Public Copy of Vaccine R&D Cost-Effectiveness Calculations
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ABCDEFGHIJKLMNOPQRSTUVWXYZAAABACADAEAFAGAHAIAJAKALAMANAO
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KeyVariables
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Based off of a source, cited in main article
$120,000
Average USD salary per researcher on a vaccine team
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Educated guess inferred from source data, cited in main article
$9,000.00
Cost per person in a medical trial
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Guess not inferred from any data
20
Years to consider benefits
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Calculation
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Vaccine
Year Developed
Total staffTotal YearsStaff costsOverhead
Number of people in trials
Trials costTotal R&D CostsPopulation receiving vaccineInitial Year 1 in rollout needed for 60% vaccination rate in SSAYear 2+ additional population needing vaccination for 60% vaccination rate in SSAPeople in rollout needed to acheive global eradication
Variable rollout cost per person
First Year variable rollout cost for 60% of SSAYear 2+ variable rollout cost for 60% of SSAPer Year rollout costs for 60% vaccination rate in SSATotal variable rollout cost to eradicationFixed rollout cost for 60% vaccination rate in SSAFixed rollout cost for eradicationTotal rollout cost for 60% vaccination rate in SSATotal rollout cost for eradicationVaccine EfficacyTotal DALY burden of 60% of SSATotal DALYs prevented by 60% vaccination rate of SSATotal annual DALYs prevented by eradicationRollout cost-effectiveness for 60% vaccination rate of SSA ($/DALY)Rollout cost-effectiveness for eradication ($/DALY)R&D cost-effectiveness for 60% vaccination rate of SSA ($/DALY)R&D cost-effectiveness for eradication ($/DALY)R&D cost-effectiveness for 60% vaccination rate of SSA (DALY/$1000)R&D cost-effectiveness for eradication (DALY/$1000)DALYs per vaccinated person - 1 yearDALYs per vaccinated person - 20 years
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Smallpox ($0.73 per person; no fixed cost)1796126$3,120,000.00$1,560,000100$900,000.00$5,580,000Everyone592,852,85821,784,378977,000,000$0.73$432,782,586.05$302,149,326.36$36,746,595.62$0.00$0.00$0.00$36,746,595.62$2,190,577,844.0095.00%7,437,600.007,065,720.0044,653,000.00$5.20$2.45$5.24$2.46190.833406.650.0119181680.14036608
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Smallpox ($0.73 per person; $100M fixed cost)1796126$3,120,000.00$1,560,000100$900,000.00$5,580,000Everyone592,852,85821,784,378977,000,000$0.73$432,782,586.05$302,149,326.36$36,746,595.62$713,210,000.00$100,000,000.00$165,000,000.00$136,746,595.62$878,210,000.0095.00%7,437,600.007,065,720.0044,653,000.00$5.91$0.98$5.95$0.99168.1291,010.490.0119181680.14036608
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Smallpox ($0.73 per person; $100M fixed cost; only 10 years of benefits)1796126$3,120,000.00$1,560,000100$900,000.00$5,580,000Everyone592,852,85821,784,378977,000,000$0.73$432,782,586.05$143,123,365.12$57,590,595.12$713,210,000.00$100,000,000.00$165,000,000.00$157,590,595.12$878,210,000.0095.00%7,437,600.007,065,720.0044,653,000.00$9.57$1.97$9.64$0.99112.3871,010.490.0119181680.14036608
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Smallpox ($0.73 per person; $100M fixed cost; 30 years of benefits)1796126$3,120,000.00$1,560,000100$900,000.00$5,580,000Everyone592,852,85821,784,378977,000,000$0.73$432,782,586.05$461,175,287.61$29,798,595.79$713,210,000.00$100,000,000.00$165,000,000.00$129,798,595.79$878,210,000.0095.00%7,437,600.007,065,720.0044,653,000.00$4.69$0.66$4.72$0.99201.4311,010.490.0119181680.14036608
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Smallpox ($0.73 per person; $100M fixed cost; 50 years of benefits)1796126$3,120,000.00$1,560,000100$900,000.00$5,580,000Everyone592,852,85821,784,378977,000,000$0.73$432,782,586.05$779,227,210.09$24,240,195.92$713,210,000.00$100,000,000.00$165,000,000.00$124,240,195.92$878,210,000.0095.00%7,437,600.007,065,720.0044,653,000.00$3.71$0.39$3.73$0.99239.3601,010.490.0119181680.14036608
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Smallpox ($0.73 per person; real time since eradication)1796126$3,120,000.00$1,560,000100$900,000.00$5,580,000Everyone977,000,000$0.73NANANANANANA$2,190,577,844.0095.00%NANA44,653,000.00NA$1.02NA$1.02NA406.65NANA
15
Smallpox ($0.73 per person; low DALYs)1796126$3,120,000.00$1,560,000100$900,000.00$5,580,000Everyone592,852,85821,784,378977,000,000$0.73$432,782,586.05$302,149,326.36$36,746,595.62$0.00$0.00$0.00$36,746,595.62$2,190,577,844.0095.00%7,437,600.007,065,720.0017,249,807.50$5.20$6.35$5.24$6.37190.833157.090.0119181680.14036608
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Smallpox ($0.73 per person; low DALYs; real time since eradication)1796126$3,120,000.00$1,560,000100$900,000.00$5,580,000Everyone977,000,000$0.73NANANANANANA$2,190,577,844.0095.00%NANA17,249,807.50NA$2.65NA$2.65NA157.09NANA
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Smallpox ($2 per person)1796126$3,120,000.00$1,560,000100$900,000.00$5,580,000Everyone592,852,85821,784,378977,000,000$2.00$1,185,705,715.20$827,806,373.60$100,675,604.44$1,954,000,000.00$100,000,000.00$165,000,000.00$200,675,604.44$2,119,000,000.0095.00%7,437,600.007,065,720.0044,653,000.00$14.96$2.37$15.00$2.3866.686420.350.0119181680.14036608
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Smallpox ($14.13 per person)1796126$3,120,000.00$1,560,000100$900,000.00$5,580,000Everyone592,852,85821,784,378977,000,000$14.13$8,376,829,762.91$5,848,325,583.13$711,257,767.30$13,804,711,529.09$100,000,000.00$165,000,000.00$811,257,767.30$13,969,711,529.0995.00%7,437,600.007,065,720.0044,653,000.00$101.37$15.64$101.41$15.659.86163.900.0119181680.14036608
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Smallpox ($14.13 per person, world pre-eradication)1796126$3,120,000.00$1,560,000100$900,000.00$5,580,000Everyone1,500,266,667NA$14.13$21,198,309,677.23$0.00$21,198,309,677.23NA$0.00NA$21,198,309,677.23NA95.00%60,000,000.0040,194,780.00NA$527.39NA$527.40NA1.896NA0.026791757NA
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Smallpox ($0.73 per person, real rate developing world pre-eradication)1796126$3,120,000.00$1,560,000100$900,000.00$5,580,000Everyone500,000,000NA$0.73$365,000,000.00$0.00$365,000,000.00NA$0.00NA$365,000,000.00NA95.00%60,000,000.0011,400,000.00NA$32.02NA$32.04NA31.209NA0.022800000NA
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Smallpox ($47.32 per person, ~developed world pre-eradication)1796126$3,120,000.00$1,560,000100$900,000.00$5,580,000Everyone1,000,266,667NA$47.32$47,332,618,682.44$0.00$47,332,618,682.44NA$0.00NA$47,332,618,682.44NA95.00%28,794,780.0028,794,780.00NA$1,643.79NA$1,643.80NA0.608NA0.028787103NA
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Measles ($1 per person; $100M fixed cost)196379$7,560,000.00$3,780,0003000$27,000,000.00$38,340,000Children under 596,301,85221,784,378675,008,634$1.00$96,301,851.60$413,903,186.80$25,510,251.92$675,008,634.00$100,000,000.00$701,000,000.00$125,510,251.92$1,376,008,634.0085.00%6,240,359.985,304,305.9999,341,000.00$5.75$0.69$6.11$0.71163.5761,404.760.0550800000.20792840
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Measles ($2 per person; $100M fixed cost)196379$7,560,000.00$3,780,0003000$27,000,000.00$38,340,000Children under 596,301,85221,784,378675,008,634$2.00$192,603,703.20$827,806,373.60$51,020,503.84$1,350,017,268.00$100,000,000.00$701,000,000.00$151,020,503.84$2,051,017,268.0085.00%6,240,359.985,304,305.9999,341,000.00$10.56$1.03$10.92$1.0591.552950.920.0550800000.20792840
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Measles ($2 per person; no fixed costs)196379$7,560,000.00$3,780,0003000$27,000,000.00$38,340,000Children under 596,301,85221,784,378675,008,634$2.00$192,603,703.20$827,806,373.60$51,020,503.84$1,350,017,268.00$0.00$0.00$51,020,503.84$1,350,017,268.0085.00%6,240,359.985,304,305.9999,341,000.00$9.62$0.68$9.98$0.70100.1991,431.060.0550800000.20792840
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Measles ($5 per person; no fixed costs)196379$7,560,000.00$3,780,0003000$27,000,000.00$38,340,000Children under 596,301,85221,784,378675,008,634$5.00$481,509,258.00$2,069,515,933.99$127,551,259.60$3,375,043,170.00$0.00$0.00$127,551,259.60$3,375,043,170.0085.00%6,240,359.985,304,305.9999,341,000.00$24.05$1.70$24.41$1.7240.970582.070.0550800000.20792840
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Measles ($10 per person; no fixed costs)196379$7,560,000.00$3,780,0003000$27,000,000.00$38,340,000Children under 596,301,85221,784,378675,008,634$10.00$963,018,516.00$4,139,031,867.98$255,102,519.20$6,750,086,340.00$0.00$0.00$255,102,519.20$6,750,086,340.0085.00%6,240,359.985,304,305.9999,341,000.00$48.09$3.40$48.45$3.4220.638292.680.0550800000.20792840
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Measles ($10 per person; $100M fixed cost)196379$7,560,000.00$3,780,0003000$27,000,000.00$38,340,000Children under 596,301,85221,784,378675,008,634$10.00$963,018,516.00$4,139,031,867.98$255,102,519.20$6,750,086,340.00$100,000,000.00$701,000,000.00$355,102,519.20$7,451,086,340.0085.00%6,240,359.985,304,305.9999,341,000.00$49.04$3.75$49.40$3.7720.244265.280.0550800000.20792840
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Measles ($23 per person; no fixed costs)196379$7,560,000.00$3,780,0003000$27,000,000.00$38,340,000Children under 596,301,85221,784,378675,008,634$23.00$2,214,942,586.80$9,519,773,296.35$586,735,794.16$15,525,198,582.00$0.00$0.00$586,735,794.16$15,525,198,582.0085.00%6,240,359.985,304,305.9999,341,000.00$110.61$7.81$110.98$7.839.011127.660.0550800000.20792840
30
Measles ($38 per person; $100M fixed cost)196379$7,560,000.00$3,780,0003000$27,000,000.00$38,340,000Children under 596,301,85221,784,378675,008,634$38.00$3,659,470,360.80$15,728,321,098.31$969,389,572.96$25,650,328,092.00$100,000,000.00$701,000,000.00$1,069,389,572.96$26,351,328,092.0085.00%6,240,359.985,304,305.9999,341,000.00$183.70$13.26$184.06$13.285.43375.290.0550800000.20792840
31
Measles ($1 per person; $100M fixed cost; full SSA population)196379$7,560,000.00$3,780,0003000$27,000,000.00$38,340,000Everyone592,852,85821,784,378675,008,634$1.00$592,852,857.60$413,903,186.80$50,337,802.22$675,008,634.00$100,000,000.00$114,000,000.00$150,337,802.22$789,008,634.0085.00%38,416,865.1732,654,335.4099,341,000.00$1.69$0.40$1.75$0.42570.3342,401.430.0550800000.64870403
32
Measles ($2 per person; $100M fixed cost; full SSA population)196379$7,560,000.00$3,780,0003000$27,000,000.00$38,340,000Everyone592,852,85821,784,378675,008,634$2.00$1,185,705,715.20$827,806,373.60$100,675,604.44$1,350,017,268.00$100,000,000.00$114,000,000.00$200,675,604.44$1,464,017,268.0085.00%38,416,865.1732,654,335.4099,341,000.00$3.24$0.74$3.29$0.76303.5001,322.470.0550800000.64870403
33
Measles ($10 per person; no fixed costs; full SSA population)196379$7,560,000.00$3,780,0003000$27,000,000.00$38,340,000Everyone592,852,85821,784,378675,008,634$10.00$5,928,528,576.00$4,139,031,867.98$503,378,022.20$6,750,086,340.00$0.00$0.00$503,378,022.20$6,750,086,340.0085.00%38,416,865.1732,654,335.4099,341,000.00$15.42$3.40$15.47$3.4264.624292.680.0550800000.64870403
34
Measles ($1 per person; $100M fixed cost; world 1960 pop)196379$7,560,000.00$3,780,0003000$27,000,000.00$38,340,000Everyone1,820,400,0000NA$1.00$1,820,400,000.00$0.00$1,820,400,000.00NA$100,000,000.00NA$1,920,400,000.00NA85.00%117,961,920.00100,267,632.0099,341,000.00$18.21NA$18.22NA54.872NA0.055080000NA
35
Measles ($2 per person; $100M fixed cost; world 1960 pop)196379$7,560,000.00$3,780,0003000$27,000,000.00$38,340,000Everyone1,820,400,0000NA$2.00$3,640,800,000.00$0.00$3,640,800,000.00NA$100,000,000.00NA$3,740,800,000.00NA85.00%117,961,920.00100,267,632.0099,341,000.00$36.36NA$36.38NA27.488NA0.055080000NA
36
Measles ($10 per person; no fixed costs; world 1960 pop)196379$7,560,000.00$3,780,0003000$27,000,000.00$38,340,000Everyone1,820,400,0000NA$10.00$18,204,000,000.00$0.00$18,204,000,000.00NA$0.00NA$18,204,000,000.00NA85.00%117,961,920.00100,267,632.0099,341,000.00$181.55NA$181.57NA5.507NA0.055080000NA
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HPV ($2.55 per person; 50M fixed costs)2006Taking the median of all other costs, due to lack of cost-specific info for HPV$872,500,000.00Everyone age 5-15157,853,70519,260,3701,255,746,704$2.55$402,526,947.24$933,164,942.00$66,784,594.46$3,202,154,095.20$50,000,000.00$398,000,000.00$116,784,594.46$3,600,154,095.2070.00%467,888.53327,521.975,173,000.00$211.54$34.80$344.74$43.232.90123.1320.0020748450.01250559
39
HPV ($2.55 per person; 100M fixed costs)2006Taking the median of all other costs, due to lack of cost-specific info for HPV$872,500,000.00Everyone age 5-15157,853,70519,260,3701,255,746,704$2.55$402,526,947.24$933,164,942.00$66,784,594.46$3,202,154,095.20$100,000,000.00$796,000,000.00$166,784,594.46$3,998,154,095.2070.00%467,888.53327,521.975,173,000.00$219.17$38.64$352.37$47.082.83821.2420.0020748450.01250559
40
HPV ($4.50 per person; 50M fixed cost)2006Taking the median of all other costs, due to lack of cost-specific info for HPV$872,500,000.00Everyone age 5-15157,853,70519,260,3701,255,746,704$4.50$710,341,671.60$1,646,761,662.36$117,855,166.70$5,650,860,168.00$50,000,000.00$398,000,000.00$167,855,166.70$6,048,860,168.0070.00%467,888.53327,521.975,173,000.00$367.47$58.47$500.67$66.901.99714.9480.0020748450.01250559
41
HPV ($4.50 per person; 100M fixed costs)2006Taking the median of all other costs, due to lack of cost-specific info for HPV$872,500,000.00Everyone age 5-15157,853,70519,260,3701,255,746,704$4.50$710,341,671.60$1,646,761,662.36$117,855,166.70$5,650,860,168.00$100,000,000.00$796,000,000.00$217,855,166.70$6,446,860,168.0070.00%467,888.53327,521.975,173,000.00$375.11$62.31$508.30$70.751.96714.1350.0020748450.01250559
42
HPV ($9 per person; 50M fixed cost)2006Taking the median of all other costs, due to lack of cost-specific info for HPV$872,500,000.00Everyone age 5-15157,853,70519,260,3701,255,746,704$9.00$1,420,683,343.20$3,293,523,324.72$235,710,333.40$11,301,720,336.00$50,000,000.00$398,000,000.00$285,710,333.40$11,699,720,336.0070.00%467,888.53327,521.975,173,000.00$727.31$113.08$860.51$121.521.1628.2290.0020748450.01250559
43
HPV ($9 per person; 100M fixed costs)2006Taking the median of all other costs, due to lack of cost-specific info for HPV$872,500,000.00Everyone age 5-15157,853,70519,260,3701,255,746,704$9.00$1,420,683,343.20$3,293,523,324.72$235,710,333.40$11,301,720,336.00$100,000,000.00$796,000,000.00$335,710,333.40$12,097,720,336.0070.00%467,888.53327,521.975,173,000.00$734.94$116.93$868.14$125.361.1527.9770.0020748450.01250559
44
HPV ($13.50 per person; 50M fixed costs)2006Taking the median of all other costs, due to lack of cost-specific info for HPV$872,500,000.00Everyone age 5-15157,853,70519,260,3701,255,746,704$13.50$2,131,025,014.80$4,940,284,987.08$353,565,500.09$16,952,580,504.00$50,000,000.00$398,000,000.00$403,565,500.09$17,350,580,504.0070.00%467,888.53327,521.975,173,000.00$1,087.15$167.70$1,220.35$176.140.8195.6770.0020748450.01250559
45
HPV ($13.50 per person; 100M fixed costs)2006Taking the median of all other costs, due to lack of cost-specific info for HPV$872,500,000.00Everyone age 5-15157,853,70519,260,3701,255,746,704$13.50$2,131,025,014.80$4,940,284,987.08$353,565,500.09$16,952,580,504.00$100,000,000.00$796,000,000.00$453,565,500.09$17,748,580,504.0070.00%467,888.53327,521.975,173,000.00$1,094.78$171.55$1,227.98$179.980.8145.5560.0020748450.01250559
46
HPV ($22.71 per person; 100M fixed costs)2006Taking the median of all other costs, due to lack of cost-specific info for HPV$872,500,000.00Everyone age 5-15157,853,70519,260,3701,255,746,704$22.71$3,584,857,636.01$8,310,657,189.38$594,775,741.27$28,518,007,647.84$100,000,000.00$796,000,000.00$694,775,741.27$29,314,007,647.8470.00%467,888.53327,521.975,173,000.00$1,831.25$283.34$1,964.45$291.770.5093.4270.0020748450.01250559
47
HPV ($49 per person; 100M fixed costs)2006Taking the median of all other costs, due to lack of cost-specific info for HPV$872,500,000.00Everyone age 5-15157,853,70519,260,3701,255,746,704$49.00$7,734,831,535.20$17,931,404,767.92$1,283,311,815.16$61,531,588,496.00$100,000,000.00$796,000,000.00$1,383,311,815.16$62,327,588,496.0070.00%467,888.53327,521.975,173,000.00$3,933.51$602.43$4,066.71$610.860.2461.6370.0020748450.01250559
48
HPV ($400 per person; 100M fixed costs)2006Taking the median of all other costs, due to lack of cost-specific info for HPV$872,500,000.00Everyone age 5-15157,853,70519,260,3701,255,746,704$400.00$63,141,481,920.00$146,378,814,432.00$10,476,014,817.60$502,298,681,600.00$100,000,000.00$796,000,000.00$10,576,014,817.60$503,094,681,600.0070.00%467,888.53327,521.975,173,000.00$32,000.95$4,862.70$32,134.15$4,871.130.0310.2050.0020748450.01250559
49
50
Rotavirus ($3 per person; 50M fixed cost; 30% efficacy)2006Calculated from source data given in article$1,140,000,000.00Children under 596,301,85221,784,378NA$3.00$288,905,554.80$1,241,709,560.39$76,530,755.76NA$50,000,000.00NA$126,530,755.76NA30.00%15,297,975.414,589,392.6227,533,000.00$17.22NA$29.64NA33.738NA0.0476563280.17990385
51
Rotavirus ($3 per person; 50M fixed cost; 54% efficacy)2006Calculated from source data given in article$1,140,000,000.00Children under 596,301,85221,784,378NA$3.00$288,905,554.80$1,241,709,560.39$76,530,755.76NA$50,000,000.00NA$126,530,755.76NA54.00%15,297,975.418,260,906.7227,533,000.00$9.57NA$16.47NA60.728NA0.0857813900.32382694
52
Rotavirus ($3 per person; 100M fixed cost; 30% efficacy)2006Calculated from source data given in article$1,140,000,000.00Children under 596,301,85221,784,378NA$3.00$288,905,554.80$1,241,709,560.39$76,530,755.76NA$100,000,000.00NA$176,530,755.76NA30.00%15,297,975.414,589,392.6227,533,000.00$17.77NA$30.18NA33.129NA0.0476563280.17990385
53
Rotavirus ($3 per person; 100M fixed cost; 54% efficacy)2006Calculated from source data given in article$1,140,000,000.00Children under 596,301,85221,784,378NA$3.00$288,905,554.80$1,241,709,560.39$76,530,755.76NA$100,000,000.00NA$176,530,755.76NA54.00%15,297,975.418,260,906.7227,533,000.00$9.87NA$16.77NA59.632NA0.0857813900.32382694
54
Rotavirus ($7 per person; 50M fixed cost; 30% efficacy)2006Calculated from source data given in article$1,140,000,000.00Children under 596,301,85221,784,378NA$7.00$674,112,961.20$2,897,322,307.58$178,571,763.44NA$50,000,000.00NA$228,571,763.44NA30.00%15,297,975.414,589,392.6227,533,000.00$39.45NA$51.87NA19.277NA0.0476563280.17990385
55
Rotavirus ($7 per person; 50M fixed cost; 54% efficacy)2006Calculated from source data given in article$1,140,000,000.00Children under 596,301,85221,784,378NA$7.00$674,112,961.20$2,897,322,307.58$178,571,763.44NA$50,000,000.00NA$228,571,763.44NA54.00%15,297,975.418,260,906.7227,533,000.00$21.92NA$28.82NA34.699NA0.0857813900.32382694
56
Rotavirus ($7 per person; 100M fixed cost; 30% efficacy)2006Calculated from source data given in article$1,140,000,000.00Children under 596,301,85221,784,378NA$7.00$674,112,961.20$2,897,322,307.58$178,571,763.44NA$100,000,000.00NA$278,571,763.44NA30.00%15,297,975.414,589,392.6227,533,000.00$40.00NA$52.42NA19.077NA0.0476563280.17990385
57
Rotavirus ($7 per person; 100M fixed cost; 54% efficacy)2006Calculated from source data given in article$1,140,000,000.00Children under 596,301,85221,784,378NA$7.00$674,112,961.20$2,897,322,307.58$178,571,763.44NA$100,000,000.00NA$278,571,763.44NA54.00%15,297,975.418,260,906.7227,533,000.00$22.22NA$29.12NA34.339NA0.0857813900.32382694
58
Rotavirus ($28 per person; 100M fixed cost; 30% efficacy)2006Calculated from source data given in article$1,140,000,000.00Children under 596,301,85221,784,378NA$28.00$2,696,451,844.80$11,589,289,230.34$714,287,053.76NA$100,000,000.00NA$814,287,053.76NA30.00%15,297,975.414,589,392.6227,533,000.00$156.73NA$169.15NA5.912NA0.0476563280.17990385
59
Rotavirus ($28 per person; 100M fixed cost; 54% efficacy)2006Calculated from source data given in article$1,140,000,000.00Children under 596,301,85221,784,378NA$28.00$2,696,451,844.80$11,589,289,230.34$714,287,053.76NA$100,000,000.00NA$814,287,053.76NA54.00%15,297,975.418,260,906.7227,533,000.00$87.07NA$93.97NA10.642NA0.0857813900.32382694
60
386,200,214
61
HIV ($2 per person; > 10)Not licensed yetCalculated from source data given in article$24,500,000,000Everyone older than 10412,101,30716,889,9406,114,140,688$2.00$824,202,613.20$641,817,715.44$73,301,016.43$12,228,281,376.00$100,000,000.00$1,484,000,000.00$173,301,016.43$13,712,281,376.0050.00%19,310,010.699,655,005.3557,575,000.00$8.11$11.91$134.99$33.187.40830.1340.0234287180.26343442
62
HIV ($2 per person; 15-49 age)Not licensed yetCalculated from source data given in article$24,500,000,000Everyone 15-49280,333,25914,680,8016,114,140,688$2.00$560,666,518.80$557,870,441.04$55,926,847.99$12,228,281,376.00$100,000,000.00$2,181,000,000.00$155,926,847.99$14,409,281,376.0050.00%19,310,010.699,655,005.3557,575,000.00$6.31$12.51$133.19$33.797.50829.5940.0344411700.34527264
63
HIV ($30 per person; > 10)Not licensed yetCalculated from source data given in article$24,500,000,000Everyone older than 10412,101,30716,889,9406,114,140,688$30.00$12,363,039,198.00$9,627,265,731.60$1,099,515,246.48$183,424,220,640.00$100,000,000.00$1,484,000,000.00$1,199,515,246.48$184,908,220,640.0050.00%19,310,010.699,655,005.3557,575,000.00$114.40$160.58$241.28$181.864.1455.4990.0234287180.26343442
64
HIV ($30 per person; > 10; 75% efficacy)Not licensed yetCalculated from source data given in article$24,500,000,000Everyone older than 10412,101,30716,889,9406,114,140,688$30.00$12,363,039,198.00$9,627,265,731.60$1,099,515,246.48$183,424,220,640.00$100,000,000.00$1,484,000,000.00$1,199,515,246.48$184,908,220,640.0075.00%19,310,010.6914,482,508.0257,575,000.00$76.27$160.58$160.85$181.866.2175.4990.0351430770.39515163
65
HIV ($30 per person; 15-49 age)Not licensed yetCalculated from source data given in article$24,500,000,000Everyone 15-49280,333,25914,680,8016,114,140,688$30.00$8,409,997,782.00$8,368,056,615.60$838,902,719.88$183,424,220,640.00$100,000,000.00$2,181,000,000.00$938,902,719.88$185,605,220,640.0050.00%19,310,010.699,655,005.3557,575,000.00$87.41$161.19$214.28$182.464.6675.4810.0344411700.34527264
66
HIV ($30 per person; 15-49 age; 75% efficacy)Not licensed yetCalculated from source data given in article$24,500,000,000Everyone 15-49280,333,25914,680,8016,114,140,688$30.00$8,409,997,782.00$8,368,056,615.60$838,902,719.88$183,424,220,640.00$100,000,000.00$2,181,000,000.00$938,902,719.88$185,605,220,640.0075.00%19,310,010.6914,482,508.0257,575,000.00$58.27$161.19$142.86$182.467.0005.4810.0516617540.51790897
67
HIV ($60 per person; > 10)Not licensed yetCalculated from source data given in article$24,500,000,000Everyone older than 10412,101,30716,889,9406,114,140,688$60.00$24,726,078,396.00$19,254,531,463.20$2,199,030,492.96$366,848,441,280.00$100,000,000.00$1,484,000,000.00$2,299,030,492.96$368,332,441,280.0050.00%19,310,010.699,655,005.3557,575,000.00$228.28$319.87$355.16$341.152.8162.9310.0234287180.26343442
68
HIV ($60 per person; 15-49 age)Not licensed yetCalculated from source data given in article$24,500,000,000Everyone 15-49280,333,25914,680,8016,114,140,688$60.00$16,819,995,564.00$16,736,113,231.20$1,677,805,439.76$366,848,441,280.00$100,000,000.00$2,181,000,000.00$1,777,805,439.76$369,029,441,280.0050.00%19,310,010.699,655,005.3557,575,000.00$174.29$320.48$301.17$341.753.3202.9260.0344411700.34527264
69
HIV ($60 per person; 15-49 age; 75% efficacy)Not licensed yetCalculated from source data given in article$24,500,000,000Everyone 15-49280,333,25914,680,8016,114,140,688$60.00$16,819,995,564.00$16,736,113,231.20$1,677,805,439.76$366,848,441,280.00$100,000,000.00$2,181,000,000.00$1,777,805,439.76$369,029,441,280.0075.00%19,310,010.6914,482,508.0257,575,000.00$116.20$320.48$200.78$341.754.9812.9260.0516617540.51790897
70
HIV ($100 per person; > 10)Not licensed yetCalculated from source data given in article$24,500,000,000Everyone older than 10412,101,30716,889,9406,114,140,688$100.00$41,210,130,660.00$32,090,885,772.00$3,665,050,821.60$611,414,068,800.00$100,000,000.00$1,484,000,000.00$3,765,050,821.60$612,898,068,800.0050.00%19,310,010.699,655,005.3557,575,000.00$380.12$532.26$507.00$553.541.9721.8070.0234287180.26343442
71
HIV ($100 per person; > 10; no fixed cost)Not licensed yetCalculated from source data given in article$24,500,000,000Everyone older than 10412,101,30716,889,9406,114,140,688$105.00$43,270,637,193.00$33,695,430,060.60$3,848,303,362.68$641,984,772,240.00$0.00$0.00$3,848,303,362.68$641,984,772,240.0050.00%19,310,010.699,655,005.3557,575,000.00$398.58$557.52$525.46$578.801.9031.7280.0234287180.26343442
72
HIV ($105 per person; > 10)Not licensed yetCalculated from source data given in article$24,500,000,000Everyone older than 10412,101,30716,889,9406,114,140,688$105.00$43,270,637,193.00$33,695,430,060.60$3,848,303,362.68$641,984,772,240.00$100,000,000.00$1,484,000,000.00$3,948,303,362.68$643,468,772,240.0050.00%19,310,010.699,655,005.3557,575,000.00$399.10$558.81$525.98$580.091.9011.7240.0234287180.26343442
73
HIV ($105 per person; > 10; 75% efficacy)Not licensed yetCalculated from source data given in article$24,500,000,000Everyone older than 10412,101,30716,889,9406,114,140,688$105.00$43,270,637,193.00$33,695,430,060.60$3,848,303,362.68$641,984,772,240.00$100,000,000.00$1,484,000,000.00$3,948,303,362.68$643,468,772,240.0075.00%19,310,010.6914,482,508.0257,575,000.00$266.07$558.81$350.65$580.092.8521.7240.0351430770.39515163
74
HIV ($105 per person; > 10; no fixed cost; 75% efficacy)Not licensed yetCalculated from source data given in article$24,500,000,000Everyone older than 10412,101,30716,889,9406,114,140,688$105.00$43,270,637,193.00$33,695,430,060.60$3,848,303,362.68$641,984,772,240.00$0.00$0.00$3,848,303,362.68$641,984,772,240.0075.00%19,310,010.6914,482,508.0257,575,000.00$265.72$557.52$350.31$578.802.8551.7280.0351430770.39515163
75
HIV ($105 per person; > 10; no fixed cost)Not licensed yetCalculated from source data given in article$24,500,000,000Everyone older than 10412,101,30716,889,9406,114,140,688$105.00$43,270,637,193.00$33,695,430,060.60$3,848,303,362.68$641,984,772,240.00$0.00$0.00$3,848,303,362.68$641,984,772,240.0050.00%19,310,010.699,655,005.3557,575,000.00$398.58$557.52$525.46$578.801.9031.7280.0234287180.26343442
76
HIV ($105 per person; 15-49 age)Not licensed yetCalculated from source data given in article$24,500,000,000Everyone 15-49280,333,25914,680,8016,114,140,688$105.00$29,434,992,237.00$29,288,198,154.60$2,936,159,519.58$641,984,772,240.00$100,000,000.00$2,181,000,000.00$3,036,159,519.58$644,165,772,240.0050.00%19,310,010.699,655,005.3557,575,000.00$304.63$559.41$431.50$580.692.3171.7220.0344411700.34527264
77
HIV ($105 per person; 15-49 age, no fixed cost)Not licensed yetCalculated from source data given in article$24,500,000,000Everyone 15-49280,333,25914,680,8016,114,140,688$105.00$29,434,992,237.00$29,288,198,154.60$2,936,159,519.58$641,984,772,240.00$0.00$0.00$2,936,159,519.58$641,984,772,240.0050.00%19,310,010.699,655,005.3557,575,000.00$304.11$557.52$430.98$578.802.3201.7280.0344411700.34527264
78
HIV ($160 per person; > 10)Not licensed yetCalculated from source data given in article$24,500,000,000Everyone older than 10412,101,30716,889,9406,114,140,688$160.00$65,936,209,056.00$51,345,417,235.20$5,864,081,314.56$978,262,510,080.00$100,000,000.00$1,484,000,000.00$5,964,081,314.56$979,746,510,080.0050.00%19,310,010.699,655,005.3557,575,000.00$607.88$850.84$734.76$872.121.3611.1470.0234287180.26343442
79
HIV ($160 per person; 15-49 age)Not licensed yetCalculated from source data given in article$24,500,000,000Everyone 15-49280,333,25914,680,8016,114,140,688$160.00$44,853,321,504.00$44,629,635,283.20$4,474,147,839.36$978,262,510,080.00$100,000,000.00$2,181,000,000.00$4,574,147,839.36$980,443,510,080.0050.00%19,310,010.699,655,005.3557,575,000.00$463.92$851.45$590.80$872.731.6931.1460.0344411700.34527264
80
81
Malaria (39% efficacy; 100M fixed cost)Not licensed yetCalculated from source data given in article$605,000,000Children under 596,301,85221,784,378675,008,634$22.00$2,118,640,735.20$9,105,870,109.55$561,225,542.24$14,850,189,948.00$100,000,000.00$701,000,000.00$661,225,542.24$15,551,189,948.0039.00%26,569,785.3310,362,216.2856,201,000.00$54.64$13.84$57.56$14.3717.37269.5720.1076014230.40619812
82
Malaria (39% efficacy; actual estimates for fixed cost)Not licensed yetCalculated from source data given in article$605,000,000Children under 596,301,85221,784,378675,008,634$22.00$2,118,640,735.20$9,105,870,109.55$561,225,542.24$14,850,189,948.00$93,080,000.00$652,000,000.00$654,305,542.24$15,502,189,948.0039.00%26,569,785.3310,362,216.2856,201,000.00$54.61$13.79$57.53$14.3317.38269.7840.1076014230.40619812
83
Malaria (50% efficacy; actual estimates for fixed cost)Not licensed yetCalculated from source data given in article$605,000,000Children under 596,301,85221,784,378675,008,634$22.00$2,118,640,735.20$9,105,870,109.55$561,225,542.24$14,850,189,948.00$93,080,000.00$652,000,000.00$654,305,542.24$15,502,189,948.0050.00%26,569,785.3313,284,892.6756,201,000.00$42.60$13.79$44.87$14.3322.28569.7840.1379505420.52076682
84
Malaria (50% efficacy; 100M fixed cost)Not licensed yetCalculated from source data given in article$605,000,000Children under 596,301,85221,784,378675,008,634$22.00$2,118,640,735.20$9,105,870,109.55$561,225,542.24$14,850,189,948.00$100,000,000.00$701,000,000.00$661,225,542.24$15,551,189,948.0050.00%26,569,785.3313,284,892.6756,201,000.00$42.62$13.84$44.90$14.3722.27269.5720.1379505420.52076682
85
Malaria (75% efficacy; actual estimates for fixed cost)Not licensed yetCalculated from source data given in article$605,000,000Children under 596,301,85221,784,378675,008,634$22.00$2,118,640,735.20$9,105,870,109.55$561,225,542.24$14,850,189,948.00$93,080,000.00$652,000,000.00$654,305,542.24$15,502,189,948.0075.00%26,569,785.3319,927,339.0056,201,000.00$28.40$13.79$29.92$14.3333.42869.7840.2069258140.78115022
86
Malaria (75% efficacy; 100M fixed cost)Not licensed yetCalculated from source data given in article$605,000,000Children under 596,301,85221,784,378675,008,634$22.00$2,118,640,735.20$9,105,870,109.55$561,225,542.24$14,850,189,948.00$100,000,000.00$701,000,000.00$661,225,542.24$15,551,189,948.0075.00%26,569,785.3319,927,339.0056,201,000.00$28.41$13.84$29.93$14.3733.40869.5720.2069258140.78115022
87
Malaria -- Levine, Kremer, & Albright (2005) parametersNot licensed yetCalculated from source data given in article$605,000,000Children under 5200,000,0000NANANANA$4,600,000,000.00NA$0.00NA$4,600,000,000.00NA60.00%55,180,216.9733,108,130.18NA$138.94NA$139.85NA7.150NA0.1655406513.31081302
88
Malaria -- Penny, et al. (2016) parametersNot licensed yetCalculated from source data given in article$605,000,000Children under 5100,0000NA$22.00$2,200,000.00NA$2,200,000.00NA$0.00NA$2,200,000.00NA25.00%27,590.116,897.53NA$318.95NA$4,704.58NA0.213NA0.0689752711.37950542
89
Malaria -- Winskill, Walker, Griffin, & Ghani (2017) parametersNot licensed yetCalculated from source data given in article$605,000,000Children under 515,5000NA$20.00$310,000.00NA$310,000.00NA$0.00NA$310,000.00NA32.20%2,059.16663.05NA$467.54NA$46,090.11NA0.022NA0.0427773540.85554709
90
Malaria (75% efficacy; actual estimates for fixed cost; DR of Congo estimate as of 2018)
Not licensed yetCalculated from source data given in article$605,000,000Children under 58,743,2111,977,796NA$22.00$192,350,650.80$826,718,760.09$50,953,470.54NA$93,080,000.00NA$144,033,470.54NA75.00%2,980,774.752,235,581.0656,201,000.00$24.87NA$38.40NA26.038NA0.2556933550.96524894
91
Malaria (60% efficacy; DR of Congo estimate as of 2004)Not licensed yetCalculated from source data given in article$605,000,000Children under 56,157,9091,392,977NA$22.00$135,474,002.40$582,264,207.70$35,886,910.50NA$93,080,000.00NA$128,966,910.50NA60.00%5,354,235.453,212,541.2756,201,000.00$12.62NA$22.04NA45.381NA0.5216935111.96940631
92
Malaria DR of Congo estimate as of 2004 -- Levine, Kremer, & Albright (2005) parameters
Not licensed yetCalculated from source data given in article$605,000,000Children under 56,157,9091,392,977NA$20.00$123,158,184.00$529,331,097.91$32,624,464.10NA$0.00NA$32,624,464.10NA60.00%5,354,235.453,212,541.2756,201,000.00$10.16NA$19.57NA51.095NA0.5216935111.96940631
93
94
EbolaNot licensed yetCalculated from source data given in article$1,500,000,000Everyone
Rollout costs for ebola are highly speculative as it is too early to have reliable information
Rollout costs for ebola are highly speculative as it is too early to have reliable information
Cost-effectiveness for ebola are highly speculative as it is too early to have reliable information
95
Ebola ($4.50; 50%; 100M fixed cost; ring vaccine pop, mean; 2014 burden)Not licensed yetCalculated from source data given in article$1,500,000,000Everyone14,550,274534,650228,390,414$4.50$65,476,233.90$45,712,560.08$5,559,439.70$1,027,756,863.00$100,000,000.00$1,570,000,000.00$105,559,439.70$2,597,756,863.0050.00%776,548.12388,274.061,294,246.86$27.20$100.36$220.36$158.314.5386.3170.0266849990.31428226
96
Ebola ($4.50 per person; 50% efficacy; 100M fixed cost; ring vaccine pop, mean)Not licensed yetCalculated from source data given in article$1,500,000,000Everyone14,550,274534,650228,390,414$4.50$65,476,233.90$45,712,560.08$5,559,439.70$1,027,756,863.00$100,000,000.00$1,570,000,000.00$105,559,439.70$2,597,756,863.0050.00%185,369.0292,684.51308,948.36$113.93$420.42$923.13$663.181.0831.5080.0063699490.07502200
97
Ebola ($4.50 per person; 50% efficacy; 100M fixed cost; ring vaccine pop, max)Not licensed yetCalculated from source data given in article$1,500,000,000Everyone183,106,6976,728,256228,390,414$4.50$823,980,138.30$575,265,853.45$69,962,299.59$1,027,756,863.00$100,000,000.00$125,000,000.00$169,962,299.59$1,152,756,863.0050.00%185,369.0292,684.51308,948.36$808.79$186.56$1,617.99$429.320.6182.3290.0005061780.00596150
98
Ebola ($4.50 per person; 50% efficacy; 100M fixed cost; outbreak pop)Not licensed yetCalculated from source data given in article$1,500,000,000Everyone137,034,2485,035,323228,390,414$4.50$616,654,117.80$430,520,155.61$52,358,713.67$1,027,756,863.00$100,000,000.00$167,000,000.00$152,358,713.67$1,194,756,863.0050.00%185,369.0292,684.51308,948.36$618.86$193.36$1,428.06$436.120.7002.2930.0006763600.00796582
99
Ebola ($4.50 per person; 50% efficacy; 100M fixed cost; region pop)Not licensed yetCalculated from source data given in article$1,500,000,000Everyone229,259,7618,424,150382,099,601$4.50$1,031,668,922.70$720,264,816.73$87,596,686.97$1,719,448,204.50$100,000,000.00$167,000,000.00$187,596,686.97$1,886,448,204.5050.00%185,369.0292,684.51308,948.36$999.05$305.30$1,808.25$548.060.5531.8250.0004042770.00476137
100
Ebola ($4.50 per person; 50% efficacy; 100M fixed cost)Not licensed yetCalculated from source data given in article$1,500,000,000Everyone592,852,85821,784,378988,088,096$4.50$2,667,837,859.20$1,862,564,340.59$226,520,109.99$4,446,396,432.00$100,000,000.00$167,000,000.00$326,520,109.99$4,613,396,432.0050.00%185,369.0292,684.51308,948.36$2,497.94$746.63$3,307.13$989.390.3021.0110.0001563360.00184125
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