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Notes/Potential SolutionsPros by HelpingCons Trying to HelpLink1Link2Global Deaths/Year [1,12]US Deaths/YearCost per DALY Min [2]Cost per DALY Max [2]Cost per Life Year Saved [3,4]
U.S. Median Base Salary (Adjusted) [6]
Bryan Caplan [7]
Robert Wright
Michael Shermer
Elon Musk [5]
Michael Huemer [8,9,10]
Bill Gates [11]
Bret Weinstein [13]
2
Death56,000,0002,626,418
3
AgingAubrey de Grey, Basis, Calico, immunotherapyArgument by Harris that ending aging might get rid of fatalism/nihilism/short-term thinking36,135,00013
4
Heart DiseaseAge-adjusted death rates going down [Link1]https://radicaloptimism.org/wiki/Death#Heart_Disease17,519,301
5
CancerAge-adjusted death rates going down [Link1]https://radicaloptimism.org/wiki/Death#Cancer8,206,214
6
Heart Disease (Ischaemic)7,356,061
7
Heart Disease (Stroke)6,670,934
8
Respiratory Disease (Pulmonary)3,104,330
9
Cancer (Trachea/Bronchus/Lung)1,599,557
10
Heart Disease (Other)1,541,476
11
HIV/AIDShttp://www.givewell.org/international/technical/programs/PMTCThttp://www.givewell.org/international/technical/programs/ART1,533,760
12
Diarrhoeal Diseases1,497,724
13
Diabetes1,497,371
14
Road InjuriesDeath rates going down [Link1]https://radicaloptimism.org/wiki/Death#Transportation1,254,526
15
Cancer (Other)1,164,756
16
Heart Disease (Hypertensive)1,141,205
17
Preterm Birth Complications1,134,954
18
Cirrhosis of the Liver1,020,891
19
Other Digestive Diseases940,721
20
Tuberculosishttp://www.givewell.org/international/technical/programs/DOTS934,879
21
Other Injuries932,484
22
Kidney Disease864,226
23
Suicide/Self-Harm803,900
24
Birth asphyxia and birth trauma
743,908
25
Cancer (Liver)740,373
26
Cancer (Stomach)733,499
27
Cancer (Colon/Rectum)723,913
28
Alzheimer's Disease/Dementia700,834
29
Falls693,131
30
Other Infectious Diseases663,507
31
MalariaDeath rates going down [Link2]http://www.givewell.org/international/technical/programs/malaria-treatmenthttps://radicaloptimism.org/wiki/Death#Malaria618,248
32
Respiratory Disease (Other)551,425
33
Cancer (Breast)536,521
34
Murder504,587
35
Heart Disease (Cardiomyopathy/Myocarditis/Endocarditis)472,290
36
Neonatal sepsis and infections
431,067
37
Endocrine/Blood/Immune Disorders410,518
38
Cancer (Oesophagus)405,803
39
Meningitis395,230
40
Respiratory Disease (Asthma)386,318
41
Other Neurological Disorders376,294
42
Drowning372,442
43
Heart Disease (Rheumatic)337,335
44
Cancer (Pancreas)331,918
45
Cancer (Prostate)321,728
46
Cancer (Lymphoma/Myeloma)312,302
47
Cancer (Mouth/Oropharynx)298,027
48
Maternal Conditions296,002
49
Other Genitourinary Diseases
285,252
50
Cancer (Leukaemia)276,097
51
Fire/Heat/Hot Substances267,889
52
Cancer (Cervix Uteri)264,225
53
Peptic Ulcer262,911
54
Congenital Heart Anomalies230,240
55
Epilepsy204,825
56
Poisoning193,460
57
Other Congenital Anomalies191,941
58
Cancer (Bladder)172,813
59
Cancer (Ovary)151,039
60
Hepatitus B149,164
61
Other Musculoskeletal Disorders
142,150
62
Measles130,461
63
Government Violence119,463
64
Parkinson's Disease119,282
65
Skin Diseases111,178
66
Alcoholism107,261
67
Cancer (Melanoma)94,973
68
Drug Overdose93,255
69
Neural Tube Defects87,527
70
Sexually Transmitted Diseases84,274
71
Cancer (Corpus Uteri)78,670
72
Encephalitis77,869
73
Arthritis70,157
74
Whooping Cough67,059
75
Tetanus66,129
76
Leishmaniasis48,404
77
Appendicits39,551
78
Hepatitus C38,914
79
Rabies35,410
80
Urolithiasis31,453
81
Dengue28,755
82
Schistosomiasis21,797
83
Down's Syndrome19,135
84
Multiple Sclerosis19,051
85
Trypanosomiasis17,971
86
Neonatal conditions (other)9,138
87
Eating Disorders9,118
88
Chagas Disease7,806
89
Leprosy7,790
90
Cleft Lip/Palate4,368
91
Roundworm (Ascariasis)3,302
92
Diphtheria2,615
93
3D PrintingBio-3D Printing for medicineshttp://foundrygroup.com/blog/2016/08/our-investment-in-formlabs/
94
Acid Rain
95
Actuary$99,507
96
Adult DevelopmentHelp adults find happiness (e.g. School of Life). Opportunity in education and re-education. People switching from dead end positions and career. Probably lots of changes coming due to roboticshttp://www.theschooloflife.com/
97
AdvocacyPromoting Effective Altruismhttps://80000hours.org/career-guide/high-impact-jobs/
98
Aerospace
99
AgricultureNeed continuing yield increases
100
Alienation
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