RESEARCH - Genetics of CIRS & Other Disease States
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REFERENCES & SOURCES
LEAD AUTHOR
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Shoemaker, R. (2010). Surviving Mold - Life in the era of dangerous buildings. Otter Bay Press. / Lab tests for Mold Illness. (n.d.). https://www.survivingmold.com/diagnosis/lab-tests
Caleb Ruddcalebrudd.com
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Shoemaker, R. (2015). State of the art answers to 500 mold questions. Surviving Mold.
Toxic Mould Support Australia
www.toxicmould.org
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HLA-DR haplotype definitions. (n.d.). https://myhousemakesmesick.com/hlacalc/details.php
CONTRIBUTORS
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Mehra, N (Ed). (2010). The HLA complex in biology and medicine - a resource book. Jaypree Brothers medical publishers.
Adam Glass
myhousemakesmesick.com
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Dr. Shoemaker nomenclatureUpdated nomenclature
Dr. Shoemaker (Surviving Mold/500)
Peer reviewed scientific literature
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DRB1DQB1DRB3DRB4DRB5DRB1DQB1DRB3DRB4DRB5CIRS SusceptibilitySusceptibilityPMIDSusceptibilityPMIDSusceptibilityPMID
Susceptibility
PMIDProtectionPMIDProtectionPMID
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13UC9178675Crohn's15626888RA16126967MSPMC1971120
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14""
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15
Low MSH (compared to controls & CIRS)
"Psoriasis15908298"Addison's11836294
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18"Addison's11836294""
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4353Multi-susceptible, CFSRAPMC130004Celiac (DQ8)28585303
Lyme arthritis (refract. to antibiotics)
PMC3106239T1D
Erlich et al., 2008
PDPMC3824116
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AD25651370SIRS/Sepsis
Eglite et al., 2014
"T1D (HER VK)8891733
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Addison's11836294Lyme borreliosisPMC3470953"
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Alopecia areataPMC6133534ASDPMC5071356"
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4453RA, Alopecia, ASDSee above"
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4753Dinoflagellates*"
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4853Dinoflagellates*"
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7253MoldCeliac24628273MS21440682
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7353"Psoriasis15908298SIRS/sepsis
Eglite et al., 2014
T1D
Erlich et al., 2008
"
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7453"
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7953Low-risk mold"
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83
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84T1D
Erlich et al., 2008
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85
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86Narcolpesy, daytime sleepiness, fragmented sleepPMC2974463
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9253
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9353
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9753
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9953Low-risk mold
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105
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11352BMulti-susceptible, CFS, Gardasil induced CFS, High TGF-b1Sarcoidosis19382531Post-Q-fever fatigue syndromeHelbig et al., 2005Hashimoto's6947505MS17845076Borrelia (protective Ab response - Mice)PMC2775539
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11452B"""""
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11552B"""""
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11752BMARCoNS"""""
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11852B"""""
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12352BAs per 11-3-52BHashimoto's6947505
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12552B""
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12752BLow-risk mold
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13352A01
Multi-susceptible (500 mold, #177)
SLE, Psoriasis, RA, SSc, MS, MG etc
PMC4641944
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13352B02""
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13652AMoldCFS (weak assoc)PMC1770867Narcolpesy, daytime sleepiness, fragmented sleepPMC2974463"
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13652B""""
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13652C03""""
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13752A"
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13752B"
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13752C"
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14352BSLE
Furukawa et al., 2014
MS17845076
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14552BMulti-susceptibleT1D
Erlich et al., 2008
"
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14752B
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15551MSSee commentAspergillosis15709450SLE
Furukawa et al., 2014
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15651Borrelia/PLS" & MS17329717Narcolpesy, daytime sleepiness, fragmented sleepPMC2974463AD25651370"T1D
Erlich et al., 2008
""
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"PMC5369701
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Lyme arthtitisPMC3106239PDPMC3824116
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"PMC3696507
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16551"MS & ""Alopecia areataPMC6133534
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16651"
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17252A3MoldMS, Lyme borreliosisSee commentsCeliac (DQ2.5)28585303T1D, Sjogren's, Addison's, Graves', RosaceaSee commentSLESee commentAlopecia areataPMC6133534
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17252B"""""""
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17252C""21440682""""
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17352A"""
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17352B"""
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17352C"""
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17452A"""
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17452B"""
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18452AMold
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If no label, haplotype is considered benign
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KEYCaveats
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SLE
Systemic Lupus Erythematosus (Lupus)
*4-7/8-53 was originally Dinoflagellate susceptible. In email communication to another physician Dr. Shoemaker said it had became multi-susceptible but as this is not published, I decided not to update (I know Adam has it as multi in HLA DR calculator)
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RA
Rheumatoid Arthritis
Many studies look at single genes only and not haplotypes (connected gene sets), usually HLA-DRB1. Thus not all susceptiblities listed will match every haplotype. There are also subtypes of each HLA.
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SSc
Systemic Sclerosis
Different races/ethnicities will have different HLA risk. Most studies are based on Caucasian/European populations
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MS
Multiple Sclerosis
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MG
Myasthenia gravis
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T1D
Type 1 diabetes
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PD
Parkinson's disease
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AD
Alzheimer's disease
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PLS
Post-Lyme Syndrome
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ASD
Autism Spectrum Disorder
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