ABCDEFGHIJKLMNOPQRSTUVWXYZ
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Parameter nameUnitSourceNotes
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Disease and demographic parameters
Assumptions and limitations
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Disability weight for diarrheoa0.188weightGBD weights
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Percent of < 5YO suffer diarrhoea per year3.90%%
https://vizhub.healthdata.org/gbd-results/
* Does not include additional benefits from increasing rates of attending ANC appointments/ births in health facilities.
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Percent of children with diarrhoea seek out treatment in absence of intervention63%%DHS
* Does not include long term benefits, so may underestimate total benefit
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Mortality rate diarrheoa <5 YO0.06rate
https://vizhub.healthdata.org/gbd-results/
Used death and prevlance numbers for diarrhoeal diseases in Burkina Faso <5 YO. Note this is for diarrheal diseases specifically, not any occurence of diarrhoea
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Disability weight for lower respiratory infection0.051weightGBD weights
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Percent of < 5YO who suffer lower respiratory infection per year0.23%%
DHS Graph 8 (note it's in French). Divided by two since it is 15% in the 2 years prior to interview
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Percent of children with lower respiratory infection who seek out treatment in absence of intervention80%%DHS
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Mortality rate lower respiratory infections < 5YO0.2rate
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7122747/#:~:text=7.4.,-5%20Case%20Fatality&text=Case%20fatality%20ratios%20for%20acute,%E2%80%93142%5D%20in%20developing%20countries.
The GBD estimates place a higher number of deaths than overall prevlance, in burkina faso? I therefore used paper instead, this is in 7.4.5. ('in developing countries').
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Percent of <5YO who have malaria35.65%%
https://vizhub.healthdata.org/gbd-results/
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Percent of children with malaria that seek out treatment in absence of intervention75%%
https://dhsprogram.com/pubs/pdf/PR139/PR139.pdf graph 8 (in french)
Not sure about this estimate, I used the percent of children with fever whose parents seek out treatment
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Disability weight for malaria0.051weightGBD weights
Weight for moderate malaria
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Mortality rate malaria <5 YO0.0118rate
https://vizhub.healthdata.org/gbd-results/
Used death and prevlance numbers for malaria in Burkina Faso <5 YO
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Lifespan Burkina Faso62years
https://data.worldbank.org/indicator/SP.DYN.LE00.IN?locations=BF
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Infant mortality rate in Burkina Faso5.30%%
https://data.worldbank.org/indicator/SP.DYN.IMRT.IN?locations=BF
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Total fertility rate for women in Burkina Faso5No. children
https://data.worldbank.org/indicator/SP.DYN.TFRT.IN?locations=BF
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Intervention parameters
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Total number of people reached per year2400000No page 2
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Number of <5YO reached per year 480000No page 2
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% increase in consultations for malaria42.60%%
This is the difference between the control and intervention arms, averaged across 3 years. 'Analysis of health facility consultation data' section
I assume a campaign would not last >3 years
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% increase in consultations for lower resp infections25%%
This is the difference between the control and intervention arms, averaged across 3 years. 'Analysis of health facility consultation data' section
I assume a campaign would not last >3 years
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% increase in consultations for diarrheoa80%%
This is the difference between the control and intervention arms, averaged across 3 years. 'Analysis of health facility consultation data' section
I assume a campaign would not last >3 years
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Generalisability discount for RCT0.55proportion
I am discounting because 1). other regions might not be so amenable to this kind of intervention (rural, cheap radio access, people who lvie within easy walking district of a clinic) and 2). the RCT used a saturation+ design, with high coverage of the radio program. A real situation would likely not achieve as high a coverage. 3). surveyors were not blinded 4). perhaps the most ill kids (who stand to benefit most from treatment) would have recieved clinic treatment anyway- i.e. many the increase in consultations is for kids who are mildly ill
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Reduction in DALYs due to treatment: diarrhoea50%%Subjective estimate
Couldn't find data. I am assuming that available treatment is not perfect, doesn't always work, isn't always available etc
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Reduction in DALYs due to treatment: malaria50%%Subjective estimate
Assuming that available treatment is not perfect, doesn't always work, isn't always available etc
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Reduction in DALYs due to treatment: lower respiratiory infections50%%Subjective estimate
Assuming that available treatment is not perfect, doesn't always work, isn't always available etc
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Reduction in death to to treatment: malaria70%%Subjective estimate
I think that treatment will be more successful in avoiding death (relative to reducing DALYs)
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Reduction in death due to treatment: diarrhoea70%%Subjective estimate
I think that treatment will be more successful in avoiding death (relative to reducing DALYs)
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Reduction in death due to treatment: lower respiratory infections70%%Subjective estimate
I think that treatment will be more successful in avoiding death (relative to reducing DALYs)
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CostsUnitSourceNotes
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Recurring costs
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Airtime71216$Supplementary material Table G
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Rent and utilities109946$Supplementary material Table G
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Supplies255790$Supplementary material Table G
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Travel242231$Supplementary material Table G
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Personnel1429020$Supplementary material Table G
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Capital costs
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Radio station equipment21209$Supplementary material Table G
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NGO office/ media production equipment59231$Supplementary material Table G
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Vehicles16438$Supplementary material Table G
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Calculations
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Illness/ death stemming from diarrhoea
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Number of children who get diarrheoa per year18720No
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Number children suffering from diarrhoea who get treatment, WO intervention11793.6No
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Number children who newly seek out treatment9434.88No
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DALYs averted, by treating more diarrhoea cases887No
disability weight of diarrhoea x number who newly get treatment x reduction in DALYs from getting treated
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Number of child diarrhoea deaths averted396.26496No
mortality rate of diarrhoea x reduction in death from getting treatment x number of children newly treated
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Illness/ death stremming from lower respiratory infections
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Number of children who get lower respiratory infections per yr1104No
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Number of children suffering from resp infections who get treatment, W/O intervention883.2No
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Number of children who newly seek out treatment220.8No
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DALYs averted, by treating more resp infections5.6304No
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Number of child resp infections deaths averted30.912No
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Illness/ death stemming from malaria
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Number of children who get malaria per year171120No
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Number of children suffering from malaria who get treatment, W/O intervention128340No
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Number children who newly seek out treatment54672.84No
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DALYs averted, by treating more malaria cases1394.15742No
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Number of child malaria deaths averted451.5976584No
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Cost effectiveness
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Total DALYs averted from preventing illness (not inc those from averting deaths), with generalisability discount1028.999943No
Doesn't include DALYs from averting childhood deaths
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Total number of childhood deaths averted, with generalisability discount395.4485783No
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Number of DALYs from averting childhood death, inc discount27800.86869DALY equivalentsUsing DALY/ lives saved conversion
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Total no. WELLBY-equivalents, inc discount96239.36711WELLBY equivalents
Using 1 DALY = 3.6 WELLBY conversion
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Total costs3381381$
Table 1, total costs (annual costs, average over study period column)
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Total recurring costs2108203$
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$/ WELLBY (capital plus recurring costs)35.1351126$/WELLBY
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$/DALY (capital plus recurring costs)121.6286094$/DALY
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GD multiples4.667695302GDX$164 per WELLBY for GD
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8550.747646
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