生化所106-1專題討論
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A Dietary Fiber-Deprived Gut Microbiota Degrades the Colonic Mucus Barrier and Enhances Pathogen Susceptibility.
Cell. 2016 Nov 17;167(5):1339-1353.e21.
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A Eukaryote without a Mitochondrial Organelle.
Curr Biol. 2016 May 23;26(10):1274-84.
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A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome.
Mol Cell. 2017 Jan 19;65(2):347-360.
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A molecular signature for anastasis, recovery from the brink of apoptotic cell death. J Cell Biol. 2017 Aug 2. pii: jcb.201706134.
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A PGC1α-mediated transcriptional axis suppresses melanoma metastasis.
Nature. 2016 Aug 31;537(7620):422-426.
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6
A recellularized human colon model identifies cancer driver genes.
Nat Biotechnol. 2016 Aug;34(8):845-51.
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A regulated PNUTS mRNA to lncRNA splice switch mediates EMT and tumour progression.
Nat Cell Biol. 2017 Sep;19(9):1105-1115.
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A regulated PNUTS mRNA to lncRNA splice switch mediates EMT and tumour progression.
Nat Cell Biol. 2017 Sep;19(9):1105-1115.
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A thiamin-utilizing ribozyme decarboxylates a pyruvate-like substrate.
Nat Chem. 2013 Nov;5(11):971-7.
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A two-photon fluorescent sensor revealing drug-induced liver injury via tracking γ-glutamyltranspeptidase (GGT) level in vivo.
Biomaterials. 2016 Feb;80:46-56. doi: 10.1016/j.biomaterials.2015.11.047. Epub 2015 Dec 2.
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A20 promotes metastasis of aggressive basal-like breast cancers through multi-monoubiquitylation of Snail1.
Nat Cell Biol. 2017 Oct;19(10):1260-1273.
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Acetyl CoA Carboxylase Inhibition Reduces Hepatic Steatosis but Elevates Plasma Triglycerides in Mice and Humans: A Bedside to Bench Investigation.
Cell Metab. 2017 Sep 5;26(3):576.
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Acetylation-regulated interaction between p53 and SET reveals a widespread regulatory mode.
Nature. 2016 Sep 14;538(7623):118-122.
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Acidosis Drives the Reprogramming of Fatty Acid Metabolism in Cancer Cells through Changes in Mitochondrial and Histone Acetylation.
Cell Metab. 2016 Aug 9;24(2):311-23.
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Activation of HIPK2 Promotes ER Stress-Mediated Neurodegeneration in Amyotrophic Lateral Sclerosis.
Neuron. 2016 Jul 6;91(1):41-55.
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AKT-phosphorylated FOXO1 suppresses ERK activation and chemoresistance by disrupting IQGAP1-MAPK interaction.
EMBO J. 2017 Apr 13;36(8):995-1010.
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ALS-Causing Mutations Significantly Perturb the Self-Assembly and Interaction with Nucleic Acid of the Intrinsically Disordered Prion-Like Domain of TDP-43.
PLoS Biol. 2016 Jan 6;14(1):e1002338.
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Alzheimer's disease-associated mutations increase amyloid precursor protein resistance to γ-secretase cleavage and the Aβ42/Aβ40 ratio.
Cell Discov. 2016 Aug 23;2:16026.
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Amyloid-like Self-Assembly of a Cellular Compartment.
Cell. 2016 Jul 28;166(3):637-50.
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An Atlas of β-Glucuronidases in the Human Intestinal Microbiome.
Structure. 2017 Jul 5;25(7):967-977.e5.
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An ID2-dependent mechanism for VHL inactivation in cancer.
Nature. 2016 Jan 14;529(7585):172-7.
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An obligatory role for neurotensin in high-fat-diet-induced obesity.
Nature. 2016 May 11;533(7603):411-5.
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Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrophages.
Science. 2017 May 5;356(6337):513-519.
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Antibodies Against Specific MUC16 Glycosylation Sites Inhibit Ovarian Cancer Growth.
ACS Chem Biol. 2017 Aug 18;12(8):2085-2096.
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Autogenous Control of 5′TOP mRNA Stability by 40S Ribosomes.
Mol Cell. 2017 Jul 6;67(1):55-70.e4.
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Autophagy Promotes Focal Adhesion Disassembly and Cell Motility of Metastatic Tumor Cells through the Direct Interaction of Paxillin with LC3.
Cell Rep. 2016 May 24;15(8):1660-72.
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Backbone NMR reveals allosteric signal transduction networks in the β1-adrenergic receptor.
Nature. 2016 Feb 11;530(7589):237-41.
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Bile Acids Protect Expanding Hematopoietic Stem Cells from Unfolded Protein Stress in Fetal Liver.
Cell Stem Cell. 2016 Apr 7;18(4):522-32.
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Bioengineering Bacterially Derived Immunomodulants: A Therapeutic Approach to Inflammatory Bowel Disease.
ACS Nano. 2017 Sep 5.
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Body Temperature Cycles Control Rhythmic Alternative Splicing in Mammals.
Mol Cell. 2017 Aug 3;67(3):433-446.e4.
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Broad Anti-tumor Activity of a Small Molecule that Selectively Targets the Warburg Effect and Lipogenesis.
Cancer Cell. 2015 Jul 13;28(1):42-56.
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Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Function.
Mol Cell. 2017 May 18;66(4):517-532.e9.
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C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector.
Science. 2016 Aug 5;353(6299):aaf5573.
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Caloric Restriction Promotes Structural and Metabolic Changes in the Skin.
Cell Rep. 2017 Sep 12;20(11):2678-2692.
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Carbohydrate-Neuroactive Hybrid Strategy for Metabolic Glycan Engineering of the Central Nervous System in Vivo.
J Am Chem Soc. 2017 Jan 18;139(2):693-700.
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Cell-targetable DNA nanocapsules for spatiotemporal release of caged bioactive small molecules.
Nat Nanotechnol. 2017 Aug 21.
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Cellular Cholesterol Directly Activates Smoothened in Hedgehog Signaling.
Cell. 2016 Aug 25;166(5):1176-1187.e14.
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Centrosome Amplification Is Sufficient to Promote Spontaneous Tumorigenesis in Mammals.
Dev Cell. 2017 Feb 6;40(3):313-322.e5.
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Chromatin Kinases Act on Transcription Factors and Histone Tails in Regulation of Inducible Transcription.
Mol Cell. 2016 Oct 20;64(2):347-361.
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Coincident Phosphatidic Acid Interaction Restrains Drp1 in Mitochondrial Division.
Mol Cell. 2016 Sep 15;63(6):1034-43.
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Compounds Triggering ER Stress Exert Anti-Melanoma Effects and Overcome BRAF Inhibitor Resistance.
Cancer Cell. 2016 Jul 11;30(1):183.
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Confinement and low adhesion induce fast amoeboid migration of slow mesenchymal cells.
Cell. 2015 Feb 12;160(4):659-72.
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Converting Adult Pancreatic Islet α Cells into β Cells by Targeting Both Dnmt1 and Arx.
Cell Metab. 2017 Mar 7;25(3):622-634.
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CRY1/2 Selectively Repress PPARδ and Limit Exercise Capacity.
Cell Metab. 2017 Jul 5;26(1):243-255.e6.
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Cytoplasmic protein aggregates interfere with nucleocytoplasmic transport of protein and RNA.
Science. 2016 Jan 8;351(6269):173-6.
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Deficiency of Parkinson's disease-related gene Fbxo7 is associated with impaired mitochondrial metabolism by PARP activation.
Cell Death Differ. 2016 Sep 30.
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Deposition of 5-Methylcytosine on Enhancer RNAs Enables the Coactivator Function of PGC-1α.
Cell Rep. 2016 Jan 26;14(3):479-92.
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Development of DNA Nanostructures for High-Affinity Binding to Human Serum Albumin.
J Am Chem Soc. 2017 May 31;139(21):7355-7362.
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Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase.
Nat Chem Biol. 2017 Jun;13(6):624-632.
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Differential Requirements for eIF4E Dose in Normal Development and Cancer.
Cell. 2015 Jul 2;162(1):59-71.
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Direct Pharmacological Targeting of a Mitochondrial Ion Channel Selectively Kills Tumor Cells In Vivo.
Cancer Cell. 2017 Apr 10;31(4):516-531.e10.
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Discovery of Cell-Type-Specific and Disease-Related Enzymatic Activity Changes via Global Evaluation of Peptide Metabolism.
J Am Chem Soc. 2017 Mar 8;139(9):3465-3472.
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DNA-PK Promotes the Mitochondrial, Metabolic, and Physical Decline that Occurs During Aging.
Cell Metab. 2017 May 2;25(5):1135-1146.e7.
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DNMT3b Modulates Melanoma Growth by Controlling Levels of mTORC2 Component RICTOR.
Cell Rep. 2016 Mar 8;14(9):2180-92.
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Drug sensitivity of single cancer cells is predicted by changes in mass accumulation rate.
Nat Biotechnol. 2016 Nov;34(11):1161-1167.
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Dub3 inhibition suppresses breast cancer invasion and metastasis by promoting Snail1 degradation.
Nat Commun. 2017 Feb 15;8:14228.
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Dynein Binding of Competitive Regulators Dynactin and NudE Involves Novel Interplay Between Phosphorylation Site and Disordered Spliced Linkers.
Structure. 2017 Jan 31.
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Ect2-Dependent rRNA Synthesis Is Required for KRAS-TRP53-Driven Lung Adenocarcinoma.
Cancer Cell. 2017 Feb 13;31(2):256-269.
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Efficient introduction of specific homozygous and heterozygous mutations using CRISPR/Cas9.
Nature. 2016 May 5;533(7601):125-9.
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EglN2 associates with the NRF1-PGC1α complex and controls mitochondrial function in breast cancer.
EMBO J. 2015 Dec 2;34(23):2953-70.
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eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation.
Nature. 2016 Aug 4;536(7614):96-9.
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Electromagnetized gold nanoparticles mediate direct lineage reprogramming into induced dopamine neurons in vivo for Parkinson's disease therapy.
Nat Nanotechnol. 2017 Jul 17.
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Enhancer Reprogramming Promotes Pancreatic Cancer Metastasis.
Cell. 2017 Aug 24;170(5):875-888.e20.
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Epigenetic gene regulation by Janus kinase 1 in diffuse large B-cell lymphoma.
Proc Natl Acad Sci U S A. 2016 Nov 15;113(46):E7260-E7267.
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EPRS is a critical mTORC1-S6K1 effector that influences adiposity in mice.
Nature. 2017 Feb 16;542(7641):357-361.
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Estrogen Receptor α Promotes Breast Cancer by Reprogramming Choline Metabolism.
Cancer Res. 2016 Oct 1;76(19):5634-5646.
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Fascin Regulates Nuclear Movement and Deformation in Migrating Cells.
Dev Cell. 2016 Aug 22;38(4):371-83.
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Fatty acid synthesis configures the plasma membrane for inflammation in diabetes.
Nature. 2016 Nov 10;539(7628):294-298.
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Feedback modulation of cholesterol metabolism by the lipid-responsive non-coding RNA LeXis.
Nature. 2016 May 11;534(7605):124-8.
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Galectin-3 Binding Protein and Galectin-1 Interaction in Breast Cancer Cell Aggregation and Metastasis.
J Am Chem Soc. 2015 Aug 5;137(30):9685-93.
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Galectin-3 directs antimicrobial guanylate binding proteins to vacuoles furnished with bacterial secretion systems.
Proc Natl Acad Sci U S A. 2017 Feb 28;114(9):E1698-E1706.
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Genetic Depletion of Adipocyte Creatine Metabolism Inhibits Diet-Induced Thermogenesis and Drives Obesity.
Cell Metab. 2017 Oct 3;26(4):693.
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Glycolipid GD3 and GD3 synthase are key drivers for glioblastoma stem cells and tumorigenicity.
Proc Natl Acad Sci U S A. 2016 May 17;113(20):5592-7.
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Glycosylation-Dependent IFN-γR Partitioning in Lipid and Actin Nanodomains Is Critical for JAK Activation.
Cell. 2016 Aug 11;166(4):920-34.
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GRID-seq reveals the global RNA-chromatin interactome.
Nat Biotechnol. 2017 Sep 18.
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Guided self-organization and cortical plate formation in human brain organoids.
Nat Biotechnol. 2017 Jul;35(7):659-666.
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Heat shock protein 47 and 65-kDa FK506-binding protein weakly but synergistically interact during collagen folding in the endoplasmic reticulum.
J Biol Chem. 2017 Oct 20;292(42):17216-17224.
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Hepatic B cell leukemia-3 promotes hepatic steatosis and inflammation through insulin-sensitive metabolic transcription factors.
J Hepatol. 2016 Dec;65(6):1188-1197.
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Heterogeneous Ribosomes Preferentially Translate Distinct Subpools of mRNAs Genome-wide.
Mol Cell. 2017 Jul 6;67(1):71-83.e7.
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High-Density Lipoproteins Exert Pro-inflammatory Effects on Macrophages via Passive Cholesterol Depletion and PKC-NF-κB/STAT1-IRF1 Signaling.
Cell Metab. 2017 Jan 10;25(1):197-207.
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Histone Degradation in Response to DNA Damage Enhances Chromatin Dynamics and Recombination Rates.
Nat Struct Mol Biol 24 (2), 99-107. 2017 Jan 09.
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Human BRCA1-BARD1 ubiquitin ligase activity counteracts chromatin barriers to DNA resection.
Nat Struct Mol Biol. 2016 Jul;23(7):647-55.
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Id2 and E Proteins Orchestrate the Initiation and Maintenance of MLL-Rearranged Acute Myeloid Leukemia.
Cancer Cell. 2016 Jul 11;30(1):59-74.
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Impaired JIP3-dependent axonal lysosome transport promotes amyloid plaque pathology.
J Cell Biol. 2017 Aug 7. pii: jcb.201612148.
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In vivo formation of vacuolated multi-phase compartments lacking membranes.
Cell Rep. 2016 Aug 2; 16(5): 1228–1236.
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Increased localization of APP-C99 in mitochondria-associated ER membranes causes mitochondrial dysfunction in Alzheimer disease.
EMBO J. 2017 Oct 10. pii: e201796797.
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Inhibiting Drivers of Non-mutational Drug Tolerance Is a Salvage Strategy for Targeted Melanoma Therapy.
Cancer Cell. 2016 Mar 14;29(3):270-84.
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Insulin post-transcriptionally modulates Bmal1 protein to affect the hepatic circadian clock.
Nat Commun. 2016 Aug 31;7:12696.
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Integrins Form an Expanding Diffusional Barrier that Coordinates Phagocytosis.
Cell. 2016 Jan 14;164(1-2):128-40.
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Intestinal Autophagy Improves Healthspan and Longevity in C. elegans during Dietary Restriction.
PLoS Genet. 2016 Jul 14;12(7):e1006135.
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Intrinsic Autophagy Is Required for the Maintenance of Intestinal Stem Cells and for Irradiation-Induced Intestinal Regeneration.
Cell Rep. 2017 Aug 1;20(5):1050-1060.
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Lactate dehydrogenase activity drives hair follicle stem cell activation.
Nat Cell Biol. 2017 Sep;19(9):1017-1026.
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Lactate Dehydrogenase B Controls Lysosome Activity and Autophagy in Cancer.
Cancer Cell. 2016 Sep 12;30(3):418-31.
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LACTB is a tumour suppressor that modulates lipid metabolism and cell state.
Nature. 2017 Mar 30;543(7647):681-686.
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LD Motif Recognition by Talin: Structure of the Talin-DLC1 Complex.
Structure. 2016 Jul 6;24(7):1130-41.
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LIN28 phosphorylation by MAPK/ERK couples signalling to the post-transcriptional control of pluripotency.
Nat Cell Biol. 2017 Jan;19(1):60-67.
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Lipid Biosynthesis Coordinates a Mitochondrial-to-Cytosolic Stress Response.
Cell. 2016 Sep 8;166(6):1539-1552.e16.
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Liquid droplet formation by HP1α suggests a role for phase separation in heterochromatin.
Nature. 2017 Jul 13;547(7662):236-240.
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Local regulation of gene expression by lncRNA promoters, transcription and splicing.
Nature. 2016 Nov 17;539(7629):452-455.
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Locally Induced Adipose Tissue Browning by Microneedle Patch for Obesity Treatment.
ACS Nano. 2017 Sep 26;11(9):9223-9230.
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