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NameInterest AreaPossible Research QuestionSPOKE Search TermsGenes / Pathways / NodesDataset / OSDR IDInteresting SPOKE ConnectionsWhy This MattersEvidence StrengthStatusNext StepNotes / Questions
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Hitaeshi Sehgal
Space Biology, Systems Biology, Knowledge Graphs, Protein Function
Can the SPOKE knowledge graph uncover biologically meaningful pathway and disease associations from NASA OSDR spaceflight omics datasets that are not obvious from differential expression analysis alone?
spaceflight, microgravity, protein localization, Gene Ontology, SPOKE, mitochondria, oxidative stress, immune response, extracellular vesicles
Gene Ontology, Oxidative Phosphorylation, Mitochondrial Function, Immune Signaling, Protein Transport, Extracellular Matrix (leave this flexible if you haven't finalized genes yet)
NASA OSDR datasets (TBD after SPOKE exploration)
Explore links between spaceflight-associated proteins, GO pathways, diseases, drugs and physiological adaptations using SPOKE.
Understanding biological mechanisms altered during spaceflight could help identify biomarkers, therapeutic targets and improve astronaut health.
PreliminaryIn Progress
Search SPOKE for candidate pathways and identify relevant OSDR datasets for validation
Looking for SPOKE-supported pathway hypotheses that can be validated using NASA OSDR omics datasets.
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Daniel StasikBone/muscle, oxidative stressWhat shared molecular and biological pathways connect bone loss and muscular degeneration in long duration spaceflightsapceflight, microgravity, osteporosis, muscular atrophy/dystrophy
Understanding the mechanisms that lead to bone/muscle loss can allow targetted research to prevent wasting or other ailments during spaceflight
Not Started
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Daniel StasikOxidative stresss, aging-related pathwaysDoes long duration spaceflight create genotypic aging changes or does it only cause analogous biologcical states? (frailty, Alzheimers, cardiovascular changes, etc.)oxidative stress, agingUnderstanding whether molecular changes cause age related changes can target further research aims or pursue more holistic methodologiesNot Started
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Daniel Stasikgut microbiome, brain/nervous systemHow does spaceflight cause disruption between interacting metabolic axis (gut - liver - brain axis)metabolic pathwaysImportant to understand how metabolic axis can be disrupted across biological systemsNot Started
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Aamir AhmadMathI can support people with my background is in applied math. SPOKE is based on graph theory, so I can help develop networks to get the info we need.Not Started
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Dirk Neefsoral healthoral microbiome changes in space and its effects on systemic healthoral health , microbiome, dentaloral and systemic health are connected
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Daniel StasikProtein function, oxidative stress. bone/musclewhat is the intersection of genotypic changes versus micro gravitational changes that leads to Spaceflight-Associated Neuro-Ocular Syndrome (SANS)
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Daniel StasikMultipleCan the KGs identify the convergence of disease-data linking immune dysfunction, oxidative stress, circadian disruption, and accelerated aging during long-duration spaceflightThis question attempts to tie together as many AWGs as possible and find the similarities between all the studies to converge on what data points are similar across the studies
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