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PRESENTERROOMTOPICJOURNALE-LINK
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CLINICAL JOURNAL CLUB
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2/22/2018M. KozickyFellows' RoomC3GN and Dense Deposit Disease- Case Discussion
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1/18/2018A. BeenkenPH4-476Nephrolithiasis
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11/30/2017E. Chavez MoralesPH4-476Glecaprevir and Pibrentasvir in Patients with HCV and Severe Renal Impairmentn engl j med 377;15 nejm.org October 12, 2017http://www.nejm.org/doi/full/10.1056/NEJMoa1704053
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10/26/2017P. KhairallahPH4-476Urine ammonium predicts clinical outcomes in hypertensive kidney disease.JASN



http://jasn.asnjournals.org/content/28/8/2483.long#F1
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9/21/2017J. StevensNCRC Conference Room- PH4-476

 Antibiotic Dosing in Continuous Renal Replacement Therapy



Adv
Chronic Kidney Dis. 2017;24(4):219-227

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8/24/2017A. BeenkenAtchley Loeb Conference Room

Biomarkers in AKIJASNhttps://www.ncbi.nlm.nih.gov/pubmed/26374609 and https://www.ncbi.nlm.nih.gov/pubmed/24375576
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7/20/2017M. KozickyNCRC Conference Room- PH4-476Hypertension Management in CKD- Review of Past
Guidelines & Recent Updates
J Am Soc Nephrol,June 22,  2017  ASN.2017020148                 http://jasn.asnjournals.org/content/early/2017/06/21/ASN.2017020148.abstract
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6/28/2017J. StevensNCRC Conference Room- PH4-476The Relation of Serum Potassium Concentration with Cardiovascular Events and Mortality in Community-Living IndividualsCJASN 2017; 12(2)245-52.https://www.ncbi.nlm.nih.gov/pubmed/28143865
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5/24/2017M. KozickyNCRC Conference Room- PH4-476“Long-term kidney outcomes among users of proton pump inhibitors without intervening acute kidney injury”J Am Soc Nephrol. 2017 Apr;28(4):1306-1313.
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4/26/2017A. HusainNCRC Conference Room- PH4-476"A Randomized, Controlled Trial of Rituximab in IgA Nephropathy with Proteinuria and Renal Dysfunction." J Am Soc Nephrol. 2017 Apr;28(4):1306-1313.https://www.ncbi.nlm.nih.gov/pubmed/27821627
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3/22/2017M. KozickyNCRC Conference RoomUse of Antidiabetic Drugs in CKD & ESRD Patients”J Am Soc Nephrol 28: 368–375, 2017
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2/22/2017T. ZachariahNCRC Conference RoomA Nationally Representaive Sudy of Calcific Uremic Arteriolopathy Risk Factors.
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1/25/2017A. BeenkenNCRC Conference RoomHypocalcemia in Critical Illness
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12/7/2016J. StevensNCRC Conference RoomContrast-Induced NephropathyJ Am Soc Nephrol. 2016 Sep 29. pii: ASN.2016010021https://www.ncbi.nlm.nih.gov/pubmed/27688297
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11/23/2016J. NestorNCRC Conference RoomAssociation between Hypertension and GFR lossKidney International (2016) 90, 404–410http://www.kidney-international.org/article/S0085-2538(16)30073-4/fulltext
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10/26/2016J. NestorNCRC Conference RoomStatin Use in Kidney Disease
Am J Kidney Dis. 2016;67(6):881-892
http://www.sciencedirect.com/science/article/pii/S0272638616001323
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9/28/2016A. BeenkenNCRC Conference RoomComparative Effectiveness of Management Strategies for Renal Artery StenosisAnnals of Internal Medicinehttps://www.ncbi.nlm.nih.gov/pubmed/27536808
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8/24/2016T. ZachariahNCRC Conference RoomClinicopathological features of acute kidney injury associated with immune checkpoint inhibitorsKidney Internationalhttp://www.kidney-international.org/article/S0085-2538(16)30164-8/pdf
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7/27/2016A. HusainNCRC Conference RoomThe Weekend Effect Alters the Procurement and Discard Rates of Deceased Donor Kidneys in the United States.Kidney International. 2016 Jul;90(1):157-63.http://www.ncbi.nlm.nih.gov/pubmed/27182001
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5/31/2016T .ZachariahNCRC Conference RoomEffect of Early vs Delayed Initiation of Renal Replacement Therapy on Mortality in Critically Ill PatientsJAMA. 2016;315(20):2190-2199. doi:10.1001/jama.2016.5828 Published online May 22, 2016.http://jama.jamanetwork.com/article.aspx?articleid=2522434
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5/25/2016A. HussainNCRC Conference RoomCJASNhttps://www.ncbi.nlm.nih.gov/pubmed/?term=integrating+a+smartphone-based+self-management+system+into+usual+care+of+advanced+CKD#https://www.ncbi.nlm.nih.gov/pubmed/?term=integrating+a+smartphone-based+self-management+system+into+usual+care+of+advanced+CKD#
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4/26/2016J. NestorNCRC Conference RoomHigh-Throughput Genetic Testing for Thrombotic Microangiopathies and C3 GlomerulopathiesJ Am Soc Nephrol 27: 1245–1253, 2016. doi: 10.1681/ASN.2015040385
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3/23/2016D. BennettNCRC Conference RoomThe Effect of Erythropoietin-Stimulating Agents on Health-Related Quality of Life in Anemia of Chronic Kidney Disease: A Systematic Review and Meta-analysis.Ann Intern Med. [Epub ahead of print 16 February 2016] doi:10.7326/M15-1839http://annals.org/article.aspx?articleid=2491918&resultClick=3
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2/24/2016B. NavaNCRC Conference Room"Ketoanalogue-Supplemented Vegetarian Very Low–Protein Diet and CKD Progression"JASN January 28, 2016 http://jasn.asnjournals.org/content/early/2016/01/28/ASN.2015040369.abstract
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2/10/2016R. RegunathanNCRC Conference RoomThe Lancet; Nov 2015.http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(15)00257-3/abstract
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12/22/2015A. HussainKimberg Conference Room (PH8E115)Parathyroidectomy versus Cincalcet for treatment of hypercalcemia in patients with hyperparathyroidism after renal transplantPLOS ONE 10/06/15
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11/24/2015T. ZachariahKimberg Conference Room (PH8E115)Results of the landmark SPRINT trial recently published in NEJMNEJMhttp://www.nejm.org/doi/full/10.1056/NEJMoa1511939
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10/20/2015J. NestorKimberg Conference Room (PH8E115)Low Potassium Dialysate
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9/29/2015D. BennettKimberg Conference Room (PH8E115)Nocturnal Hemodialysis StudyFHN
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8/25/2015R. RegunathanKimberg Conference Room (PH8E115)A randomized trial of intravenous and oral iron in chronic kidney diseaseKI June 2015
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7/28/2015B. NavaKimberg Conference Room (PH8E115)?
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RENAL JOURNAL CLUB
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10/30/2018Kimberg Conf Room (PH8E-115)
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10/23/2018Kimberg Conf Room (PH8E-115)
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10/16/2018Kimberg Conf Room (PH8E-115)
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10/9/2018Kimberg Conf Room (PH8E-115)
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10/2/2018Kimberg Conf Room (PH8E-115)
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9/25/2018Appel, Gerald BKimberg Conf Room (PH8E-115)
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9/18/2018Barasch, Jonathan Kimberg Conf Room (PH8E-115)
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9/11/2018Al-Awqati, Qais Kimberg Conf Room (PH8E-115)
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6/26/2018Chavez Morales, Efren A. Kimberg Conf Room (PH8E-115)
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6/19/2018Canetta, Pietro Kimberg Conf Room (PH8E-115)
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6/12/2018Khairallah, Pascale Kimberg Conf Room (PH8E-115)
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6/5/2018Kiryluk, KrzystofKimberg Conf Room (PH8E-115)Phenotype risk scores identify patients with unrecognized Mendelian disease patterns.Science. 2018 Mar 16;359(6381):1233-1239.doi: 10.1126/science.aal4043.
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5/1/2018Mohan, SumitKimberg Conf Room (PH8E-115)
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4/24/2018Beenken, Andrew Kimberg Conf Room (PH8E-115)α-Klotho is a non-enzymatic molecular scaffold for FGF23 hormone signalling.Nature. 2018 Jan 25;553(7689):461-466.
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4/17/2018Valeri, AnthonyKimberg Conf Room (PH8E-115)Lysine methyltransferase SMYD2 promotes cyst growth in autosomal dominant polycystic kidney diseaseJ Clin Invest. 2017;127(7):2751–2764.https://doi.org/10.1172/JCI90921
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4/3/2018Crew, JKimberg Conf Room (PH8E-115)Salt-responsive gut commensal modulates TH17 axis and diseaseNature 2017, 551: 585-589https://www.nature.com/articles/nature24628
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3/27/2018Kozicky, Mark Kimberg Conf Room (PH8E-115)Balanced Crystalloids versus Saline in Critically Ill AdultsNEJM 2018; 378: 9
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3/20/2018Ahn, WooinKimberg Conf Room (PH8E-115)Phenotypic and pharmacogenetic evaluation of patients with thiazide-induced hyponatremiaJCI 2017;127:3367https://www.jci.org/articles/view/89812
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3/13/2018Stevens, JacobKimberg Conf Room (PH8E-115)Tolvaptan in Later-Stage Autosomal Dominant Polycystic Kideny DiseaseNEJM 2017; 377:1930http://www.nejm.org/doi/pdf/10.1056/NEJMoa1710030
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3/6/2018Emily GroopmanKimberg Conf Room (PH8E-115) 45 minAnalysis of 589,306 genomes identifies individuals resilient to severe Mendelian childhood diseasesChen et al. Nat Biotechnol 34, 531-538, doi:10.1038/nbt.3514 (2016).https://www.nature.com/articles/nbt.3514
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2/27/2018Husain, Syed A.Kimberg Conf Room (PH8E-115)Intermittent Fasting Promotes White Adipose Browning and Decreases Obesity by Shaping the Gut Microbiota.Cell Metab. 2017 Oct 3;26(4):672-685.e4.https://www.ncbi.nlm.nih.gov/pubmed/28918936
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2/13/2018Nestor, JordanKimberg Conf Room (PH8E-115)Factor H Competitor Generated by Gene Conversion
Events Associates with Atypical Hemolytic Uremic
Syndrome
J Am Soc Nephrol 29: 240–249, 2018http://jasn.asnjournals.org/content/29/1/240.long
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2/6/2018Mitrotti, AdeleKimberg Conf Room (PH8E-115)B cell–derived IL-4 acts on podocytes to induce proteinuria and foot process effacementJCI insight November 2, 2017https://insight.jci.org/articles/view/81836#sd
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1/30/2018Mattoo, AprajitaKimberg Conf Room (PH8E-115)Serum iron protects from renal post ischemic injuryJASNhttps://www.ncbi.nlm.nih.gov/pubmed/28784700
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1/23/2018Shirazian, Shayan Kimberg Conf Room (PH8E-115)A small-molecule inhibitor of TRPC5 ion channels suppresses progressive kidney disease in animal models.Science. 2017 Dec 8;358(6368):https://www.ncbi.nlm.nih.gov/pubmed/29217578
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1/9/2018Gharavi, Ali Richard-Cournand Library (PH9E101)A tripartite complex of suPAR, APOL1 risk variants and αvβ3 integrin on podocytes mediates chronic kidney disease.Nat Med. 2017 Aug;23(8):945-953.https://www.ncbi.nlm.nih.gov/pubmed/28650456
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12/19/2017Sumit MohanRichard-Cournand Library (PH9E101)CXL'D
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12/12/2017Ahram, DinaRichard-Cournand Library (PH9E101)Genetic-Variation-Driven Gene-Expression Changes Highlight Genes with Important Functions for Kidney DiseaseAmerican Journal of Human Genetics, Volume 100, Issue 6, 1 June 2017http://www.sciencedirect.com/science/article/pii/S000292971730191X
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12/5/2017Chang, Jae Hyung Richard-Cournand Library (PH9E101)Targeting mTOR Signaling Can Prevent the Progression of FSGShttp://jasn.asnjournals.org/content/early/2017/03/06/ASN.2016050519.abstract
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11/28/2017Milo Rasouly, Hila Richard-Cournand Library (PH9E101)The who, what, and why of research participants’ intentions to request a broad range of secondary findings in a diagnostic genomic sequencing studyGenetics in Medicine doi:10.1038/gim.2017.176https://www.nature.com/articles/gim2017176
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11/21/2017Lau, Wai LRichard-Cournand Library (PH9E101)“Autoantibodies against c reactive protein influence complement activation and clinical course in Lupus Nephritis”JASN 2017 OCT 28: 3044-3054http://jasn.asnjournals.org/content/28/10/3044.long
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11/14/2017Oliver, Juan A. Richard-Cournand Library (PH9E101)ELABELA deficiency promotes preeclampsia and cardiovascular malformations in miceScience 18 Aug 2017:Vol. 357, Issue 6352, pp. 707-713http://science.sciencemag.org/content/357/6352/707.long
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10/24/2017Sanna-Cherchi, SimoneRichard-Cournand Library (PH9E101)Use of Exome Sequencing for Infants in Intensive Care Units: Ascertainment of Severe Single-Gene Disorders and Effect on Medical Management.JAMA Pediatr. 2017 Oct 2:e173438. doi: 10.1001/jamapediatrics.2017.3438.https://www.ncbi.nlm.nih.gov/pubmed/28973083
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10/17/2017Barasch, Jonathan Richard-Cournand Library (PH9E101)HRG1 is essential for heme transport from the phagolysosome of macrophages during erythrophagocytosis.Cell Metabolism 17, 261–270, February 5, 2013 https://www.ncbi.nlm.nih.gov/pubmed/23395172
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10/10/2017Steers, Nicholas J.Richard-Cournand Library (PH9E101)Inflammatory Ly6Chigh Monocytes Protect against Candidiasis through IL-15-Driven NK Cell/Neutrophil ActivationImmunity Volume 46, Issue 6, p1059–1072.e4, 20 June 2017http://www.cell.com/immunity/fulltext/S1074-7613(17)30225-X
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10/3/2017Richard-Cournand Library (PH9E101)CXLD
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9/26/2017Appel, Gerald Richard-Cournand Library (PH9E101)"DNAJB9 is a Specific Immunochemical Marker for Fibrillary Glomerulonephritis"Kidney International Reports 2017.07.017http://www.kireports.org/article/S2468-0249(17)30341-8/pdf
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9/19/2017Sampogna, RosemaryRichard-Cournand Library (PH9E101)Thirst-associated preoptic neurons encode an aversive motivational driveScience Sept 2017 - Vol. 357, Issue 6356, pp. 1149-1155http://science.sciencemag.org/content/357/6356/1149
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9/12/2017Al-Awqati, Qais Richard-Cournand Library (PH9E101)Selective depletion of uropathogenic E. coli from the gut by a FimH antagonist. Nature.2017 Jun 22;546(7659):528-532.DOI: 10.1038/nature22972
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6/27/2017Beenken, AndrewRichard-Cournand Library (PH9E101)The calcineurin inhibitor tacrolimus activates the renal sodium chloride cotransporter to cause hypertensionNat Med. 2011 Oct; 17(10): 1304–1309.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3192268/
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6/20/2017Campbell, Sean R. Richard-Cournand Library (PH9E101)Erythropoietin Receptor-Mediated Molecular Crosstalk Promotes T Cell Immunoregulation and Transplant Survival.J Am Soc Nephrol. 2017 Mar 16. pii: ASN.2016101100. doi: 10.1681/ASN.2016101100https://www.ncbi.nlm.nih.gov/pubmed/28302753
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6/13/2017Fernandez, Hilda E.Richard-Cournand Library (PH9E101)“High salt intake reprioritizes omolyte and energy metabolism for body fluid conservation.”Kitada K, et al. 2017. JCI.https://www.jci.org/articles/view/88532/pdf
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6/6/2017Stevens, Jacob Richard-Cournand Library (PH9E101)“Long-term space flight simulation reveals infradian rhythmicity in human Na(+) balance.”Cell Metab. 2013 Jan 8;17(1):125-31.https://www.ncbi.nlm.nih.gov/pubmed/?term=23312287
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5/30/2017Nickolas, Thomas Richard-Cournand Library (PH9E101)Klotho preservation via histone deacetylase inhibition attenuates chronic kidney disease-associated bone injury in mice.Sci Rep. 2017 Apr 7;7:46195. doi: 10.1038/srep46195.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5384196/
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5/23/2017Kiryluk, KrzystofRichard-Cournand Library (PH9E101)Overexpression of the Cytokine BAFF and Autoimmunity RiskN Engl J Med. 2017 Apr 27;376(17):1615-1626.http://www.nejm.org/doi/10.1056/NEJMoa1610528
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5/16/2017Kozicky, Mark Richard-Cournand Library (PH9E101)FGF23 signaling impairs neutrophil recruitment and host defense during CKDJ Clin Invest. 2016;126(3):962–974. doi:10.1172/JCI83470.https://www.jci.org/articles/view/83470
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5/9/2017Morris, HeatherRichard-Cournand Library (PH9E101)Transgenic expression of human APOL1 risk variants in podocytes induces kidney disease in miceNature Medicine. 2017 Feb 20. doi: 10.1038/nm.4287. [Epub ahead of print]http://www.nature.com/nm/journal/vaop/ncurrent/full/nm.4287.html
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5/2/2017Siddall, Eric Russ Berrie 4th Floor Conference Room RB419JAK3-STAT pathway blocking benefits in experimental lupus nephritisArthritis Research & Therapy 2016; 18: 134https://arthritis-research.biomedcentral.com/articles/10.1186/s13075-016-1034-x
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4/25/2017Bomback, AndrewRuss Berrie 4th Floor Conference Room RB419Maternal Gestational Hypertension-Induced Sensitization of Angiotensin II Hypertension Is Reversed by Renal Denervation or Angiotensin-Converting Enzyme Inhibition in Rat OffspringHypertension. 2017;69:669-677https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5344733
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4/18/2017Husain, AliRichard-Cournand Library (PH9E101)The Secreted Enzyme PM20D1 Regulates Lipidated Amino Acid Uncouplers of Mitochondria.Cell. 2016 Jul 14;166(2):424-35.http://www.sciencedirect.com/science/article/pii/S0092867416306754
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4/11/2017Zachariah, TeenaRichard-Cournand Library (PH9E101)Reducing VEGF-B Signaling Ameliorates Renal Lipotoxicity and Protects against Diabetic Kidney DiseaseFalkevall et al., 2017, Cell Metabolism 25, 1–14http://www.sciencedirect.com/science/article/pii/S1550413117300396
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4/4/2017Radhakrishnan, JaiRichard-Cournand Library (PH9E101)VEGF regulates local inhibitory complement proteins in the eye and kidney.J Clin Invest. 2017 Jan 3;127(1):199-214.https://www.jci.org/articles/view/86418
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3/28/2017Balaraman, VasanthiRichard-Cournand Library (PH9E101)Inhibition of Activin Signaling Slows Progression of Polycystic Kidney DiseaseJASNhttp://m.jasn.asnjournals.org/content/27/12/3589
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3/21/2017Lin, Fangming Richard-Cournand Library (PH9E101)Interspecies Chimerism with Mammalian Pluripotent Stem CellsCell. 2017 Jan 26;168(3):473-486http://ac.els-cdn.com/S0092867416317524/1-s2.0-S0092867416317524-main.pdf?_tid=490a6ae2-05df-11e7-bb58-00000aab0f27&acdnat=1489184401_fde4ddf36fe55d59be2bb2f35380b9d8
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3/14/2017Pai, AkshtaRichard-Cournand Library (PH9E101)Improved renal ischemia tolerance in females influences kidney transplantation outcomes.The Journal of clinical investigation 126.5 (2016): 1968-1977https://www.jci.org/articles/view/84712
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3/7/2017Nestor, JordanRichard-Cournand Library (PH9E101)Moss-Produced, Glycosylation-Optimized Human Factor H for Therapeutic Application in Complement DisordersJ Am Soc Nephrol 28: ccc–ccc, 2016. doi: 10.1681/ASN.2015070745
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2/28/2017Groopman, Emily E. Richard-Cournand Library (PH9E101)Genomic and clinical profiling of a national nephrotic syndrome cohort advocates a precision medicine approach to disease management.Kidney Int (2017).http://www.sciencedirect.com/science/article/pii/S0085253816306123
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2/14/2017Majed, Batoule HRichard-Cournand Library (PH9E101)Matrix Metalloproteinase-7 Is a Urinary Biomarker and Pathogenic Mediator of Kidney FibrosisJ Am Soc Nephrol. 2016 Sep 13. pii: ASN.2016030354http://jasn.asnjournals.org/content/early/2016/09/12/ASN.2016030354.long
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2/7/2017Cohen, DavidRichard-Cournand Library (PH9E101)Bone marrow-derived immature myeloid cells are a main source of circulating suPAR contributing to proteinuric kidney diseasedoi:10.1038/nm.4242http://www.nature.com.ezproxy.cul.columbia.edu/nm/journal/v23/n1/pdf/nm.4242.pdf
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1/31/2017Valeri, A Richard-Cournand Library (PH9E101)Pericyte MyD88 and IRAK4 control inflammatory and fibrotic responses to tissue injury J Clin Invest. 2017;127(1):321–334. doi:10.1172/JCI87532.https://www.jci.org/articles/view/87532
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1/24/2017Regunathan, RenuRichard-Cournand Library (PH9E101)Autoantibodies against thrombospondin type 1 domain–containing 7A induce membranous nephropathyJ Clin Invest. 2016;126(7):2519–2532. doi:10.1172/JCI85265.http://www.jci.org/articles/view/85265
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1/10/2017Dube, Geoffrey K.Richard-Cournand Library (PH9E101)Urea impairs β cell glycolysis and insulin secretion in chronic kidney diseaseJ Clin Invest. 2016;126(9):3598–3612. doi:10.1172/JCI86181.https://www.jci.org/articles/view/86181
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1/3/2017Gharavi, Ali Richard-Cournand Library (PH9E101)Genetic identification of familial hypercholesterolemia within a single U.S. health care system / Distribution and clinical impact of functional variants in 50,726 whole-exome sequences from the DiscovEHR study.Science016 Dec 23;354(6319). pii: aaf7000. doi: 10.1126/science.aaf7000. / Science. 2016 Dec 23;354(6319). pii: aaf6814. doi: 10.1126/science.aaf6814.https://www.ncbi.nlm.nih.gov/pubmed/28008010 / https://www.ncbi.nlm.nih.gov/pubmed/28008009
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