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1 | Timestamp | Email Address | Name (First, Last) | Research Concentration (select all that apply) | Link to your lab page or bio (if applicable) | Rotation Project Name | Rotation Project Description | Student Slots Available (GEMS First Year) | ||||||
40 | 2/21/2024 9:27:27 | mkhan268@uic.edu | Wasim Khan | Cancer Biology, Integrative and Translational Physiology (ITP) | Role of the novel hexokinase, HKDC1 in liver disease progression. | Metabolic associated steatitic liver disease (MASLD) formerly known as nonalcoholic liver disease ranges from simple steatosis to hepatocellular carcinoma (HCC). HCC ranks as the 4th leading cause of cancer-related deaths. The recently identified hexokinase, Hexokinase Domain Containing 1 (HKDC1), plays a crucial role in MASLD development by influencing cellular metabolism and mitochondrial function. Despite its recognized importance, the precise mechanism through which HKDC1 modulates cell metabolism remains elusive. Our preliminary investigations, conducted across various cell and animal models, have unveiled novel insights, demonstrating that HKDC1 exerts its influence on glucose flux by interacting with mitochondria. This interaction, in turn, mediates the stability of YAP—an established driver of liver disease—and significantly impacts the progression of HCC. Our aim is to form a comprehensive research framework aimed at establishing the pivotal role of HKDC1 in MASLD progression. The outcomes of our study not only promise to enhance our understanding of HCC pathogenesis but also hold the potential to identify HKDC1 as a viable therapeutic target for MASLD including HCC. | 2 | |||||||
41 | 2/26/2024 15:47:11 | avlasits@uic.edu | Anna Vlasits | Neurobiology | vlasitslab.org | Modeling color-motion integration in the retina | The retina’s neurons are specialized for detecting and computing different types of visual information, such as specific wavelengths of light (color) and speeds of motion. It is an open question whether single neurons can detect multiple types of information, like both motion AND color, and if so, how neurons accomplish this. In this rotation projection, the student will extend an existing simulation of motion processing by retinal neurons into the color domain to study how color and motion are integrated with one another. | 1 | ||||||
42 | 3/7/2024 13:58:56 | jalilian@uic.edu | Elmira Jalilian | Cell Biology and Regenerative Medicine (CBRM), Neurobiology | Mesenchymal Stem Cells and Their Secreted Factors as Therapeutic Applications in Corneal Diseases | Corneal diseases, exacerbated by conditions like diabetes mellitus, result in vision impairment due to nerve damage and decreased tear production. Current treatments are limited and often ineffective, necessitating innovative therapies. Mesenchymal stem cells (MSCs) and their secreted factors, particularly exosomes, show promise in tissue repair. This study aims to investigate the therapeutic potential of MSCs and exosomes in corneal nerve regeneration, examining their effects in vitro and in vivo and elucidating underlying signaling pathways. The findings will advance the development of novel therapeutics for diabetic corneal neuropathy and potentially other conditions, addressing an urgent clinical need. | 3 | |||||||
43 | 3/7/2024 15:27:20 | jalilian@uic.edu | Elmira Jalilian | Cell Biology and Regenerative Medicine (CBRM), Neurobiology | https://chicago.medicine.uic.edu/ophthalmology-visual-sciences/opth-research/labs/jalilian-lab/ | Mesenchymal Stem Cells and Their Secreted Factors as Therapeutic Applications in Corneal Diseases | Corneal diseases, exacerbated by conditions like diabetes mellitus, result in vision impairment due to nerve damage and decreased tear production. Current treatments are limited and often ineffective, necessitating innovative therapies. Mesenchymal stem cells (MSCs) and their secreted factors, particularly exosomes, show promise in tissue repair. This study aims to investigate the therapeutic potential of MSCs and exosomes in corneal nerve regeneration, examining their effects in vitro and in vivo and elucidating underlying signaling pathways. The findings will advance the development of novel therapeutics for diabetic corneal neuropathy and potentially other conditions, addressing an urgent clinical need. | 3 | ||||||
44 | 3/25/2024 5:35:08 | nakamut@uic.edu | Toru Nakamura | Cancer Biology, Molecular Biology and Genetics (MBG) | https://chicago.medicine.uic.edu/bmg/profiles/nakamura-toru/ | Regulation of telomere maintenance. | Telomeres are specialized nucleoprotein structures at the end of linear chromosomes, essential for stable maintenance of eukaryotic genomes. We currently have two possible GEMS student rotation projects. The first project will be based on the characterization of a novel RPA (Replication Protein A) mutant that fails to maintain telomeres and survive by circularizing chromosomes in fission yeast, even though telomerase is robustly recruited to telomeres in this mutant. The second project will be characterizing various mutants that affect the transcription of long noncoding RNA (lncRNA) known as TERRA and cause telomere elongation. If interested, please also visit our lab website (nakamura.lab.uic.edu) to see what types of papers we have published. Currently, we are also very much interested in students who would also be interested in expanding our research into the mammalian system in the future to take advantage of insights we have gained from studying fission yeast telomere regulation. | 1-2 | ||||||
45 | 4/24/2024 10:11:41 | mcaule1@uic.edu | Mark McCauley | Integrative and Translational Physiology (ITP), Cell Biology and Regenerative Medicine (CBRM) | Protein Phosphatases and Cardiac Contractility | We study the intersection of heart contractile function and arrhythmias. | 3 | |||||||
46 | 4/24/2024 11:08:28 | mkhan268@uic.edu | Wasim Khan | Cancer Biology, Integrative and Translational Physiology (ITP) | Role of the novel Hexokinase, HKDC1 in metabolic dysfunction-associated steatotic liver disease (MASLD) progression. | Liver disease is a serious health concern affecting many people in the US. One common type is metabolic dysfunction-associated steatotic liver disease (MASLD), which used to be called non-alcoholic fatty liver disease (NAFLD). It can range from a simple fat buildup in the liver to a more severe condition called metabolic-associated steatohepatitis (MASH), which can lead to cirrhosis and be life-threatening. Unfortunately, being overweight or obese can increase the risk of developing liver disease and liver cancer, such as hepatocellular carcinoma (HCC). However, more research is needed to fully understand the connection between MASLD, HCC, and cancer incidence. Our research team is studying energy production from sugar and the role of Hexokinases (HKs). In cancer, the activity of these proteins can become irregular. About ten years ago, we discovered a new type of hexokinase called HKDC1. Our latest research shows that HKDC1 plays a role in the progression of both MASH and HCC. We also found that HKDC1 interacts with mitochondria, which is responsible for energy production in the cell. This interaction is believed to be significant in the advancement of these diseases. We think HKDC1 may be the reason why one disease can lead to the other. This proposal is about studying a potential new way to treat cancer. The goal is to find a way to target cancer cells in a different way than current treatments. This is important because it could lead to new treatments for people with cancer. | 2 | |||||||
47 | 8/2/2024 13:33:13 | mwietec2@uic.edu | Mateusz Wietecha | Molecular Biology and Genetics (MBG), Integrative and Translational Physiology (ITP), Cell Biology and Regenerative Medicine (CBRM) | https://go.uic.edu/WietechaLab | Studying the spatio-temporal cellular dynamics of wound healing with bioinformatics | The student will get training in bioinformatics and systems biology, including coding in R and the use of state-of-the-art computational tools, for single-cell and spatial transcriptomics analyses of wound healing. | 1 | ||||||
48 | 9/17/2024 10:00:58 | eer@uic.edu | Ekrem Emrah Er | Cancer Biology, Cell Biology and Regenerative Medicine (CBRM) | https://er.lab.uic.edu/ | Regulation of breast cancer metastasis | We have several active projects about determining the role of transcription factors, ion channels and interferon signaling on regulating cancer cells' biophysics and thereby regulating the immune response and metastasis. We anticipate a rotation project will make a meaningful contribution to one of these projects. | 2 | ||||||
49 | 9/17/2024 10:54:51 | swethag@uic.edu | Swetha Gowrishankar | Cell Biology and Regenerative Medicine (CBRM), Neurobiology | Mechanistic studies relating to lysosome transport in neurons, astrocytes and glia; understanding mechanisms underlying lysosome dysfunction in neurodevelopment and neurodegenerative disorders | Mechanistic studies relating to lysosome transport in neurons, astrocytes and glia; understanding mechanisms underlying lysosome dysfunction in neurodevelopment and neurodegenerative disorders (pls see zoom presentation recording for details or chat with me in person) | 1 or 2 | |||||||
50 | 9/17/2024 10:55:23 | shahrara@uic.edu | Shiva Shahrara | Microbiology, Immunity and Inflammation (MII) | https://chicago.medicine.uic.edu/medicine/divisions/rheumatology/research-rheumatology/shahrara-lab/ | Understanding the impact of immune cells in rheumatoid arthritis pathogenesis | Third rotation | Third slot only | ||||||
51 | 9/17/2024 11:00:18 | ak20@uic.edu | Andrius, Kazlauskas | Integrative and Translational Physiology (ITP), Cell Biology and Regenerative Medicine (CBRM) | https://chicago.medicine.uic.edu/physiology/profiles/kazlauskas-andrius/ | Resilience to Diabetic Retinopathy | Investigate the retina's endogenous defense against diabetes-driven damage, which results in diabetic retinopathy. Mentored rotations using a variety of experimental approaches. | Three | ||||||
52 | 9/17/2024 11:07:01 | yteja@uic.edu | Tejabhiram Yadavalli | Microbiology, Immunity and Inflammation (MII) | https://yteja2.wixsite.com/odddlab | Infectious and non-infectious etiologies or ocular inflammation | The corneal is an immune-privileged site that encounters innumerable antigens everyday. To remain transparent, corneal microenvironment ensures heightened inflammatory processes do not occur. However, microbial infections, injuries or idiopathic etiologies lead to opacification, edema or permanent scarring leading to vision loss. Main causes include immune cell infiltration, fibroblast-myofibroblast transformation and recurrent microbial infections. This rotation project aims to study each of these processes in depth. | 1 | ||||||
53 | 9/17/2024 11:09:36 | kiwook@uic.edu | Kiwook Kim | Cell Biology and Regenerative Medicine (CBRM), Microbiology, Immunity and Inflammation (MII) | The role of retinal macrophages in age-related macular degeneration (AMD) | We will define the heterogeneity, origins and in vivo roles of murine retinal macrophages in health and disease | 1 | |||||||
54 | 9/17/2024 11:11:49 | dshukla@uic.edu | Deepak Shukla | Cancer Biology, Molecular Biology and Genetics (MBG), Microbiology, Immunity and Inflammation (MII) | https://chicago.medicine.uic.edu/ophthalmology-visual-sciences/profiles/shukla-deepak/ | Herpes in the brain | Join us to help explore why herpes, a common neurotropic virus, typically does not cause infections of the central nervous system and why herpes simplex virus, unlike gamma herpesviruses, does not lead to cancer. | 4 | ||||||
55 | 9/17/2024 11:19:36 | anaba@uic.edu | Alexandra Naba | Cancer Biology, Cell Biology and Regenerative Medicine (CBRM) | https://nabalab.uic.edu | https://sites.google.com/a/uic.edu/nabalab/join-us | https://drive.google.com/file/d/1EHjVKGXLwGqzsNo-SmIcdhHy03vFeEt1/view?usp=sharing | 2 | ||||||
56 | 9/17/2024 11:19:48 | arana@uic.edu | Ajay Rana | Cancer Biology | NA | Role of Novel Kinases in Pancreatic and Breast Cancer | The rotation students will be involved in defining the roles of MLK kinase in Pancreatic and Breast Cancer. We do in vitro and animal work. | Two | ||||||
57 | 9/17/2024 11:20:00 | nnieto@uic.edu | Natalia Nieto | Cancer Biology, Molecular Biology and Genetics (MBG), Integrative and Translational Physiology (ITP), Cell Biology and Regenerative Medicine (CBRM), Microbiology, Immunity and Inflammation (MII) | "Role of SPP1 in chronic liver disease" | Understanding the mechanisms driving primary slerosing cholangitis onset and progression is key for identifying novel biomarkers and therapeutic targets. In this project we will establish a new role for osteopontin in biliary epithelial cells and determine how biliary epithelial cells develop a liver progenitor cell-like phenotype to promote liver repair. This improved understanding of the molecular pathogenesis of this disease may define new targets for therapy and potentially alter the approach to patients with primary sclerosing cholangitis and other cholangiopathies. | One | |||||||
58 | 9/17/2024 11:20:08 | gmorfini@uic.edu | Gerardo Morfini, PhD | Neurobiology | Pathogenic mechanisms of neurodegenerative diseases | The project involve biochemical, genetic and immunohistochemistry experiments in mouse models of neurodegenerative diseases. | YES | |||||||
59 | 9/17/2024 11:23:13 | ykomarov@uic.edu | Yulia Komarova | Integrative and Translational Physiology (ITP), Cell Biology and Regenerative Medicine (CBRM) | 1) COVID-19 l- mediated pathology of brain vasculature using single cell omics; 2) the effects of VT109 on lung regeneration following Covid 19 induced injury in green monkey; 3) the role of neutrophil Puezo1 in sterile lung injury | Bioinformatic analysis of sc omic data, BAL cytokine measurements | 3 | |||||||
60 | 9/17/2024 11:25:04 | star1@uic.edu | Amy Kenter | Molecular Biology and Genetics (MBG), Microbiology, Immunity and Inflammation (MII) | Transcription and recombination in the 3D nucleus | You will be involved in visualizing the Igh locus in the 3D nucleus and linking this to locus function | One | |||||||
61 | 9/17/2024 11:28:09 | mkhan268@uic.edu | Wasim Khan | Cancer Biology, Integrative and Translational Physiology (ITP) | Deciphering the Role of HKDC1 in Liver Disease: From Fibrosis to Hepatocellular Carcinoma (HCC) | 1. Project Title Deciphering the Role of HKDC1 in Liver Disease: From Fibrosis to Hepatocellular Carcinoma (HCC) 2. Background and Rationale Liver disease encompasses a wide range of pathological conditions, including fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). Understanding the molecular mechanisms that drive liver disease progression is critical to identifying therapeutic targets. HKDC1 (Hexokinase Domain Containing 1), a protein involved in glucose metabolism, is upregulated during fibrogenesis and in HCC. HKDC1’s role, however, extends beyond its metabolic functions. Emerging evidence suggests that HKDC1 influences the extracellular matrix (ECM) remodeling and cellular signaling pathways in liver fibrosis and HCC development. In mouse models, the knockout of HKDC1 has been observed to attenuate liver fibrosis and reduce the expression of ECM-related genes. The inhibition of HKDC1 also appears to slow the progression of HCC. However, the detailed mechanisms by which HKDC1 contributes to fibrotic processes and tumorigenesis remain poorly understood. This project aims to explore HKDC1's molecular functions in the progression of liver disease, focusing on fibrosis and the development of HCC. We hypothesize that HKDC1 plays a key role in liver disease progression through its dual involvement in metabolic regulation and ECM remodeling. 3. Hypothesis HKDC1 promotes liver disease progression by modulating metabolic pathways and extracellular matrix dynamics, contributing to fibrosis and hepatocellular carcinoma development. Inhibiting HKDC1 could serve as a potential therapeutic strategy for preventing fibrosis and liver cancer. 4. Objectives The specific aims of this project are to: 1. Investigate the role of HKDC1 in liver fibrosis by studying its effect on ECM-related gene expression and fibrosis signaling pathways. 2. Assess the contribution of HKDC1 to HCC progression by evaluating cell proliferation, apoptosis, and tumor growth in HCC models. 3. Determine the molecular mechanisms by which HKDC1 influences both metabolic and fibrotic processes in liver cells. 4. Evaluate the therapeutic potential of HKDC1 inhibition in animal models of liver disease, particularly in preventing the progression from fibrosis to HCC. 5. Methodology Aim 1: Investigate the Role of HKDC1 in Liver Fibrosis - In vitro studies: Primary hepatic stellate cells (HSCs) and fibrotic liver cell lines will be used to study HKDC1 expression under fibrotic conditions. Knockdown and overexpression experiments will be conducted to evaluate changes in ECM-related gene expression (e.g., collagen 1A1, α-SMA, TGF-β). - In vivo studies: Liver fibrosis will be induced in mice using carbon tetrachloride (CCl₄) or bile duct ligation (BDL). HKDC1 knockout mice will be used to assess the extent of fibrosis through histological analysis (Masson’s trichrome staining) and gene expression profiling (qPCR and RNA-seq). Aim 2: Assess HKDC1's Role in HCC Progression - Cell-based assays: HCC cell lines with varying HKDC1 expression will be used to study cell proliferation, migration, invasion, and apoptosis using assays such as BrdU incorporation, wound healing, transwell invasion, and Annexin V/PI staining. - In vivo studies: Subcutaneous and orthotopic liver cancer models will be generated by injecting HCC cells into nude mice. Tumor growth will be monitored, and tumor tissues will be analyzed for HKDC1 expression, apoptotic markers, and proliferation indices. Aim 3: Molecular Mechanisms of HKDC1 in Metabolic and Fibrotic Processes - Metabolomic profiling will be performed on HKDC1-overexpressing and knockout liver cells to identify changes in metabolic pathways. Key metabolites involved in glycolysis, the pentose phosphate pathway, and fatty acid metabolism will be quantified. - ECM remodeling and signaling pathway activation (e.g., TGF-β/Smad, Wnt/β-catenin) will be analyzed through Western blot, immunofluorescence, and phosphoproteomic analysis. Aim 4: Therapeutic Potential of HKDC1 Inhibition - Small-molecule inhibitors of HKDC1 will be identified or designed and tested for efficacy in cell-based assays and animal models of fibrosis and HCC. - Combination therapies involving HKDC1 inhibition and existing anti-fibrotic or anti-HCC treatments will be explored in animal models to determine synergistic effects. 6. Expected Outcomes - The project will clarify the role of HKDC1 in liver fibrosis and HCC, particularly its involvement in ECM regulation and metabolic pathways. - It is expected that HKDC1 inhibition will reduce fibrosis severity and slow the progression of HCC, supporting its potential as a therapeutic target. - Understanding the dual role of HKDC1 in metabolic reprogramming and ECM remodeling will provide new insights into the molecular mechanisms of liver disease progression. 7. Significance This study will enhance our understanding of the role of HKDC1 in liver disease, particularly its contribution to the transition from fibrosis to HCC. If successful, the findings could lead to the development of novel therapeutic strategies aimed at targeting HKDC1 to prevent or treat advanced liver disease. | 1 | |||||||
62 | 9/17/2024 11:28:51 | avlasits@uic.edu | Anna Vlasits | Neurobiology | vlasitslab.org | Cell type specific labeling of retinal neurons and modeling retinal circuits | The retina boasts over 100 different types of neurons. Transgenic tools and viral vectors allow for cell type specific labeling of different cell types. This rotation project will explore different cre lines for labeling cell types in the retina, performing immunohistochemistry. A second project will focus on computational modeling of color and motion processing in retinal circuits. | 2 | ||||||
63 | 9/17/2024 11:45:41 | jjun7@uic.edu | Joonil Jun | Molecular Biology and Genetics (MBG) | 1. Intestinal regeneration modeling using organoid 2. Cellular senescence in mouse model of colitis | 1. Intestinal stem cells are vital for regeneration during homeostasis and after injury. Severe injuries often result in stem cell loss, and intestinal regeneration can only resume upon restoring the stem cell pool through reprogramming or dedifferentiation. 3D organoid culture provides a great platform to study molecular mechanisms. However, a suitable organoid model for post-injury stem cell regeneration is not readily available. We are developing a new genetically engineered organoid model. 2. We identified cellular senescence as a wound-healing response critical for injury repair. During chemicals-induced colitis in mice, cellular senescence occurs in mesenchymal cells (fibroblasts). We study the interaction of mesenchymal cells and intestinal epithelial cells for intestinal regeneration and the effect of cellular senescence on stem cells and regeneration. | Available for 2 | |||||||
64 | 9/17/2024 12:03:44 | ameen@uic.edu | Ameen Salahudeen | Cancer Biology, Molecular Biology and Genetics (MBG), Cell Biology and Regenerative Medicine (CBRM), Microbiology, Immunity and Inflammation (MII) | Dissecting immune cell populations in tissue homeostasis and cancer | We are examining what immune cells infiltrate and promote tissue regeneration and whether these same cells play a role in the initial steps of tumor formation. We are utilizing mouse models, patient samples, and are conducting assays using spatial transcriptomics, single cell RNA-seq, explant cultures, and conventional histology and other cell biology techniques. | 3 rotation slots | |||||||
65 | 9/17/2024 12:04:08 | cjpeters@uic.edu | Christian Peters | Molecular Biology and Genetics (MBG), Neurobiology | https://peters.lab.uic.edu/home | Nicotinic acetylcholine receptors in pain or addiction. | Use molecular techniques to examine the expression and/or function of ion channel proteins (with a focus on the ligand-gated nicotinic acetylcholine receptors) as a lead-in to a thesis project focusing on their role in neuropathic pain and/or addiction. Please contact PI for more details. | Yes | ||||||
66 | 9/17/2024 12:23:01 | sorousht@uic.edu | Soroush, Tahmasebi | Cell Biology and Regenerative Medicine (CBRM) | https://tahmasebilab.com/ | Role of protein synthesis in regulating tissue resident macrophage | To study the role of GCN2-eIF2 pathway in regulating tissue resident macrophages. | Yes | ||||||
67 | 9/17/2024 12:54:03 | olazarov@uic.edu | Orly Lazarov | Neurobiology | https://sites.google.com/uic.edu/lazarovlab/home | Molecular pathways of learning and memory function and dysfunction in Alzheimer's disease | Several projects are available: examination of the role of amyloid precursor protein in Down syndrome and Alzheimer's disease using iPSCs; Vascular factors leading to Alzheimer's disease; The role of neural stem cells in hippocampal plasticity, learning and memory and Alzheimer's disease | 3 | ||||||
68 | 9/17/2024 13:01:02 | kvp@uic.edu | Kostandin Pajcini | Cancer Biology, Cell Biology and Regenerative Medicine (CBRM) | thepajcinilab.com | Investigating the expansion of hematopoietic stem cells during development and regeneration. | The Rotation Project includes two main projects that focus on 1). the developmental origins and expansion of fetal HSCs during their time in the fetal liver and 2). during the regeneration of the bone marrow niche after chemotherapy and irradiation damage. The work involves flow cytometry, tissue sections and transgenic mouse models. The lab is mostly composed of grad students (3) with 1 or 2 postdocs and a technician that helps maintains the mouse colony. | 1 | ||||||
69 | 9/17/2024 13:06:45 | tshima2@uic.edu | Takeshi Shimamura | Cancer Biology | http://www.chicagoshimamuralab.org/ | Characterization of KRAS PROTACs in Non-Small Lung Cancer. | We are collaborating with a pharmaceutical company to characterize KRAS G12C, KRAS G12D, and Pan-KRAS PROTACs in non-small cell lung carcinoma (NSCLC). This project aims to investigate the effects of KRAS depletion in NSCLC, focusing on identifying biomarkers associated with response and resistance to these targeted therapies. Bioinformatic and molecular techniques will be employed to thoroughly dissect the role of KRAS in NSCLC biology using PROTACs. | 1 | ||||||
70 | 9/17/2024 14:37:32 | pk434@uic.edu | Preetish Kadur Lakshminarasimha Murthy | Cancer Biology, Cell Biology and Regenerative Medicine (CBRM) | Lung regeneration and cancer | Study alveolar and small airway stem cells in lung regeneration after injury. Further use the stem cells to generate novel lung cancer models. | 1 | |||||||
71 | 9/19/2024 9:45:19 | abmalik@uic.edu | Asrar Malik | Cell Biology and Regenerative Medicine (CBRM), Microbiology, Immunity and Inflammation (MII) | https://mcph.uic.edu/malik/ | Using Stem Cells to Make Human Organoids | Learning to make human organoids and testing their importance in disease modeling. | 2 | ||||||
72 | 9/20/2024 14:40:09 | fyh@uic.edu | Fan, Yuhang | Molecular Biology and Genetics (MBG), Cell Biology and Regenerative Medicine (CBRM) | https://sites.google.com/view/fanyuhang | RNA biochemistry in animal development and regeneration | RNA and its chemical modifications are key regulators of cell fate decisions and represent promising functional targets for regenerative biology. However, their collective roles in animal development and tissue regeneration remain largely unexplored. To address this gap, we will utilize planarians and sea squirts as model organisms to investigate the dynamics and functions of RNA biochemistry. Our study aims to compare RNA biochemistry and RNA-binding landscapes across organisms with varying regenerative capacities. By integrating advanced genomics and biochemistry approaches, we will investigate the non-canonical roles of RNA biochemistry during cell differentiation. This research seeks to uncover evolutionarily novel mechanisms driving regeneration and identify new epigenetic targets for therapeutic intervention. | 1 | ||||||
73 | 9/22/2024 9:41:00 | xtan25@uic.edu | Xiao-Di Tan | Cell Biology and Regenerative Medicine (CBRM), Microbiology, Immunity and Inflammation (MII), Neurobiology | https://chicago.medicine.uic.edu/pediatrics/pediatric-research/centers-and-labs/dr-xiao-di-tans-lab/ | Insights into microbiota and gut mucosa in organ inflammation and regeneration | Complex dialogs are taken place among intestinal microbes, epithelium, and cells in lamina propria. Tan Lab has long standing interests in in exploring how interactions within the intestinal mucosa regulate homeostasis, inflammation, and regeneration in the gut and beyond. Currently, our ongoing research is centered to address following two critical questions in the field of mucosal immunology and pathophysiology research: (1) How does microbiota colonization regulate intestinal epithelial integrity? and (2) How does the crosstalk between different types of cells in vivo regulates wound healing and regeneration in the gut and beyond? We have utilized cutting-edge technology such as genetical modification of mouse models, organoid culture, knockdown of gene expression with siRNA and CRISPR/Cas9 methods, omics approaches (i.e. 16S RNA sequencing, RNAseq and scRNAseq analysis), multiplex RNAscope in situ hybridization, and metabolomics analysis. Our research will advance knowledge in intestinal epithelial biology, mucosal immunology, intestinal inflammation and regeneration, and the impact of gut mucosa on tissue injury in not only intestines but also remote organs such as liver, lung, and brain. Citations: 1. Bu HF, Zuo XL, Wang X, Ensslin MA, Koti V, Hsueh W, Raymond AS, Shur BD, Tan XD. Milk fat globule-EGF factor 8/lactadherin plays a crucial role in maintenance and repair of murine intestinal epithelium. 2007. J. Clin. Invest. 117:3673-3683. PMCID: PMC2075476. 2. Geng H, Bu HF, Liu F, Wu L, Pfeifer K, Chou PM, Wang X, Sun J, Lu L, Pandey A, Bartolomei MS, De Plaen IG, Wang P, Yu J, Qian J, Tan XD. In inflamed intestinal tissues and epithelial cells, interleukin 22 signaling increases expression of H19 long noncoding RNA, which promotes mucosal regeneration. Gastroenterology. 2018; 155:144-155. PMCID: PMC6475625. 3. Subramanian S, Bu HF, Chou PM, Wang X, Geng H, Akhtar S, Du C, Tan SC, Ideozu JE, Tulluri A, Sun Y, Ding WX, De Plaen IG, Tan XD. Scattered crypt intestinal epithelial cell apoptosis induces necrotizing enterocolitis via intricate mechanisms. Cell Mol Gastroenterol Hepatol. 2024;18:101364. PMCID: PMC11278878. (Note: The journal's editorial team published a commentary to highlight this article). 4. Subramanian S, Geng H, Wu L, Du C, Peiper AM, Bu HF, Chou PM, Wang X, Tan SC, Iyer NR, Khan NH, Zechner EL, Fox JG, Breinbauer R, Qi C, Yamini B, Ting JP, De Plaen IG, Karst SM, Tan XD. Microbiota regulates neonatal disease tolerance to virus-evoked necrotizing enterocolitis by shaping the STAT1-NLRC5 axis in the intestinal epithelium. Cell Host & Microbe. 2024. Online ahead of print. PMID: 39293437. 5. Bu HF, Subramanian S, Chou PM, Liu F, Sun L, Geng H, Wang X, Liao J, Du C, Hu J, Tan SC, Nathan N, Yang GY, Tan XD. A novel mouse model of hepatocyte-specific apoptosis-induced myeloid cell-dominant sterile liver injury and repair response. Am J Physiol Gastrointest Liver Physiol. 2024; 327(4):G499-G512. PMID: 39104322 | 3 | ||||||
74 | 12/6/2024 13:47:03 | bisheng@uic.edu | Bisheng Zhou | Cell Biology and Regenerative Medicine (CBRM) | https://www.the-zhou-lab.com | Vascular Biology, Immunology and Regenerative Medicine | Study the vascular and immune regulation of lung injury, repair, and regeneration | 2 | ||||||
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