Travis's Nootropics
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NameCommon PositivesCommon NegativesLow Daily DoseHigh Daily DoseComments - ROA/InteractionsComments - Mode of Action Comments - OtherLink/Info
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Acetyl-L-TyrosineMore bioavailable than L-TyrosineOften comes with folate
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Alpha GPCCounteracts Racetam headaches and brainfog. Boosts HGH levels.300mgProbably only need one choline source. Better bioavailabilityExpensive
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Alpha Lipoic AcidReduces oxidative damage caused by ALCAR, recycles vitamin C100mg300mgAble to cross the BBB.
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BacopaLong-term benefits to Memory (increase noticed quicker when using daily high doses), Sleep/dream enhancer, anxiolytic. Some have reported immediate and subtle gains to clarity of thought. Residual drowsiness100mg700mgSome find it preferable to take at night due to drowsiness.Active chemicals are Bacosides. Extracts of 45% (Bacognize) and 50% available commerciallyEffects and quality may vary from brand to brand. Higher percentage of bacosides don't necessarily indicate a better product; other active molecules have been identified.
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CaffeineFocus, attention and stimulation, possible euphoria (at high doses)Jitteriness, anxiety, tolerance, withdrawal headaches, heartrate increase, increased BP50mg (cup of tea)300mg however doses up to 1.5g aren't uncommonComplete tolerance after 2 days to 2 weeks depending on dosage and frequency. Headaches/fatigue upon cessation.
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CDP CholineCounteracts Racetam headaches and brainfogProbably only need one choline source. Not quite as good bioavailability, but faster acting than AlphaGPC
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DMAEReduce and/or prevent DNA damage. Enhance brain activity.Enhance ability to fight stressors.Improve learning, memory, creativity, and verbal fluency.Reduce and/or remove lipofuscin - age spots.There are no known negative drug or nutrient interactions. It is thought that DMAE can make epilepsy and bipolar depression worse100mgthe benefits of therapy are seen only after long term use. Studies lasting only four weeks showed no improvement..
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Green and white teaEnhances angiogenesis and retention of spatial information. Contains L-Theanine an anti-anxiolytic. Antioxidant. Anticancer in large doses (ECGC).Obstipation, see caffeine for high doses1 double brewed cup5 double brewed cupsPolyphenols, ECGC, caffeine. ECGC may be weak MAO-B inhibitorCaffeine-free formulations available for bedtime use or if stacking
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Huperzine AMemory, Vivid dreamsHeadaches50mcg1000mcgAcetylcholinesterase inhibition and NMDA receptor antagonism
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L-TheanineAnti-anxiety. Increases dopamine. Promotes relaxation100mg
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L-TyrosineAlertness, replenishes NTs. Increases dopamineDownregulation of dopamine receptors. Sleepyness, brain fog.500mg4gCompetes with tryptophan for crossing BBBPrecursor to dopamine, norepinephrine, epinephrine, thyroid hormones
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MelatoninPromotes sleep (helps reset circadian rhythm), antioxidant, promotes immune functionChanges in sex hormone levels and prolactin in large doses, headaches, depression, delayed gut transit.3 mg60mgCounterindicated in autoimmune conditionsTake at night after turning off the light for maximum effect
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Methylcobalamin (methyl-B12)Short-term memory improvementphysical anxiety (symptom your body is saturated?)1mg10mgSublingualInjections also available via RxIt's identical to normal vitamin B12 in mode of action, only slightly better retained
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ModafinilLarge increase in focus, alertness, motivation and agility. Irritability, tunnel vision, panic, adverse skin reactions (rare), talking to yourself, circular thoughts, emotional dulling.25-100mg400mgStrong wakefulness promotor - sleep difficult within 8 - 12 hoursPrescription only in most countries (Ok to import into UK). Can cause short term paralysis ( 50mg personal experience), so take in a low dose if first time to find out if you are hypersensitive/allergichttp://en.wikipedia.org/wiki/Modafinil
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Mucuna Puriens (Velvet bean)Growth hormone release, Libido, Relaxation and focus (for some)Peripheral dopamine side effects50mg L-DOPA content400mg L-DOPA content (very high end)Source of L-DOPA60% extracts available.
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NoopeptSupposedly 1000x more potent than piracetam10mg?50mg?Multiple small doses needed
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Omega 3 Fatty Acids (EPA, DHA) (Fish Oil, Flaxseed Oil)Promotes muscle growth and general health, neuroprotective, anti-inflammatoryGood sources are canola and olive oil, certain fatty fish (e.g. cod family)
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Phenylpiracetam (Phenotropil)Improves tolerance to cold weather and increases productivityAvailable only in/from Russia. Expensive.
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Phosphatidyl Serine (PS)Lower cortisol levels, reduced stress, improved moodExpensive, from soyFat soluble (usually comes in oil base)Seems ineffective to supplement
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SulbutiamineFocus, stimulation, high/relentless energyLoss of creativity100mg400mgFat soluble - take with foodTastes awful
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Valerianrelaxationbrain fog similar to Benzodiazepines and GABA
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VinpocetineAnti-oxidant, helps all round brain improvementNMDA/AMPA receptor antagonist10mg40mgEffective vasodilator that is cheap and should be in everyone's stack. Do not mix with methylphenidate, which is a vasoconstrictor.
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Experiments
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Phosphatidyl Serine Taken twice in the morning seemed to make me almost anixous, quick rapid thoughts but able to maintain a central focusAfter the initial feelings where off I seem to be pretty focused.
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