Aging Companies
 Share
The version of the browser you are using is no longer supported. Please upgrade to a supported browser.Dismiss

View only
 
 
 
ABCDEFGHIJKLMNOPQRSUVWXYZAAABACADAEAFAGAHAI
1
(How to Use
This Table)
company
is it
aging
?
operating statusshort summary
(intended to be objective, usually from company website, edited for brevity)
clinical stage / pipelineTx or DxAging Biotech
.info company
categories
hallmarks
of aging
SENS damage categoriesdiseases / indicationsclin. trialsmodalitiesregulatory categoryteam/principals
(esp. scientific)
advisors (scientific)contact infogeo(s)public?ticker Y!market cap (M)employees, Y! publicsemployees LIyear foundedpriv. fund. stagenotable investorstot. raised ($M)other relationslead product(s)publicationspatentsdate updatedadd date if >Oct'19notes
2
5 Alarm Bioyesoperatingdrugs to boost natural cell defenses against damaging chemicals that arise naturally & accumulate w/ agepre-clinicalTxproteostasisproteostasisex-cell aggregates?small moleculespharmaWilliam BainsAubrey de Grey, Joao Pedro de Magalhaeswilliam@fivealarmbio.comCambridge, UKno2016FAB0012019-08-28
3
712 North Incyesoperatingmitochondria modulators for age-related diseasespre-clinicalTxmitochondriamitochondriamitochondriaAD, cancer, glaucoma,
CVD, unspecificed orphan pediatric disease
pharmaMarcel AlaviSan Franciscono22016QB32019-09-04
4
Aeovian
(was Aeonian)
yesoperatingselective mTORC1 inhibitionpre-clinicalTxmetabolism / mTORnutri-sensesmall moleculepharma
Stelios Tzannis, Curtis Scribner
Ian Massey, David Lowe, Dudley Lamming, Mustafa Sahin, Jacqueline French
form
San Francisco
no32012raised A
Apollo, venBio, Sofinnova
37AE116paper2019-10-08
5
Age LabsyesoperatingML on methylation data mortality clock from longitudinal (45yrs) data, for improved clinical trialspre-commercialDxbiomarkers / methylome clockepigeneticblood testunreg testEspen Riskedal, Arne Soraas, Karl KallebergOslo, Norwayno22017Norway2019-09-04
6
AgeCurve LimitedyesoperatingDTC proteomics from saliva using mass spec & ML covering 7 of 9 hallmarkscommercial Dxbiomarkers / proteomesaliva sampleunreg testAttila CsordasAubrey de Grey, Daniel Reda, Kathryn LilleyCambridge, UKno22015raising seed
LongevityTechFund
2020-09-01
7
AgeX Ther. / Reverse Bioyesoperatingallogeneic stem cells w/ tech for stable engraftment & low immunogenicity; tissue regeneration drugspre-clinicalTxstem cells, reprogrammingstem cells, epigeneticcell lossIHD, T2D, CHF, scarless healingcell therapy, small moleculespharmaMike West, Aubrey de GreySan FranciscoyesAGE$8112132017Juvenescence, Jim Mellon, John Mauldin, KizooJuvenescenceVASC1, BAT1, iTR1547, Renelon2020-01-29AgeX has spun its iTR (reprogramming) work into a subsidiary called Reverse Bioengineering.
8
Alectoronly
brain
operatingmodulate immune system to cure dementias w/ leads based on GWAS & guided by biomarkersph.2 trialsTx, Dxproteostasisproteostasisex-cell aggregatesAD, FTD, neuroDs4biologicspharmaArnon Rosenthal, Robert PaulAdam Boxer, Marco Colonna, Stephen Hauser, Michael Heneka, Lewis Lanier, Liqun Luo, Richard Scheller, Thomas Christian Südhof, Robert Vassar, Berislav ZlokovicSan
Francisco
yesALEC$1,3751011042013Orbimed, Polaris, GV, Merck, MBC, AbbVie, AmgenAbbVieAL001, AL101, AL002, AL003many papers2019-09-18
9
Alkahestyesoperatingleads from blood proteins that go up or down with age, eg young blood fractionsph.2 trialsTxfactorscell commAD, PD, (wet) AMD, ESRD MCI11drugs, biologics,
blood fractions
pharmaKaroly Nikolich, Steven BraithwaiteTony Wyss-Coray, Jeffrey Cummings, Lennart Mucke, Thomas Rando, Eric Reiman, Lee Rubin, Elia Stupka, Saul Villeda
info@alkahest.com
San Francisco
acquired (by Grifols)
712014acquiredGrifols, MJFox Found50GrifolsAKST4290, AKST/GRF6019/6021, AKST1210papers2020-09-10
10
Altoidaonly
brain
operatingaugmented reality & AI mobile app 10min cognitive test, FDA cleared & covered by MedicarecommercialDxbiomarkers, proteostasis?proteostasis?ex-cell aggregates?AD, other MCI1mobile appreg Dx (SaMD)Richard Fischer, Ioannis TarnanasWalter Greenleaf, Jon VanLeeuwen, Phil Polakoffcontact@altoida.comHoustonno132016raised AM Ventures, Fyrfly8.3NMI (Neuro Motor Index)peer reviewed paper2019-07-22
11
Ambrosiayes
operating,
see notes
infusions of young blood from donors aged 16-25 for 30+ year-olds for $5500+clinical trial,
phase n/a
Txfactorscell comm1blood transfusion?Jesse Karmazinform
San Francisco
no120162020-01-23
Back to operating? ambrosiaplasma.com & linkedin.com/in/jessekarmazin down in Aug'19 but back in Jan'20. See also: bloomberg.com/news/articles/2019-02-25/the-bloody-tale-of-ambrosia-the-startup-that-wants-to-slow-aging,
webmd.com/healthy-aging/news/20190220/young-blood-clinics-shut-down-after-fda-action, & longevity.technology/young-blood-back-on-the-menu/
12
Ampriononly
brain
operatingamplification of misfolded proteins for sensitive detection in CSF & blood, for αS (1st), Aβ, tau
pre-clinical,
breakthrough
Dxproteostasisproteostasisex-cell aggregatesPD, ADCSFreg test? device?
Russ Lebovitz, Claudio Soto, Luis Concha
Info@AmprionMe.com
San Diego, San Francisco
no820072019-09-30Breakthrough device designation from FDA in May 2019 for alpha-Synuclein. Not to be confused with the Germany electrical grid company of the same name.
13
Animal Biosciencesyesoperatinghealthy longevity for pets (primarily dogs, cats, horses)pre-vet-clinicalTxsmall molecules, supplemensveterinaryDoug Korn, Nick SinclairformBostonno6Life BioLife Bio2019-10-08
14
AntoxisyesIP only?platform for mito drugs, 1st as co-treatments for regen. med. & cancer therapies, & for neuroDspre-clinicalTxmitochondriamitochondriamitochondrianeuroDs, cancer, regenerative med.drugspharmaonly board?Donald McPhail
info@antoxis.com
Aberdeen, Scotland
no02005Grampian, Genomia, TriCap£ 2M
Proxison, Oncamex
2018 paper
4 patents
2020-01-032020-01-03Company has a 2nd LinkedIn page: https://www.linkedin.com/company/antoxis-limited/ Also see news piece from 2012: https://www.sciencescotland.org/feature.php?id=182
15
Athersys Incyesoperatingallogeneic stem cells for neuro, inflammatory, immune, & CV diseasesph.3 trialsTxstem cellsstem cellscell lossneuroDs, CVD, others9cell therapypharmaGil Van Bokkelen, John Harrington, William (BJ) Lehmann, Robert (Willie) Mays, Anthony Tinginfo@athersys.comCleveland, OHyesATHX$43175891995MultiStem2019-07-11
16
Atropos Therapeuticsyesoperatingdrug platform for modulators of entering senescence, for aging (suppress) & cancer (stimulate) pre-clinicalTxsenescencesenescencesenescencecancer, progeroidDs,
undecided agingDs
small molecules?pharmaAndrew Koff, Nathanie TrisnadiJan Vijg, John Sedivy, William Tap, John Petrini, Oliver Stauch, Teresa Calarcoinfo@atroposthera.comSan Franciscono52018QB3,
Atomwise
some relevant papers2020-02-04Sept'19 announced partnership with Atomwise to do AI for drug discovery for cancer via senescence modulation.
17
Aurora Bioyesoperatingdiagnosis & therapy for systemic non-CSF amyloid diseases (AL, ATTR, LECT2) ph.1 trialsDx, Txproteostasisproteostasisex-cell aggregatessystemic amyloidosis1peptidespharma, reg DxSpencer Guthrie, Jonathan Wall, Nancy Miller-Rich
Jeff Kelly, Morie Gertz, Matthew Maurer
form
San Francisco
no
? (no page & too many name conflicts)
2019QB3
AUR01 / P5+14
2020-01-042020-01-04Not to be confused with several other companies called Aurora Bio: Sydney based medical device maker Aurora BioScience, cancer company Aurora BioPharma, drug discovery system company Aurora Biosciences (acquired by Vertex in 2001)
18
Beiwe Healthyesoperatingnon-rapalog mTORC1 inhibitors using new site on mTOR, for aging & cancer (esp. glioblastoma) pre-clinicalTxmetabolism / mTORnutri-sensecancerpharmaSonia Allen, Alexey Tomilov, Gino Cortopassiform
Sacramento, CA
no120182020-03-022020-03-02
19
BHB Therapeuticsyesoperatingbeta-hydroxybutyrate (BHB)TxEric Verdin? John Newman?noraised seedJuvenescence3Juvenescence2020-03-022020-03-02
20
BioAge Labsyesoperatinghuman 20+yr biobanks + multiomics + AI drug platform; leads: HIF signaling, PGD2 DP1 for immune agingpre-clinical ph.2 readyTxbiomarkers,
immune, stem cells? or factors?
cell comm
muscleDs,
immuneDs, COVID-19
drugspharmaKristen Fortney, Eric Morgen, Paul Rubin, Klaus Klumpp, Robert Hughes, Justin ReboGeorge Hartman, Elad Gil, Joe Betts-Lacroix, Eric Verdin, Peter Dilaura, ...info@bioagelabs.comSan Franciscono302015closed BFelicis, Andreessen Horowitz, Khosla, AME Cloud, Pear, Redpoint, Caffeinated Captial, Elad Gil34
BGE117,
BGE-175
paper (not core)2020-08-30
21
BioChange ltd
22
Biophytisyesoperatingdrug discovery platform for aging based on plant secondary metabolitesph.2 trialsTxsarcopenia, AMD, MD2small moleculespharmaStanislas Veillet, Rene Lafont, Samuel Agus, Pierre Dilda, Waly DiohJean Mariani, Roger Fielding, Thomas Voit, Jose-Alain Sahel, Ivana KimformParisyesALBPS.PA$14530262006Sarconeos (BIO101), Macuneos (BIO201)several papers & posters2019-07-11
23
Bioquarkyesoperatingbiologics for regeneration, repair, degenerative diseases w/ leads from regenerative animalsph.1 trialsTxcancer, kidneyDs,
neuroDs, brain death
1biologics, cell therapypharmaIra Pastor, Sergei PaylianCalixto Machado, Melisa Cooper, Alejandro Mesples, Nikolai SkibaformPhiladelphia, Tampano102007BQ-Atwo (see bottom)2019-07-28
24
BioVivayesoperatingplatform for health tests & treatments (via partners) w/ focus on gene & cell therapies, also counselingcommercialElizabeth Parrish, Jason Williams, Anca Selariu, Mitch Fernandez, David KekichGeorge Church, Bill Zheng, Anders Sandberg, John Schloendorn, Ali Fallah, Aubrey de Grey, Matthew Scholz, Hernando Ramirez LlinasformSeattleno32015Integrated Health Systems2019-08-13CEO Parrish underwent out-of-USA gene therapy to extend her telomeres w/ hTERT and for myostatin inhibition then claimed positive results, back when company focus was more directly telomere extension therapy. See also https://en.wikipedia.org/wiki/BioViva
25
Blue Rock Therapeuticsyesoperatinguniversal pluripotent stem cell lines for allogeneic cell therapies for neuro-/cardio-/immunologypre-clinicalTxstem cellsstem cellscell lossPD, neuroDs, HFcell therapy, gene therapypharmaEmile Nuwaysir, Robert Deans, Joachim FruebisGordon Keller, Michael Laflamme, Lorenz Studer, Viviane Tabar, Bruce BlazarformBoston, New York, Toronto
acquired (by Bayer)
1242016acquiredBayer225Bayer2020-01-052020-01-05
26
BYOMass Therapeuticsyesoperatingcontrol of metabolism for aging / age-related diseasespre-clinicalTxmetabolismnutri-sensepharmaMargaret Jackson
chris@juvenescence.ltd
Massachusettsno12017raised seedJuvenescence6.5Juvenescence2020-04-29
27
Calicoyesoperatingbroad mission to improve health and longevity using technology to advance biological scienceTxpharmaArthur Levinson, David Botstein, Cynthia Kenyon, Daniel Gottschlingpress@calicolabs.comSan Franciscono18020132 roundsGoogle, Abbvie2500Google, AbbVieseveral2019-08-19Initially funded/created within Google/Alphabet.
28
Celevity /
Cellular Longevity
yesoperatingdrug(s) to treat aging in dogspre-vet-clinicalTxdrugsveterinaryCeline Haliouano02019fundedLongevity Fund, Collaborative Fund, Bedrock, Village
Longevity Fund
2019-12-192019-12-19
29
CellAgeyesoperating?develop new, more accurate senescent cell measurement based on synthetic promotersresearch,
pre-commercial
Dxsenescencesenescencesenescenceunreg testMantas Matjusaitis, Azuolas CiukasAlexandra Stolzing, Juan Carlos AcostaINFO@CELLAGE.ORGGlasgow, Scotlandno22016raised seedKizooCircularis2019-08-02Website is .org. Seed raise was 2017 & involved crowdfunding. No mention of total raised. Still only 2 employees? Is this a for-profit company?
30
Celularityyesoperatingallogeneic cell therapies from postpartum human placentas, for cancer & functional regenerationph.2 trialsTxstem cellsstem cellscell losscancer (solid & blood), otherscell therapypharmaRobert Hariri, Xiaokui Zhang, Nassir Habboubimedia@celularity.comNew Yorkno1552016Celgene, Bill Maris, Tony Robbins, Human Longevity290CYNK-001thousands2019-08-19Also run income generating programs to bank placental stem cells and to treat burns & wounds, with projected $40M revenue.
31
Centaurayesstarting?reverse aging by affecting core biological mechanisms at the cellular level using multi-omics dataTxBrian Kennedy, Joao Pedro De Magalhaes, Vadim Gladyshev, Vera Gorbunova, Andrei Seluanov, Jerry Shay
Info@centaura.com
Zurichno720182020-09-012020-09-01
32
Centers for Age Controlyesoperatingsells AgeMeter multimodal test of biological age (successor to H-SCAN test)commercialDxbiomarkersmultimodal testunreg testElliot Smallinfo@agemeter.comLas Vegasno12005crowdfundedAgeMeter2019-08-22
33
Cerevanceonly
brain
operatingdrug discovery platform by analyzing brain cell transcriptome diffs by age, cell type, region, & diseaseph.2 trialsTxPD, AD, ALS, neuroDs5small molecules, mAbspharmaBrad Margus, Mark Carlton, David Margolin, Lee Dawson, Roland BurliNathaniel Heintz, William Ray, Robert Malenka, James Summers, Jeremy Nathans, Rudolph Tanziinfo@cerevance.comBostonno352016raised ATakeda Pharm, Dementia Discovery Fund, Lightstone26.5CVN424paper2020-03-04
34
ChromaDexyesoperatingnutraceuticals for aging, esp. flagship product Niagen w/ nicotinamide riboside (NR), an NAD+ precursorcommercial,
ph.3 trials
TxNAD+cancer, MCI, HF,
mitoDs, more...
25nutraceuticalssupplementRob Fried, Frank Jaksch Jr., Matthew RobertsRoger Kornberg, John Walker, Rudolph Tanzi, Charles Brenner, Rob Beudeker, Bruce Germanmultiple emails & formLos AngelesyesCDXC$589100951999Niagenmany2019-08-0513 clinical trials mentioning Chromadex, but fewer sponsored by Chromadex and 23 trials using Niagen (some just not mentioning Chromadex by name).
35
ChronomicsyesoperatingDTC saliva methylation clock, plus software to improve healthcommercialDxbiomarkers / methylome clocksaliva sampleunreg testTom Stubbs, Robin Thompson, Daniel HerranzJanet Thornton, Paolo Vineisinfo@chronomics.co.ukLondonno122017raised seed
SOSV, Anthemis, RebelBio
1.3EpiHealth2019-10-18
36
Cleara Biotechyesoperatingsenolytics, initially based on FOXO4-p53 interfering peptidepre-clinicalTxsenescencesenescencesenescencepeptide or small molecules?pharmaPeter De Keizer, Tobias Madl, Marco DemariaBoudewijn BurgeringformNetherlandsno52018raised seedApolloseveral, esp. Cell 20172019-07-11
37
CohBar Incyesoperatingfind mtDNA peptides (eg that decrease w/ age) & optimized analogs to treat metabolic dysfunctionph.1 trialsTxmitochondriamitochondriamitochondriaNASH, obesity, T2D,
cancer, other ageDs
1peptidespharmaSteven Engle, Kenneth Cundy, Nir Barzilai, ...Amir Lerman, David Sinclair, Ronald Kahn, James Livingston, Frank Calzoneinfo@cohbar.comSan FranciscoyesCWBR$9611142007CB4211papers & posters2019-10-16
38
Continuum Biosciencesyesoperatingdrugs to improve mitochondria health & metabolism (eg to increase metabolism)pre-clinicalTxmitochondriamitochondria, nutri-sensemitochondriaNASH, obesity, diabetesdrugspharmaSimon Tucker, Webster Santos, Kyle HoehnJohn Amatruda, David SinclairformBlacksburg, VAno22017raised seedLife Bio0.5Life Bio2019-10-17Not to be confused with Continuum Biosciences Consulting: https://www.continuumbiosciences.com/
39
Covalent Bioscienceyesoperatingplatform for catalytic antibodies (w/ advantages over mAbs) 1st for ATTR & Aβ, electrophilic vaccinespre-clinicalTx,
preventative
proteostasis,
targeted elimination
proteostasisex-cell aggregatesCVD, AD, HIVpharmaRichard Massey, Sudhir Paul, Stephanie PlanqueRobert Friedland, Joel Buxbaum, Miguel Escobar, Carl Hanson, Seth PincusformHouston, New Yorkno32011several peer reviewed2019-08-03
40
Cytegenyesoperatingexercise mimetic biologics to treat mitochondria dysfunctionpre-clinicalTxmitochondria, metabolismmitochondriamitochondriaAD, Parkinson'sbiologicspharmaGeorge Ugras, Blake HillSan Franciscono22015raised
unspecified
Breakout12019-12-19
41
Daphnia Labsyesoperatingdrug discovery platform via in-vivo phenotypic screens of daphnia water fleas w/ video & ML for anti-agingpre-clinicalTxlifespan screenspharmaSarah Constantininfo@daphnia-labs.comSan Franciscono220192019-08-02
42
Deciduous Therapeuticsyesoperatingactivate endogenous immune cells to clear senescent cellspre-clinicalTxsenescencesenescencesenescencepharmaRobin MansukhaniSan Franciscono52018raised seed
JLABS, MBC, Longevity Fund, CRV
5.9QB3, Age12020-02-20
43
Denali Therapeuticsonly
brain
operatingdrug discovery for neurodegeneration, optimized for brain delivery, guided by genetics & biomarkersph.1 trialsTxPD, ALS, AD, FTD, MS, neuroDs5small molecules, biologicspharmaRyan Watts, Carole Ho, Zach SweeneyScott Biller, David Holtzman, Eric Reiman, Kevan Shokat, Henrik Zetterberg, Huda Zoghbi, Marc Tessier-LavigneformSan FranciscoyesDNLI$7,7532302372015DNL201, DNL151, DNL7472019-08-22
44
Dorian Therapeuticsyesoperatingblock cellular senescencepre-clinicalTxsenescencesenescencesenescencepharmaMaddalena Adorno, Benedetta di RobilantformSan Franciscono42018Longevity Fund, YC, BlumbergMBC2019-08-06
45
Elevianyesoperatingregulate GDF11 & other circulating factors to restore regenerative capacitypre-clinicalTxfactorscell commCVD, T2D, AD, sarcopeniapharmaMark Allen, Tony Sandrassagra, Manisha Sinha, Orit Foord, Vongting WangBrock Reeve, Luis Alvarez, Scott Dylla, James Larrickinfo@elevian.comBostonno122017raised seedKizoo, Thynk, Longevity Fund, Bold5.5several2019-08-22
46
Elysium Healthyesoperatingsupplement called Basis: NR + pterostilbene for boosting NAD+; plus DTC epigenetic clockcommercial, ph.1 trialsTx, DxNAD+,
biomarkers / methylome clock
epigenetic7nutraceuticals, saliva samplesupplement,
unreg test
Eric Marcotulli, Leonard Guarente, Mark Morris, Morgan Levine25+ inc. George Church, Ana Maria Cuervo, Vera Gorbunova, Jim Kirklandcare@elysiumhealth.comNew Yorkno552014raised BSV Bank, General Catalyst71Basis, Indexpaper2020-01-06To launch epigenetic age clock in Jan 2020 based on work by new head of bioinformatics Morgan Levine.
47
Enclear Therapiesonly
brain
operatingdevices to access & filter toxic proteins from CSF, 1st for ALSpre-clinicalTxproteostasisproteostasisex-cell aggregatesALS, neuroDsCSF accessdeviceAnthony DePasqua, Kevin Kalish, Kasper Roet, William GormleyKevin Eggan, Clifford Woolf, Manuel Navia, Bernhardt TroutformBostonno92018raised A20/20 HealthCare, Thiel Capital, Amgen Ventures, Bioverge, Sanford Biosciences, Presight Capital12LabCentral2020-02-20Mostly a therapeutic company, but various company summaries also mention monitoring of CSF.
48
Epimorphy LLCyesoperatingDTC Horvath methylation clockcommercialDxbiomarkers / methylome clockepigeneticblood test, urine testunreg testLarry Jiainfo@myDNAge.comLos Angelesno02017Zymo ResearchmyDNAge2019-08-02
49
EterlyyesoperatingAI based anti-aging health & fitness monitoring and recs app w/ blockchain coins for incentivesapp launchedrecssoftwareunreg appAndrew AhachinskyformVancouver, BCno102016raised seedDeep Knowledge VenturesLongevity Token?2019-08-22What is the relationship to Longevity Token (LTY) / Longevity United, whose website mentions Eterly as its front-facing app and some team members overlap based on LinkedIn, but CEOs are different, LTY's website doesn't seem to have updates since early 2018, and Eterly website doesn't mention Longevity Token. Are they distinct legal organizations?
50
Eternansyesoperatingsenolytics, peptide (see patent)pre-clinicalsenescencesenescencesenescencepharmaYavuz A.formUKno32017patent2019-08-22
51
Everon Biosciencesyesdefunct?small molecules & biologics platform based on proprietary aging biomarkers including a frailty index pre-clinicalTxAlexander Polinsky, Andrei Gudkov, Olga Chernovainfo@everonbio.comBuffalo, NYno62010several22020-08-30News & publications end mid-2017.
52
Fauna Biomaybeoperatingcomparative animal genomics & multi-omics for drug discovery to improve human healthpre-clinicalTxformSan Franciscono52018raised seedLongevity Fund, True Ventures (lead)4.1Age12019-07-15Appears more committed to idea of using insights f/ non-model non-human organisms for human health broadly, not specifically for aging. In favor of categorizing as aging: Hibernation is a focus & relevant for age-related diseases. Aging is mentioned as a (distant) future area. Investment by Longevity Fund. Conclusion: Include but re-evaluate after seeing what indications, targets, pathways they go after initially.
53
Fountain Therapeuticsyesoperatingunbiased screening platform for new aging targets using AI, vision, & cellular model of aging hallmarkspre-clinicalTxinfo@fountaintx.comSan Franciscono42018Bold5QB32019-07-24
54
FoxBio / Antoxereneyesoperatingdrug platform using protein manufacturing tech, senolytics targeting p53 pathways (eg p53/FOXO4)pre-clinicalTxsenescencesenescencesenescencesmall moleculespharmaKelsey Moody, Adam Blanden, Cees Wortelinfo@ichortherapeutics.comSyracuse, NYno52016raised seedJuvenescence, Kizoo11.5Ichor, Juvenescence2019-08-09Ichor spun out Antoxerene. Antoxerene & Juvenescence created FoxBio as a 50-50 joint venture. Considering them (A & FB) as one here for now since FB has no website nor LIn employees.
55
FOXO Bioscience
(was Life Epigenetics)
yesoperatingB2B epigenetic tests as a service (for pharma & nutraceutical clients, research, insurance)commercialDxbiomarkers / methylome clocklife insurancesaliva sampleunreg testJon Sabes, Brian Chen, Randy OlsonMichael Curran, Morgan Levine, Raymond McCuley, Andreas Mullerinfo@lifeegx.comMinneapolisno192016subsidiary of GWG Holdings (a public company)GWG Holdings2019-07-30[Company name updated 4/28/2020, but rest of row needs update, including rest of this cell.] Sister company YouSurance (also a subsidiary of GWG) in beta beginning to sell DTC life insurance (using Life Epigenetics service?)
56
GEn1E Lifesciencesyesoperatingdrug discovery platform for inflammatory & aging diseases; lead is p38α kinase inhibitorpre-clinicalTxacute lung injury, agingD?pharmaRitu Lal, Clint Webb, Wendy LuoDavid Young, Alan Levy, Robert Booth, Leonard HayflickInfo (@) GEn1Elifesci.comSan Franciscono320182019-07-30Some profiles on 3rd party sites (older material?) omit mention of aging, instead saying a pipeline for rare diseases. No explanation p38 kinase inhibition's larger role in aging. Giving benefit of doubt for now for putting aging front and center and pledging age-related disease indications coming.
57
GenFlow Biosciencesyesoperatinggene therapies for aging in dogs & humans, especially relating to SIRT6pre-clinicalTxDNADNAgene therapypharmaEric Leire, Tongtis TongyaiEric Verdin, Matthew Hirschey, Vera Gorbunova, Aubrey de Grey, Manlio Vinciguerraeric@genflowbio.comBelgiumno22020
SIRT6 related
2020-10-012020-10-01
58
Genome Protectionyesoperatingentolimod & other drugs for anti-aging & cancer, esp. by protecting genome, esp. against transposonsph.2 trialsTxDNA / transposonsDNAcancervarious cancers3small moleculespharmaAndrei Gudkov, Yakov Kogan, Katerina Andrianovainfo@genomeprotection.comBuffalo, NYno32018seedNorma Investments10.5Everon, Cleveland Biolabsentolimod (drug)several inc. peer-reviewed2019-07-17also started with a portfolio of other anti-aging and anti-cancer drugs from parent Everon Biosciences
59
GenSight Biologicsyesoperatingallotopic expression w/ targeting to deliver mRNA to mitochondria, for retinal & neuro mito diseasesph.3 trialsTxmitochondriamitochondriamitochondriaNA eyeDs, AMD8viral gene therapypharmaBernard Gilly, Magali Taiel, Catherine CancianBotond Roska, Jose-Alain Sahel, Jean Bennett, Ernst Bamberg, Connie Cepko, Serge Picaud, Luk VandebergheformParis, New YorkyesSIGHT.PA$344283920122020-01-06allotopic expression of mtDNA w/ targeting to deliver the mRNA to mitochondria could rescue mito aging; also in pre-clinical development for age-related dementias
60
Geras Bio
no website yet? mentioned in https://www.nature.com/articles/s41587-020-00750-1/tables/1
61
Geroyesoperatingphysics based data/AI biomarkers for licensing & therapy developmentcommercial,
pre-clinical
Dx, TXbiomarkerslife insurance, ?unreg testPeter Fedichev, Maxim Kholininfo@gero.aiMoscow, Singaporeno352015several, inc. peer reviewed2020-01-15
62
Gerostate Alphayesoperatingpharmaceutical scerening platform to treat agingpre-clinicalTxlifespan screenspharmaSimon Melov, Gordon Lithgow, Mark LucanicSMELOV@GEROSTATEALPHA.COMSan Franciscono52018YC, CRCM0.152019-09-12
63
Gordian Biotechnologyyesoperatingunbiased, high-throughput, in-vivo screening platform for aging w/ gene therapy & single-cell RNAseqpre-clinicalTxgene therapypharmaFrancisco LePort, Martin Borch Jensen, Daniel Fuentes, Chris TowneTom Rando, Randy Platt, David Schaffer, Laura Deming, Edward Lanphier, Thomas Ebelinginfo@gordian.bioSan Franciscono52018Longevity Fund, NJFQB3, Age12019-08-06
64
Guided Clarityyesoperatingmitochondria-targeted therapies: trigger apoptosis in cancer, increase mitophagy for agingpre-commercialTxmitochondriamitochondriamitochondriacancer, ageDs, neuroDsHelen Chen, Olof MollstedtformSan Franciscono22018SOSV/IndieBio2019-11-07
65
Hanako Biotechyesoperatingscreening platfom for oligonucleotide senolytics with high selectivity & senolytic activitypre-clinicalTxsenescencesenescencesenescenceoligonucleotidespharmaYuri Shoshan, Noam Pilpel, Amir Bar-Shai, Yossi Ovadya, Dina RaichlinIdo Bacheletinfo@hanako.bioIsraelno120192019-11-132019-11-13
66
Human Rejuvenation
Biotechnologies
yesdefunctclearance of 7-ketocholesterol (a type of lipofuscin) for atherosclerosispre-clinicalTxatherosclerosispharmacontact@human.bioPhoenix, AZno02014Jason Hope2020-08-30Defunct: The handful of employeees on LinkedIn say their employment here ended. William Adams' (linked in this cell) says "closure of company".
67
Humanity Incyesoperatingaging-focused health/wellness platform using biomarkers & self-experimentationpre-commercialrecssoftwareunreg appMichael Geer, Peter Ward
info@humanity.email
UKno320192020-02-07
68
Ichor Ttherapeuticsyesoperatingbiopharma that spins off subsidiaries inc. senolytics, enzymes for lipofuscin, a CRO, & oral mAb mimeticspre-clinicalTxAMD, other undisclosedsmall molecules, biologicspharmaKelsey Moody, Aaron Wolfe, Cornelis Wortel
info@ichortherapeutics.com
Syracuse, NYno372013raised seedKizoo4.5Antoxerene, FoxBio, LysoClear, Auctus Biologicsseveral2019-08-24LysoClear itself doesn't qualify for this list due narrow 1-body-part (eye) & 1-disease focus, but the platform approach it came from does & lives in Ichor. Auctus could eventually qualify itself w/ similarities to Longevity Biotech, but too little info currently available publicly on indications it will target.
69
InSilico Med. / GeneraityesoperatingInsilico: AI for drug discovery, biomarkers, & aging. Generait (formerly Juvenescence AI): JV for aging.biomarkersAlex Zhavoronkov, Marine Bozdaganyan, Ivan Ozerov, Jimmy Yen-Chu Lin, Polina MamoshinaCharles Cantor, Michael Levitt, Bud Mishra, Donald Small, Yuri Nikolsky, Kristen Fortney, Alexey Moskalev, Ulrich Muehlnerzhu@insilicomedicine.comHong Kong, Moscowno532014raised BQiming, Wuxi AppTec, Deep Knowledge Ventures, Juvenescence, Bold, Jim Mellon51.3Juvenescencesevenal2019-09-10Mostly AI for drug discovery (like many others not focused on aging) but also consistently focused on aging, publishing on aging, launching aging-focused sites, creating aging-related partnerships, etc. Recent post on Medium suggests shifting focus away from aging. If that happens, Insilico will drop off this list though perhaps Generait might stay if a proper 1st-class company in the sense of others here by then.
70
Integrated
Health Systems
yesoperatinggives patients access to gene & cell therapies for anti-aging esp. telomeres & myostatin, BioViva partnercommercialTxtelomerestelomeresAD, cancer, kidneyDsviral gene therapymedical tourisma team of doctorsinfo@integrated-health-systems.comBritish Virgin Islandsno1BioViva2019-08-14Ex-USA travel not mentioned explicitly but apply-for-study link leads to https://mailchi.mp/bioviva-science.com/alzheimers/ which mentions travel to Mexico. Not to be confused with the other Integrated Health System (same exact name) at https://ihs911.com/ which does IT for senior living and related care facilities.
71
Intervene Immuneyesoperatingreverse thymus involution & (immune) aging w/ HGH+DHEA+more; provide thru collaborating drs.commercial, pre-clinicalTximmunecell lossGreg Fahy, Bobby Brookeinfo@interveneimmune.comLos Angelesno22011Aging Cell, 2019patent2019-09-12TRIIM trial results published in 2019 showed Horvath clock reversal of 2.5yrs over 1yr of study.
72
iuve bioyesoperatingDTC biomarkers of systemic chronic inflammation based on Stanford 1000 immunomes project & AIcommercialDxbiomarkersblood testunreg testWolfgang Daum, Zuzana Krejciova-RajaniemiMark Davis, David Furman, Joseph Wuinfo@iuvebio.comSan Franciscono22018Age1iAge2019-08-02
73
Juvena Therapeuticsyesoperatingdiscovery platform for proteins promoting tissue regeneration, using proteomics, vision, MLpre-clinicalTxstem cells, factorsstem cells, cell commcell lossbiologicspharmaHanadie Yousef, Jeremy O'ConnellMike Nohaile, David Schaffer, Joe Wu, Peter Jackson, Irina ConboyformSan Franciscono102017raised seedFelicis, Compound, Front Seat, Barney Pell4.3Youssef's patents2019-09-13
74
Juvenescenceyesoperatingbiopharma umbrella company that creates/invests-in other companies for aging therapeuticssee portfolioTxumbrellaGreg Bailey, Declan Doogan, Colin Watts, Alexander Pickett, Margaret Jackson, Nafees MalikAnnalisa Jenkins, Steve Felstead, Howard Federoff, Sef Kurstjens, Charlie Roberts, Jeff SprouseformLondonno102016raised BForesite, Grok, IPGL, Jim Mellon165several portfolio companies2019-08-26
75
Life Biosciencesyesoperatingbiopharma umbrella company that creates/invests-in other companies for aging therapeuticssee portfolioTxumbrellaMehmood Khan, Tristan Edwards, John Amatruda, Jennifer Cermak, William AveryNir Barzilai, Lindsay Wuinfo@lifebiosciences.comBostonno532017raised B75several portfolio companies2019-08-26
76
Life Lengthyesoperatingtelomere testing DTC & for drs & as contract research, also for cancer diagnosticscommercialDx
biomarkers / telomeres
telomerescancerunreg testStephen Matlin, Pilar Najarro, Lissette Otero, Nuria De PedroBill Andrews, Sandy Chang, Inderjeet Dokal, Mark Rosenberg, Jerry Shay, Takuji Shirasawainfo@lifelength.com
Madrid, Spain
no3820102020-02-052020-02-05
77
LipidEv (Lipid Evolution Ltd.)yesoperatinganti-inflammatory lipids (specialized proresolving mediators) that decline w/ agepre-clinicalTxvarious agingDs & inflammatoryDsDerek Clissoldinfo@lipidev.co.ukReading, UKno12014related papers2019-08-02
78
Longeveronyesoperatingallogeneic mesenchymal stem cells f/ bone marrowph.2 trialsTxstem cellsstem cellscell lossAF, AD, metabolicDs5cell therapypharmaGeoff Green, Joshua Hare, Anthony OlivaJeremy Walston, Laura Dugan, Elena Volpi, Hidenori AraiformMiamino122014raised seed72019-08-23
79
Longevity Biotechyes
but see notes
operatingplatform peptides long-lived w/ oral administration, 1st or neurodegeneration (via VIP receptors) & T2Dclinical trialsTxPD, neuroDs, T2D, cancer1peptidespharmaScott Shandler, Samuel Gellman, Uma sinhaWilliam Degrado, Howard Gendelman, Soumitra Ghosh, Chris Rhodes, James WaschekInfo@LongevityBiotech.comPhiladelphiano62010NMSS, Thiel/Breakout, MJF0.8LBT-3627, LBT-6030several2019-08-23Longevity in the name appears to refer to the stability of the peptides, not longevity of the patient. Nonetheless, the platform's early pipeline indications include a variety of age-related diseases, and mostly age-related diseases, even though aging/longevity doesn't seem to be a company mission or criterion, eg based on interview here: https://www.sciwri.club/archives/7375
80
Longevity Bridgeyesoperatingbiomarkers of aging esp. NAD biomarkers, 1st through patient-funded study (also see notes)pre-commercialDxNAD+blood testsunreg testMaria Entraigues Abramson, Gary AbramsonGreg Fahy, Aubrey de Grey, Alexandra Stolzig, Michael Rae, Mike Kopemail@longevitybridge.comLos Angelesno220172019-07-30LinkedIn company page self description suggests plan for DTC products/services for healthspan/lifespan.
81
LyGenesisyesoperatingregrow organs in lymph nodes f/ donor cells, 1st for liver diseases, later thymus, pancreas, & kidneyspre-clinical
ph.2 ready
Txstem cells, immunestem cellscell lossliverDs1pharmaMichael Hufford, Paulo Fontes, Eric LagasseformPittsburghno52017raised AJuvenescence,
Longevity Vision Fund
7Juvenescence
LYG-LIV0001
2 on liver, 2 on kidney2020-08-30
82
Mesoblastyesoperatingallogeneic mesenchymal stem cells for inflammatory conditionsph.3 trials,
JP EU approved
Txstem cellsstem cellscell lossGVHD, HF, chronic back pain,
OA, diabetic nephropathy
34cell therapypharmaSilviu Itescu, Fred Grossman, Roger Browninfo@mesoblast.comMelbourneyesMESO
?: Y&G
disagree
81912004Revascor, Remestemcel-L, MPC-06-IDmanysome info2019-08-23A lot of focus on non-age-related conditions, but stem-cell tech clearly applicable to aging too with several aging-related indications. Claimed first allogeneic stem-cell therapy approved in Japan & first in Europe.
83
Methuselah Healthyesoperatingprotein post-translational modification analysis for drug discovery for proteostasispre-clinicalTxproteostasisproteostasisex-cell aggregatesdrugspharmaDavid Grainger, David Mosedale, Mary Donnellyinfo@methuselah-health.com
Cambridge, UK
no22015Medicxi, Index Ventures2019-11-142019-11-14
84
Minovia Therapeuticsyesoperatingautologous stem cells enriched w/ mitochondria to transfer to other cells, for mitochondria dysfunctionph.2 trialsTx
mitochondria / mito-transfusion,
stem cells
mitochondria, stem cells?mitochondriaNA mitoDs, AD, PD, AMD2cell therapypharmaNatalie Yivgi-Ohana, Noa Sher, Eyal Shoshaniinfo@minoviatx.comIsraelno192011https://patents.justia.com/assignee/minovia-therapeutics-ltd2020-01-06Approval in Japan (see pipeline). Other company details at http://minovia.com/mitochondrial-augmentation-therapy/ & http://minovia.com/open-questions/
85
Mitochondrial Transfusionyesoperatingextract stem cells, expand & extract youthful mitochondria, transfuse back to bodypre-clinicalTxmitochondria / mito-transfusionmitochondriamitochondriaAD, PD, CVD, sarcopeniacell/organelle therapypharmaTom B.form
San Francisco
no120182020-04-29
86
Mitoconix Bio
(not responding)
only
brain
defunct?drugs for mitochondria health for dementias, 1st by inhibiting pathological mito fissionpre-clinicalTxmitochondriamitochondriamitochondriaHD, PD, ADpeptidespharmawas Gili Hart, Lior Weissma but LinkedIn reports both left summer 2019Daria Mochly-Rosen, Orian ShirihaiIsraelno42016raised A ('17)FutuRx, Remiges, OrbiMed, Dementia Discovery Fund, Arix Bioscience, RMGP202020-01-06Failed?: Website not responding on 1/6/2020 executives report having ended employment there summer 2019 according to their LinkedIn profiles.
87
Mitokininonly
brain
operatingdevelop neo-substrates that modify kinase activity for mitochondria & neuro diseases, 1st for PDpre-clinicalTxmitochondriamitochondriamitochondriaPD, HD, other mito & neuroDs?pharmaKevan Shokat, Nicholas Hertz, Daniel de LouretM. Flint Beal, X. William Yang, Ray TruantSan Franciscono1020175QB3https://patents.justia.com/assignee/mitokinin-llc2019-07-10
88
Mount Tam ->
Torcept
yes
rebooting?
see notes
drug platform for mTOR modulating rapalogs with selective inhibition of mTORC1pre-clinicalTxmetabolism / mTORnutri-senseLupus, MS, cancer, PD, HDsmall moleculespharmaRichard MarshakBryan Cox, Jim Stolzenbachjim@mounttambiotech.comBurlington, VTyesMNTMnot found222014TAM-012020-01-30
Rebooting as Torcept Tx?: Mt Tam website not responding & seems delisted f/ markets. Richard Marshak's LI page says Torcept current. And SEC form says Mt Tam assets sold to Torcent. See:
https://www.linkedin.com/in/richard-marshak-129a527/ & https://finance.yahoo.com/news/banner-announces-completion-merger-agreement-140000266.html & https://www.streetinsider.com/SEC+Filings/Form+8-K+Mount+TAM+Biotechnologie+For%3A+Nov+13/16156270.html
89
MyndYouonly
brain
operatingcognition eval app w/ AI to passively track movement & conversation, platform for therapistscommercialDxbiomarkersAD, other MCImobile app, telecom?Ruth Poliakine Baruchi, Itay Baruchi, formIsraelno112016raised seedAmplifyher, Female Founders Fund, Howard MorganMizuho2019-07-22Company webpage indicates more palliative focus than other cognitive testing app companien (eg NeuroTrack, Altoida), but clearly the technology has the potential to be used as cognitive decline biomarker/diagnostic. Being deployed currently as more of a augmentative tool for therapists?
90
Napa Therapeuticsyesoperatingdrug discovery pursuing novel targets related to NAD metabolism using drug discovery AI + NAD sciencepre-clinicalTxNAD+small moleculespharma
Qiuxia Wu
Eric Verdin (presumably not employee?)
San Francisco
no12019Juvenescence3Juvenescence, Insilico Medicine2020-02-20
91
Navitor
Pharmaceuticals
yesoperatingdrug discovery targeting mTORC1 modulationph.1 trialsTxmetabolism / mTORnutri-senseHD, MCI, depression
muscle wasting
1small moleculespharmaGeorge Vlasuk, Eddine Saiah, James ("Randy") OwenDavid Sabatini, Michael Hall, Brian Hubbard, Brendan Manning, Mark Murcko3 emailsBostonno242010raised C
Brace Pharma, J&J, Sanofi, SR One, Polaris, Longevity Fund
78NV-5138several peer reviewed2019-07-31
92
NemaLife Inc.yesoperatingautomating C.elegans HTS inc. healthpan/lifespan w/ microfluidics, computer vision, & data intelligencecommercial?toollifespan screenssome specific worm
disease models
tool as product, serviceunreg toolSiva Vanapalli, Mizanur Rahmaninfo@nemalifeinc.comLubbock, TXno42018
bioRxiv preprint
2019-07-17the microfluidics approach distinguishes this from some other worm automation work, eg allowing automated removal of offspring to allow focus on the aging adult worms
93
NeuroTrackonly
brain
operatingeye-tracking cognitive (esp. memory) 5min test & multimodal lifestyle digital intervention programcommercial?Dx, TxbiomarkersMCI3mobile appreg Dx?Elli Kaplan, Nick Bott, Jordan GlennJohn Harrison, Richard Isaacson, Dorene Rentz, Mike Poolesupport@neurotrack.comSan Franciscono432012raised CFounders Fund, Khosla, Marc Benioff, Social Capital, Sozo Ventures50Imprint Memory Assessmenthttps://aging.jmir.org/2018/2/e12031/2019-07-22
94
Newomics
maybe
operatingmicrofluidics platform based on new emitter for improved LC-MS for multi-omicscommercialDxbiomarkers, senescencesenescencesenescenceAD, T2DDaojing Wang, Doug Henry, Frank Slovenec, Pan Mao
Michael MacCoss, Jonathan Sweedler, Glenn Takayama
info@newomics.com
San Francisco
no152013raised seed
Berkeley Catalyst, Photon
3.9QB3
M3 Emitters, MEA Chip, Senescence Chip
several; notably for aging the senescence chip paper: https://www.ncbi.nlm.nih.gov/pubmed/?term=293361052019-12-252019-12-27Broader technology platform than aging. But the only specific diagnostics mentioned on about page were all aging related: diabetes, Alzheimer's, & senescent cells tests. Conclusion: include for now but re-evaluate later to see if non-aging is majority of the business.
95
Nuchidoyesoperatingnutraceutical for NAD+ w/o NR, includes regulators of pathways that make/lower NAD+pre-commercialTxNAD+nutraceuticalssupplementNichola ConlonTom KirkwoodNewcastle, UKno52017DeepbridgeTime Capsuleposter2019-08-09List of ingredients does not seem to be available yet.
96
NuSirtyesoperatingsupplements + existing drugs for low-cost discovery, targeting sirtuins (esp. Sirt1) for metabolic diseasesph.2 trialsTxmetabolismnutri-senseNAFLD, NASH, T2D, obesity, hypertension4small molecules,
nutraceuticals
pharma,
supplement
Joseph Cook, Michael Zemel, Barbara CannonAlan Cherrington, Zan Fleming, Orville Kolterman, Mary Rinella, Naga Chalasani
Info@NuSirt.com
Knoxville, TN
no32007
raised C
16NS-0100several papers2020-10-122020-10-12
97
Oisin Bio (& OncoSenX)yesoperatingtargeted non-viral gene therapy based on DNA expression, for senescent cells & cancer (via spinout)pre-clinicalTxsenescence, DNA,
targeted elimination
senescence, DNAsenescence, cancercancer (all solids), more TBDnon-viral gene therapypharmaMatt Scholz, Gary Hudson, John LewisformSeattleno122014closed seedMethuselah, Kizoo3Entos Pharmaceuticals2019-07-31Spun out OncoSenX for cancer (not on this list since devoted only to cancer, but for the purposes of this list the 2 companies are best considered as one).
98
OneSkin Technologiesyesoperatingscreening platform using 3D human skin culture & skin age clock, 1st therapy a topical senolytic peptidepre-clinicalTxsenescencesenescencesenescencepeptide for topical usereg cosmeticCarolina Oliveira, Andres Ochoa, Alessandra Zonari, Mariana Boroniinformation@oneskintech.comSan Franciscono102016raised seedSOSV/IndieBio2.2QB3OS-1, OS-22019-08-02
99
OpenCures
(was OpenOme)
yesoperatingDTC metabolomics & proteomics tests; plasmalogen supplementcommercial (limited early access)Dxbiomarkersblood testunreg testKevin Perrott, Mark Hamalainen, Chandra Duggirala
Aubrey de Grey, Nathan Price, Jim O'Neill, Lei Ding, Christine Peterson, Michael MacCoss
contact@opencures.orgSan Franciscono120182020-04-28
100
Osiris Greenyesdefunct?DTC methylation clock, but probably gone nowcommercialDxbiomarkers / methylome clockepigeneticblood test or urine testunreg testNeil CopesformTampa, FL?no120162020-01-06Probably out of business: As of July 2019 website wasn't accepting orders. As of Jan 2020, website no longer exists. Founder Copes' LinkedIn page doesn't suggest a newer job yet though.