Insecticide resistance adjustment [October 2021]

	A	B	C	D
1	Insecticide resistance adjustment including PBO nets
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3		Uganda	Togo	Nigeria
4	Synergist bioassay results (IR Mapper data), 2015-2019
5	Number of synergist bioassays conducted (with matching bioassays with pyrethroid insecticide only)	43	4	203
6	Average mosquito mortality in bioassays with pyrethroid insecticide + PBO	95%	93%	93%
7	Average mosquito mortality in same bioassays with pyrethroid insecticide only	51%	11%	69%
8	Initial proportion of resistance that remains when using PBO (tested areas)	9%	8%	24%
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10	External validity adjustments for country representativeness
11	Number of test sites with confirmed pyrethroid insecticide resistance (IR Mapper data, 2015-2019)	75	19	243
12	Number of test sites without confirmed pyrethroid insecticide resistance (IR Mapper data, 2015-2019)	1	0	146
13	Proportion of test sites with confirmed pyrethroid insecticide resistance (IR Mapper data, 2015-2019)	99%	100%	62%
14	Proportion of sites detected to have relevant resistance mechanism (WHO Malaria Threat Map data, 2010-2017)	83%	79%	79%
15	Estimated proportion of country where PBO nets are more effective than standard LLINs	82%	79%	49%
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17	Estimated adjustment incorporating PBO net adjustment
18	Reduction in effectiveness due to insecticide resistance without PBO nets	45%	61%	22%
19	Reduction in effectiveness due to insecticide resistance in areas where PBO nets are effective	4%	5%	5%
20	Reduction in effectiveness due to insecticide resistance in areas covered by PBO nets, untargeted	11%	17%	14%
21	Proportion of PBO nets purchased	100%	50%	100%
22	Assumed scenario: perfect targeting of PBO nets	11%	33%	14%
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24	Final reduction in effectiveness due to insecticide resistance including PBO nets (entire country)	11%	33%	14%
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