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1 | Timestamp | Email Address | Name (First, Last) | Research Concentration (select all that apply) | Link to your lab page or bio (if applicable) | Rotation Project Name | Rotation Project Description | Student Slots Available (GEMS First Year) | Term Availability | ||||||
76 | 8/6/2025 13:28:10 | mlujan@uic.edu | Miguel Lujan | Neurobiology | https://lujanlab.org/ | Mapping the Neural Basis of Motivational Resilience | Despite substance use disorders (SUD) affecting approximately 10% of the population, it is well established that only a minority of individuals who use drugs go on to develop SUDs. Moreover, nearly one-third of those diagnosed eventually achieve spontaneous remission. These patterns suggest the existence of intrinsic resiliency mechanisms that counterbalance excessive reward pursuit, even in the face of highly reinforcing substances. However, these protective brain processes remain largely unexplored, as addiction research has traditionally focused on ‘what goes wrong’ in the brain. In contrast, our approach shifts the spotlight to the majority who remain resilient despite drug exposure. We aim to uncover the corticolimbic underpinnings of this resilience and investigate how specific neuronal populations dynamically shape adaptive decision-making in high-stakes contexts. | 1 | Fall and Spring | ||||||
77 | 8/6/2025 13:30:04 | evb@uic.edu | Elizaveta Benevolenskaya | Cancer Biology, Molecular Biology and Genetics (MBG) | https://chicago.medicine.uic.edu/bmg/profiles/benevolenskaya-elizaveta/ | Epigenetic regulation of drug tolerance to anti-cancer therapies | We are studying the effect of the histone demethylase KDM5A on cell tolerance to targeted therapies using cell biology assays informed by single-cell RNA and chromatin sequencing. In particular, we are interested in better understanding of the KDM5A role in cell plasticity. | 1 | Fall and Spring | ||||||
78 | 8/6/2025 13:34:20 | mlujan@uic.edu | Miguel Lujan | Neurobiology | https://lujanlab.org/ | Dopaminergic Determinants of the Pregnant and Postpartum Brain | To expand the scope of vulnerable individuals considered in addiction research, the Luján Lab investigates understudied neurodevelopmental trajectories of the dopamine system during pregnancy and the postpartum period. During the last decade, the use of prescription opioids during pregnancy has reached notably high rates (14-22%), yet systems neuroscience evidence on the mental health status of postpartum individuals remains scarce. Our research addresses this gap by investigating how exposure to drugs during gestation disrupts maternal brain circuits, with a focus on the dopamine system and its role in postpartum motivation and reward. Using rodent models, this work integrates in vivo imaging, behavioral economics, and electrophysiology to provide a mechanistic understanding of how gestational drug exposure reshapes postpartum motivation and mental health beyond caregiving behaviors. | 1 | Fall and Spring | ||||||
79 | 8/6/2025 13:37:27 | mlujan@uic.edu | Miguel Lujan | Neurobiology | https://lujanlab.org/ | Endocannabinoid Control of Dopamine-based Action Selection | To better understand how neuronal populations assign value to rewards–and to ultimately improve outcomes for individuals affected by addiction–the Luján Lab investigates the dynamic interplay between the dopamine and endocannabinoid systems. The ability to assign survival relevance (salience) to environmental stimuli is essential for adaptive decision-making. Our research investigates how endocannabinoid signaling in the prefrontal cortex modulates attention towards reward- and punishment-predictive stimuli. We dissect the molecular machinery responsible for the generation, reception, and computation of this lipid-based signal, and examine how it shapes dopamine-based cortical encoding of motivational salience. By identifying the circuit and cellular mechanisms through which endocannabinoids regulate attention and motivation, we aim to uncover how dysregulation of this metamodulatory system contributes to decision making, and how it might be harnessed pharmacologically to treat psychiatric conditions. | 1 | Fall and Spring | ||||||
80 | 8/6/2025 13:58:48 | jalilian@uic.edu | Elmira Jalilian | Cell Biology and Regenerative Medicine (CBRM), Neurobiology | https://chicago.medicine.uic.edu/ophthalmology-visual-sciences/opth-research/labs/jalilian-lab/ | Role of Extracellular vesicles in corneal disease and repair | Our lab investigates how corneal sensory nerves contribute to ocular surface homeostasis and vision by using approaches in neurobiology, regenerative medicine, and extracellular vesicle (EV) biology. We focus on defining the molecular mechanisms that regulate corneal nerve repair after injury and nerve–epithelial communication in the cornea. During the rotation, students will contribute to one of two ongoing projects: Assessing the regenerative potential of mesenchymal stem cell-derived EVs in models of corneal nerve injury. Defining how nerve-derived EVs from corneal neurons regulate epithelial wound healing and renewal. Students will gain hands-on experience with primary cell culture, EV isolation and characterization, corneal epithelial assays, imaging techniques and molecular biology. This rotation will provide opportunities to explore EV-based regenerative strategies for treating neurotrophic keratitis and other corneal nerve disorders. Motivated students may also contribute to ongoing publications and presentations. | Yes | Fall and Spring | ||||||
81 | 8/6/2025 14:06:14 | pk434@uic.edu | Preetish, Kadur Lakshminarasimha Murthy | Cancer Biology, Cell Biology and Regenerative Medicine (CBRM) | Stem cell models of lung cancer | Develop novel human stem cell based models for lung cancer. | 1 | Fall and Spring | |||||||
82 | 8/6/2025 15:38:06 | shahrara@uic.edu | Shiva Shahrara | Microbiology, Immunity and Inflammation (MII) | https://chicago.medicine.uic.edu/medicine/divisions/rheumatology/research-rheumatology/shahrara-lab/ | Role of metabolic dysregulation in RA | The instigators and the mechanism by which oxidatively stressed RA macrophages cross-regulate fibroblasts and endothelial cells to advance pannus formation are unclear. We have uncovered that activated RA macrophages reprogram fibroblasts and endothelial cells to influence their inflammatory and metabolic reconfiguration via a shared signaling pathway. The outlined studies will reconceptualize how the blockade of the shared pathway will counteract the crosstalk between RA-immune and non-immune cells to repair pannus hyperplasia. | Third slot only | Fall and Spring | ||||||
83 | 8/6/2025 17:41:37 | kvp@uic.edu | Kostandin Pajcini | Molecular Biology and Genetics (MBG), Cell Biology and Regenerative Medicine (CBRM) | thepajcinilab.com | 1). Tmtc1-mediated enhancement of the endothelial barrier to prevent edema and acute lung injury. 2). Determining the niche of hematopoietic stem cells in extramedullary hematopoiesis | 1). The vascular barrier is key to maintaining organ function, especially in the lungs where the tight barrier is critical for keeping the airways clean for efficient gas exchange. We have shown that Notch signaling regulates the novel ER-localized transmembrane mannosylation transferring cadherin Tmtc1. We know that tmtc1 binds VE-cadherin the key protein in maintaining junctional integrity so we have generated the first tmtc1 conditional knockout mouse and we will analyze how tmtc1 loss of function affects the lung function in resting or inflammatory (sepsis or LPS) conditions. We will then determine if Notch agonist stimulation or tmtc1 stabilizing peptides will improve barrier function in lung disease (ALI or ARDS). Methods will involve transgenic mouse analysis, cell culture, flow cytometry and confocal imaging. Molecular biology and biochemistry background is preferred. 2). The bone marrow is the niche for all hematopoietic stem and progenitor cells, however under pathological conditions (ex. hemolytic anemia, myelofibrosis or leukemic infiltration), the bone marrow becomes inhospitable and the HSCs and progenitors vacate their natural niche and home to the liver and spleen. We have shown that genuine, long term and functional HSCs are in the adult liver under the conditions of acute hemolytic anemia. We will test if the same occurs in conditions of myelofibrosis or leukemia. The goal is to determine how the HSCs home and lodge in the liver, what cells are supporting their function and what cell signaling mechanism is employed by both the stem cell and the niche cells. We will use injectable inhibitors and whole mount liver imaging analysis to test the hypothesis of homing and niche cell identity. We will also perform flow cytometry and sorting with single cell RNAseq to establish comprehensive identity of niche cells. This project is heavily based on in vivo approaches and models of disease, so hands on animal training is required, including injections (IP and IV) and liver and bone marrow tissue preparations. | 1 | Fall and Spring | ||||||
84 | 8/7/2025 1:29:23 | xdu@uic.edu | Xiaoping Du | Integrative and Translational Physiology (ITP), Cell Biology and Regenerative Medicine (CBRM), Microbiology, Immunity and Inflammation (MII) | thrombi-inflammation and its role in cardiovascular and inflammatory diseases. | Depending on the student interests,, student can choose to study characterize the interaction between G protein and integrin cytoplasmic domain, and its role in the treatment and mechanisms of thrombi-inflammatory conditions associated with myocardial ischemia-reperfusion injury, sickle cell diseases and sepsis. | 1-2 | Fall and Spring | |||||||
85 | 8/8/2025 11:51:49 | mfrolov@uic.edu | Max Frolov | Cancer Biology, Molecular Biology and Genetics (MBG), Cell Biology and Regenerative Medicine (CBRM) | To investigate how the Retinoblastoma (RB) and Hippo tumor suppressor pathways regulate cell proliferation and differentiation in Drosophila | To analyze cell proliferation and differentiation in RB and Hippo mutant tissues using immunofluorescence and confocal microscopy. To explore single-cell genomics data from RB and Hippo mutant tissues generated in the lab with the Seurat computational pipeline. Recent publications: https://www.ncbi.nlm.nih.gov/myncbi/maxim.frolov.1/bibliography/public/ | One slot for each rotation | Fall and Spring | |||||||
86 | 8/19/2025 16:38:34 | avlasits@uic.edu | Anna Vlasits | Neurobiology | vlasitslab.org | Visual processing in the retina in Fragile X syndrome | There is a broad spectrum of visual symptoms in Fragile X syndrome. This includes lower contrast sensitivity, lower temporal resolution, light hypersensitivity and challenges with visual learning. Yet, the role of the retina vs. the brain in these symptoms is not well understood. We found that retinal cells in mouse model of Fragile X syndrome have dampened sensitivity to light. However, the details of how these cells respond to a variety of stimuli (bright vs. dark; small vs. big; moving vs. stationary) are not known. This project aims to study how loss of the Fragile X-related gene Fmr1 affects these visual responses in the retina. | 1 | Fall and Spring | ||||||
87 | 8/22/2025 15:16:14 | reshmamd@uic.edu | Reshma Shah | Neurobiology | https://www.preschoolandme.org/ ; https://www.pathwaysforpreschoolers.org/ | Developmental Pediatrics Lab | Rotation Opportunity with Dr. Shah’s Lab Dr. Shah’s lab is accepting GEMS applicants for a research rotation. Dr. Shah is an Associate Professor of Pediatrics. Her research focuses on addressing longstanding healthcare and educational disparities, including access to school-based therapy services, among children with developmental delays and disabilities, as well as supporting their families and communities. She is currently the Principal Investigator on two NIH-funded projects, and leads a team of more than 30 research assistants and student volunteers. Rotation Objectives: During the rotation, the student will have the opportunity to: 1. Support website feasibility project (Preschool and Me): Contribute to an ancillary study of the Preschool and Me trial, a hybrid implementation-effectiveness randomized controlled waitlist trial of a medical-educational linkage model, by assisting with developing, prototyping and testing a web-based navigation tool. The student may also have the opportunity to participate in data collection and analysis for this project. 2. Assist with research activities: Assist with recruitment efforts at community events and by phone, as well as support research assessments with participants, for the Preschool and Me study. 3. Develop research and writing skills: Gain experience with study design and implementation planning and potentially contribute to manuscript preparation and dissemination. This rotation offers exposure to multidisciplinary research at the intersection of health and education, with opportunities to engage directly in both community-based and academic research activities. | Yes | Spring | ||||||
88 | 8/26/2025 14:15:54 | merrillb@uic.edu | Brad Merrill | Molecular Biology and Genetics (MBG), Cell Biology and Regenerative Medicine (CBRM) | https://chicago.medicine.uic.edu/bmg/profiles/merrill-brad/ | New SynBio tools for directing differentiation of stem cells | We will be inventing new nucleic acid based tools that use CRISPR-derived enzymes to deliver sophisticated sets of genetic instruction to stem cells. They will share some similarities with the proGuides that we recently described (https://doi.org/10.1101/2024.09.17.613466, https://doi.org/10.1016/j.molcel.2020.12.003). New designs will seek improvements for how they can control a program of gene regulation in individual cells. Projects will involve recombinant DNA techniques, cell culture, and flow cytometry. | 1 | Fall and Spring | ||||||
89 | 8/27/2025 15:33:55 | zhengyh@uic.edu | Yonghui, Zheng | Microbiology, Immunity and Inflammation (MII) | https://chicago.medicine.uic.edu/microbiology/mb-research/zheng-lab/ | HIV-1 and SARS-CoV-2 interactions with the host | We will investigate how the class I fusion proteins from these viruses are expressed and inhibited by different types of host factors. | Two | Fall and Spring | ||||||
90 | 8/27/2025 16:58:29 | ak20@uic.edu | Andrius | Integrative and Translational Physiology (ITP) | https://chicago.medicine.uic.edu/ophthalmology-visual-sciences/opth-research/labs/kazlauskas-lab/ | Resilience to diabetic retinopathy | The overall goal of a rotation is to determine whether the student and lab are a good match. Typically, the student is paired with a lab member and works collaboratively on that person’s research project. During this process, the student learns new techniques, experiences the lab environment, and contributes to the lab’s broader research program. Projects cover diverse areas of vascular and retinal biology, ranging from endothelial cell biology to single-cell transcriptomics. As one example, students may participate in investigations of resilience to diabetic retinopathy (RDR)—a phenomenon in which some patients maintain healthy retinas despite decades of diabetes. By contributing to this type of project, the student gains exposure to both fundamental biology and translational approaches aimed at developing new therapies. | 2 | Fall and Spring | ||||||
91 | 8/28/2025 12:55:03 | horiguch@uic.edu | Kaori Yamada | Cancer Biology | https://ykaori07.wixsite.com/yamada | The mechanisms of how uveal melanoma escapes from the eyes to metastasize to the liver. The mechanisms of how breast cancer invades the brain through the tightest barrier of the BBB. The mechanisms of subretinal fibrosis development in neovascular AMD | First project is to define the adhesion molecules expressed on metastatic uveal melanoma that affect endothelial permeability and cancer cell transmigration. Second project is to define the mechanisms of expression and glycosylation of the molecules in metastatic breast cancer cells that facilitate transmigration of breast cancer cells through the BBB. Third project is to examine whether endothelin2 induces mesenchymal transition, endothelial permeability, and leukocyte transmigration. | 1 person per slot for 1st~3rd rotation slots (total 3) | Fall and Spring | ||||||
92 | 8/28/2025 13:35:40 | dshukla@uic.edu | Deepak Shukla | Cancer Biology, Molecular Biology and Genetics (MBG), Microbiology, Immunity and Inflammation (MII) | https://chicago.medicine.uic.edu/ophthalmology-visual-sciences/profiles/shukla-deepak/ | Herpes infection: cell biology, immunology and neuroscience | 3 | Fall and Spring | |||||||
93 | 8/28/2025 13:57:07 | mmpot@uic.edu | Marta Markiewicz-Potoczny | Cancer Biology, Molecular Biology and Genetics (MBG), Cell Biology and Regenerative Medicine (CBRM) | N/A | The role of early embryonic genes in telomere maintenance in stem cells and cancer | Zscan4, a gene highly expressed at very early stages of embryogenesis, was found expressed in 1-2% of mouse embryonic stem cells (mESCs) in vitro culture. Interestingly, this gene is overexpressed in response to DNA damage caused by chemicals that induce DNA double-strand breaks (DSBs). Zscan4 was shown to protect the genome integrity, and to promote telomere elongation in mESCs. Can Zscan4 be activated in response to, specifically, telomeric damage? This project will involved mESCs culture, immunofluorescence experiments and microscopy, validation of Zscan4 expression by qPCR, western blotting for protein levels. | yes, 2 slots available | Fall and Spring | ||||||
94 | 8/30/2025 16:08:02 | falonzo@uic.edu | Francis Alonzo | Microbiology, Immunity and Inflammation (MII) | https://chicago.medicine.uic.edu/microbiology/profiles/alonzo-francis/ | Staphylococcus aureus Pathogenesis | Rotation projects will consider several aspects of Staphylococcus aureus pathogenesis and will involve bacterial genetics, innate immunity, metabolism, and protein biochemistry. | 1 | Fall and Spring | ||||||
95 | 9/5/2025 11:16:28 | ldpalmer@uic.edu | Lauren Palmer | Microbiology, Immunity and Inflammation (MII) | https://sites.google.com/uic.edu/palmer-lab/ | Gut colonization by the multidrug resistant pathogen Acinetobacter baumannii | Our laboratory is investigating mechanisms of asymptomatic gut colonization by Acinetobacter baumannii. A. baumannii is leading cause of multidrug resistant healthcare-associated infections. In healthcare environments, the gut is thought to be a major reservoir of multidrug resistant organisms including A. baumannii. However, we know little about how A. baumannii colonizes the gut and how the resident microbiota resists colonization. Rotation projects in the lab focus on understanding (1) how A. baumannii metabolism, physiology, and regulation allow it to colonize and infect the host, and (2) how the host and resident microbiota resist A. baumannii colonization. | 2 | Fall and Spring | ||||||
96 | 9/11/2025 13:48:27 | anaba@uic.edu | Alexandra Naba | Cancer Biology, Cell Biology and Regenerative Medicine (CBRM) | https://sites.google.com/a/uic.edu/nabalab/ | See: https://drive.google.com/file/d/1EHjVKGXLwGqzsNo-SmIcdhHy03vFeEt1/view | See: https://drive.google.com/file/d/1EHjVKGXLwGqzsNo-SmIcdhHy03vFeEt1/view | 2 per rotation | Spring | ||||||
97 | 9/11/2025 13:48:31 | vadimg@uic.edu | Vadim Gaponenko | Molecular Biology and Genetics (MBG) | What is the mechanism of biased antagonism? | Exploring the binding sites of biased antagonists within chemokine receptors. | 1/2 | Fall and Spring | |||||||
98 | 9/11/2025 14:07:49 | jalilian@uic.edu | Elmira Jalilian | Cell Biology and Regenerative Medicine (CBRM), Neurobiology | https://chicago.medicine.uic.edu/ophthalmology-visual-sciences/opth-research/labs/jalilian-lab/ | Therapeutic application of mesenchymal stem cell derived extracellular vesicles (MSC EVs) in corneal nerve regeneration | Using MSC EVs to regenerate nerves in the cornea after injury and understand the mechanism of nerve regeneration to improve novel therapeutic for ocular nerve injuries | 1 | Spring | ||||||
99 | 9/11/2025 14:53:53 | monicayl@uic.edu | Monica, Lee | Integrative and Translational Physiology (ITP) | www.leelabuic.com | Nucleoporins in EC biology | Aiding in active projects at the time deciphering the role of nucleoporins in endothelial biology | 0 (contingent on funding status) | Spring | ||||||
100 | 9/11/2025 14:55:33 | lijun@uic.edu | Lijun Rong | Microbiology, Immunity and Inflammation (MII) | https://ronglabmates.wixsite.com/ronglab | Bio antiviral assays | Make viruses and test drug efficacy | 1 | Fall and Spring | ||||||
101 | 9/11/2025 15:21:04 | nava@uic.edu | Nava, Segev | Cancer Biology, Molecular Biology and Genetics (MBG), Cell Biology and Regenerative Medicine (CBRM), Neurobiology | https://chicago.medicine.uic.edu/bmg/profiles/segev-nava/ | Trafficking inside cells: from yeast to human cells and disease | Using cell, molecular and genetic analyses to follow aberrant protein accumulation and clearance | 1-2 | Spring | ||||||
102 | 9/15/2025 13:24:11 | yuweij@uic.edu | Yuwei, Jiang | Integrative and Translational Physiology (ITP), Cell Biology and Regenerative Medicine (CBRM) | thejianglab.com | Targeting NAD Metabolism to Improve adipose browning | Beige adipocytes are inducible thermogenic fat cells that emerge within white adipose tissue (WAT) in response to thermogenic stimuli and confer metabolic benefits. However, obesity impairs beige adipocyte generation, and the underlying mechanisms remain poorly understood. Here, we show that obesity leads to a loss of adipose progenitor cells (APCs) in WAT, accompanied by reduced estrogen (E2) levels and NAMPT expression. Supplementation with E2 or NMN, a NAMPT-derived NAD⁺ precursor, restores beige adipogenesis in diet-induced obese mice. The rotation project will be focusing on understanding the molecular basis underlying the beige fat rejuvenation. | Yes | Spring | ||||||
103 | 9/17/2025 17:04:17 | cabrams1@uic.edu | Charles Abrams | Neurobiology | https://chicago.medicine.uic.edu/neurology-rehabilitation/neuro-research/research-labs/dr-charles-abrams-lab/ | Connexin Variants in CMT1X | 1. Developing new methods for high throughput analysis of connexin variants 2. Examining the roles of anti-inflammatory treatment as modifiers of an inherited peripheral neuropathy. | Yes | Fall and Spring | ||||||
104 | 10/17/2025 10:29:08 | suelleno@uic.edu | Suellen D. Oliveira | Integrative and Translational Physiology (ITP) | https://vascularimmunobiology.com | Endothelial-Immune cell crosstalk in infectious cardiopulmonary disease | Pulmonary Arterial Hypertension (PAH) is a life-threatening disease highly incident in women, characterized by pulmonary vasoconstriction and vascular remodeling, which elevates the mean PA pressure and leads to right ventricular hypertrophy. Among the signaling pathways contributing to PAH onset, deficiency of pulmonary BMPR2 expression contributes to the hyperactivation of profibrotic TGF-β and vascular remodeling. Although the primary cause of PAH may be multifactorial, studies indicate that it results from chronic pulmonary inflammation. Curiously, infection by the intravascular parasite S. mansoni recapitulates several aspects of widespread inflammation that lead to PAH, providing a unique model where molecular alterations leading to vascular cell hyperproliferation can be unraveled and hopefully leveraged for the development of clinical solutions for PAH. | 1 | Fall and Spring | ||||||
105 | 10/24/2025 0:55:30 | seanq@uic.edu | John Quigley | Cancer Biology, Molecular Biology and Genetics (MBG), Cell Biology and Regenerative Medicine (CBRM), Neurobiology | https://chicago.medicine.uic.edu/medicine/profiles/quigley-john/ | FLVCR and its partners | Feline leukemia virus subgroup C receptor, FLVCR1, functions as a heme exporter and, importantly, has also recently been demonstrated to be involved in choline import. While the neurologic pathology of FLVCR gene mutation is likely linked to decreased choline import, it is unclear whether heme export or choline import is important for erythroid development, and whether transport of one impacts transport of the other. There is a large discrepancy between FLVCR1 mRNA and protein levels suggesting post-translational regulation, a focus of our lab. We have previously described interactions between FLVCR1 and PTPN3, a protein tyrosine phosphatase recently linked to TGF-beta receptor regulation. Moreover, our laboratory has recently discovered linkage between all 3 proteins using our cas9/crispr FLVCR knockout cell line and an antibody (Fc portion) fused to the FLVC envelope that binds to FLVCR1 both intra-cellularly and on the cell surface. Interestingly, apart from its important role in cancer and EMT regulation to prevent cancer cell metastases, TGF-beta receptor function is critical for erythropoiesis and it may be that known effects of FLVCR1 knockdown on inhibition of erythroid development are actually related to regulation of TGF-beta receptor. We seek to investigate these interactions both in cell lines and models of human erythropoiesis to determine who is regulating who, how we can modulate expression of both TGF-beta receptor and FLVCR1 and the relevance for human diseases including anemia and potentially cancer. Relevent refs: 1. PMID: 23506900 Heme and FLVCR-related transporter families SLC48 and SLC49. Khan AA, Quigley JG. Mol Aspects Med. 2013 Apr-Jun;34(2-3):669-82. 2. PMID: 23187127 The mitochondrial heme exporter FLVCR1b mediates erythroid differentiation. Chiabrando D, Marro S, Mercurio S, Giorgi C, Petrillo S, Vinchi F, Fiorito V, Fagoonee S, J Clin Invest. 2012 Dec;122(12):4569-79. 3. PMID: 22483575 Mutations of FLVCR1 in posterior column ataxia and retinitis pigmentosa result in the loss of heme export activity. Yanatori I, Yasui Y, Miura K, Kishi F. Blood Cells Mol Dis. 2012 Jun 15;49(1):60-6. 4. PMID: 18258918 A heme export protein is required for red blood cell differentiation and iron homeostasis. Keel SB, Doty RT, Yang Z, Quigley JG, Chen J, Knoblaugh S, Kingsley PD, De Domenico I, Science. 2008 Feb 8;319(5864):825-8. 5. PMID: 15996880 Investigation of a putative role for FLVCR, a cytoplasmic heme exporter, in Diamond-Blackfan anemia. Quigley JG, Gazda H, Yang Z, Ball S, Sieff CA, Abkowitz JL. Blood Cells Mol Dis. 2005 Sep-Oct;35(2):189-92. 6. PMID: 15369674 Identification of a human heme exporter that is essential for erythropoiesis. Quigley JG, Yang Z, …, Wood BL, Abkowitz JL. Cell. 2004 Sep 17;118(6):757-66. 7. PMID: 35882937 Exploiting gene dependency to inform drug development for multiple myeloma. Went M, Hoang PH, Law PJ, Kaiser MF, Houlston RS. Sci Rep. 2022 Jul 26;12(1):12696. 8. PMID: 36250027 Identification of the hub and prognostic genes in liver hepatocellular carcinoma via bioinformatics analysis. Gao Q, Fan L, Chen Y, Cai J. Front Mol Biosci. 2022 Sep 29;9:1000847. 9. PMID: 37100056 Integrative genetic analysis identifies FLVCR1 as a plasma-membrane choline transporter in mammals. Kenny TC, Khan A, Son Y, … Alwaseem H, Hite RK, Birsoy K. Cell Metab. 2023 Jun 6;35(6):1057-1071.e12. 10. PMID: 38693265 Structural basis of lipid head group entry to the Kennedy pathway by FLVCR1. Son Y, Kenny TC, Khan A, Birsoy K, Hite RK. Nature. 2024 May;629(8012):710-716. 11. PMID: 38778100 Molecular mechanism of choline and ethanolamine transport in humans. Ri K, .., Doty RT, Gursu G…Abkowitz JL, Hummer G, Wu D, Nguyen LN, Safarian S. Nature. 2024 Jun;630(8016):501-508. 12. PMID: 39019006 Dysregulation of FLVCR1a-dependent mitochondrial calcium handling in neural progenitors causes congenital hydrocephalus. Bertino F, Mukherjee D, …Arnold T, Tolosano E, Chiabrando D. Cell Rep Med. 2024 Jul 16;5(7):101647. 13. PMID: 40146399 Identification of FLVCR1 as the iron metabolism-related gene of statin-associated diabetes. Huang Y, Chen K, Xiao X, Zhong S. Acta Diabetol. 2025 Mar 27. 14. PMID: 40858607 Heme allocation in eukaryotic cells relies on mitochondrial heme export through FLVCR1b to cytosolic GAPDH. Jayaram DT, Sivaram P, Biswas P, Dai Y, Sweeny EA, Stuehr DJ. Nat Commun. 2025 Aug 26;16(1):7972. | 1 | Fall and Spring | ||||||
106 | 2/9/2026 12:56:03 | bisheng@uic.edu | Bisheng Zhou | Cell Biology and Regenerative Medicine (CBRM) | https://www.the-zhou-lab.com | Vascular niche regulation of stem cells and regeneration | Explore how cells and signals derived from the vascular niche control stem cell function and regeneration | 2026 | Spring | ||||||
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