2CRS Effect Cheatsheets
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STONE-FACEDMONGOOSEWALLABYVOLEPLATYPUSOPOSSUMMARMOTWOMBATBLENDERPACKRATLEGEND
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Stone wool is arguably the most important buff in 2CRS; if it isn't easily available in your seed, you essentially need to own a corked genie bottle in order to double-wish for the Stone-Faced effect to get through the hidden temple and unlock the hidden city.

It is, however, worth noting that if you DO have the genie it isn't a seed-killer. I did several runs in seeds without accessible stone-faced; it hurts to do the two wishes, but if you can avoid the two zeppelin effect wishes, you're in the same place as standard, which is perfectly fine for speed. If you don't have a genie, tho? Be wary.

Of these, I would specifically highlight SC poss and TT poss as great seeds for stone-faced. Others in orange aren't awful, though almost all of the rest of them will require some deviation from your normal run path or re-routing to get. I think invisible seam ripper is technically available through a weird bug, but it's a wildly huge pain, and I don't recommend it.
Seal Clubberembezzler's oilvoodoo glowskullbottle of goofballsNorthern pemmican
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Usable, feasible in HC
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Usable, but requires a pull
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Turtle Tamerevil vihueladucha de oro (size 5)centipede eggsoil of slipperinessmurderbot shield unitglowing el vibrato droneOut of standard / inaccessible
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fitspiration poster
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Italics indicates avatar potion.
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SaucerorHow to Avoid Scams
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Pastamancergrisly shell fragmentcold hots candycandied koboldexcitement pillSazerorc (decent/2)
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fettucini inconnu (decent/3)Lucky Strikes holo-record
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Disco Banditruby on canesRumpelstiltzblack eyedrops (haunted library semirare)invisible seam ripperrobot greaseice-cold Willer (epic/3)powdered dice
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whole roasted chickenlove song of icy revenge
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Accordion Thiefunholy waterroasted duck (crappy/4)Dweebisol inhalerCharity's choker
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pirate pamphlet
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