Conditional power assessment
 Share
The version of the browser you are using is no longer supported. Please upgrade to a supported browser.Dismiss

 
$
%
123
 
 
 
 
 
 
 
 
 
 
ABCDEFGHIJKLMNOPQRSTUVWXYZ
1
Conditional Power Assessment for Binomial Event
2
3
Study Planning Parameters
4
False Postive Rate (Alpha) =5.00%
5
False Negative Rate (Beta) =20.00%
6
 1 sided/2 sided test =2
7
% Randomized to Arm with Higher event rate =50.00%
8
Higher Event Arm (ARM A) Rate =60.00%
9
Lower Event Arm (ARM B) Rate =45.00%
10
Sample Size in Higher Event Rate Group =171
11
Sample Size in Lower Event Rate Group =171
12
Expected value of Final Test Statistic under alternate hypothesis =2.802
13
14
Interim Results
15
Interim Sample in ARM A =60
16
Number of Events in ARM A =37
17
Interim Sample in ARM B =62
18
Number of Events in ARM B =31
19
Interim Estimated Test Statistic =1.307
20
B-value at Interim =0.781
21
22
Frequentist Conditional Power
23
Information Fraction at Interim =0.358
24
Projected Expected value of Final Test Statistic given B-value at Interim on assuming null hypothesis effect =0.781
25
Conditional Power Under Null Effect =7.07%
26
Projected Expected value of Final Test Statistic given B-vallue at Interim on assuming current trend continues =2.185
27
Conditional Power Under Current Trend =61.06%
28
Projected Expected value of Final Test Statistic given B-vallue at Interim on assuming future alternate hypothesis effects =2.581
29
Conditional Power Under Alternate =78.08%
30
31
Bayesian Predictive Power
32
Weight on Prior Hypothesized Opinion =20.00%
33
Predictive Power =63.21%
34
Predictive Power under a weight of 100*(1-information fraction) =72.85%
35
36
37
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
88
89
90
91
92
93
94
95
96
97
98
99
100
101
102
103
104
105
106
107
108
109
110
111
112
113