Program Element (Number/Name)

Type of Spending

PE 0601384BP / Chemical and Biological Defense Program

LF1: Life Sciences (Basic Research)

Previously "Life Sciences (Enabling Research)." This program element (PE) resources Enabling Research efforts directed at promoting theoretical and experimental research in Life and Physical Sciences. These efforts are part of an integrated portfolio addressing emerging chemical and biological (CB) threats, and are a key enabler supporting the Mitigate, Protect, and Understand portfolios. Enabling Research focuses on pursuing fundamental science to advance a greater understanding of threats, improve situational awareness of emerging threats, and support transformative research in emerging research areas that can potentially foster paradigm shifts in the CB defense research arena to a rapid response capability. Life Sciences (LF1): fundamental efforts to understand living systems' response to biological or chemical agents, to support detection, diagnostics, protection, and medical treatment (e.g. microbiology, biochemistry, pathogenic mechanisms, cell and molecular biology, immunology, nanoscale science, and information science).

PE 0601384BP / Chemical and Biological Defense Program

PS1: Physical Sciences (Enabling Research)

This program element (PE) resources Enabling Research efforts directed at promoting theoretical and experimental research in Life and Physical Sciences. These efforts are part of an integrated portfolio addressing emerging chemical and biological (CB) threats, and are a key enabler supporting the Mitigate, Protect, and Understand portfolios. Enabling Research focuses on pursuing fundamental science to advance a greater understanding of threats, improve situational awareness of emerging threats, and support transformative research in emerging research areas that can potentially foster paradigm shifts in the CB defense research arena to a rapid response capability. Life Sciences (LF1): fundamental efforts to understand living systems' response to biological or chemical agents, to support detection, diagnostics, protection, and medical treatment (e.g. microbiology, biochemistry, pathogenic mechanisms, cell and molecular biology, immunology, nanoscale science, and information science). Physical Sciences (PS1): fundamental scientific phenomena to support investigation of physical and chemical properties and interactions for enhanced functionalities important to detection, diagnostics, protection, and decontamination (e.g. chemistry, physics, materials science, nanotechnologies, nanoscale science, and environmental science).

PE 0602384BP / Chemical and Biological Defense Program

UN2: CBRN Battlespace Sensing, Alerting, and Response

This thrust area invests in breakthrough technology to improve wearable device-based early warning capabilities by conducting data collection trials to support algorithm development; leveraging artificial intelligence (AI) to identify key indicators of exposure, combinations of indicators, and sensing modalities; and exploring alternative methods for non-invasive early warning of chemical and biological (CB) exposure. This will reduce false alarms and strengthen predictions of potential CB exposure— including emerging threats. This thrust area will enable the ability to achieve CB information dominance and make hard decisions easier.

PE 0602384BP / Chemical and Biological Defense Program

FY26: In order to achieve chemical and biological (CB) information dominance and unencumber the warfighter at the tactical edge, efforts continue to develop and transition science & technology (S&T) for CB Defense Decision Aids on end user devices (EUDs) in both connected and disconnected operations by leveraging increased automation, reducing the burden experienced by the warfighter, and providing accurate, actionable information. || In order to unencumber the Warfighter at the tactical edge, efforts continue to develop and transition science & technology for CBRN Decision Aids on End User Devices (EUDs) in both connected and disconnected operations. Focus on utilizing automation, reducing the burden experienced by the warfighter, while providing accurate, actionable information. Develop a Contamination Avoidance Decision Aid to inform the warfighter on how to avoid, respond to and plan routes around CB hazards. Develop an Autonomous Asset Guidance capability to optimize their use and reduce the burden incurred by the warfighter in order to operate them. Fuse and utilize data from Autonomous Assets to improve and refine other CBRN Decision Aids.

PE 0602384BP / Chemical and Biological Defense Program

Understanding how various chemical and biological (CB) threats—both traditional and emerging—interact with the environment and impact the human body is essential to support CB information dominance and enables the Joint Force to operate effectively in a CB-contested environment. Leveraging data from other science and technology (S&T) programs, CB Defense Situational Awareness creates forecasting models and hazard assessments to provide warfighters with optimal situational awareness in these environments. This thrust area is also exploiting advances in eXtended Reality (XR), Virtual Reality (VR) and Augmented Reality (AR) to provide warfighters with an immersive environment for realistic training and mission rehearsal opportunities and will explore the development of a digital human representation.

PE 0602384BP / Chemical and Biological Defense Program

Rapid diagnostics enables the use of MCMs to save warfighters’ lives and minimize the impact chemical and biological threats have on Joint Force operations. Operational Diagnostics is investing in far-forward, point of care medical diagnostics to support the Joint Force’s concepts of operations in priority theaters. It is also focused on producing platforms that can test for a wide variety of chemical and biological threats, including new and emerging ones.

PE 0602384BP / Chemical and Biological Defense Program

Develop novel, state of the art capabilities that lay the foundation for modernizing other areas within the diagnostics portfolio. This includes exploiting areas such as synthetic biology and chemistry to develop novel and rapid diagnostic tests for utilization in the event of an outbreak of an unknown threat. Invest in efforts that lead to accelerated assay development timelines and optimized test parameters through leveraging artificial intelligence (AI) and machine learning (ML) to allow us to quickly pivot and develop assays for emerging threats and speed up development to days instead of weeks.

PE 0602384BP / Chemical and Biological Defense Program

UN2: Diagnostic Building Blocks - Enhanced Biodefense (ENBD)

This effort will focus on Assay Development and Delivery Pipeline, Expand Biological Artificial Intelligence for Diagnostics (BioAID) Efforts as well as developing novel, state of the art capabilities that lay the foundation for modernizing other areas within the diagnostics portfolio. This includes exploiting areas such as synthetic biology and chemistry to develop novel and rapid diagnostic tests for utilization in the event of an outbreak of an unknown threat. Invest in efforts that lead to accelerated assay development timelines and optimized test parameters through leveraging artificial intelligence (AI) and machine learning (ML) to allow us to quickly pivot and develop assays for emerging threats and speed up development to days instead of weeks.

PE 0602384BP / Chemical and Biological Defense Program

FY26: To address the proliferation of potential CB threats, Emerging Threats invests in technologies that can provide actionable information on various characteristics of novel threats even before the threat is known. This works in conjunction with threat-agnostic medical countermeasures to allow the Joint Force to fight through initial exposure to novel threats before they are characterized as part of the new Chemical and Biological Defense Program (CBDP) Medical Countermeasures (MCM) approach || Push beyond the boundaries of the traditional threat list in the field of diagnostics to better prepare for surprise. Development of diagnostic systems that leverage novel approaches to characterize pathogen or host response and can identify the classification of threat (e.g., bacterial vs viral) from an unknown sample. Invest in diagnostic tests that enable the delivery of actionable information, such as administering the appropriate medical countermeasure (e.g. antibiotic, antiviral, vaccine), by a medic or primary care provider greatly improves turnaround time for soldier wellness and return to duty.

PE 0602384BP / Chemical and Biological Defense Program

UN2: Emerging Threats - Enhanced Biodefense (ENBD)

This effort will focus on Novel Non-Invasive Screening and Characterization. It will push beyond the boundaries of the traditional threat list in the field of diagnostics to better prepare for surprise. Development of diagnostic systems that leverage novel approaches to characterize pathogen or host response and can identify the classification of threat (e.g., bacterial vs viral) from an unknown sample. Invest in diagnostic tests that enable the delivery of actionable information, such as administering the appropriate medical countermeasure (e.g. antibiotic, antiviral, vaccine), by a medic or primary care provider greatly improves turnaround time for soldier wellness and return to duty.

PE 0602384BP / Chemical and Biological Defense Program

UN2: Unconventional Detection Modalities - Enhanced Biodefense (ENBD)

In 2025, this program has matured from Project UN2 to Project UN3 Emerging and Enhanced Biothreat Sensing. Develop disruptive technologies to identify unknown or emerging threats and develop sensors that can operate in complex threat environments with high fidelity. This thrust area supports others as appropriate to the Joint Force mission needs (e.g., expeditionary, perimeter defense, or unmanned reconnaissance. FY 2023 Plans: - Expand Assays on Demand (AoD) for emerging biological threat detection. AoD will allow for real time assay manufacturing reducing supply chain constraints typically seen in currently fielded systems. FY 2024 Plans: - Continue Assays on Demand (AoD) for emerging biological threat detection. AoD will allow for real time assay manufacturing reducing supply chain constraints typically seen in currently fielded systems. FY 2023 to FY 2024 Increase/Decrease Statement: Decrease due to change in program/project technical parameters.

PE 0602384BP / Chemical and Biological Defense Program

UN2: Distributed CB Reconnaissance - Biological Detection

In 2025, project funding is moved to the Operational Biological Sensing thrust area for better project alignment. Developing capability to warn and inform the Joint Force of operationally-relevant threat utilizing sampling and sensing payloads on manned and unmanned systems (e.g. UAS, UGS). Point sensors on manned and unmanned assets will remotely sense threats relevant to mission environment at presumptive echelon of Integrated Layered Defense and Integrated Early Warning.

PE 0602384BP / Chemical and Biological Defense Program

UN2: Operational Biological Sensing

The Operational Biological Sensing Thrust Area aims to inform and alert the warfighter of biological hazards they may encounter in an operational setting, including technologies to support field-confirmatory and theater-level validation to support Joint Force operational concepts. This thrust area continues to develop fieldable technologies capable of collecting and detecting biological hazards in the battlespace.

PE 0602384BP / Chemical and Biological Defense Program

UN2: Emerging and Enhanced Biothreat Sensing

Establish a capability to rapidly develop advanced, agile, pathogen-agnostic laboratory and field forward detection capabilities to detect emerging and enhanced biological threats across all force echelons (presumptive, field confirmatory, theater validation, and definitive identification). Further, multi-omics and data sciences (MODS) - multiple biological measurements - will be used to modernize laboratory capabilities and leverage synthetic biology methods and tools to deliver enhanced biothreat sensing/detection capabilities to the Joint Force.

PE 0602384BP / Chemical and Biological Defense Program

UN2: Unattended Perimeter Monitoring - Biological Detection

In 2025, funding moved to Operational Biological Sensing thrust area for better project alignment. Aims to enhance situational awareness against potential biological hazards by developing monitoring solutions to provide continuous, synchronous information of the operational environment and dynamic threat landscape. Capabilities developed here will focus on autonomy and improved accuracy and reliance that decreases operational burden to the Warfighter. FY 2023 Plans: - Continue to evaluate the use of computational tools, like machine learning, into detector/identifier technologies to further reduce false reporting due to environmental factors. - Continue to make technological improvements to enhance early warning of aerosolized biological threats. FY 2024 Plans: - Continue to make technological improvements to enhance early warning of aerosolized biological threats.

PE 0602384BP / Chemical and Biological Defense Program

UN2: Unconventional Detection Modalities - Biological Detection

Develops disruptive technologies to identify unknown or emerging biological threats as well as sensors that can operate in complex threat environments with high accuracy. Efforts in this area pursue a “fail fast” approach, with promising technologies transferred to other thrust areas/budget lines for further development. FY 2023 Plans: - Continue refinement of novel optical detector for bioaerosols modernizing current technologies. - Explore innovative detection methods such as synthetic or organ on a chip biosensors to provide agent agnostic techniques that identify an unknown as hazardous to a human. - Continue to integrate advanced computational tools, Artificial Intelligence (AI)/Machine Learning (ML) into sensor development to improve speed of detection, reduce false alarms and enable integration of data from multiple detection sources. - Initiate Assays on-Demand efforts aimed to rapidly deliver novel assay solutions to be used in the field. FY 2024 Plans: - Continue Assays on Demand (AoD) to augment targeted detection modalities that focus on rapid delivery of novel assay development solutions. - Continue investigating alternative optical detection development not reliant on fluorescence for real-time detection of anomalous biological activity. - Continue evaluating the feasibility of organ-on-a-chip technologies for agent-agnostic techniques.

PE 0602384BP / Chemical and Biological Defense Program

UN2: Employment Characterization

Employment characterization provides the Chemical and Biological Defense Program (CBDP) with the data necessary to achieve information dominance enabling capability development by refining threat assessments and potential impacts of indoor or outdoor releases of threat agents on CBDP operations, strategy, and capabilities. This is accomplished by examining current and emerging technologies through the lens of adversarial exploitation and informing potential gaps in chemical biological defensive capabilities. The data from these efforts then feeds into auxiliary efforts designed to reduce defensive risk identified under this effort.

PE 0602384BP / Chemical and Biological Defense Program

Environmental response provides the Chemical and Biological Defense Program (CBDP) with the data necessary to achieve information dominance and underpins capability development by providing critical agent characteristics to support hazard mitigation, hazard models, and operational decision making. This is accomplished by evaluating the behavior of CB threats in the environment (e.g. persistence, degradation, decomposition), along with the effects of environmental conditions (e.g. ozone, ultraviolet (UV), humidity, etc.) on those agents

PE 0602384BP / Chemical and Biological Defense Program

UN2: First Look (Chemical and Biological)

First Look delivers the Chemical and Biological Defense Program (CBDP) with the data necessary to achieve information dominance and underpins capability development by providing initial characterization of potential Chemical Biological (CB) threats and a fundamental assessment of the potential risk they pose (including complexity of accessibility, infectivity assessments and initial pathology/toxicology screening) It also includes the development of agnostic methods and capabilities to rapidly and accurately characterize the properties of chemical, biological, and toxin threat agents.

PE 0602384BP / Chemical and Biological Defense Program

Host Response provides the Chemical and Biological Defense Program (CBDP) with the data necessary to achieve information dominance and underpins capability development by characterizing the effects from exposure to toxic or infectious for chemical and biological (CB) threat agents using operationally relevant exposure scenarios/exposure routes and appropriate assessment methods and models. This supports medical and physical countermeasure development, diagnostic opportunities, health effects models, and operational decision making.

PE 0602384BP / Chemical and Biological Defense Program

This effort will focus on Advanced Pathogen and Emerging Threat Characterization with attention on characterizing host responses and pathogen signatures using multi-omic analyses and enabling technologies to develop the ability to characterize known and emerging threats. This effort will include understanding the host response to various pathogen insults to identify patterns of response that allow for the prediction of novel threat agents based on the host responses they generate. Evaluations of pathogenesis and viral transmission to understand differences in disease severity will also be conducted. Within this program, efforts to characterize synthetic and natural viral pathogens to compare varying gene expressions between the two will be executed. This program accelerates the ability to characterize emerging threats and will generate more robust data sets for training threat agnostic tools to provide better characterization capabilities.

PE 0602384BP / Chemical and Biological Defense Program

Technical surprise provides the Chemical and Biological Defense Program (CBDP) with the data necessary to achieve information dominance and enables capability development by assessing technological advancements for potential implications on threat agent use and release. Threat Agent Science develops and utilizes advanced horizon scanning technologies to monitor new technologies and identify areas of potential concern, including those that can improve our chemical and biological (CB) defenses.

PE 0602384BP / Chemical and Biological Defense Program

UN2: Technical Surprise - Enhanced Biodefense (ENBD)

The Technical Surprise Enhanced Biological Defense investments augment chemical and biological (CB) defense capabilities by adopting state of the art synthetic biology tools, enhancing methods development and characterizing host responses via multiomics. Technical Surprise ENBD augments the capabilities to assess pathogenesis/transmissibility, to characterize the full spectrum of emerging biothreats, and to conduct signature assessments to accelerate threat understanding. This provides the Chemical and Biological Defense Program (CBDP) with the data and tools necessary to achieve information dominance.

PE 0602384BP / Chemical and Biological Defense Program

PT2: Biological Warfare Defense Prophylaxis

Medical countermeasure (MCM) strategies against broader classes of biological agents will be pursued with emphasis on broad-spectrum protection, platform technologies to enable rapid response, rapid onset to protection, fewer doses required, no cold chain required, and needle-free administration.

PE 0602384BP / Chemical and Biological Defense Program

PT2: Biological Warfare Defense Prophylaxis - Enhanced Biodefense (ENBD)

Investments include efforts to develop technologies that strengthen and tune the host immune system and identifying appropriate vaccine platform technologies

PE 0602384BP / Chemical and Biological Defense Program

PT2: Air Purification Enhancements

Air purification filters go on individual protective gear (masks) and collective protection (i.e., military systems such as tanks, ships, and buildings). Current filters are expensive and do not alert operators when they are no longer effective at blocking Chemical and Biological (CB) threats. Air Purification Enhancements develops filters that last longer and reduce lifecycle costs, as well as devices to monitor their effectiveness throughout their lifecycle. The thrust areas filters will develop and mature enhanced protection technologies against both traditional and advanced threats.

PE 0602384BP / Chemical and Biological Defense Program

PT2: All-Hazards & Respiratory Protection

Current individual protective gear can be uncomfortable to wear for extended periods of time and the gear can make it less natural to perform essential warfighting functions. All-Hazards and Respiratory Protection designs and develops reduced burden, low encumbrance respiratory and ocular (eye) protection. This will make it easier for the warfighter to perform mission essential tasks while operating in individual protective gear. Current Chemical and Biological (CB) protective masks don’t integrate with current optical sites and developmental optical systems, such as heads up displays. All-Hazards Respiratory Protection works to develop CB defense masks that integrate with these combat systems.

PE 0602384BP / Chemical and Biological Defense Program

PT2: Dynamic Multifunction Materials for Second Skin

Efforts will utilize responsive technologies to provide chemical biological protective suits that adapt to the environment by synthesizing scaled samples via roll-to-roll manufacture which exhibit materials properties that reduce thermal burden and integrate with current combat garments. These technologies include interpenetrating polymer networks that will change moisture permeability and molecular selectivity on demand, and membranes with higher moisture vapor transfer rates than existing fabrics.

PE 0602384BP / Chemical and Biological Defense Program

Advances garment material and ensemble technologies with revolutionary capability improvements using integrated, low encumbrance garment designs and fabrication processes for thermal burden reduction, greater mobility, longer service life, and simplified logistics. Incorporates state-of-the-art threat protection technologies and develops supporting test methodologies and methods that provide operationally relevant, consistently comparable test data on protective garments.

PE 0602384BP / Chemical and Biological Defense Program

PT2: Multifunctional Materials for Protection

Develops next generation protection materials for protective garments, masks, and filters. It identifies and tests new materials that absorb, neutralize, and repel chemical and biological warfare agents with high efficiency, which will reduce costs by extending service life. New materials can also reduce the heat burden of individual protection and make it more natural to operate. This will allow warfighters to operate in individual protection gear for extended periods of time, reducing the necessity of early warning. Multifunctional Materials for Protection (MMfP) replaces per- and polyfluoroalkyl substances (PFAS)-based textile finishes and surface coatings. MMfP begins manufacturing and scaling processes for technologies that transition to all physical protection thrust areas.

PE 0602384BP / Chemical and Biological Defense Program

MT2: Biological Warfare Defense Therapeutics

This effort funds biomedical research focused on the early discovery and evaluation of broadly-acting therapeutic countermeasures that support development of novel and repurposed therapeutic interventions

PE 0602384BP / Chemical and Biological Defense Program

MT2: Discovery of Medical Countermeasures Against New and Emerging (DOMANE)

Project terminated in FY24 | Develop and successfully transition emerging technology platforms to identify MCMs, targets, as well as innovative platforms that will support transition to applied programs for clinical trials. These developmental and translational studies will provide a knowledge foundation and broad candidate pipeline that will underpin the availability (via FDA-regulated Expanded Access, Compassionate Use and Emergency Use authorities) of BW MCM to the Joint Force at the speed of relevance to allow freedom of action.

PE 0602384BP / Chemical and Biological Defense Program

Equipment Decontamination develops decontaminant systems, formulations, and procedures that reduce or eliminate residual contamination hazards; enable decentralized unit-level decontamination with rapid unmasking; reduce manpower and logistics (e.g., water) needed to accomplish the task; enable rapid sorting of clean from dirty to rapidly return highvalue equipment to normal, unprotected use; develop improved realistic test methods.

PE 0602384BP / Chemical and Biological Defense Program

MT2: Multifunctional Materials for Protection

Add-on to description: MMfP begins manufacturing and scaling processes for technologies that transition to all physical hazard mitigation thrust areas.

PE 0602384BP / Chemical and Biological Defense Program

Personnel Decontamination provides new personnel decontamination kits with reduced costs and logistics (storage and shelf-life limitations) compared to the currently fielded product and provides new processes and methods for decontamination of unbroken skin.

PE 0602384BP / Chemical and Biological Defense Program

EN2: Biological Warfare Defense Prophylaxis - Comparing Animal Models to Organ (CAMO)

This effort will focus on the characterization of alternative to animal models that mimic the human response to biological and chemical agents to enable rapid response. In FY25 Funds were moved from Project EN3 Medical Countermeasures Initiative to better align requirements within Budget Activity 2 to support investments in alternatives to animal models supporting rapid response for new and emerging threats.

PE 0602384BP / Chemical and Biological Defense Program

This effort is aimed at identifying what alterations (policy, processes and facilities) will be required in order to attain the ability to conduct classified defensive DoD work in biosafety laboratories. This will necessarily include training and maintaining sufficient scientists and technicians able to execute S&T in high containment at various levels of classification. This effort executes a robust emerging biothreat portfolio to enable readiness for future incidents.

PE 0602384BP / Chemical and Biological Defense Program

CB2: Material Contamination Mitigation

Develop highly effective non-traditional or novel decontamination technologies that integrate with current procedures and support non-material improvements of the overall decontamination effort.

PE 0602384BP / Chemical and Biological Defense Program

CB2: Respiratory and Ocular Protection

RDT&E Project NT2, Techbase Non-Traditional Agents Defense, will merge into this program starting in FY21 | Development and integration of novel filtration media into a lightweight, low-profile, and low-burden individual protective filter, which has enhanced performance against a broader range of challenges that include Chemical Warfare Agents (CWA), Biological Weapons Agents (BWA), and Toxic Industrial Chemicals (TICs). Development of respiratory protection and design for better interoperability to support longer range missions.

PE 0602384BP / Chemical and Biological Defense Program

RDT&E Project NT2, Techbase Non-Traditional Agents Defense, will merge into this program starting in FY21 | Develop advanced ensemble prototypes with state-of-the art materials that address the full spectrum of threats and provide a range of solutions optimized for protection, thermal comfort, and mission performance.

PE 0602384BP / Chemical and Biological Defense Program

CB2: Detection Sensor Technologies

This effort is being separated into five thrust areas starting in FY21: Distributed CB Reconnaissance, Enhanced/Emerging Biothreat Sensing, Expeditionary Analytical Toolkit (ExAnT), Unattended Perimeter Monitoring, and Unconventional Detection Modality.

PE 0602384BP / Chemical and Biological Defense Program

This effort is transitioning to the CBRN Battlespace Surveillance, Alerting & Response thrust area starting in FY21 | Integrate and fuse disparate sensor data, leverage non-invasive physiological data for detection of threat exposure prior to symptom onset, and provide timely data-driven predictions and warnings.

PE 0602384BP / Chemical and Biological Defense Program

Improve battlespace awareness by accurately predicting hazardous material releases, atmospheric transport and dispersion, and resulting human effects. Develop capability for predicting the source term of releases of chemical, biological, and industrial materials. ---- Program merged in FY20 under RDT&E Project CB2, Decision Management.

PE 0602384BP / Chemical and Biological Defense Program

Develop CBRN data sharing capabilities and simulation tools. Develop chapters of the Chemical and Biological Agent Effects Manual Number 1 (CB-1), an authoritative source capturing analytical methods for evaluating the effects of Chemical Biological (CB) agents on equipment, personnel, and operations. These chapters are developed by a mix of contractors and labs, employing experts in each subject area.------Program closed out in FY20, funding covered under RDT&E Project CB2, Decision Analysis and Management

PE 0602384BP / Chemical and Biological Defense Program

CB2: Decision Analysis and Management

This effort is being separated into two thrust areas starting in FY21: CBRN Decision Aids and CBRN Situational Awareness.

PE 0602384BP / Chemical and Biological Defense Program

RDT&E Project NT2, Techbase Non-Traditional Agents Defense, will merge into this program starting in FY21.

PE 0602384BP / Chemical and Biological Defense Program

Program merged in FY20 under Research Development Test & Evaluation (RDT&E) Project CB2, Decision Management.

PE 0602384BP / Chemical and Biological Defense Program

PE 0602384BP / Chemical and Biological Defense Program

CB2: CARES Act: - ProBE: Proteomic/Multi-omic Biothreat Evaluation

Provides the ability to conduct comprehensive assessments and characterizations of emerging pathogens using interdisciplinary approaches.

PE 0602384BP / Chemical and Biological Defense Program

CB2: CARES Act: Reusable N95 Masks to DEVCOM CBC

Provides reusable N95 Masks to the Combat Capabilities Development Command (DEVCOM) Chemical Biological Center (CBC).

PE 0602384BP / Chemical and Biological Defense Program

CB2: Internal COVID: Virus decon to DEVCOM CBC

PE 0602384BP / Chemical and Biological Defense Program

CB2: Internal COVID: Portable bio containment module testing at DEVCOM SC

PE 0602384BP / Chemical and Biological Defense Program

CB2: Distributed CB Reconnaissance

FY23 funding ($3.614 Million) transferred to UN2 | Focus of this effort is to develop capabilities to detect and identify chemical and biological threats. This activity includes development of point, remote, or standoff sensors as appropriate, to address both conventional and non-traditional chemical and biological threats. These efforts are being developed to further the detection capability for early warning of contamination exposure to the warfighter. This effort is being separated into five thrust areas starting in FY21: Distributed CB Reconnaissance, Enhanced/Emerging Biothreat Sensing, Expeditionary Analytical Toolkit (ExAnT), Unattended Perimeter Monitoring, and Unconventional Detection Modality.

PE 0602384BP / Chemical and Biological Defense Program

CB2: Enhanced/Emerging Biothreat Sensing

FY23 funding ($12.853 Million) transferred to UN2 | Establish capability to rapidly develop sensors to detect enhanced or emerging biological threats via quickly adaptable or analyte-agnostic laboratory and field-forward detection capabilities. This will provide improved detection capabilities for unknown or novel threats across the spectrum of detection and validation assets. This thrust area leverages multi-omics data science to inform rational and rapid development of synthetic biological sensing platforms as well as improved laboratory methods

PE 0602384BP / Chemical and Biological Defense Program

CB2: Unattended Perimeter Monitoring

FY23 funding ($4.871 Million) transferred to UN2 | Develop automated technologies to improve detection of aerosolized hazards while minimizing or removing user intervention to enable a reliable detect-to-warn capability, providing a capability for unattended monitoring of perimeters for temporary defense positioning, including base camps, to enable early indication of threats. This thrust area will evaluate current and novel technologies to provide improved chemical threat detection and automated biological detection capabilities.

PE 0602384BP / Chemical and Biological Defense Program

CB2: Unconventional Detection Modalities

FY23 funding ($6.681 Million) transferred to UN2 | Develop disruptive technologies to identify unknown or emerging threats and develop sensors that can operate in complex threat environments with high fidelity. This thrust area supports others as appropriate to the Joint Force mission needs (e.g., expeditionary, perimeter defense, or unmanned reconnaissance.

PE 0602384BP / Chemical and Biological Defense Program

CB2: Enhanced Survivability Coatings

FY23 funding transferred to MT2 ($1.071)and PT2 ($1.178) | This effort supports the Materiel Contamination Mitigation Core Capability Area. Military equipment coatings are challenging and logistically intensive to decontaminate. Efforts within this thrust seek to produce enhanced coatings that increase chemical warfare agent survivability and decontaminability of military equipment to levels comparable to that of stainless steel. Improved coatings will resist chemical agent absorption and be quickly decontaminated in field, to rapidly return equipment to mission operations level.

PE 0602384BP / Chemical and Biological Defense Program

FY23 funding ($5.774 Million) transferred to MT2 | This effort supports the Materiel Contamination Mitigation Core Capability Area. The Warfighter has a limited capability to decontaminate personal equipment, weapons, vehicles, ships, and facilities; Sensitive equipment (weapon system optics, electronic equipment, interior spaces, and aircraft); and hazardous waste. Efforts within this thrust seek to develop decontaminant formulations and procedures that reduce or eliminate residual contamination hazards; enable unit-level decontamination with rapid unmasking; reduce logistic needs (need for water); enable rapid sorting of clean from dirty to rapidly return high-value equipment to normal use; and develop improved realistic test methods.

PE 0602384BP / Chemical and Biological Defense Program

Wide Area Decontamination efforts will not be conducted during FY22-FY25 due to funding reductions. Efforts are scheduled to resume in FY26 | This effort supports the Materiel Contamination Mitigation Core Capability Area. Warfighters lack capability to rapidly restore critical DoD infrastructure (e.g., sea port or air base) that will mitigate contamination spread and enable normal, unprotected operations. Efforts within this thrust seek to improve contamination mitigation logistics/cost reduction, effectiveness, compatibility/safety, and environmental compatibility.

PE 0602384BP / Chemical and Biological Defense Program

CB2: CBRN Battlespace Surveillance, Alerting & Response

FY23 funding ($8.000 Million) transferred to UN2 | Improve the Department of Defense's capability to detect, identify, alert, and responds to deliberate releases and naturally occurring outbreaks of chemical and biological threat agents. Current predictive algorithms in development by JSTO are based on large in-hospital datasets from patients with comorbidities. Improving on the applicability and efficacy of these algorithms will focus on large, real-time human data collects of chemical and biological agent / agent proxy exposures. Additionally, studies will focus on examining the feasibility of specifically isolating indicators of respiratory infection, determining severity of infection, and predicting return to mission readiness after exposure. This capability will enable early implementation of countermeasures such as isolation, quarantine, and removal from an area, thus potentially reducing transmission, morbidity, and mortality rates. The maturation of algorithms will incorporate Machine Learning (ML) approaches for refining sensitivity and specificity.

PE 0602384BP / Chemical and Biological Defense Program

FY23 funding ($4.667 Million) transferred to UN2 | In order to unencumber the warfighter at the tactical edge, JSTO will continue to develop and field CBRN Decision Aids on End User Devices (EUDs) in both connected and disconnected operations.

PE 0602384BP / Chemical and Biological Defense Program

FY23 funding ($11.812 Million) transferred to UN2 | To enhance CB Situational Awareness, JSTO will expand the types of threats that can be modeled with hazard assessment capabilities to include fixed-wing and rotary-wing drones of interests. These capabilities will allow for single drones and swarms to be modeled.

PE 0602384BP / Chemical and Biological Defense Program

FY23 funding ($4.657 Million) transferred to UN2 | Employment Characterization studies refine threat assessments and identify potential impacts of indoor and/or outdoor releases of threat agents on CBDP operations, strategy, and capabilities. These studies directly define the Warfighter threat space by determining how chemical and biological agents behave when released. This thrust area reduces risk to the CBDP Enterprise by closing knowledge gaps and informing on the type, extent and magnitude of a potential hazard a warfighter may face in an operational environment.

PE 0602384BP / Chemical and Biological Defense Program

FY23 funding ($6.042 Million) transferred to UN2 | Environmental Response evaluates CB threats to understand how they will behave in the environment (e.g. persistence, degradation, decomposition), along with the effects of environmental conditions (e.g. ozone, UV, humidity, etc.) on those agents. Studies include evaluations of chemical and biological threat agents on soil, water, and plants, and operational surfaces such as clothing, structures, and equipment. This thrust area reduces risk to the CBDP Enterprise by closing knowledge gaps and informing on the type, extent and magnitude of a potential hazard a warfighter may face in an operational environment. Small-scale laboratory measurements are used to predict the larger-scale behavior and fate of the agents in outdoor and operational settings, while examining agents deposited on operationally relevant substrates refines our understanding of their environmental persistence and hazards. Knowledge obtained from Environmental Response is used to inform operators, predictive model development, and capability development.

PE 0602384BP / Chemical and Biological Defense Program

CB2: First Look (Chemical and Biological)

FY23 funding ($9.850 Million) transferred to UN2 | First Look provides the initial evaluation of known and emerging threat agents to determine their potential hazard to the Warfighter. For both chemical and biological agents, this initial fundamental risk assessment includes evaluation of synthesis and toxicity screening for chemicals and toxins and growth and/or virulence for biological agents as well as production and feasibility of weaponization for all agents.

PE 0602384BP / Chemical and Biological Defense Program

FY23 funding ($14.453 Million) transferred to UN2 | Host Response assesses the human response of exposure to biological and chemical threat agents using operationally relevant exposure scenarios (acute versus chronic) and exposure routes (e.g., .inhalation, dermal, ingestion, etc.) and appropriate assessment methods and models. Data from host response studies are used to develop quantitative exposure limits (e.g. LD50 or ID50) and qualitative information (e.g. mechanism of action) to inform warfighter mission planning, requirements generation, capability development, model development, the larger CBDP Enterprise, Intelligence and other government stakeholders.

PE 0602384BP / Chemical and Biological Defense Program

FY23 funding ($4.500 Million) transferred to UN2 | Technical Surprise assesses technological advancements for potential implications to the threat space, including agent use and release. Technical Surprise includes horizon scanning to identify potential areas of concern as well as conducts technical assessments of emerging technological advancements (e.g. biotechnology, artificial intelligence, machine learning, quantum computing). This program develops capabilities to evaluate and assess technical enhancements that may alter the nature or magnitude of a threat agent.

PE 0602384BP / Chemical and Biological Defense Program

CB2: All-Hazards & Respiratory Protection

FY23 funding ($1.482 Million) transferred to PT2 | This effort supports the Respiratory and Ocular Protection. Efforts will improve chemical and biological agent protection while maintaining warfighter capability through integrated research on respirator, seams, closures, and new materials; perform early surveys for end-user jury input; frequent user operational evaluation; focus on closed circuit full spectrum respiratory protection.

PE 0602384BP / Chemical and Biological Defense Program

CB2: Air Purification Enhancements

FY23 funding ($0.662 Million) transferred to PT2 | This effort supports the Expeditionary Collective Protection (CP). Existing CP systems have high life cycle costs driven by maintenance and limited service life. JSTO efforts will focus on optimizing and extending filter life to reduce lifecycle costs while maintaining or improving protection.

PE 0602384BP / Chemical and Biological Defense Program

NT2: Respiratory and Ocular Protection

This program will merge to RDT&E Project CB2, Chemical Biological Defense starting in FY21 | Development and analysis of design alternatives for chemical and biological air-purifying respirators that provide enhanced protection with lower physiological burden and improved interface with mission equipment.

PE 0602384BP / Chemical and Biological Defense Program

This effort is being separated into three thrust areas starting in FY21: Chemical Diagnostics, Diagnostic Building Blocks, and Emerging Threats | Investigate medical diagnostics ubiquitous and comprehensive against chemical and biological threats (including NTAs, pharmaceutical-based agents, and toxins) by advancing diagnostic innovations; investigating emerging technologies; ensuring medical diagnostics rapid adaptation to emerging threats; harvesting and synergizing the immense volume of diagnostic data; and aligning medical diagnostics capabilities with the FDA pipeline and larger commercial supply chain.

PE 0602384BP / Chemical and Biological Defense Program

TM2: Bacterial/Viral/Toxins/ Broad Spectrum Prophylaxis

FY23 funding ($26.699 Million) transferred to PT2 | The ultimate protection of the Warfighter is achieved by pretreating the Warfighter to withstand any biological threat with no adverse side effects from the pretreatment. Such pretreatment would enable the Warfighter to work in a less restrictive environment, absent of any personal protective equipment, facilitating the Warfighter to operate at peak performance. Investments in this Program Element support innovative concepts in prophylaxis that support needs specific to the warfighter such as broad spectrum protection, rapid onset to protection, fewer doses required, no cold chain required, and needle-free administration.

PE 0602384BP / Chemical and Biological Defense Program

TM2: Vaccine Platforms and Research Tools

Use novel technology and methods to support development of vaccine candidates. Conduct studies to determine potential immune interference between lead vaccine candidates, the effect of alternative vaccine delivery methods, and thermostabilization technologies on the efficacy of lead vaccine candidates. Identify correlates of protection in humans, and predict the success of lead vaccine candidates in humans.

PE 0602384BP / Chemical and Biological Defense Program

FY23 funding transferred to MT2. Beginning in FY23, the Viral/ Bacterial/Toxin Therapeutics bullets will be consolidated into Biological Warfare Defense Therapeutics | Discover and develop therapeutic countermeasures to mitigate the effects of known and emerging viral threats to the warfighter.

PE 0602384BP / Chemical and Biological Defense Program

FY23 funding transferred to MT2. Beginning FY23, Viral/ Bacterial/Toxin Therapeutics bullets will be consolidated into Biological Warfare Defense Therapeutics | Discover and develop therapeutic countermeasures to mitigate the effects of known and emerging bacterial threats to the warfighter.

PE 0602384BP / Chemical and Biological Defense Program

FY23 funding transferred to MT2. Beginning FY23, Viral/ Bacterial/Toxin Therapeutics bullets will be consolidated into Biological Warfare Defense Therapeutics | Identify, optimize and evaluate therapeutic candidates that are effective against biological toxin agents.

PE 0602384BP / Chemical and Biological Defense Program

FY23 funding ($3.466 Million) transferred to UN2 | Develop novel, state of the art capabilities that lay the foundation for modernizing other areas within the diagnostics portfolio. This includes exploiting areas such as synthetic biology and chemistry to develop novel and rapid diagnostic tests for utilization in the event of an outbreak of an unknown threat. Invest in efforts that lead to accelerated assay development timelines and optimized test parameters through leveraging artificial intelligence (AI) and machine learning (ML) to allow us to quickly pivot and develop assays for emerging threats and speed up development to days instead of weeks.

PE 0602384BP / Chemical and Biological Defense Program

FY23 funding ($2.773 Million) transferred to UN2 | Push beyond the boundaries of the traditional threat list in the field of diagnostics to better prepare for surprise. Development of diagnostic systems that leverage novel approaches to characterize pathogen or host response and can identify the classification of threat (e.g., bacterial vs viral) from an unknown sample. Invest in diagnostic tests that enable the delivery of actionable information, such as administering the appropriate medical countermeasure (e.g. antibiotic, antiviral, vaccine), by a medic or primary care provider greatly improves turnaround time for soldier wellness and return to duty.

PE 0602384BP / Chemical and Biological Defense Program

FY23 funding ($13.134 Million) transferred to MT2 | Protection of the Warfighter against Chemical Warfare Agents (CWAs) to maintain force lethality is the ultimate goal of the Enabling Sciences portfolio. The portfolio leverages innovative approaches and emerging technologies to support modernization of chemical medical countermeasure (cMCM) pipeline. The portfolio is designed to develop and deploy cMCMs more rapidly to the warfighter.

PE 0602384BP / Chemical and Biological Defense Program

TM2: Biological Warfare Defense Therapeutics

Congressional Add: For PUL 042 (Burkholderia, Tularemia), proof of concept small animal efficacy studies will be completed with options for non human primate pharmacokinetics studies, and GMP manufacturing. The candidate will then be ready to transition to advanced development.

PE 0603384BP / Chemical and Biological Defense Program - Advanced Development

CB3: Material Contamination Mitigation

This effort is being separated into three thrust areas starting in FY21: Enhanced Survivability Coatings, Equipment Decontamination, and Personnel Decontamination | Develop highly effective non-traditional or novel decontamination technologies that integrate with current procedures and support non-material improvements of the overall decontamination effort.

PE 0603384BP / Chemical and Biological Defense Program - Advanced Development

This effort is being separated into two thrust areas in FY22: Lightweight Protective Garments and Dynamic Multifunction Materials for Second Skin | Develop advanced ensemble prototypes with state-of-the art materials that address the full spectrum of threats and provide a range of solutions optimized for protection, thermal comfort, and mission performance.

PE 0603384BP / Chemical and Biological Defense Program - Advanced Development

CB3: Respiratory and Ocular Protection

This effort is being separated into two thrust areas starting in FY21: All-Hazards & Respiratory Protection and Multifunction Materials for Protection | Develop novel filtration media that are lighter weight and lower burden while capable of protecting against a broader range of challenges that includes toxic industrial chemicals (TICs).

PE 0603384BP / Chemical and Biological Defense Program - Advanced Development

This effort is being separated into five thrust areas in FY21: Distributed CB Reconnaissance, Enhanced/Emerging Biothreat Sensing, Expeditionary Analytical Toolkit (ExAnT), Unattended Perimeter Monitoring, Unconventional Detection Modality | Advance and mature technologies and capabilities to detect and identify chemical and biological threats to the point of transitioning to customers for advanced development. This activity includes development of point, remote, or standoff sensors as appropriate, to address both chemical and biological threats. These efforts develop transitionable detection capabilities for early warning of contamination exposure to the warfighter.

PE 0603384BP / Chemical and Biological Defense Program - Advanced Development

This program merged to RDT&E Project CB3, Chemical Biological Defense (Decision Management) in FY20 | Improve battlespace awareness by accurately predicting hazardous material releases, atmospheric transport and dispersion, and resulting human effects. Develop predictive capability for the source term of releases of chemical, biological, and toxic industrial materials.

PE 0603384BP / Chemical and Biological Defense Program - Advanced Development

This program merged to RDT&E Project CB3, Chemical Biological Defense (Decision Analysis and Management) in FY20 | : Develop CBRN data-sharing capabilities. Develop chapters of the Chemical and Biological Warfare Agent Effects Manual Number 1 (CB-1), an authoritative source capturing analytical methods for evaluating the effects of CB warfare agents on equipment, personnel, and operations. Create a framework for implementing CB-1 and provide CBRN defense community access to CB-1. T

PE 0603384BP / Chemical and Biological Defense Program - Advanced Development

This program merged to RDT&E Project CB3, Chemical Biological Defense (Decision Analysis and Management) in FY20 | Develop decision support tools and information management capabilities for planning and real-time analysis to determine and assess operational effects, risks, and overall impacts of Chemical Biological Radiological and Nuclear (CBRN) incidents on decision-making. Focus areas include consequence management, population modeling, and knowledge management.

PE 0603384BP / Chemical and Biological Defense Program - Advanced Development

CB3: Decision Analysis and Management

This effort is being separated into two thrust areas starting in FY21: CBRN Decision Aids and CBRN Situational Awareness | Enable the prediction of chemical and biological hazards, exposures, casualties, and infections along with providing timely and accurate warnings and recommended courses of action. Develop methods to utilize non-traditional detection methods to provide indications of Chemical and Biological exposure risk.

PE 0603384BP / Chemical and Biological Defense Program - Advanced Development

This program merged to RDT&E Project CB3, Chemical Biological Defense (Warning and Reporting) in FY20 | Integrate disparate military and civilian datasets, investigate methodologies to appropriately integrate open source data into advanced chemical and biological threat warning systems, tactical decision aids, and leverage and enhance advanced epidemiological models and algorithms for disease prediction, forecasting, impact and biological threat assessment.

PE 0603384BP / Chemical and Biological Defense Program - Advanced Development

This effort is transitioning to the CBRN Battlespace Surveillance, Alerting & Response thrust area starting in FY21 | : Develop a framework for integrating and correlating timely, relevant information sources. Investigate new approaches and methodologies such as machine learning, artificial intelligence, and advanced data analysis to accelerate analytical processes and provide early warning of chemical and biological threats.

PE 0603384BP / Chemical and Biological Defense Program - Advanced Development

This effort will add additional tasks to provide a COVID detection/diagnostic assay, optimize sample preparation methods for SARS CoV-2, and evaluate the performance of CRISPR based assays for SARS CoV-2.

PE 0603384BP / Chemical and Biological Defense Program - Advanced Development

CB3: CARES Act - EpiGrid, Advanced Capabilities for Human Health Effects Modeling, Interior Modeling

Expand and enhance epidemiological modeling capabilities to allow for modeling of COVID-19 in populations. Enhance hazard prediction capabilities for use in COVID-19 scenarios.

PE 0603384BP / Chemical and Biological Defense Program - Advanced Development

CB3: CARES Act - Rapid Detection and Identification of Biological Events Testing

Further evaluate Zeteo Tech BioFlyte prototype which is a MALDI-TOF MS instrument and supplement the library build with SARS CoV-2 in order to benchmark the prototype instrument compared to other MS technologies for desired DoD and Defense applications.

PE 0603384BP / Chemical and Biological Defense Program - Advanced Development

CB3: CARES Act - RATE Operationalization

Rapidly enhance non-invasive physiological detection algorithms for pre-symptomatic prediction of COVID-19 infection. Conduct multiple, large cohort studies to include warfighters across the Services and other DoD personnel to collect, analyze and interpret data to improve early detection algorithms.

PE 0603384BP / Chemical and Biological Defense Program - Advanced Development

CB3: Air Purification Enhancements

FY23 funding ($0.287 Million) transferred to PT3 | This effort supports the Expeditionary Collective Protection (CP) Core Capability Area. Existing CP systems have high life cycle costs driven by maintenance and limited service life. Science & Technology efforts will focus on optimizing and extending filter life to reduce lifecycle costs while maintaining or improving protection.

PE 0603384BP / Chemical and Biological Defense Program - Advanced Development

CB3: All-Hazards & Respiratory Protection

FY23 funding ($1.345 Million) transferred to PT3 | This effort supports the Respiratory and Ocular Protection. Efforts will improve chemical and biological agent protection while maintaining warfighter capability through integrated research on respirator, seams, closures, and new materials; perform early surveys for end-user jury input; frequent user operational evaluation; focus on closed circuit Self-Contained Breathing Apparatus.

PE 0603384BP / Chemical and Biological Defense Program - Advanced Development

CB3: CBRN Battlespace Surveillance, Alerting & Response

FY23 funding ($5.171 Million) transferred to UN3 | Improve the Department of Defense's capability to detect, identify, alert, and responds to deliberate releases and naturally occurring outbreaks of chemical and biological threat agents. JSTO will expand on developing predictive CB exposure algorithms based on non-invasively collected human biomarkers. Current predictive algorithms in development by JSTO are based on large in-hospital datasets from patients with comorbidities. Improving on the applicability and efficacy of these algorithms will focus on large, real-time human data collects of chemical and biological agent / agent proxy exposures. Additionally, studies will focus on examining the feasibility of specifically isolating indicators of respiratory infection, determining severity of infection, and predicting return to mission readiness after exposure. This capability will enable early implementation of countermeasures such as isolation, quarantine, and removal from an area, thus potentially reducing transmission, morbidity, and mortality rates. The maturation of algorithms will incorporate Machine Learning (ML) approaches for refining sensitivity and specificity.

PE 0603384BP / Chemical and Biological Defense Program - Advanced Development

FY23 funding ($3.000 Million) transferred to UN3 | In order to unencumber the warfighter at the tactical edge, continue to develop and field CBRN Decision Aids on End User Devices (EUDs) in both connected and disconnected operations. Capabilities will focus on utilizing automation, reducing the burden experienced by the warfighter, while providing accurate, actionable information. During this time period, a focus will be put on developing a Contamination Avoidance Decision Aid to inform the warfighter on how to avoid, respond to and plan routes around CB hazards.

PE 0603384BP / Chemical and Biological Defense Program - Advanced Development

FY23 funding ($3.888 Million) transferred to UN3 | : To enhance CB Situational Awareness, JSTO will expand the types of threats that can be modeled with hazard assessment capabilities to include fixed-wing and rotary-wing drones of interests. These capabilities will allow for single drones and swarms to be modeled.