ABCDEFGHIJKLMNOPQRSTU
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AntiretroviralsResistance
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Analog blockingExcision enhancement
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Fixed Dose CombinationClassARVClass ToxicitySpecific ToxicityWtPregHBV3A4UGT1A1M184VQ151MQ151M*TAMs
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NRTI
nucleoside RT inhibitors
ddIdidanosine (A), Videxperipheral neuropathy
lipodystrophy
pancreatitis
LA w/ hepatic steatosis
++++
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d4Tstavudine (T), Zerit++++
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AZTzidovudine (T), RetrovirBM suppression, myopathy+↑ sus.+++++
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EpzicomTriumeqABCabacavir (G), ZiagenCVD, hypersensitivity (HLA-B*5701)3 kg±+++
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EpzicomDelstrigo
Symfi
Triumeq
Dovato
Dutrebis
Bictarvy
3TClamivudine (C), Epivirdose adjust CrCl < 30++++
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Truvada
Descovy
Complera
Atripla
OdefseySymtuzaStribild GenvoyaFTCemtricitabine (C), Emtrivahyperpigmentation
dose adjust CrCl << 30
++++
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TruvadaComplera
Atripla
Delstrigo
Symfi
StribildTDFtenofovir (A), VireadAKI, Fanconi, osteopenia
dose adjust CrCl < 50
2 kg↑ sus.
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DescovyOdefseySymtuzaGenvoya
Bictarvy
TAFtenofovir (A), Vemlidydon't use if CrCl < 154 kg
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AtriplaSymfiNNRTI
non-
nucleoside RT inhibitors
EFVefavirenz, SustivaSJS, TEN

hepatotoxicity
CNS toxicity, SI, gynecomastia, ↑ QTc, FP THC and BDZø+++++
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NVPnevirapine, Viramune+++++
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DLVdelavirdine, Rescriptorø++++
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ETRetravirine, Intelence++++
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Cabenuva
Juluca
CompleraOdefseyRPVrilpivirine, Edurantmilder CNS toxicity, ↑ QTc++++
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DelstrigoDORdoravirine, Pifeltro↓ dizziness, N, abnormal dreams
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PI
protease inhibitors
IDVindinavir, CrixivanFood ↑ absor., ↓ GI SE

HLD, lipohypertrophy

⇥ glucose tolerance

Drug-induced hepatitis
crystal-induced nephropathyL100IK103NK101EY181/8C/LG190E
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SQVsaquinavir, InviraseEntranceInsideSterics
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Kaletra/rritonavir, NorvirEFV/NVP pressure: L100I, Y181C/I, K103N, V106A/M, V108I, Y188C/H/L and G190A/S
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KaletraLPVlopinavir
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EvotazATVatazanavir, Reyatazbenign ↑ indirect bilirubin, PR/QRS prolongation, nephrolithiasis+
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FPVfosamprenavir, Lexiva
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PrezcobixSymtuzaDRVdarunavir, PrezistaSJS/TEN reported 1st mo+
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Prezcobix
Evotaz
SymtuzaStribild GenvoyaPK Enhancer/ccobicistat, Tybost↑ Cr (artifact), proteinuria⇥⇥
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DutrebisINSTI
Integrase Strand Transfer Inhibitors
RALraltegravir, IsentressFew SE for insomnia, neuropsychiatric effects

↓ absorption w/ cations

HA
myopathy, depression, insomnia, HA, hypersensitivity+
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Stribild GenvoyaEVGelviregravir, VitektaHLD, rash, N, Dx
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JulucaTriumeq
Dovato
DTGdolutegravir, Tivicayhepatic toxicity, DILI
depression, rash
4 kgok1090
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BictarvyBICbictegravirN, D4 kg5050
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CabenuvaCABcabotegravir, Vocabriax
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Entry InhibitorsT-20enfuvirtide, FuzeonAdherance (incl. oral co-meds) is criticalinjection site eosinophilia
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MVCmaraviroc, Selzentryhepatotoxicity
requires baseline tropism test (X4)
x
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IBAibalizumab, Trogarzoinjected q2wk
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FTRfostemsavir, Rukobiax