Tabla para cálculos de BED y EQD2.xlsx

	A	B	C	D	E	F	G	H	I	J	K	L	M	N	O	P	Q	R	S	T	U	V	W	X	Y	Z	AA	AB	AC	AD	AE	AF	AG
1	BED (Biologic EFFECTIIVE dose)		Video instructions						d (dose per fraction)	n (number of fractions)	D (total dose)	a/b = X	a/b = 10	a/b = 3	BED a/b = X	BED a/b = 10	BED a/b = 3	EQD2 a/b = X	EQD2 a/b = 10	EQD2 a/b = 3	EQD1.8 a/b = X	EQD1.8 a/b = 10	EQD1.8 a/b = 3			d (dose per fraction)	n (number of fractions)	D (total dose)	α	D0	Dq	BED (with USC calc)	SFED
2									2	30	60	2	10	3	120.00	72.00	100.00	60.00	60.00	60.00	63.16	61.02	62.50			34	1	34	0.33	1.25	1.8	78.06	34
3									4	10	40	2	10	3	120.00	56.00	93.33	60.00	46.67	56.00	63.16	47.46	58.33			20	3	60	0.33	1.25	1.8	132.36	56.4
4									6	5	30	2	10	3	120.00	48.00	90.00	60.00	40.00	54.00	63.16	40.68	56.25			18	3	54	0.33	1.25	1.8	117.82	50.4
5									1.8	25	45	2	10	3	85.50	53.10	72.00	42.75	44.25	43.20	45.00	45.00	45.00			20	3	60	0.33	1.25	1.8	132.36	56.4
6									2	25	50	2	10	3	100.00	60.00	83.33	50.00	50.00	50.00	52.63	50.85	52.08			8	5	40	0.33	1.25	1.8	75.15	32.8
7									8	1	8	10	10	3	14.40	14.40	29.33	12.00	12.00	17.60	12.20	12.20	18.33			10	5	50	0.33	1.25	1.8	99.39	42.8
8																										20	3	60	0.33	1.25	1.5	134.55	57
9																										20	3	60	0.33	1.25	2	130.91	56
10																										20	3	60	0.33	1.25	2.5	127.27	55
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12																										Values taken from Park et al. 2008, average of 12 NCI studies ^
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15								Use this to plug in a BED value and determine the dose required to achieve it
16								with the number of fractions you want.
17									2.00	30	60.00	3	--	--	100.00
18	Quadratirc Formula								2.27	30	68.25	3	--	--	120.00
19	(-b + squareroot(b^2 - 4ac) ) / 2a								2.53	30	75.93	3	--	--	140.00
20	ax^2 + bx + c = 0								1.52	30	45.50	2	--	--	80.00
21	a=	10							1.70	30	51.05	3	--	--	80.00
22	b=	30							2.19	30	65.64	10	--	--	80.00
23	c=	-100
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25	x =	2
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31	BED with radiobiologic compensation for treatment interruptions								d (dose per fraction)	n (number of fractions)	D (total dose)	a/b = X	K factor	Tdelay	T that you originally wanted	Days of interruption (including weekends)	T that is anticipated after adding interruptions	BED #1 a/b = X	BED #2 a/b = X	Extra BED needed to make up for gap	Next --> columns provide optional support.	Number of fractions you've already given	Number of fractions remaining in original schedule	Dose per fraction for remaining fractions (to make up the BED gap)	Does this make sense to do? (Is this additional BED less than the original prescription?)	Additional BED remaining (simple calculation) a/b = X	vs. Original BED (simple calculation) a/b = X
32								H&N SCC	2	35	70	10	0.9	28	46	7	53	67.80	61.50	6.30		9	26	2.237	Yes, but proceed with caution	71.16	84
33								H&N SCC	2.12	33	69.96	10	0.9	28	44	31	75	70.39	42.49	27.90		9	24	3.172	No, the new prescription is stronger than just restarting treatment from scratch. Recommend re-simulating patient and considering alternative treatment approach.	100.27	84.79
34								H&N SCC	2	30	60	10	0.9	28	39	14	53	62.10	49.50	12.60		20	10	3.132	Yes, but proceed with caution	41.13	72.00
35								Cervix SCC	1.8	25	45	10	0.5	19	32	14	46	46.60	39.60	7.00		10	15	2.247	Yes, but proceed with caution	41.27	53.10
36								Cervix SCC	2	25	50	10	0.5	19	32	14	46	53.50	46.50	7.00		10	15	2.447	Yes, but proceed with caution	45.68	60.00
37								Cervix SCC	2	25	50	10	0.5	19	32	14	46	53.50	46.50	7.00		10	15	2.447	Yes, but proceed with caution	45.68	60.00
38								Breast*	2	25	50	4	0.3	28	32	14	46	73.80	69.60	4.20		10	15	2.263	Yes, but proceed with caution	53.14	75.00
39								Breast*	2	25	50	4	0.3	28	32	14	46	73.80	69.60	4.20		10	15	2.263	Yes, but proceed with caution	53.14	75.00
40								Prostate*	2	39	78	3	0.2	35	52	14	66	126.60	123.80	2.80		10	29	2.094	Yes, but proceed with caution	103.09	130.00
41								Prostate*	2.53	28	70.84	3	0.2	35	37	14	51	130.18	127.38	2.80		10	18	2.678	Yes, but proceed with caution	91.25	130.58
42								NSCLC*	2	30	60	10	0.5	28	39.00	14	53.00	66.50	59.50	7.00		10	20	2.339	Yes, but proceed with caution	57.71	72.00
43								NSCLC*	2	30	60	10	0.5	28	39.00	14	53.00	66.50	59.50	7.00		10	20	2.339	Yes, but proceed with caution	57.71	72.00
44								Esophagus*	2	25	50	10	0.6	28	32.00	30	62.00	57.60	39.60	18.00		10	15	3.083	No, the new prescription is stronger than just restarting treatment from scratch. Recommend re-simulating patient and considering alternative treatment approach.	60.50	60.00
45								Esophagus*	2	25	50	10	0.6	28	32.00	10	42.00	57.60	51.60	6.00		10	15	2.385	Yes, but proceed with caution	44.31	60.00
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47								Online calculator:
48								http://radiobiology.org/bed1c.asp
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63	Bonus Tool
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68		Ref d	2	Gy	1+d/(a/b) =		1.67
69		Alph Beta	3
70		d per fraction	5.0	4.0	3.0	2.0	1.5
71		1	8.0	5.6	3.6	2.0	1.4
72		2	16.0	11.2	7.2	4.0	2.7
73		3	24.0	16.8	10.8	6.0	4.1
74		4	32.0	22.4	14.4	8.0	5.4
75		5	40.0	28.0	18.0	10.0	6.8
76		6	48.0	33.6	21.6	12.0	8.1
77		7	56.0	39.2	25.2	14.0	9.5
78		8	64.0	44.8	28.8	16.0	10.8
79		9	72.0	50.4	32.4	18.0	12.2
80		10	80.0	56.0	36.0	20.0	13.5
81		11	88.0	61.6	39.6	22.0	14.9
82		12	96.0	67.2	43.2	24.0	16.2
83		13	104.0	72.8	46.8	26.0	17.6
84		14	112.0	78.4	50.4	28.0	18.9
85		15	120.0	84.0	54.0	30.0	20.3
86		16	128.0	89.6	57.6	32.0	21.6
87		17	136.0	95.2	61.2	34.0	23.0
88		18	144.0	100.8	64.8	36.0	24.3
89		19	152.0	106.4	68.4	38.0	25.7
90		20	160.0	112.0	72.0	40.0	27.0
91		21	168.0	117.6	75.6	42.0	28.4
92		22	176.0	123.2	79.2	44.0	29.7
93		23	184.0	128.8	82.8	46.0	31.1
94		24	192.0	134.4	86.4	48.0	32.4
95		25	200.0	140.0	90.0	50.0	33.8
96		26	208.0	145.6	93.6	52.0	35.1
97		27	216.0	151.2	97.2	54.0	36.5
98		28	224.0	156.8	100.8	56.0	37.8
99		29	232.0	162.4	104.4	58.0	39.2
100		30	240.0	168.0	108.0	60.0	40.5