RESEARCH - Genetics of CIRS & Other Disease States

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1	REFERENCES & SOURCES															LEAD AUTHOR
2	Shoemaker, R. (2010). Surviving Mold - Life in the era of dangerous buildings. Otter Bay Press. / Lab tests for Mold Illness. (n.d.). https://www.survivingmold.com/diagnosis/lab-tests															Caleb Rudd	calebrudd.com
3	Shoemaker, R. (2015). State of the art answers to 500 mold questions. Surviving Mold.															Toxic Mould Support Australia	www.toxicmould.org
4	HLA-DR haplotype definitions. (n.d.). https://myhousemakesmesick.com/hlacalc/details.php															CONTRIBUTORS
5	Mehra, N (Ed). (2010). The HLA complex in biology and medicine - a resource book. Jaypree Brothers medical publishers.															Adam Glass	myhousemakesmesick.com
6
7	Dr. Shoemaker nomenclature					Updated nomenclature					Dr. Shoemaker (Surviving Mold/500)	Peer reviewed scientific literature
8	DRB1	DQB1	DRB3	DRB4	DRB5	DRB1	DQB1	DRB3	DRB4	DRB5	CIRS Susceptibility	Susceptibility	PMID	Susceptibility	PMID	Susceptibility	PMID	Susceptibility	PMID	Protection	PMID	Protection	PMID
9	1	3										UC	9178675			Crohn's	15626888	RA	16126967	MS	PMC1971120
10	1	4										"								"
11	1	5									Low MSH (compared to controls & CIRS)	"				Psoriasis	15908298			"		Addison's	11836294
12	1	8										"				Addison's	11836294			"		"
13	4	3		53							Multi-susceptible, CFS	RA	PMC130004	Celiac (DQ8)	28585303	Lyme arthritis (refract. to antibiotics)	PMC3106239	T1D	Erlich et al., 2008	PD	PMC3824116
14												AD	25651370	SIRS/Sepsis	Eglite et al., 2014	"		T1D (HER VK)	8891733
15												Addison's	11836294	Lyme borreliosis	PMC3470953	"
16												Alopecia areata	PMC6133534	ASD	PMC5071356	"
17	4	4		53								RA, Alopecia, ASD	See above			"
18	4	7		53							Dinoflagellates*	"
19	4	8		53							Dinoflagellates*	"
20	7	2		53							Mold	Celiac	24628273									MS	21440682
21	7	3		53							"	Psoriasis	15908298	SIRS/sepsis	Eglite et al., 2014					T1D	Erlich et al., 2008	"
22	7	4		53																		"
23	7	9		53							Low-risk mold											"
24	8	3
25	8	4										T1D	Erlich et al., 2008
26	8	5
27	8	6										Narcolpesy, daytime sleepiness, fragmented sleep	PMC2974463
28	9	2		53
29	9	3		53
30	9	7		53
31	9	9		53							Low-risk mold
32	10	5
33	11	3	52B								Multi-susceptible, CFS, Gardasil induced CFS, High TGF-b1	Sarcoidosis	19382531			Post-Q-fever fatigue syndrome	Helbig et al., 2005	Hashimoto's	6947505	MS	17845076	Borrelia (protective Ab response - Mice)	PMC2775539
34	11	4	52B									"				"		"		"		"
35	11	5	52B									"				"		"		"		"
36	11	7	52B								MARCoNS	"				"		"		"		"
37	11	8	52B									"				"		"		"		"
38	12	3	52B								As per 11-3-52B	Hashimoto's	6947505
39	12	5	52B									"	"
40	12	7	52B								Low-risk mold
41	13	3	52A					01			Multi-susceptible (500 mold, #177)									SLE, Psoriasis, RA, SSc, MS, MG etc	PMC4641944
42	13	3	52B					02			"									"
43	13	6	52A								Mold	CFS (weak assoc)	PMC1770867			Narcolpesy, daytime sleepiness, fragmented sleep	PMC2974463			"
44	13	6	52B								"	"				"				"
45	13	6	52C					03			"	"				"				"
46	13	7	52A																	"
47	13	7	52B																	"
48	13	7	52C																	"
49	14	3	52B																	SLE	Furukawa et al., 2014	MS	17845076
50	14	5	52B								Multi-susceptible									T1D	Erlich et al., 2008	"
51	14	7	52B
52	15	5			51							MS	See comment					Aspergillosis	15709450			SLE	Furukawa et al., 2014
53	15	6			51						Borrelia/PLS	" & MS	17329717	Narcolpesy, daytime sleepiness, fragmented sleep	PMC2974463	AD	25651370	"		T1D	Erlich et al., 2008	"	"
54																"	PMC5369701
55												Lyme arthtitis	PMC3106239			PD	PMC3824116
56																"	PMC3696507
57	16	5			51						"	MS & "	"			Alopecia areata	PMC6133534
58	16	6			51											"
59	17	2	52A			3					Mold	MS, Lyme borreliosis	See comments	Celiac (DQ2.5)	28585303	T1D, Sjogren's, Addison's, Graves', Rosacea	See comment	SLE	See comment	Alopecia areata	PMC6133534
60	17	2	52B			"					"	"		"		"		"		"
61	17	2	52C			"						"	21440682	"		"		"		"
62	17	3	52A			"						"								"
63	17	3	52B			"						"								"
64	17	3	52C			"						"								"
65	17	4	52A			"						"								"
66	17	4	52B			"						"								"
67	18	4	52A								Mold
68											If no label, haplotype is considered benign
69
70	KEY										Caveats
71	SLE	Systemic Lupus Erythematosus (Lupus)									*4-7/8-53 was originally Dinoflagellate susceptible. In email communication to another physician Dr. Shoemaker said it had became multi-susceptible but as this is not published, I decided not to update (I know Adam has it as multi in HLA DR calculator)
72	RA	Rheumatoid Arthritis									Many studies look at single genes only and not haplotypes (connected gene sets), usually HLA-DRB1. Thus not all susceptiblities listed will match every haplotype. There are also subtypes of each HLA.
73	SSc	Systemic Sclerosis									Different races/ethnicities will have different HLA risk. Most studies are based on Caucasian/European populations
74	MS	Multiple Sclerosis
75	MG	Myasthenia gravis
76	T1D	Type 1 diabetes
77	PD	Parkinson's disease
78	AD	Alzheimer's disease
79	PLS	Post-Lyme Syndrome
80	ASD	Autism Spectrum Disorder
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