Intervene_flagship_endpoint_collection.xlsx

	A	B	C	D	E	F	G
1	Endpoint	Progression	Endpoint family	PhenoID	FinnGen endpoint	Comments	Previously harmonized with EstBB
2	All Cancers		Oncology	canc	C3_CANCER		yes
3	Malignant neoplasm of colon and rectum	x	Oncology	col	C3_COLORECTAL	Colorectal cancer added instead of only colon cancer	yes (only colon cancer)
4	Malignant neoplasm of breast	x	Oncology	bre	C3_BREAST		yes
5	Type 2 diabetes, definitions combined	x	Endocrinology	T2D	T2D	Note: T1D patients excluded	yes
6	Malignant neoplasm of prostate	x	Oncology	pros	C3_PROSTATE		yes
7	Coronary heart disease		Cardiometabolic	CHD	I9_CHD		yes
8	Subarachnoid haemmorrhage		Neurology	SAH	I9_SAH		?
9	Melanoma of skin		Oncology	mel	C3_MELANOMA_SKIN		?
10	Asthma		Pulmonology	ast	J10_ASTHMA		yes
11	Heart Failure	x	Cardiometabolic	HF	I9_HEARTFAIL_NS		?
12	Stroke excluding SAH		Cardiometabolic	str	I9_STR		yes
13	Alzheimer's disease (any)		Neurology	AD	G6_AD_WIDE		yes
14	BMI	x	Endocrinology	BMI	-	No need for harmonization
15	Type1 diabetes	x (all diabetes)	Endocrinology	T1D	T1D	Note: T2D patients excluded	yes
16	Atrial fibrillation and flutter		Cardiometabolic	AF	I9_AF		yes
17	Chronic Kidney Disease		Cardiometabolic	CKD	N14_CHRONKIDNEYDIS		yes
18	Covid-19 severity	xxxx (only interested in progression)	Infectious disease	cov	COVHOSP	Custom endpoint - see 'FinnGen endpoints' (from row 2800)	?
19	Depression	xxxx (only interested in progression)	Psychiatric	dep	F5_DEPRESSIO	Would benefit from inclusion of primary care data?	yes
20	Malignant neoplasm of bronchus and lung		Oncology	lung	C3_BRONCHUS_LUNG		yes
21	Seropositive rheumatoid arthritis	x	Rheumatology	RA	RHEUMA_SEROPOS_OTH		yes
22	Inflammatory bowel disease	x	Gastroenterology	IBD	K11_IBD_STRICT		yes
23	Venous thromboembolism		Cardiometabolic	VTE	I9_VTE		yes
24	Thoracic aortic aneurysm	x	Cardiometabolic	TAA	I9_THAORTANEUR		no
25	Abdominal aortic aneurysm	x	Cardiometabolic	AAA	I9_ABAORTANEUR		no
26	Hip-Osteoarthritis	x (including hip and knee)	Muscoloskeletal	hosta	COX_ARTHROSIS	Would benefit from inclusion of primary care data?	no
27	Knee-Osteoarthritis	x (including hip and knee)	Muscoloskeletal	kosta	KNEE_ARTHROSIS	Would benefit from inclusion of primary care data?	no
28	Osteoporosis	x	Muscoloskeletal	ostp	M13_OSTEOPOROSIS		?
29	Alcohol use disorder		Psychiatric	alc	AUD_SWEDISH	Complex phenotype, avoid selecting as the first ones	?
30	Hypothyroidism		Endocrinology	hypot	E4_HYTHYNAS		?
31	Hyperthyroidism		Endocrinology	hypert	E4_THYTOXGOITDIF
32	Sleep apnoea		Pulmonology	SA	G6_SLEEPAPNO		yes
33	Idiopathic pulmonary fibrosis	x	Pulmonology	IPF	IPF	Included in ILD	yes
34	Interstitial lung disease		Pulmonology	ILD	ILD	Added separately as ILD is used if IPF-like symptoms occur in e.g. patients with inflammatory diseases	no
35	Gout	x	Muscoloskeletal	gout	GOUT	Would benefit from inclusion of primary care data?	yes (only in strict format requiring hospital visit + medication purchase)
36	Primary open-angle glaucoma	x	Opthalmology	POAG	H7_GLAUCOMA		yes
37	Epilepsy	x	Neurology	epil	G6_EPLEPSY	Main epilepsy endpoint	?
38	Generalized epilepsy		Neurology	geepil	GE_STRICT		no
39	Focal epilepsy		Neurology	feepil	FE_STRICT		no
40	Appendicitis		Gastroenterology	app	K11_APPENDACUT		yes
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