A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | Antiretrovirals | Resistance | |||||||||||||||||||
2 | Analog blocking | Excision enhancement | |||||||||||||||||||
3 | Fixed Dose Combination | Class | ARV | Class Toxicity | Specific Toxicity | Wt | Preg | HBV | 3A4 | UGT1A1 | M184V | Q151M | Q151M* | TAMs | |||||||
4 | NRTI nucleoside RT inhibitors | ddI | didanosine (A), Videx | peripheral neuropathy lipodystrophy pancreatitis LA w/ hepatic steatosis | + | ++ | + | ||||||||||||||
5 | d4T | stavudine (T), Zerit | + | ++ | + | ||||||||||||||||
6 | AZT | zidovudine (T), Retrovir | BM suppression, myopathy | + | ↑ sus. | + | ++ | ++ | |||||||||||||
7 | Epzicom | Triumeq | ABC | abacavir (G), Ziagen | CVD, hypersensitivity (HLA-B*5701) | 3 kg | ± | ++ | + | ||||||||||||
8 | Epzicom | Delstrigo Symfi | Triumeq Dovato | Dutrebis Bictarvy | 3TC | lamivudine (C), Epivir | dose adjust CrCl < 30 | + | + | + | + | ||||||||||
9 | Truvada Descovy | Complera Atripla | Odefsey | Symtuza | Stribild Genvoya | FTC | emtricitabine (C), Emtriva | hyperpigmentation dose adjust CrCl << 30 | + | + | + | + | |||||||||
10 | Truvada | Complera Atripla | Delstrigo Symfi | Stribild | TDF | tenofovir (A), Viread | AKI, Fanconi, osteopenia dose adjust CrCl < 50 | 2 kg | ↑ sus. | ||||||||||||
11 | Descovy | Odefsey | Symtuza | Genvoya Bictarvy | TAF | tenofovir (A), Vemlidy | don't use if CrCl < 15 | 4 kg | |||||||||||||
12 | Atripla | Symfi | NNRTI non- nucleoside RT inhibitors | EFV | efavirenz, Sustiva | SJS, TEN hepatotoxicity | CNS toxicity, SI, gynecomastia, ↑ QTc, FP THC and BDZ | ø | + | + | + | + | + | ||||||||
13 | NVP | nevirapine, Viramune | + | + | + | + | + | ||||||||||||||
14 | DLV | delavirdine, Rescriptor | ø | + | + | + | + | ||||||||||||||
15 | ETR | etravirine, Intelence | + | + | + | + | |||||||||||||||
16 | Cabenuva Juluca | Complera | Odefsey | RPV | rilpivirine, Edurant | milder CNS toxicity, ↑ QTc | + | + | + | + | |||||||||||
17 | Delstrigo | DOR | doravirine, Pifeltro | ↓ dizziness, N, abnormal dreams | |||||||||||||||||
18 | PI protease inhibitors | IDV | indinavir, Crixivan | Food ↑ absor., ↓ GI SE HLD, lipohypertrophy ⇥ glucose tolerance Drug-induced hepatitis | crystal-induced nephropathy | ⇥ | L100I | K103N | K101E | Y181/8C/L | G190E | ||||||||||
19 | SQV | saquinavir, Invirase | ⇥ | Entrance | Inside | Sterics | |||||||||||||||
20 | Kaletra | /r | ritonavir, Norvir | ⇥ | EFV/NVP pressure: L100I, Y181C/I, K103N, V106A/M, V108I, Y188C/H/L and G190A/S | ||||||||||||||||
21 | Kaletra | LPV | lopinavir | ⇥ | |||||||||||||||||
22 | Evotaz | ATV | atazanavir, Reyataz | benign ↑ indirect bilirubin, PR/QRS prolongation, nephrolithiasis | + | ⇥ | |||||||||||||||
23 | FPV | fosamprenavir, Lexiva | ⇥ | ||||||||||||||||||
24 | Prezcobix | Symtuza | DRV | darunavir, Prezista | SJS/TEN reported 1st mo | + | ⇥ | ||||||||||||||
25 | Prezcobix Evotaz | Symtuza | Stribild Genvoya | PK Enhancer | /c | cobicistat, Tybost | ↑ Cr (artifact), proteinuria | ⇥⇥ | |||||||||||||
26 | Dutrebis | INSTI Integrase Strand Transfer Inhibitors | RAL | raltegravir, Isentress | Few SE for insomnia, neuropsychiatric effects ↓ absorption w/ cations HA | myopathy, depression, insomnia, HA, hypersensitivity | + | ||||||||||||||
27 | Stribild Genvoya | EVG | elviregravir, Vitekta | HLD, rash, N, D | x | ||||||||||||||||
28 | Juluca | Triumeq Dovato | DTG | dolutegravir, Tivicay | hepatic toxicity, DILI depression, rash | 4 kg | ok | 10 | 90 | ||||||||||||
29 | Bictarvy | BIC | bictegravir | N, D | 4 kg | 50 | 50 | ||||||||||||||
30 | Cabenuva | CAB | cabotegravir, Vocabria | x | |||||||||||||||||
31 | Entry Inhibitors | T-20 | enfuvirtide, Fuzeon | Adherance (incl. oral co-meds) is critical | injection site eosinophilia | ||||||||||||||||
32 | MVC | maraviroc, Selzentry | hepatotoxicity requires baseline tropism test (X4) | x | |||||||||||||||||
33 | IBA | ibalizumab, Trogarzo | injected q2wk | ||||||||||||||||||
34 | FTR | fostemsavir, Rukobia | x |