb3c5hNidmTXTOsE05LNR4c8KMs37L/view?usp=sharing | ||||||||||||
11 | 10 | Executive function network coherence will be related to both a willingness to wait and a willingness to work for reward, whereas a willingness to wait relates to executive function and salience network coherence | Casey Armstrong, Kate Damme, Kelley, N. J., Chat, I. K., Quinn, M. E., Young, K. S., Nusslock, R., Zinbarg, R. E., Bookheimer, S., & Craske, M. E. | Northwestern University | Graduate student (PI: Robin Nusslock) | caseyArmstrong2021@u.northwestern.edu | Publication | 2/15/2018 | |||||||||||||||
12 | 11 | The role of Emotion Regulation during Fear Conditioning | Michael Sun, Craske, M. G., & Young, K. S. | UCLA | Graduate student (PI: Michelle Craske) | sunm@ucla.edu | Publication; PhD dissertation/Master's thesis | 4/6/2018 | |||||||||||||||
13 | 12 | Poor sleep quality is significantly associated with effort but not temporal discounting of monetary rewards. | Elaine Boland, Kelley, N. J., Chat, I. K.-Y., Zinbarg, R., Craske, M. G., Bookheimer, S., & Nusslock, R. | Philadelphia VA Medical Center | Research Psychologist (Robin Nusslock's K award mentee) | boland.elaine@gmail.com | Publication | 6/29/2018 | https://doi.org/10.1037/mot0000258 | Experimental sleep deprivation has been shown to differentially affect behavioral indices of effort and temporal discounting, 2 domains of reward processing often observed to be impaired in depression. Experimental sleep deprivation is phenomenologically different from sleep deprivation in everyday life (e.g., poor quality sleep or habitual short sleep duration). Thus, experimental findings may not explain how sleep disturbance impacts reward processing in everyday life. The present study examined associations of past-month self-reported typical sleep quality and duration among 325 young adults who completed behavioral tasks of effort and temporal discounting. Analyses accounted for the potential influence of self-reported mood symptoms and reward sensitivity. Results showed that poorer sleep quality, but not shorter sleep duration, was associated with less preference for high effort/high reward choices on the Effort Expenditure for Reward task (EEfRT) and was significant when accounting for depression and reward sensitivity, neither of which significantly predicted effort. Neither poorer sleep quality nor shorter sleep duration was significantly associated with a preference for smaller, more immediate reward on a delay discounting task. Findings suggest sleep quality, irrespective of total hours of sleep, may independently affect reward-relevant effort, which may have implications for the study and treatment of depression. | https://drive.google.com/file/d/1-6TRs0D2C3gHoCTMDg2oCrcpNNDYEAla/view?usp=share_link | ||||||||||||
14 | 13 | Emotion regulation tendencies and behavioral measures of reward responsivity | Nick Kelley, & Young, K. S. | Northwestern University | Post-doc on BrainMAPD | nicholasjkelley@gmail.com | Poster; Publication | 6/8/2018 | |||||||||||||||
15 | 14 | Relationship between fractional anisotropy (FA) and both general distress and anhedonia using diffusion tensor imaging (DTI) | Sekine Ozturk, Armstrong, C. C., Carroll, A. L., Damme, K., Young, K. S., Chat, I. K., Kelley, N. J., Zinbarg, R. E., Craske, M. G., & Nusslock, R. | Northwestern University | MRI research assistant | sekine.ozturk@northwestern.edu | Poster | 9/11/2018 | |||||||||||||||
16 | 15 | Relationship between motor inhibition and affect regulation | Aileen Echiverri, Young, K. S., Glazer, J., Perez, M., Bookheimer, S. Y., Nusslock, R., Zinbarg, R. E., Bilder, R., & Craske, M. G. | UCLA | Post-doc on BrainMAPD | echiverri@gmail.com | Publication | 10/10/2018 | |||||||||||||||
17 | 16 | The Effect of Emotion Regulation Style on Fear Generalization | Adrian Jones | UCLA | Undergraduate Research Assistant | ajj.1234@yahoo.com | Poster | 4/20/2018 | |||||||||||||||
18 | 17 | Latent Class Analysis of Transdiagnostic Features of Anxiety and Depression | Julia Yarrington, Craske, M.G., Zinbarg, R. E., & Reise, S. | UCLA | Graduate student (PI: Michelle Craske) | yarringtonjs@g.ucla.edu | Publication; PhD dissertation/Master's thesis | 11/16/2018 | |||||||||||||||
19 | 18 | Early life adversity, working memory and fear conditioning: Predictive models of mood and anxiety symptomatology in young adults | Meghan Vinograd | UCLA | Graduate student (PI: Michelle Craske) | mvinograd@ucla.edu | Master's thesis | 2015 | |||||||||||||||
20 | 19 | Early life adversity and psychiatric symptomatology in late adolescence: Neural, cognitive and inflammatory processes | Meghan Vinograd | UCLA | Graduate student (PI: Michelle Craske) | mvinograd@ucla.edu | PhD dissertation | ||||||||||||||||
21 | 20 | Relationship between trait measures and neural sensitivity to pain | Ben Smith | UCLA | Post-doc on BrainMAPD | benjsmith@gmail.com | Publication | 12/7/2018 | |||||||||||||||
22 | 21 | Exploring associations between the Pavlovian-instrumental transfer and anhedonia. | Metts, A. V., Arnaudova, I., and Craske, M. G. | UCLA | Graduate student (PI: Michelle Craske) | ametts@g.ucla.edu | Poster | 11/30/2018 | |||||||||||||||
23 | 22 | Disruption in Pavlovian-instrumental transfer as a function of depression and anxiety. | Metts, A. V., Arnaudova, I., Staples-Bradley-L., Sun, M., Zinbarg, R., Nusslock, R., Wassum, K. M., and Craske, M. G. | UCLA | Graduate student (PI: Michelle Craske) | ametts@g.ucla.edu | Publication | 11/30/2018 | |||||||||||||||
24 | 23 | Relationship between resting-state connectivity and dimensional symptoms of psychopathology | Ben Rosenberg, & Craske, M. G. | UCLA | Graduate student (PI: Michelle Craske) | benrosenberg92@gmail.com | Publication; PhD dissertation/Master's thesis | 1/4/2019 | |||||||||||||||
25 | 24 | Impulsive Decision-Making: A neuroimmune perspective | Ann Carroll & Nusslock, R. | Northwestern University | Graduate student (PI: Robin Nusslock) | anncarroll2021@u.northwestern.edu | Publication; PhD dissertation/Master's thesis; Grant application | 4/19/2019 | |||||||||||||||
26 | 25 | Courage in the context of anxiety disorders | Amanda Kramer & Zinbarg, R. | Northwestern University | Graduate student (PI: Rick Zinbarg) | amkramer2010@gmail.com | Poster; Oral talk/symposium; Publication | 5/31/2019 | |||||||||||||||
27 | 26 | Major Childhood Trauma Predicts Increased Delay Discounting in Young Adults | Corinne Mielhausen, Sandman, C., Rosenberg, B., Murillo, A., & Craske, M. | UCLA | Undergraduate Research Assistant (PI: Michelle Craske) | corinnem@email.arizona.edu | Poster | 7/25/2019 | |||||||||||||||
28 | 27 | Co-occurring Increases in General Distress and Resting-State Functional Connectivity during Young Adulthood. | Rosenberg, B.M., Nusslock, R., Zinbarg, R.E., & Craske, M.G. | UCLA | Graduate student (PI: Michelle Craske) | benrosenberg92@gmail.com | Publication, Poster, PhD Dissertation | 11/20/2019 | |||||||||||||||
29 | 28 | Emotion regulation tendencies moderate relationship between childhood trauma and nucleus accumbens activation to loss | Ann Carroll., Kelley, N.J., Armstrong, C.C., Ozturk, S., Young, K.S., Chat, I.K., Damme, K.S.F., Perez, M., Craske, M.G., Zinbarg, R.E., & Nusslock, R | Northwestern University | Graduate student (PI: Robin Nusslock) | anncarroll2021@u.northwestern.edu | Poster | 2019 | |||||||||||||||
30 | 29 | Early adversity and cortico-amygdala activation during fear conditioning among adolescents | Vinograd, M., Young, K. S., Sun, M., Staples-Bradley, L. K., Damme, K. S. F., Kelley, N. J., Chat, I. K., Bookheimer, S. Y., Zinbarg, R. E., Nusslock, R., & Craske, M. G. | UCLA | Graduate student (PI: Michelle Craske) | mvinograd@ucla.edu | Symposium and Publication | 2019 | |||||||||||||||
31 | 30 | Symptom dimensions of anxiety and depression are related to dissociable disruptions in threat neurocircuitry during fear conditioning, Presentation at the European Meeting of Human Fear Conditioning (EMHFC), Würzburg, Germany, 2019 | Young, K.S. | UCLA | Post-doctoral Researcher | katherine.s.young@kcl.ac.uk | Presentation | 2019 | |||||||||||||||
32 | 31 | Threat Neurocircuitry predicts the development of anxiety and depression symptoms in a longitudinal study | Yujia Peng, Jeffrey Knotts, Katherine Young, Susan Bookheimer, Robin Nusslock, Richard Zinbarg, Michelle Craske | UCLA | Post-doc on BrainMAPD | yjpeng@ucla.edu | Poster | 2020 | |||||||||||||||
33 | 32 | Relationship between emotion regulation tendencies and frontal-striatal neural activity during reward processing | Brooke Feinstein, Carroll, A.L, Chat, I.K., Ozturk, S., Damme, K.S.F., Cichocki, A.C., Anderson, Z., Young, K.S., Craske, M.G, Bookheimer, S., Zinbarg, R.E, & Nusslock, R | Northwestern University | BrainMAPD Research Coordinators | brookefeinstein2017@u.northwestern.edu | Poster | 2020 | |||||||||||||||
34 | 33 | Reward-Related Brain Function in Lifetime Depression, Anxiety, and Comorbid Depression and Anxiety | Zachary Anderson, Carroll, A.L, Chat, I.K., Ozturk, S., Damme, K.S.F., Young, K.S., Craske, M.G., Bookheimer, S., Zinbarg, R.E., & Nusslock, R | Northwestern University | Graduate student (PI: Robin Nusslock) | zacharyanderson2024@u.northwestern.edu | Poster | 2020 | |||||||||||||||
35 | 34 | Alterations in Reward Related Functional Connectivity Above and Beyond General Distress and Fears | Zachary Anderson, Carroll, A., *Chat, I.K., *Ozturk, S., *Damme, K.S.F., Young, K.S., Craske, M.G., Bookheimer, S., Zinbarg, R.E., & Nusslock, R | Northwestern University | Graduate student (PI: Robin Nusslock) | zacharyanderson2024@u.northwestern.edu | Poster | 2020 | |||||||||||||||
36 | 35 | Inflammatory signaling and corticostriatal functional connectivity to anticipated valence and salience of reward and threat stimuli: An investigation in depressed versus non-depressed young adults. | Iris Chat., Bart, C.P., Dennison, J., Smith, D.V., Miller, G.E., Nusslock, R., Alloy, L.B. | Temple University | Graduate student on BrainMAPD | kychat@temple.edu | Poster | 2020 | |||||||||||||||
37 | 36 | Anhedonia associated with attenuated reward-related neural activity during cue-evaluation and motor-preparation | James Glazer, Gaumond, J., Liebman, E. Syed, S., & Nusslock, R | Northwestern University | Graduate student (PI: Robin Nusslock) | jamesglazer2020@u.northwestern.edu | Poster | 2020 | |||||||||||||||
38 | 37 | Predicting Dimensional Symptoms of Psychopathology from Task-Based fMRI using Support Vector Regression | Garcia, K., Anderson, Z., Chat, I. K., Damme, K., Bookheimer, S.Y., Zinbarg, R., & Craske, M., Nusslock, R | Northwestern University | Research Assistant | kathy.garcia@northwestern.edu | Poster | 2020 | |||||||||||||||
39 | 38 | Stimulus frequency and outcome valence modulate reward- positivity during reward and punishment feedback evaluation | James Glazer. & Nusslock, R | Northwestern University | Graduate student (PI: Robin Nusslock) | jamesglazer2020@u.northwestern.edu | Poster | 2020 | |||||||||||||||
40 | 39 | Reward related brain function in mood disorders | Robin Nusslock | Northwestern University | Principal Investigator | nusslock@gmail.com | Presentation | 2020 | |||||||||||||||
41 | 40 | Childhood adversity is associated with the diversity of the gut microbiota in young adults | Sarah Etuk, Kuthyar, S., Shirola, W., Chat, I.K., Craske, M.G., Bookheimer, S., Vinograd, M., Echiverri, A., Zinbarg, R.E., Amato, K., & Nusslock, R | Northwestern University | Research Assistant | sarahetuk2020@u.northwestern.edu | Poster | 2020 | |||||||||||||||
42 | 41 | Neuroanatomical differences associated with lifetime history of depression, anxiety, and comorbid depression-anxiety | Anna Cichocki, Tanda, N., Damme, K.S.F., Young, K.S., Craske, M.G., Bookheimer, S.Y., Zinbarg, R.E., & Nusslock, R | Northwestern University | Graduate student (PI: Robin Nusslock) | anna.cichocki@u.northwestern.edu | Poster | 2020 | |||||||||||||||
43 | 42 | Ventral striatum activation is not significantly associated with future microbial gut diversity in young adults. | Sarah Etuk, Chat, I.K., Kuthyar, S., Shirola, W., Smith, E., Craske, M.G., Bookheimer, S., Amato, K. , Zinbarg, R.E., & Nusslock, R | Northwestern University | Research Assistant | sarahetuk2020@u.northwestern.edu | Poster | 2020 | |||||||||||||||
44 | 43 | Relationship between threat- and reward-related brain structure and symptom dimensions of anxiety and depression | Anna Cichocki, Tanda, N., Ozturk, S., Damme, K.S.F., Carroll, A.L., Armstrong, C.C., Young, K.S., Craske, M.G., Bookheimer, S.Y., Zinbarg, R.E., Nusslock, R | Northwestern University | Graduate student (PI: Robin Nusslock) | anna.cichocki@u.northwestern.edu | Poster | 2020 | |||||||||||||||
45 | 44 | Decreased dorsolateral prefrontal cortex responses to monetary rewards is predictive of future substance use | Bart, C.P., Chat, I.K., Carroll, A.L., Armstrong, C.C., Nusslock, R., & Alloy, L.B | Presentation | 2020 | ||||||||||||||||||
46 | 45 | Positive social feedback alters emotional ratings and increases reward value of neutral faces, Quarterly Journal of Experimental Psychology. https://doi.org/10.1177/1747021819890289 | Young, K.S.,Hasratian A.M., Parsons C.P., Zinbarg, R.E., Nusslock R., Bookheimer S.Y., Craske M.G. | UCLA | Post-doctoral Researcher | katherine.s.young@kcl.ac.uk | Publication | 2020 | |||||||||||||||
47 | 46 | Relationship between Frontostriatal-amygdala Volume and Tri-level Symptoms of Depression and Anxiety | Anna C. Cichocki, Katherine S.F. Damme, Ann Carroll, Katherine S. Young, Michelle Craske, Susan Bookheimer, Richard Zinbarg, & Robin Nusslock | Northwestern University | Graduate student (PI: Robin Nusslock) | anna.cichocki@u.northwestern.edu | Poster | 2021 | |||||||||||||||
48 | 47 | A multivoxel pattern analysis of anhedonia during fear extinction – implications for safety learning | Rosenberg, B.M., Taschereau-Dumouchel, V., Young, K.S., Lau, H., Zinbarg, R.E., Nusslock, R., & Craske, M.G. | UCLA | Graduate student (PI: ) | benrosenberg92@gmail.com | Publication | 2021 | |||||||||||||||
49 | 48 | Dysregulation of threat neurocircuitry during fear extinction: the role of anhedonia. Neuropsychopharmacology. https://doi.org/10.1038/s41386-021-01003-8 | Young, K.S.,Bookheimer S.Y., Nusslock R, Zinbarg R.E., Damme K.S.F., Chat I.K., Kelley N.J., Vinograd M., Perez M., Chen K., Echiverri-Cohen A., Craske M.G. (2021) | UCLA | Post-doctoral Researcher | katherine.s.young@kcl.ac.uk | Publication | 2021 | |||||||||||||||
50 | 49 | Threat neurocircuitry predicts the development of anxiety and depression symptoms in a longitudinal study. Biological psychiatry: cognitive neuroscience and neuroimaging. | Peng, Y., Knotts, J. D., Young, K. S., Bookheimer, S. Y., Nusslock, R., Zinbarg, R. E., ... & Craske, M. G. (2022). | UCLA | Assistant Professor | yjpeng@ucla.edu | Publication | 2021 | |||||||||||||||
51 | 50 | Individual differences in threat and reward neural circuitry activation: Testing dimensional models of early adversity, anxiety and depression. https://doi.org/10.1111/ejn.15592 | KS Young, C Ward, M Vinograd, K Chen, SY Bookheimer, R Nusslock, RE Zinbarg, MG Craske | UCLA/King’s College London | Postdoc/Lecturer | katherine.s.young@kcl.ac.uk | Publication | 2020 | |||||||||||||||
52 | 51 | Association Between Childhood Trauma and Neural Activation During Reward Processing | Nina C. Kougan, Zachary Anderson, Meghan Vinograd, Katharina R. Seitz, Susan Y. Bookheimer, Michelle G. Craske, Richard E. Zinbarg, and Robin Nusslock | Northwestern University | Research Coordinator | ninakougan@northwestern.edu | Poster | 2/1/2023 | Trauma during adolescence is known to affect neural systems related to reward processing. Most of this research has focused on brain systems involved in the frontostriatal reward network, including the ventral striatum and medial orbitofrontal cortex. To extend this literature, we conducted whole-brain analyses to examine the association of childhood trauma on brain activity. Participants (N=222, 18-19 years old) were recruited based on trait neuroticism and reward sensitivity. Brain function was assessed using the Monetary Incentive Delay Task during fMRI scanning, and trauma was assessed using the Childhood Trauma Inventory. We performed a whole-brain regression to examine the effect of summed severity across all traumas on reward processing, looking at anticipation and outcome separately. We adjusted for sex, scanner site, medication status, and hit rate during the task. Voxel-wise regression analyses identified 5 regions in which gain anticipation activation was significantly predicted by trauma severity. Voxel-wise regression analyses identified 10 regions in which loss anticipation activation was significantly predicted by trauma severity. Clusters from both contrasts fell into several canonical networks, notably ventral/dorsal attention, frontoparietal, and somatomotor networks. Whole-brain contrast t-maps that identified these clusters adjusted for false discovery rate (all p’s<0.05, k=5 voxel minimum cluster size). Contrary to our hypothesis, we did not find increased activation in the frontostriatal network. However, trauma was associated with activation in motor and attentional networks during reward processing. This could suggest those with a history of childhood trauma are allocating more motor and attentional resources during this task. | ||||||||||||||
53 | 52 | Investigating the role of Stress Resilience in the relationship between Early Life Adversity and Threat/Reward Functioning | Kristen Chu | UCLA | PhD Student | kristenchu@g.ucla.edu | PhD dissertation/Master's thesis | 10/31/2022 | I am interested in the idea of stress resilience, conceptualized as the result of the dynamic process of adapting to stressors, or the maintenance/recovery from mental health during and after adversity. I would like to explore the relationship between early life adversity, stress resilience, and performance on several task behaviors such as threat, social reward, and executive functioning. One way I am interested in operationalizing stress resilience is as a factor of stress reactivity following current life stress. I predict that stress resilience in this context moderates the relationship between early life adversity exposure and threat, reward, and executive functioning. A second possibility may be to operationalize stress resilience as stress reactivity following early life stress. In this conceptualization, I am interested in identifying whether stress reactivity as a function of early life adversity predicts performance on task functioning (e.g. Threat, Reward, and Executive Functioning). As an extension of this work, I would also be interested in investigating how these factors impact symptoms of Depression and Anxiety. | ||||||||||||||
54 | 53 | A neuroimmune network model of depression and anxiety related symptoms: A multimodal longitudinal analysis | Zachary Anderson | Northwestern University | PhD Student | zacharyanderson2024@u.northwestern.edu | PhD dissertation | 1/20/23 | Major depression and anxiety related disorders are prevalent and recurrent public health problems. Research identifies adolescence as a period of high risk for first episodes of depression and anxiety. Frontoamygdala and frontostriatal circuits are implicated in the development of these disorders. Most research on depression and anxiety has been cross-sectional, limiting power to detect subtle changes in biology related to each disorder. This emphasizes a need for longitudinal data to note changes in biology that may be linked to immune signaling throughout development. In addition, it is important to understand how inflammation may impact frontolimbic connectivity. Growing evidence suggests that stress affects bidirectional relationships between the immune system and the brain, which has important implications for depression and anxiety. This relationship is adaptive in the short term and when regulated. However, chronic stress dysregulates these systems and may preferentially modulate frontostriatal and frontoamygdala circuits via immune-to-brain signaling. While this does not guarantee emotion related dysfunction, when coupled with preexisting vulnerabilities in frontolimbic circuits, this is associated with maladaptive health behaviors that further dysregulate these circuits. These changes have consequences as frontoamygdala changes have been associated with anxiety disorders while frontostriatal changes are often associated with mood related problems. This project proposes an innovative approach to explore brain-immune interactions as they pertain to mood and anxiety related symptoms. Past research employs categorical diagnoses to study biological systems in clinical populations but overlap of clinical symptoms and comorbidity have led to poor reliability of previous findings. This has led to the development of dimensional models of clinical symptoms, which offer increased clinical precision. In the context of mood and anxiety disorders, the trilevel model may be particularly useful in understanding associations with biology. This model provides several dimensions that account for experiences common (General Distress) and specific to domains of mood (Anhedonia) and anxiety (Fears) related problems. The application of this model to the proposed innovative neuroimmune framework may provide increased clinical precision to relate brain-immune signaling to the development of mood and anxiety related symptoms. For the present project, it will be important to look at frontolimbic connectivity in the context of reward (using the monetary incentive delay task; MID) as well as resting state scanning. There are two reasons for including both scanning modalities. Conceptually, changes in functional circuits are most often seen in the context of a task. This follows the idea that circuit level connections become more unstable when task demands are present. A growing literature also notes frontolimbic abnormalities in populations with elevated depression and anxiety symptoms in the context of resting state. Including both in the present analyses will provide a complete story of frontolimbic changes in our sample. There are methodological concerns as well. The MID is often used to study reward processing in the brain, however a weakness of the task involves a lack of true baseline where the brain is able to return to rest. This lack of baseline condition reduces the signal present in the task and artificially weakens results. By including resting state scanning, we will be better able to compare reward related changes in connectivity with a baseline resting state condition. This may yield more directional insights as well, as was noted in the limitations section of our recent paper (Anderson et al, 2023). As such, for the proposed project I hope to use the monetary incentive delay task as well as our 10-minute resting state scan (rsfMRI). I hope to make use of four time points worth of self-report data as well. More specifically, this will include the trilevel symptom estimates and demographic questionnaires. In addition, we will incorporate the two time points of immune cytokine data. MID and rsfMRI data will be used to generate connectivity matrices that reflect correlations between activation of specific regions of the brain over time. Finally, to address recent literature that notes reliability problems in fMRI, this project proposes an innovative computational method to align individual brain data based on functional and not anatomical data. This method, hyperalignment, is shown to increase reliability in brain data and generates outcomes that pertain to individual specific functional brain organization. In sum, the addition of immune data and the use of computational methods build on the parent R01 and allow this work to pursue innovative questions related to brain-immune signaling and its relationship to clinical symptom progression. Aim 1: Relate cross sectional and longitudinal frontoamygdala and frontostriatal pathways to measures of peripheral inflammation. Negative connectivity in the frontoamygdala and the frontostriatal pathway will correspond with increased inflammation at the first time point. Over time, greater reductions in connectivity within these circuits will relate to heightened inflammation at follow up. Aim 2: Baseline inflammation will relate to stronger associations between the brain and clinical symptoms. Reduced frontostriatal connectivity will relate to heightened Anhedonia severity. Reduced frontoamygdala connectivity will relate to heightened General Distress/Fears severity. Heightened baseline inflammation will amplify these relationships as part of a two-hit model of vulnerability for clinical symptoms. Aim 3: Prediction of longitudinal changes in symptoms based on baseline and longitudinal brain by immune interactions. Heightened inflammation and reduced connectivity in frontostriatal and frontamygdala circuits will predict more severe progressions of anhedonia and general distress/fears respectively. Worsening symptoms will relate to longitudinal reductions in respective frontolimbic circuits and increases in inflammation. Exploratory Aim: Assess the degree to which individual differences in brain data can be addressed by computational transformations. Hyperalignment will improve the reliability and sensitivity of analyses corresponding to Aims 1-3. Transformation matrices generated by hyperalignment will reflect functional reorganization of brain networks and will relate to clinical and immune outcomes. Translation coefficients are expected to reveal differences in multivariate brain states that may pertain to particular mental experiences during scanning. Rotation coefficients may pertain to the reassignment of voxels that typically fall into frontostriatal/frontoamygdala circuits. This reassignment is thought to be maladaptive and may act as a more precise measure of alterations in functional connectivity. Scaling components will reflect global increases or decreases in within network connectivity. All measures have been previously associated with autonomic nervous system activation and may yield unique insights. All analyses related to this final aim are exploratory and, as such, I do not have directional predictions. | ||||||||||||||
55 | 54 | Exercise Moderates the Relationship between Amygdala Volume and Inflammation | Katharina R. Seitz, Anna Cichocki, Iris Ka-Yi Chat, Nina C. Kougan, Katherine S. Young, Meghan Vinograd, Michelle G. Craske, Susan Y. Bookheimer, Richard E. Zinbarg, Gregory E. Miller, Robin Nusslock | Northwestern University | Research Coordinator | katharina.seitz@northwestern.edu | Poster | 12/14/22 | Previous research has identified associations between the amygdala, hippocampus, and prefrontal cortex with peripheral inflammation. Regular aerobic exercise reduces peripheral inflammation. Research has yet to examine whether exercise moderates the relationship between peripheral inflammation and the brain regions which we examine in the current study. 193 young adults (mean age=19.2) who were selected based on their risk for mood and anxiety disorders completed a structural brain MRI, a blood draw to assess five inflammatory biomarkers, CRP, TNFα, and IL-6, -8, and -10 (which were averaged to form a composite score), and health behavior surveys on frequency and duration of exercise (which was combined to establish weekly minutes exercised). Data were analyzed using multiple-linear regressions and corrected for multiple comparisons. Larger amygdala volume and less exercise were separately associated with more inflammation (t=2.56, p=0.011, t=2.53, p=0.012, respectively). This association was qualified by a significant interaction. Individuals who exercised more and had larger amygdalae had the lowest levels of inflammation. By contrast, individuals who exercised less and had larger amygdala had the highest levels of inflammation. Regarding the hippocampus, larger hippocampal volume was associated with increased inflammation (t=2.96, p=0.003). There were no significant associations or moderations for the prefrontal cortex. These results were maintained after accounting for age, sex, race, family income, medications, and scan site. These findings have important implications for understanding basic associations between the brain and immune system and for developing and refining behavioral and exercise interventions to maximize mental and physical health. | ||||||||||||||
56 | 55 | The effect of inflammation on Neuroanatomical differences in Anxiety and Depression | Anna Cichocki | Northwestern University | PhD Student | anna.cichocki@u.northwestern.edu | Publication | 11/14/22 | I plan to explore how inflammation effects structural brain differences and performance on the Delayed discounting task (DDT). I specifically am interested in how inflammation (composite score for cytokines) effects threat (amygdala, hippocampus) and reward (basal ganglia) related brain structures of individuals with depression, anxiety, comorbid anxiety-depression, and healthy controls. I am additionally interested in how the interaction of inflammation and childhood trauma (CTI) effect these brain regions. I expect that individuals with high levels of inflammation and stress (number and severity) show greater reductions in gray matter volume in these structures, particularly in the psychopathology groups. I expect to see greater changes in gray matter volume over time in these groups as well. I plan to use both timepoint’s structural MRI data with FreeSurfer to estimate gray matter volume. I plan to look at stress measures of type, severity, timing, acute vs chronic, etc using the CTI and inflammation (composite scores) as separate and interacting predictors of gray matter volume of these ROIs. | ||||||||||||||
57 | 56 | Investigating the Role of Resting-State Functional Connectivity in the Relationship Between Early Adversity and Depressive Symptoms | Kaylee Null | UCLA | PhD Student | knull.g.ucla.edu | PhD Dissertation | 10/21/22 | I am interested in exploring the relationship between early life adversity (ELA; broadly conceptualized to include childhood trauma, stress, and SES) and future depression symptom severity, and how resting-state functional connectivity between key emotion regulation network regions are implicated in this relationship. I am predicting that resting-state functional connectivity will play a mediating role in the relationship between ELA and depression severity in this sample of young adults. Similar work has been done in children and adolescents demonstrating an effect of ELA on depressive symptoms through resting state functional connectivity between regions such as the amygdala and ventromedial prefrontal cortex (e.g., Hanson et al., 2019). As an extension of this work, I would be interested in investigating the effects of more recent life stress on these relationships over time. | ||||||||||||||
58 | 57 | Positive Affect, Cognitive Reappraisal, and Inflammation: Intervening Mechanisms in the Relationship Between Life Events and Transdiagnostic Symptoms of Depression and Anxiety | Julia Yarrington, Michelle Craske, Rick Zinbarg, Robin Nusslock, Connie Hammen, Kate Taylor | UCLA | PhD Student | yarringtonjs@g.ucla.edu | PhD Dissertation | 6/8/22 | Recent studies have demonstrated that positive aspects of significant life events may buffer against negative aspects of these events, in turn reducing symptoms of psychopathology. Mechanisms by which positive aspects of life events confer their beneficial effects have yet to be explored. Positive affect, cognitive reappraisal, and inflammation are three such mechanisms which may play a role in the relationship between positivity life events and protection from psychopathology. The proposed study seeks to examine these mechanisms in a longitudinal sample of 373 young adults. A series of path analyses will assess 1) the relationship between positivity and negativity of life events, positive affect, cognitive reappraisal, and psychopathology, and 2) the relationship between positivity and negativity of life events, positive affect, inflammation, and psychopathology. We hypothesize that positivity of life events will be associated with increases in positive affect and cognitive reappraisal, which will be associated with reductions in psychopathology. We also expect that positive affect linked to positivity of life events will be associated with reductions in inflammation and related reductions in psychopathology. We anticipate that consistent with prior work, negativity of life events will be predictive of lower positive affect and reappraisal, higher inflammation, and higher levels of psychopathology. | ||||||||||||||
59 | 58 | Lifetime Depression and Comorbid Depression-Anxiety is Associated with Heightened Putamen Activation to Rewards | Defne S. Cezayirli, Zachary Anderson, Ann L. Carroll, Iris Ka-Yi Chat, Katharina R. Seitz, Katherine S. Young, Michelle Craske, Susan Bookheimer, Richard E. Zinbarg, Robin Nusslock | Northwestern University | Lab Manager | defne-cezayirli@northwestern.edu | Poster | 9/8/0223 | |||||||||||||||
60 | 60 | Prediction in Psychiatry Needs Information | Brian Kraus | Northwestern University | PhD Student | btkraus@u.northwestern.edu | Publication | 8/28/23 | In the field of psychopathology, an increasing emphasis is being placed on the potential for machine learning (ML) approaches to aid in classification and treatment selection. The benefits of this approach are clear, as they support the aims of “precision medicine” to develop individual-specific interventions and risk profiles. However, for optimal performance there is an inherent prerequisite: ML models must have access to enough information in a given dataset in order to accurately predict outcomes at the individual-level. Otherwise, with inadequate informational content, they will remain unable to reach their true potential in precision medicine contexts. Although it is unclear exactly how much information is necessary for accurate prediction, a good heuristic for this is whether an individual’s data can be distinguished from other individuals in a sample. This is because in order to decipher why two individuals are different, a model must first be able to tell that they are different. Thus, uniqueness is a necessary but not sufficient property of a given dataset in order to achieve accurate prediction. In ML contexts, it is common to attempt to predict psychiatric symptom severity from neuroimaging measures, such as functional connectivity in functional magnetic resonance imaging (fMRI). In past reports, identifying individual subjects using functional connectivity in fMRI have been very accurate, with most papers finding a > 90% identification accuracy. However, a functional connectivity matrix in fMRI is typically comprised of at least 50,000 features, while in psychopathology this number of measures is unheard of. Thus, it is unclear whether individuals could be identified using their psychopathology scores between measurement timepoints as they can be using functional connectivity. To test this, individuals in BrainMAPD will be classified on their T1 versus T4 data for both their psychopathology and fMRI functional connectivity measures. Psychopathology measures will include structured interviews, self-report measures, and dimensional scores while all fMRI scans will be used to calculate functional connectivity metrics. I hypothesize that while identification accuracy for fMRI functional connectivity will be high, the classification accuracy for psychopathology data will be much lower. This hypothesized low identifiability in psychopathology data thus hinders the potential of ML approaches in precision psychiatry. | ||||||||||||||
61 | 61 | Network variants and the longitudinal relationship between functional connectivity and internalizing symptoms | Brian Kraus, Caterina Gratton, Robin Nusslock | Northwestern University | PhD Student | btkraus@u.northwestern.edu | PhD Dissertation | 2/26/19 | Every year, a sizeable plurality of the global population experiences clinically significant symptoms of a mental health disorder (Bunting et al., 2012; Whitney & Peterson, 2019). One category of psychiatric illnesses are internalizing disorders, which are primarily characterized by self-criticism, withdrawal from the external world, and high levels of negative affect (Krueger et al., 1998), and are predominantly associated with depressive mood and anxiety disorders (Krueger & Markon, 2006). Approximately 15% of individuals experience clinically significant symptoms of internalizing disorders annually, highlighting their high prevalence in the population (Ferrari et al., 2013; Grant et al., 2005). The burden to society of these disorders is high, with their treatment costs totaling billions of dollars each year (Simon et al., 1995; Wittchen, 2002). Several theories outlining the etiology of internalizing disorders posit that they share a deficit in disengaging attention from negatively-valenced stimuli (Keller et al., 2019; Moser et al., 2013; Okon-Singer, 2018). Like many other psychiatric illnesses, internalizing disorders are associated with disruptions in cognitive, emotional, and behavioral functioning (Beck, 1979). Substantial evidence suggests that these disorders are associated with dysfunction in the neural circuits and systems governing these processes, rather than dysfunction in isolated brain regions (Drevets, 2001). In humans, large-scale systems (i.e., brain networks) can be measured using functional connectivity (FC) methods from functional magnetic resonance imaging (fMRI) signals. FC tracks correlations in the blood oxygenated level-dependent (BOLD) fMRI signal between regions of the brain (Biswal et al., 1995; Friston, 1994). Past research on FC fMRI suggests that there is a core organization to brain networks shared across individuals (Fig. 1;). However, individual differences exist relative to this core organization (Bijsterbosch et al., 2018; Finn et al., 2015; E. M. Gordon, Laumann, Adeyemo, Gilmore, et al., 2017; Mueller et al., 2013). These individual differences in FC have also been associated with symptoms of internalizing disorders (Kaiser et al., 2015; Mulders et al., 2015; L. M. Williams, 2017; Xu et al., 2019). Yet, despite the plethora of evidence for a relationship between FC and internalizing disorders, to date reliable neural correlates have not been identified (Winter et al., 2023). Thus, to identify potential neural correlates, this proposal aims to evaluate how individually-defined measures of FC are related to transdiagnostic symptoms of internalizing disorders. | ||||||||||||||
62 | 62 | Identification of distinct symptom cluster profiles in depression and anxiety based on task-based connectivity during the Monetary Incentive Delay Task | Courtney Forbes, Cody Cushing, Michelle Craske | UCLA | former postdoc | courtney.n.forbes@gmail.com | Publication | ||||||||||||||||
63 | 63 | The Role of Heart Rate Variability in Transdiagnostic Depression and Anxiety Symptom Trajectory | Alainna Wen, Tomislav Zbozinek, Richard Zinbarg, Robin Nusslock | UCLA | postdoc | aaqwen@g.ucla.edu | Publication | 3/31/23 | |||||||||||||||
64 | 64 | Association between reward-related functional connectivity and tri-level mood and anxiety symptoms | Zachary Anderson, Katherine S.F. Damme, Ann L. Carroll, Iris Ka-Yi Chat, Katherine S. Young, Michelle G. Craske, Susan Bookheimer, Richard Zinbarg, Robin Nusslock | Northwestern University | PhD Student | zacharyanderson2024@u.northwestern.edu | Publication | 2023 | https://doi.org/10.1016/j.nicl.2023.103335 | Depression and anxiety are associated with abnormalities in brain regions that process rewards including the medial orbitofrontal cortex (mOFC), the ventral striatum (VS), and the amygdala. However, there are inconsistencies in these findings. This may be due to past reliance on categorical diagnoses that, while valuable, provide less precision than may be required to understand subtle neural changes associated with symptoms of depression and anxiety. In contrast, the tri-level model defines symptom dimensions that are common (General Distress) or relatively specific (Anhedonia-Apprehension, Fears) to depression and anxiety related disorders, which provide increased precision. In the current study, eligibility was assessed by quasi-orthogonal screening questionnaires measuring reward and threat sensitivity (Behavioral Activation Scale; Eysenck Personality Questionnaire-Neuroticism). These participants were assessed on tri-level symptom severity and completed the Monetary Incentive Delay task during fMRI scanning. VS-mOFC and VS-amygdala connectivity were estimated during reward anticipation and reward outcome. Heightened General Distress was associated with lower VS-mOFC connectivity during reward anticipation (b = -0.064, p = 0.021) and reward outcome (b = -0.102, p = 0.014). Heightened Anhedonia-Apprehension was associated with greater VS-amygdala connectivity during reward anticipation (b = 0.065, p = 0.004). The present work has important implications for understanding the coupling between the mOFC and vS and the amygdala and the vS during reward processing in the pathophysiology of mood and anxiety symptoms and for developing targeted behavioral, pharmacological, and neuromodulatory interventions to help manage these symptoms. | |||||||||||||
65 | 65 | Transdiagnostic symptom of depression and anxiety associated with reduced gray matter volume in prefrontal cortex | Anna C. Cichocki, Richard E. Zinbarg, Michelle G. Craske, Iris K.-Y. Chat, Katherine S. Young, Susan Y. Bookheimer, & Robin Nusslock | Northwestern University | PhD Student | anna.cichocki@u.northwestern.edu | Publication | 2023 | under review, Psychiatry Research: Neuroimaging | ||||||||||||||
66 | 66 | Association between impulsivity and inlammatory markers. | Cecilia Hollenhorst | Northwestern University | Psychiatry Resident | cecilia.hollenhorst@northwestern.edu | Poster | 2023 | |||||||||||||||
67 | 67 | Courage Predicts Pre-COVID-19 to COVID-19 Trajectories of Transdiagnostic Anxiety and Depression Symptoms | Evan Reynolds, Richard E. Zinbarg | Northwestern University | PhD Student | evanreynolds2028@u.northwestern.edu | Publication | 2023 | |||||||||||||||
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