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curation_datecohortage_minage_maxage_unitsnumber_subjectstissue_typetissue_type_term_idmethodresponse_componentis_modelresponse_behavior_typeresponse_behaviorcomparisonbaseline_time_eventtime_pointtime_point_unitsexposure_materialexposure_material_idexposure_processdisease_namedisease_stagepublication_reference_idpublication_datepublication_reference_urlsignature_sourcecommentscurator_comments
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subjectcell_subset(will be added by processing script)pathogen
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evidencelabellabellabellabellabellabellabellabellabellabellabellabellabellabellabellabellabellabellabellabellabelurllabellabellabel
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rolebackgroundobservedobservedobservedobservedobservedbackgroundtissuebackground(will be added by processing script)backgroundbackgroundmeasuredbackgroundbackgroundobservedobservedbackgroundpathogenbackgroundbackgroundobservedbackgroundbackgroundreferencebackgroundbackgroundobserved
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mime_type
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numeric_units
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descriptive text on Dashboardcuration date YYYY-MM-DDcohort - any characteristics of the population(s) studied, plus whether the result was taken from a subgroup of the broader cohort tested.age_min - age of youngest subject including both cases and controlsage_max - age of oldest subject including both case and controlsage unitsnumber of subjects - count of case plus control subjects used in the measurement.tissue typetissue (Cell Ontology)method - primary experimental method used to measure the responseresponse componentsignature was derived from a computational modelresponse behavior typeresponse behavior (direction, correlation type etc.)comparison (affected vs control, correlated variable, time vs baseline event)baseline time eventtime point relative to baseline event at which response was measuredtime point unitsexposure material (NCBI pathogen name)exposure material (NCBI taxid)exposure process - method by which immune exposure  occurreddisease namedisease stage - reported disease stage(s) of affected subjectspublication reference (PMID, bioRxiv etc)print publication date or posted date (YYYY-MM-DD)publication URLsignature source - figure, table or text section comments and additional detailscurator comments
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vocabulary, separatorYYYY-MM-DDfree textnumbernumberchoose from listnumberAs reported. Only one entry allowed.Choose from list or lookup Cell Ontology code. Use format type:code e.g. CL:0000236, UBERON:0000178.Choose from list. Only one entry expected. You can add new methods.Gene or protein symbols can be separted with commas, spaces, or semicolons. Cell types or other names must be separated using semicolons.Y/NChoose from list. Only one entry allowed. Choose from list. Only one entry allowed. Add new behaviors if required.Free text. Use "vs" rather than a dash to separate comparison terms (A vs B). Separate multiple comparison entries with semicolons (A vs B; C vs D).Free text. Use "none" if no time was reported.Number. Use "none" if no time was reported.Choose from list. Lowercase onlyfree text
Choose from list or use format ncbi_taxid:2697049
Choose from list. Enter new process if needed.free textfree texttype:idYYYY-MM-DDThe URL only, not any associated display textFree text. Up to two entries, separated by semicolonsFree text, limit of 255 charactersFree text, no limit
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Additional information for curatorsAny characteristics of the population(s) studied, besides age. Example:
Hong Kong, Atlanta

Also report if the result was limited to a subgroup of the tested cohort, e.g.
- subjects suffering adverse events
- particular threshold levels of antibody titer level
- based on a receiving a particular treatment		Include both case/affected and control subjectsInclude both case/affected and control subjectshours, days, months, yearsOften differs by signature within a publication. If number of subjects for a particular signature is not clear in text, use total for cohort.The parent tissue of the response components. Report multiple tissues in different rows. For cell-type results, the tissue is often PBMCs. For gene expression, the tissue might be a particular cell-type.If there is no matching cell type in the pulldown list, the curator can try to look up a matching term in the Cell Ontology. If there is no appropriate Cell Ontology term, UBERON codes can also be used.The primary experimental method used to measure the response, e.g. RNA-seq, CyTOF, CITE-seq. The entities whose response is being measured. Please copy symbols and names exactly as reported in the publication - except spell out greek letters. For cell types, this includes all markers.
Examples for a signature with three cell types:
T cells CD3+/CD4+/Ki67+; T cells CD3+/CD8+/Ki67+
CD86+ myeloid dendritic cell (DC); CD86+ monocyte		Were the response components chosen using a classification or other model-building strategy?The type of change being measured, e.g. gene expression, cell-type frequency.Common values in the pulldown list:
- up, down
- positively correlated, negatively correlated, correlated
- positively predictive, negatively predictive, predictive		Comparisons are typically between two groups, or may reflect a correlation of the response component with some other measured variable. Only report significant results. Examples:
- severe COVID-19 cases vs healthy
- moderate COVID-19 cases vs healthy; severe COVID-19 cases vs healthy
- interferon-stimulated genes in COVID-19 vs healthy
- bacterial DNA levels across COVID-19 and healthy subjects
Include time comparison if relevant, e.g. 7d vs 0d, where the times are relative to the baseline reference event time (0d). Times before baseline event can be entered as negative numbers, e.g. days before vaccination (7d vs -1d).
**Please be concise.**		The reference event from which the time of the experimental response is measured, e.g. hospital admission, onset of symptomsTime point when response was measured, if available. Days, months etc.Enter the pathogen or vaccine underlying the immune exposure as reported in the publication or use the NCBI Taxonomy term nameExposure material NCBI taxonomy ID. NCBI Taxonomy ID of pathogen causing disease. Use format id_type:id, e.g. ncbi_taxid:2697049Method by which exposure to pathogen occurredReported disease stage(s) of affected subjects in all comparisons entered in row (not including control subjects). We will not attempt to match these directly with the comparisons.Enter an official identifier for the article curated, using format type:idPartial dates are OK, e.g. YYYY-MMURL of the article curated. Please use PubMed if availableFigure, table number etc. where the signature was found, as given in the publication listed in publication_reference_urlDetails clarifying any aspect of the signature not captured in other fieldsQuestions or notes for further examination from curator. Will not appear in Dashboard
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