MoH Clinical Data Model v2 - Feb 2023

	A	B	C	D	E	F	G	H	I	J	K
1	Schema	MoHCCN Clinical Field (Fields in italics are identifier fields. Fields in bold are required for data integrity purposes.)	Data Tier	Requirements	Field Description	Type	Permissible Values	Source	mCODE Profile Name(s)	mCODE FHIR Element / ARGO Data Element Name	Notes

2	Sample Registration	program_id	ID	Required	Unique identifier of the program.	Text	Unique identifier of the MOH program.	ICGC ARGO		program_id
3	Sample Registration	submitter_donor_id	ID	Required	Unique identifier for the donor, assigned by the data provider.	Text	Values must meet the regular expression ^[A-Za-z0-9\-\._]{1,64} Examples: 90234, BLD_donor_89, AML-90	mCODE	mCODE STU1: Cancer Patient mCODE STU2: Cancer Patient	mCODE STU1: Patient: Identifier mCODE STU2: Patient: Identifier
4	Sample Registration	submitter_specimen_id	ID	Required	Unique identifier of the specimen, assigned by the data provider.	Text	Values must meet the regular expression ^[A-Za-z0-9\-\._]{1,64} Examples: LAML_PO, 00445, THY_099-tumour	mCODE	mCODE STU1: Genetic Specimen mCODE STU2: Genomic Specimen	mCODE STU1: Specimen.Identifier mCODE STU2: Specimen.identifier
5	Sample Registration	specimen_tissue_source	Core	Required	Tissue source of the biospecimen.	Text	Abdominal fluid (NCIt: C77611) Amniotic fluid (NCIt: C13188) Arterial blood (NCIt: C78729) Bile (NCIt: C13192) Blood derived - bone marrow Blood derived - peripheral blood Bone marrow fluid (SNOMED: 413679007) Bone marrow derived mononuclear cells Buccal cell (NCIt: C172264) Buffy coat (NCIt: C84507) Cerebrospinal fluid (NCIt: C12692) Cervical mucus (SNOMED: 26859008) Convalescent plasma (NCIt: C173750) Cord blood (NCIt: C13300) Duodenal fluid (SNOMED: 122574004) Female genital fluid (SNOMED: 50473004) Fetal blood (SNOMED: 737357006) Hydrocele fluid (SNOMED: 725093005) Male genital fluid (SNOMED: 23378005) Pancreatic fluid (SNOMED: 17387004) Pericardial effusion (NCIt: C3319) Pleural fluid (NCIt: C77613) Renal cyst fluid (SNOMED: 734111007) Saliva (NCIt: C13275) Seminal fluid (NCIt: C33529) Serum (NCIt: C13325) Solid tissue (NCIt: C164014) Sputum (NCIt: C13278) Synovial fluid (NCIt: C33718) Urine (NCIt: C13283) Venous blood (NCIt: C78730) Vitreous fluid (NCIt: C13323) Whole blood (Reference: NCIt: C41067) Wound (Reference: SNOMED: 122566000)	mCODE	mCODE STU1: Genetic Specimen mCODE STU2: Genomic Specimen	mCODE STU1: Specimen.type mCODE Value Set:Genetic Specimen Type Value Set mCODE STU2: Genomic Specimen Specimen Type Value Set
6	Sample Registration	tumour_normal_designation	Core	Required	Description of specimen's tumour/normal status for data processing.	Text	Normal Tumour	ICGC ARGO		tumour_normal_designation
7	Sample Registration	specimen_type	Core	Required	Description of the kind of specimen that was collected with respect to tumour/normal tissue origin.	Text	Cell line - derived from normal Cell line - derived from primary tumour Cell line - derived from metastatic tumour Cell line - derived from xenograft tumour Metastatic tumour - additional metastatic Metastatic tumour - metastasis local to lymph node Metastatic tumour - metastasis to distant location Metastatic tumour Normal - tissue adjacent to primary tumour Normal Primary tumour - additional new primary Primary tumour - adjacent to normal Primary tumour Recurrent tumour Tumour - unknown if derived from primary or metastatic tumour Xenograft - derived from primary tumour Xenograft - derived from metastatic tumour Xenograft - derived from tumour cell line	ICGC ARGO		specimen_type
8	Sample Registration	submitter_sample_id	ID	Required	Unique identifier of the sample, assigned by the data provider.	Text	Values must meet the regular expression ^[A-Za-z0-9\-\._]{1,64} Examples: hnc_12, CCG_34_94583, BRCA47832-3239	ICGC ARGO		submitter_sample_id
9	Sample Registration	sample_type	Core	Required	Description of the type of molecular sample used for testing.	Text	Amplified DNA ctDNA Other DNA enrichments Other RNA fractions polyA+ RNA Protein rRNA-depleted RNA Total DNA Total RNA	ICGC ARGO		sample_type
10	Donor	program_id	ID	Required	Unique identifier of the program.	Text	Unique identifier of the MOH program.	ICGC ARGO		program_id
11	Donor	submitter_donor_id	ID	Required	Unique identifier of the donor, assigned by the data provider.	Text	Values must meet the regular expression ^[A-Za-z0-9\-\._]{1,64}} Examples: 90234, BLD_donor_89, AML-90	mCODE	mCODE STU1: Cancer Patient mCODE STU2: Cancer Patient	mCODE STU1: Patient: Identifier mCODE STU2: Patient: Identifier
12	Donor	gender	Core	Required	Description of the donor self-reported gender. Gender is described as the assemblage of properties that distinguish people on the basis of their societal roles.	Text	Man Woman Non-binary	Statistics Canada
13	Donor	sex_at_birth	Core	Required	Indicate donor's sex assigned at birth.	Text	Male Female Other
14	Donor	is_deceased	Core	Required	Indicate if donor's last known status is deceased.	Boolean	Yes No	mCODE	mCODE STU1: Cancer Patient mCODE STU2: Cancer Patient	mCODE STU1: Patient.deceased.boolean mCODE STU2: Patient.deceased.boolean
15	Donor	lost_to_followup_after_clinical_event_identifier	Extended	Optional/Conditional This field can only be submitted if "is_deceased" = "No"	If the donor became lost to follow up, indicate the identifier of the clinical event (eg. submitter_primary_diagnosis_id, submitter_treatment_id or submitter_follow_up_id) after which the donor became lost to follow up.	Text		ICGC ARGO
16	Donor	lost_to_followup_reason	Extended	Optional/Conditional This field should only be submitted if "lost_to_followup_after_clinical_event" was submitted.	Indicate reason the donor was lost to follow up.	Text	Completed study Discharged to palliative care Lost contact Not applicable Unknown Withdrew from study
17	Donor	date_alive_after_lost_to_followup	Extended	Optional/Conditional If this field is submitted, then "lost_to_followup_after_clinical_event_identifier" must be submitted to indicate when the donor was lost to follow up.	Indicate the date when donor was discovered to be alive with unknown disease status after they had been lost to follow up.	Integer	Format YYYY-MM				This field should only be submitted if the donor was lost to follow up but discovered to be alive later on without knowing any cancer status information. The "lost_to_followup_after_clinical_event_identifier" field must be submitted if this field is submitted.
18	Donor	cause_of_death	Extended	Conditional Only required if "is_deceased" is "Yes"	Indicate the cause of a donor's death.	Text	Died of cancer Died of other reasons Unknown	ICGC ARGO		cause_of_death
19	Donor	date_of_birth	Core	Required	Indicate donor's date of birth.	Integer	Format YYYY-MM	mCODE	mCODE STU1: Cancer Patient mCODE STU2: Cancer.Patient	mCODE STU1: Patient.birthDate mCODE STU2: Patient.birthDate	This field is required in order to calculate ARGO's required "age_at_diagnosis" field, which is recorded in years.
20	Donor	date_of_death	Core	Conditional Only required if "is_deceased" is "Yes"	Indicate donor's date of death.	Integer	Format YYYY-MM	mCODE	mCODE STU1: Cancer Patient mCODE STU2: Cancer.Patient	mCODE STU1: Patient.deceased.dateTime mCODE STU2: Patient.deceased.dateTime	This field is required in order to calculate ARGO's required "survival_time" field which is recorded in days.
21	Donor	primary_site	Core	Required	The text term used to describe the primary site of disease, as categorized by the World Health Organization's (WHO) International Classification of Diseases for Oncology (ICD-O). This categorization groups cases into general categories.	Text	Breast (Reference: ICD-O C50)	ICGC ARGO		primary_site	To include multiple values, separate values with a pipe delimiter '\|' within your file.
22	Specimen	program_id	ID	Required	Unique identifier of the program.	Text	Unique identifier of the MOH program.	ICGC ARGO		program_id
23	Specimen	submitter_donor_id	ID	Required	Unique identifier for the donor, assigned by the data provider.	Text	Values must meet the regular expression ^[A-Za-z0-9\-\._]{1,64} Examples: 90234, BLD_donor_89, AML-90	mCODE	mCODE STU1: Cancer Patient mCODE STU2: Cancer Patient	mCODE STU1: Patient: Identifier mCODE STU2: Patient: Identifier
24	Specimen	submitter_specimen_id	ID	Required	Unique identifier of the specimen, assigned by the data provider.	Text	Values must meet the regular expression ^[A-Za-z0-9\-\._]{1,64}} Examples: LAML_PO, 00445, THY_099-tumour	mCODE	mCODE STU1: Genetic Specimen mCODE STU2: Genomic Specimen	mCODE STU1: Specimen.Identifier mCODE STU2: Specimen.identifier
25	Specimen	submitter_primary_diagnosis_id	ID	Required	Indicate the primary diagnosis event in the clinical timeline that this specimen acquisition was related to.	Text	Values must meet the regular expression ^[A-Za-z0-9\-\._]{1,64} Examples: LAML_PO, 00445, THY_099-tumour	mCODE	mCODE STU1: Primary Cancer Condition mCODE STU2: Primary Cancer Condition	mCODE STU1: Condition.identifier mCODE STU2: Condition.identifier
26	Specimen	pathological_tumour_staging_system	Core	Required/Conditional This field is only required if the specimen is a tumour, and if clinical staging was not submitted.	Specify the tumour staging system used to assess the cancer at the time the tumour specimen was resected. Pathological classification is based on the clinical stage information (acquired before treatment) and supplemented/modified by operative findings and pathological evaluation of the resected specimen.	Text	AJCC 8th edition AJCC 7th edition AJCC 6th edition Ann Arbor staging system Binet staging system Durie-Salmon staging system FIGO staging system International Neuroblastoma Risk Group Staging System International Neuroblastoma Staging System Lugano staging system Rai staging system Revised International staging system (R-ISS) SEER staging system St Jude staging system	ICGC ARGO		pathological_tumour_staging_system	Either the clinical or pathological staging must be submitted.
27	Specimen	pathological_t_category	Core	Required/Conditional This field is required only if the selected pathological_tumour_staging_system is any edition of the AJCC cancer staging system	The code to represent the stage of cancer defined by the size or contiguous extension of the primary tumour (T), according to criteria based on multiple editions of the AJCC's Cancer Staging Manual.	Text	Click for drop-down list of AJCC T category values	mCODE STU 1	mCODE STU1: TNM Pathological Primary Tumor Category mCODE STU2: Staging Type for Primary Tumor Category Value Set: LOINC 21899-0 T category: TNM Primary Tumor Category Profile	mCODE STU1: Observation.value[x]:valueCodeableConcept AJCC values from TNM Primary Tumor Category Value Set mCODE STU2: Observation.value[x] TNM Primary Tumor Category Value Set
28	Specimen	pathological_n_category	Core	Required/Conditional This field is required only if the selected pathological_tumour_staging_system is any edition of the AJCC cancer staging system	The code to represent the stage of cancer defined by whether or not the cancer has reached nearby lymph nodes (N), according to criteria based on multiple editions of the AJCC's Cancer Staging Manual.	Text	Click for drop-down list of AJCC N category values	mCODE STU 1	TNM Pathological Regional Nodes Category	Observation.value[x]:valueCodeableConcept AJCC values from TNM Regional Nodes Category Value Set
29	Specimen	pathological_m_category	Core	Required/Conditional This field is required only if the selected pathological_tumour_staging_system is any edition of the AJCC cancer staging system	The code to represent the stage of cancer defined by whether there are distant metastases (M), meaning spread of cancer to other parts of the body, according to criteria based on multiple editions of the AJCC's Cancer Staging Manual.	Text	Click for drop-down list of AJCC M category values	mCODE STU 1	TNM Pathological Distant Metastases Category	Observation.value[x]:valueCodeableConcept AJCC values from TNM Distant Metastases Category Value Set
30	Specimen	pathological_stage_group	Core	Required/Conditional This field is only required if the specimen is a tumour, and if clinical staging was not submitted.	Specify the tumour stage, based on pathological_tumour_staging_system, used to assess the cancer at the time the tumour specimen was resected.	Text	Click for drop-down list of pathological stage groups	ICGC ARGO		pathological_stage_group	This field is dependent on the selected pathological_tumour_staging_system. Please refer to the documentation for Tumour Staging Classifications
31	Specimen	specimen_collection_date	Core	Required	Indicate the date when the specimen was collected from donor.	Text	Format YYYY-MM	mCODE STU 1	mCODE STU1: Genetic Specimen mCODE STU2: Genomic Specimen	Specimen.collection.collected.dateTime Specimen.collection.collected[x].dateTime	This field is required in order to calculate the required ARGO "specimen_acquisition_interval" field which is recorded in days. ([specimen_collection_date] - [primary_diagnosis_date])
32	Specimen	specimen_storage	Extended	Required	Indicate the method of long term storage for specimen that were not extracted freshly or immediately cultured.	Text	Cut slide Frozen in -70 freezer Frozen in liquid nitrogen Frozen in vapour phase Not Applicable Other Paraffin block RNA later frozen Unknown	ICGC ARGO		specimen_storage
33	Specimen	specimen_processing	Extended	Optional	Indicate the technique used to process specimen.	Text	Cryopreservation in liquid nitrogen (dead tissue) Cryopreservation in dry ice (dead tissue) Cryopreservation of live cells in liquid nitrogen Cryopreservation - other Formalin fixed & paraffin embedded Formalin fixed - buffered Formalin fixed - unbuffered Fresh Other Unknown	ICGC ARGO		specimen_processing
34	Specimen	tumour_histological_type	Core	Required/Conditional This field is only required if the specimen is a tumour.	The code to represent the histology (morphology) of neoplasms that is usually obtained from a pathology report, according to the International Classification of Diseases for Oncology, 3rd Edition (WHO ICD-O-3). Refer to the ICD-O-3 manual for guidelines at https://apps.who.int/iris/handle/10665/42344.	Text	ICD-O-3 morphology codes Values must meet the regular expression ^[8,9]{1}[0-9]{3}/[0,1,2,3,6,9]{1}[1-9]{0,1}$ Examples: 8260/3, 9691/36	mCODE	mCODE STU1: Primary Cancer Condition mCODE STU2: Primary Cancer Condition	mCODE STU1: Condition.extension:histologyMorphologyBehavior ICD-O-3 codes from Histology Morphology Behavior Value Set mCODE STU2: Condition.extension:histologyMorphologyBehavior ICD-O-3 codes from https://terminology.hl7.org/3.0.0/CodeSystem-icd-o-3.html
35	Specimen	specimen_anatomic_location	Core	Required	Indicate the ICD-O-3 topography code for the anatomic location of a specimen when it was collected. Refer to the guidelines provided in the ICD-O-3 manual at https://apps.who.int/iris/handle/10665/42344	Text	ICD-O-3 topography codes Values must meet the regular expression ^[C][0-9]{2}(.[0-9]{1})?$ Examples: C50.1, C18	mCODE	mCODE STU1: Primary Cancer Condition mCODE STU2: Primary Cancer Condition	mCODE STU1: Condition.bodySite ICD-O-3 topography codes from CancerBodyLocationVS ValueSet mCODE STU2: ICD-O-3 topography codes from Condition.bodySite
36	Specimen	specimen_laterality	Extended	Optional	For cancer in a paired organ, indicate the side on which the specimen was obtained. (Reference caDSR CDE ID 2007875)	Text	Left Not applicable Right Unknown	ICGC ARGO		specimen_laterality
37	Specimen	reference_pathology_confirmed_diagnosis	Core	Required/Conditional This field is only required if the specimen is a tumour.	Indicate whether the pathological diagnosis was confirmed by a (central) reference pathologist.	Text	Yes No Not done	ICGC ARGO		reference_pathology_confirmed
38	Specimen	reference_pathology_confirmed_tumour_presence	Core	Required/Conditional This field is only required if the specimen is a tumour.	Indicate whether the (central) reference pathologist confirmed the presence of tumour in the specimen.	Text	Yes No Not done
39	Specimen	tumour_grading_system	Core	Required/Conditional This field is only required if the specimen is a tumour.	Specify the tumour grading system used to assess the description of a tumour based on how abnormal the tumour cells and the tumour tissue look under a microscope. Tumour grade is an indicator of how quickly a tumour is likely to grow.	Text	FNCLCC grading system Four-tier grading system Gleason grade group system Grading system for GISTs Grading system for GNETs IASLC grading system ISUP grading system Nottingham grading system Nuclear grading system for DCIS Scarff-Bloom-Richardson grading system Three-tier grading system Two-tier grading system WHO grading system for CNS tumours	ICGC ARGO		tumour_grading_system
40	Specimen	tumour_grade	Core	Required/Conditional This field depends on the selected tumour_grading_system, and is only required if the specimen is a tumour.	Grade of the tumour as assigned by the reporting tumour_grading_system.	Text	Low grade High grade GX G1 G2 G3 G4 Low High Grade 1 Grade 2 Grade 3 Grade 4 Grade I Grade II Grade III Grade IV Grade Group 1 Grade Group 2 Grade Group 3 Grade Group 4 Grade Group 5	ICGC ARGO		tumour_grade	Refer to the documentation for Tumour Grading Classifications
41	Specimen	percent_tumour_cells_range	Core	Required/Conditional This field is only required if the specimen is a tumour.	Select the range representing the percent of tumour cells compared to the number of total cells in a specimen. (Reference: NCIt: C159484)	Text	0-19% 20-50% 51-100%	ICGC ARGO		percent_tumour_cells
42	Specimen	percent_tumour_cells_measurement_method	Core	Required/Conditional This field is only required if the specimen is a tumour.	Indicate method used to measure percent_tumour_cells.	Text	Genomics Image analysis Pathology estimate by percent nuclei
43	Primary Diagnosis	program_id	ID	Required	Unique identifier of the program.	Text	Unique identifier of the MOH program.	ICGC ARGO		program_id
44	Primary Diagnosis	submitter_donor_id	ID	Required	Unique identifier for the donor, assigned by the data provider.	Text	Values must meet the regular expression ^[A-Za-z0-9\-\._]{1,64} Examples: 90234, BLD_donor_89, AML-90	mCODE	mCODE STU1: Cancer Patient mCODE STU2: Cancer Patient	mCODE STU1: Patient: Identifier mCODE STU2: Patient: Identifier
45	Primary Diagnosis	submitter_primary_diagnosis_id	ID	Required	Unique identifier of the primary diagnosis event, assigned by the data provider.	Text	Values must meet the regular expression ^[A-Za-z0-9\-\._]{1,64} Examples: 90234, BLD_donor_89, AML-90	mCODE	mCODE STU1: Primary Cancer Condition mCODE STU2: Primary Cancer Condition	mCODE STU1: Condition.identifier mCODE STU2: Condition.identifier
46	Primary Diagnosis	date_of_diagnosis	Core	Required	Date that the donor was first diagnosed with cancer. This date should be based on the earliest diagnosis.	Integer	Format YYYY-MM	mCODE	mCODE STU1: Primary Cancer Condition mCODE STU2: Primary Cancer Condition	Condition.extension:assertedDate (Primary Cancer Condition) or Condition.extension:assertedDate (Secondary Cancer Condition)	This field is required in order to calculate the required ARGO "age_at_diagnosis" field which is recorded in years (ie. [date_of_diagnosis]-[date_of_birth]).
47	Primary Diagnosis	cancer_type_code	Core	Required	The code to represent the cancer type using the WHO ICD-10 code (https://icd.who.int/browse10/2019/en) classification.	Text	ICD-10 code	mCODE	mCODE STU1: Primary Cancer Condition mCODE STU2: Primary Cancer Condition	Condition.code (Primary Cancer Condition) or Condition.code (Secondary Cancer Condition) ICD-10 codes from PrimaryOrUncertainBehaviorCancerDisorderVS or SecondaryCancerDisorderVS
48	Primary Diagnosis	basis_of_diagnosis	Core	Required	Indicate the most valid basis of how the primary diagnosis was identified. Terms are ordered in hierarchical order according to IACR guidelines, with the term at the top of the list ("Histology of primary tumour") being the more valid basis. If more than one diagnosis technique was used, select the most valid basis.	Text	Histology of a primary tumour Histology of a metastasis Cytology Specific tumour markers Clinical investigation Clinical Death certificate only Unknown	IACR Standard for Basis of Diagnosis/ICGC ARGO		basis_of_diagnosis	IACR Definitions: Death certificate only: Information provided is from a death certificate. Clinical: Diagnosis made before death. Clinical investigation: All diagnostic techniques, including X-ray, endoscopy, imaging, ultrasound, exploratory surgery (such as laparotomy), and autopsy, without a tissue diagnosis. Specific tumour markers: Including biochemical and/or immunologic markers that are specific for a tumour site. Cytology: Examination of cells from a primary or secondary site, including fluids aspirated by endoscopy or needle; also includes the microscopic examination of peripheral blood and bone marrow aspirates. Histology of a metastasis: Histologic examination of tissue from a metastasis, including autopsy specimens. Histology of a primary tumour: Histologic examination of tissue from primary tumour, however obtained, including all cutting techniques and bone marrow biopsies; also includes autopsy specimens of primary tumour. Unknown: No information on how the diagnosis has been made.
49	Primary Diagnosis	laterality	Extended	Optional	For cancer in a paired organ, indicate the side of the body on which the primary tumour or cancer first developed at the time of primary diagnosis. (Reference caDSR CDE ID 827)	Text	Bilateral Left Midline Not a paired site Right Unilateral, side not specified Unknown	ICGC ARGO		laterality
50	Primary Diagnosis	lymph_nodes_examined_status	Core	Required	Indicate if lymph nodes were examined for metastases.	Text	Cannot be determined No No lymph nodes found in resected specimen Not applicable Yes	ICGC ARGO		lymph_nodes_examined_status
51	Primary Diagnosis	lymph_nodes_examined_method	Core	Required/Conditional This field is only required if "lymph_nodes_examined_status" is "Yes"	Indicate method used to examine lymph nodes.	Text	Imaging Lymph node dissection/pathological exam Physical palpation of patient	ICGC ARGO		lymph_nodes_examined_method
52	Primary Diagnosis	number_lymph_nodes_positive	Core	Required/Conditional This field is only required if "lymph_nodes_examined_status" is "Yes"	The number of regional lymph nodes reported as being positive for tumour metastases (Reference: NCI CDE ID: 6113694)	Integer		ICGC ARGO		number_lymph_nodes_positive
53	Primary Diagnosis	clinical_tumour_staging_system	Core	Required/Conditional This field is only required if pathological staging is not submitted.	Indicate the tumour staging system used to stage the cancer at the time of primary diagnosis (prior to treatment).	Text	AJCC 8th edition AJCC 7th edition AJCC 6th edition Ann Arbor staging system Binet staging system Durie-Salmon staging system FIGO staging system International Neuroblastoma Risk Group Staging System International Neuroblastoma Staging System Lugano staging system Rai staging system Revised International staging system (R-ISS) SEER staging system St Jude staging system	ICGC ARGO		clinical_tumour_staging_system	Either the clinical or pathological staging must be submitted.
54	Primary Diagnosis	clinical_t_category	Core	Required/Conditional This field is required only if the selected clinical_tumour_staging_system is any edition of the AJCC cancer staging system	The code to represent the extent of the primary tumour (T) based on evidence obtained from clinical assessment parameters determined at time of primary diagnosis and prior to treatment, according to criteria based on multiple editions of the AJCC's Cancer Staging Manual.	Text	Click for drop-down list of AJCC T category values	mCODE STU 1	TNM Clinical Primary Tumor Category	Observation.value[x]:valueCodeableConcept AJCC values from TNM Primary Tumor Category Value Set
55	Primary Diagnosis	clinical_n_category	Core	Required/Conditional This field is required only if the selected clinical_tumour_staging_system is any edition of the AJCC cancer staging system	The code to represent the stage of cancer defined by the extent of the regional lymph node (N) involvement for the cancer based on evidence obtained from clinical assessment parameters determined at time of primary diagnosis and prior to treatment, according to criteria based on multiple editions of the AJCC's Cancer Staging Manual.	Text	Click for drop-down list of AJCC N category values	mCODE STU 1	TNM Clinical Regional Nodes Category	Observation.value[x]:valueCodeableConcept AJCC values from TNM Regional Nodes Category Value Set
56	Primary Diagnosis	clinical_m_category	Core	Required/Conditional This field is required only if the selected clinical_tumour_staging_system is any edition of the AJCC cancer staging system	The code to represent the stage of cancer defined by the extent of the distant metastasis (M) for the cancer based on evidence obtained from clinical assessment parameters determined at time of primary diagnosis and prior to treatment, according to criteria based on multiple editions of the AJCC's Cancer Staging Manual. MX is NOT a valid category and cannot be assigned.	Text	Click for drop-down list of AJCC M category values	mCODE STU 1	TNM Clinical Distant Metastases Category	Observation.value[x]:valueCodeableConcept AJCC values from TNM Distant Metastases Category Value Set
57	Primary Diagnosis	clinical_stage_group	Core	Required/Conditional This field is dependent on the selected clinical_tumour_staging_system. Refer to the documentation for Tumour Staging Classifications	Stage group of the tumour, as assigned by the reporting clinical_tumour_staging_system, that indicates the overall prognostic tumour stage (ie. Stage I, Stage II, Stage III etc.).	Text	Click for drop-down list of clinical stage groups	ICGC ARGO		clinical_stage_group
58	Treatment	program_id	ID	Required	Unique identifier of the program.	Text	Unique identifier of the MOH program.	ICGC ARGO		program_id
59	Treatment	submitter_donor_id	ID	Required	Unique identifier for the donor, assigned by the data provider.	Text	Values must meet the regular expression ^[A-Za-z0-9\-\._]{1,64} Examples: 90234, BLD_donor_89, AML-90	mCODE STU 1	Cancer Patient	Patient.Identifier
60	Treatment	submitter_treatment_id	ID	Required	Unique identifier of the treatment, assigned by the data provider.	Text	Values must meet the regular expression ^[A-Za-z0-9\-\._]{1,64} Examples: 90234, BLD_donor_89, AML-90	mCODE STU 1	CancerRelatedRadiationProcedure or CancerRelatedMedicationStatement or CancerRelatedSurgicalStatement	Procedure.identifier
61	Treatment	submitter_primary_diagnosis_id	ID	Required	Indicate the primary diagnosis event in the clinical timeline that this treatment was related to	Text	Values must meet the regular expression ^[A-Za-z0-9\-\._]{1,64} Examples: 90234, BLD_donor_89, AML-90	mCODE STU 1	Primary Cancer Condition or Secondary Cancer Condition	Condition.identifier
62	Treatment	treatment_type	Core	Required	Indicate the type of treatment regimen that the donor completed.	Text	Bone marrow transplant Chemotherapy Hormonal therapy Immunotherapy No treatment Other targeting molecular therapy Photodynamic therapy Radiation therapy Stem cell transplant Surgery	ICGC ARGO		treatment_type	Depending on the treatment_type(s) selected, additional treatment details may be required to be submitted. For example, if treatment_type includes 'Chemotherapy', the supplemental Chemotherapy treatment type file is required. To include multiple values, separate values with a pipe delimiter '\|' within your file.
63	Treatment	is_primary_treatment	Core	Required	Indicate if the treatment was the primary treatment following the initial diagnosis (Reference: NCI)	Text	Yes No	ICGC ARGO		is_primary_treatment
64	Treatment	line_of_treatment	Extended	Optional	Indicate the line of treatment.	Integer		ICGC ARGO		line_of_treatment
65	Treatment	treatment_start_date	Core	Required	Indicate the date treatment was initiated.	Integer	Format YYYY-MM	mCODE STU 1	If treatment_type = 'Radiation therapy' or 'Surgery': CancerRelatedRadiationProcedure or CancerRelatedSurgicalStatement Otherwise extend mCODE to use Procedure Profile	Procedure.performed.Period.start.dateTime (Radiation) or Procedure.performed.Period.start.dateTime (Surgery) or Procedure.performed.Period.start.dateTime (for all other treatment_types)	This field is required in order to calculate the ARGO required "treatment_start_interval" field which is recorded in days (ie. [treatment_start_date] - [date_of_diagnosis])
66	Treatment	treatment_end_date	Core	Required	Indicate the date treatment ended.	Integer	Format YYYY-MM	mCODE STU 1	If treatment_type = 'Radiation therapy' or 'Surgery': CancerRelatedRadiationProcedure or CancerRelatedSurgicalStatement Otherwise extend mCODE to use Procedure Profile	Procedure.performed.Period.end.dateTime (Radiation) or Procedure.performed.Period.end.dateTime (Surgery) or Procedure.performed.Period.end.dateTime (for all other treatment_types)	This field is required in order to calculate the ARGO required "treatment_duration" field which is recorded in days (ie. [treatment_end_date] - [treatment_start_date])
67	Treatment	treatment_setting	Core	Required	Indicate the treatment setting, which describes the treatment's purpose in relation to the primary treatment. (Reference: CDISC [NCIt code: C124308])	Text	Adjuvant (Reference: NCIt C15675) Advanced/Metastatic (Reference: NCIt: C14174) Neoadjuvant (Reference: NCIt: C15665) Conditioning (Reference: NCIt C188745) Induction (Reference: NCIt C158876) Locally advanced (Reference: NCIt C124451) Maintenance (Reference NCIt C15688) Mobilization (Reference: NCIt C62604) Preventative (Reference: NCIt C124454) Radiosensitization (Reference: NCIt C156596 and C15464) Salvage (Reference: NCIt C15359)	ICGC ARGO		treatment_setting
68	Treatment	treatment_intent	Core	Required	Indicate the intended disease outcome for which the treatment is given. (Reference: CDISC [NCIt code: C124307])	Text	Curative (Reference: SNOMED: 373808002) Palliative (Reference: SNOMED: 363676003) Supportive (Reference: SNOMED: 399707004) Diagnostic (Reference: SNOMED: 261004008) Preventive (Reference: SNOMED: 129428001) Guidance (Reference: SNOMED: 429892002) Screening (Reference: SNOMED: 360156006) Forensic (Reference: SNOMED: 447295008)	mCODE STU	CancerRelatedRadiationProcedure or CancerRelatedMedicationStatement or CancerRelatedSurgicalStatement	mCODE Value Set: Procedure Intent
69	Treatment	days_per_cycle	Extended	Optional	Indicate the number of days in a treatment cycle.	Integer		ICGC ARGO		days_per_cycle
70	Treatment	number_of_cycles	Extended	Optional	Indicate the number of treatment cycles.	Integer		ICGC ARGO		number_of_cycles
71	Treatment	response_to_treatment_criteria_method	Core	Required	Indicate the criteria used to assess the donor's overall response to the applied treatment regimen.	Text	Click for drop-down list of response criteria methods	ICGC ARGO		response_to_treatment_criteria_method
72	Treatment	response_to_treatment	Core	Required	Indicate the donor's response to the applied treatment regimen as assigned by the reporting response_to_treatment_criteria_method.	Text	Physician assessed partial response	ICGC ARGO		response_to_treatment
73	Treatment	status_of_treatment	Extended	Optional	Indicate the donor's status of the prescribed treatment.	Text	Treatment completed as prescribed Treatment incomplete due to technical or organizational problems Treatment incomplete because patient died Patient choice (stopped or interrupted treatment) Physician decision (stopped or interrupted treatment) Treatment stopped due to lack of efficacy (disease progression) Treatment stopped due to acute toxicity Other Not applicable Unknown	ICGC ARGO		outcome_of_treatment
74	Chemotherapy	program_id	ID	Required	Unique identifier of the program.	Text	Unique identifier of the MOH program.	ICGC ARGO		program_id
75	Chemotherapy	submitter_donor_id	ID	Required	Unique identifier for the donor, assigned by the data provider.	Text	Values must meet the regular expression ^[A-Za-z0-9\-\._]{1,64} Examples: 90234, BLD_donor_89, AML-90	mCODE STU 1	Cancer Patient	Patient.Identifier
76	Chemotherapy	submitter_treatment_id	ID	The Chemotherapy file is only required if "Chemotherapy" is selected in "treatment_type" field	Unique identifier of the treatment, assigned by the data provider.	Text	Values must meet the regular expression ^[A-Za-z0-9\-\._]{1,64}	mCODE STU 1	Cancer Related Medication Statement	MedicationStatement.identifier
77	Chemotherapy	drug_reference_database	Core	Required	Indicate the reference drug database where drug name is found.	Text	RxNorm PubChem NCI Thesaurus
78	Chemotherapy	drug_name	Core	Required	Name of agent or drug administered to patient as part of the treatment regimen.	Text	Indicate the drug name as it exists in the database specified in the drug_reference_database.	ICGC ARGO		drug_name	RxNorm: You can search for RXNorm values through the web interface (https://mor.nlm.nih.gov/RxNav/) or API (https://lhncbc.nlm.nih.gov/RxNav/APIs/RxNormAPIs.html). PubChem: https://pubchem.ncbi.nlm.nih.gov/ NCI Thesaurus: https://ncithesaurus.nci.nih.gov/ncitbrowser/
79	Chemotherapy	drug_reference_identifier	Core	Required	Indicate the unique drug database identifier assigned to the treatment regimen drug.	Text	Indicate the identifier from the "drug_reference_database" for the drug.	mCODE STU 1	Cancer-Related Medication Administration	MedicationAdministration.medication[x]	This field is required in order to validate required ARGO 'drug_name' field - RxNorm requires the RXCUI. For example, to find the rxnormcui based on drug name, you can use: https://rxnav.nlm.nih.gov/REST/rxcui.json?name=leucovorin or https://mor.nlm.nih.gov/RxNav/search?searchBy=String&searchTerm=leucovorin - PubChem requires the PubChem Concept ID - NCI Thesaurus requires the NCI Thesaurus code
80	Chemotherapy	chemotherapy_drug_dose_units	Core	Required if cumulative drug dose is submitted.	Indicate units used to record chemotherapy drug dose.	Text	mg/m2 IU/m2 ug/m2 g/m2 mg/kg IU/kg	ICGC ARGO		chemotherapy_dosage_units
81	Chemotherapy	prescribed_cumulative_drug_dose	Extended	Optional	Indicate the total prescribed cumulative drug dose in the same units specified in chemotherapy_drug_dose_units.	Number	Indicate the total prescribed cumulative drug dose in the same units specified in chemotherapy_drug_dose_units.	ICGC ARGO		cumulative_drug_dosage
82	Chemotherapy	actual_cumulative_drug_dose	Extended	Optional	Indicate the total actual cumulative drug dose in the same units specified in chemotherapy_drug_dose_units.	Number	Indicate the total actual cumulative drug dose in the same units specified in chemotherapy_drug_dose_units.	ICGC ARGO		cumulative_drug_dosage
83	Hormone Therapy	program_id	ID	Required	Unique identifier of the program.	Text	Unique identifier of the MOH program.	ICGC ARGO		program_id
84	Hormone Therapy	submitter_donor_id	ID	The Hormone Therapy file is only required if "Hormonal Therapy" is selected in "treatment_type" field	Unique identifier for the donor, assigned by the data provider.	Text	Values must meet the regular expression ^[A-Za-z0-9\-\._]{1,64}} Examples: 90234, BLD_donor_89, AML-90	mCODE STU 1	Cancer Patient	Patient.Identifier
85	Hormone Therapy	submitter_treatment_id	ID	Required	Unique identifier of the treatment, assigned by the data provider.	Text	Values must meet the regular expression ^[A-Za-z0-9\-\._]{1,64} Examples: 90234, BLD_donor_89, AML-90	mCODE STU 1	Cancer Related Medication Statement	MedicationStatement.identifier
86	Hormone Therapy	drug_reference_database	Core	Required	Indicate the reference drug database where drug name is found.	Text	RxNorm PubChem NCI Thesaurus
87	Hormone Therapy	drug_name	Core	Required	Name of agent or drug administered to patient as part of the treatment regimen.	Text	Indicate the drug name as it exists in the database specified in the drug_reference_database.	ICGC ARGO		drug_name	You can search for RX Norm values through the web interface (https://mor.nlm.nih.gov/RxNav/) or API (https://lhncbc.nlm.nih.gov/RxNav/APIs/RxNormAPIs.html). For example, to find the rxnormcui based on drug name, you can use: https://rxnav.nlm.nih.gov/REST/rxcui.json?name=leucovorin or https://mor.nlm.nih.gov/RxNav/search?searchBy=String&searchTerm=leucovorin
88	Hormone Therapy	drug_reference_identifier	Core	Required	Indicate the unique drug database identifier assigned to the treatment regimen drug.	Text	Indicate the identifier from the "drug_reference_database" for the drug.	mCODE STU 1	Cancer-Related Medication Administration	MedicationAdministration.medication[x]	This field is required in order to validate required ARGO 'drug_name' field - RxNorm requires the RXCUI. For example, to find the rxnormcui based on drug name, you can use: https://rxnav.nlm.nih.gov/REST/rxcui.json?name=leucovorin or https://mor.nlm.nih.gov/RxNav/search?searchBy=String&searchTerm=leucovorin - PubChem requires the PubChem Concept ID - NCI Thesaurus requires the NCI Thesaurus code
89	Hormone Therapy	hormone_drug_dose_units	Core	Required if cumulative drug dose is submitted.	Indicate the units used to record hormone drug dose.	Text	mg/m2 IU/m2 ug/m2 g/m2 mg/kg IU/kg	ICGC ARGO		hormone_drug_dosage_units
90	Hormone Therapy	prescribed_cumulative_drug_dose	Extended	Optional	Indicate the total prescribed cumulative drug dose in the same units specified in hormone_drug_dose_units.	Number	Indicate the total prescribed cumulative drug dose in the same units specified in chemotherapy_drug_dose_units.	ICGC ARGO		cumulative_drug_dosage
91	Hormone Therapy	actual_cumulative_drug_dose	Extended	Optional	Indicate the total actual cumulative drug dose in the same units specified in hormone_drug_dose_units.	Number	Indicate the total actual cumulative drug dose in the same units specified in chemotherapy_drug_dose_units.	ICGC ARGO		cumulative_drug_dosage
92	Radiation	program_id	ID	Required	Unique identifier of the program.	Text	Unique identifier of the MOH program.	ICGC ARGO		program_id
93	Radiation	submitter_donor_id	ID	The Radiation file is only required if "Radiation therapy" is selected in "treatment_type" field	Unique identifier for the donor, assigned by the data provider.	Text	Values must meet the regular expression ^[A-Za-z0-9\-\._]{1,64} Examples: 90234, BLD_donor_89, AML-90	mCODE STU 1	Cancer Patient	Patient.Identifier
94	Radiation	submitter_treatment_id	ID	Required	Unique identifier of the treatment, assigned by the data provider.	Text	Values must meet the regular expression ^[A-Za-z0-9\-\._]{1,64} Examples: 90234, BLD_donor_89, AML-90	mCODE STU 1	Cancer Related Radiation Procedure	Procedure.identifier
95	Radiation	radiation_therapy_modality	Core	Required	Indicate the method of radiation treatment or modality.	Text	Megavoltage radiation therapy using photons (procedure) Teleradiotherapy using electrons (procedure) Teleradiotherapy protons (procedure) Teleradiotherapy neutrons (procedure) Brachytherapy (procedure) Radiopharmaceutical Other	mCODE STU 1	Cancer Related Radiation Procedure	Procedure.code mCODE Value Set: Radiation Procedure Value Set
96	Radiation	radiation_therapy_type	Core	Required	Indicate type of radiation therapy administered.	Text	External Internal	ICGC ARGO		radiation_therapy_type
97	Radiation	radiation_therapy_fractions	Core	Required	Indicate the total number of fractions delivered as part of treatment.	Integer		mCODE STU 1	Cancer Related Radiation Procedure	RadiationFractionsDelivered
98	Radiation	radiation_therapy_dosage	Core	Required	Indicate the total dose given in units of Gray (Gy).	Integer		mCODE STU 1	Cancer Related Radiation Procedure	TotalRadiationDoseDelivered
99	Radiation	anatomical_site_irradiated	Core	Required	Indicate localization site where radiation therapy was administered.	Text	Click for drop-down list of sites.	Cancer Care Ontario
100	Radiation	radiation_boost	Extended	Optional	A radiation boost is an extra radiation treatment targeted at the tumor bed, given after the regular sessions of radiation is complete (Reference NCIt: C137812). Indicate if this radiation treatment was a radiation boost.	Text	Yes No