CF - 5T calculations
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ABCDEFGHIJKLMN
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Total US PopulationTotal US births / yearAllelic frequency of M (major CF mutation)Carrier frequency of MTotal US population of M carriersAllelic frequency of 5TCarrier frequency of 5TFrequency of TG # per 5T carrierTotal US population of 5T carriersPresumed frequency of 5T / MTotal US population of 5T/M compound heterozygotesNumber of 5T carriers born/yearNumber of 5T / M born each year
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from census1 in 581 in 29 (2* allelic freq 1/58)=Per GromanPer GromanPer Groman*1/4
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313,900,0003,953,5900.01720.034510,824,1380.04300.086026,995,4000.000741232,719340,0092,931
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5T TG110.033050.06610.768520,746,4650.000570178,849261,3032,253
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5T TG120.009160.01830.21305,749,0200.00015849,56172,409624
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5T TG130.000800.00160.0185499,9150.0000144,3106,29654
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5T total0.043000.08601.000026,995,4000.000741232,719340,0092,931
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Source: CFSmackdown.com
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Based on Groman et al. 2006
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