osm_target_prediction_OpenSourceMalaria

	A	B	C	D	E	F	G	H	I	J	K	L	M	N	O
1	CHEMBL ID	ROCS_TanimotoCombo	target__name	target__chemblid	target__confidence	reference	name__in__reference	organism	bioactivity__type	operator	value	units	assay__chemblid	assay__type	assay__description
2	CHEMBL86751	1.409	Carbonic anhydrase II	CHEMBL205	9	J. Med. Chem., (1999) 42:14:2641	4A	Homo sapiens	Ki	='	250	nM	CHEMBL657148	B	Inhibitory activity against human cloned Carbonic anhydrase II (hCA II, cytosolic form).
3	CHEMBL86751	1.409	Carbonic anhydrase IV	CHEMBL281	8	J. Med. Chem., (1999) 42:14:2641	4A	Bos taurus	Ki	='	305	nM	CHEMBL657025	B	Inhibitory activity against bovine lung microsomes carbonic anhydrase isozyme IV (bCA IV).
4	CHEMBL2205773	1.365	PI3-kinase p110-gamma subunit	CHEMBL3267	8	Bioorg. Med. Chem. Lett., (2012) 22:14:4613	10	Homo sapiens	IC50	='	19.95	nM	CHEMBL2215893	B	Inhibition of PI3Kgamma by kinobeads assay
5	CHEMBL2069711	1.218	Cyclin-dependent kinase 2/cyclin E1	CHEMBL1907605	7	Bioorg. Med. Chem. Lett., (2012) 22:18:5919	4a	Homo sapiens	IC50	='	4500	nM	CHEMBL2072226	B	Inhibition of human recombinant Cdk2/cyclin E incubated for 40 mins by scintillation proximity assay
6	CHEMBL2069711	1.218	Cyclin-dependent kinase 5/CDK5 activator 1	CHEMBL1907600	7	Bioorg. Med. Chem. Lett., (2012) 22:18:5919	4a	Homo sapiens	IC50	='	551	nM	CHEMBL2072225	B	Inhibition of human recombinant Cdk5/p25 incubated for 15 mins by scintillation proximity assay
7	CHEMBL1423690	1.166	M18 aspartyl aminopeptidase	CHEMBL1293263	9	Unspecified	SID3716671	Plasmodium falciparum 3D7	IC50	='	4284	nM	CHEMBL1614006	B	PUBCHEM_BIOASSAY: QFRET-based biochemical high throughput dose response assay for inhibitors of the Plasmodium falciparum M18 Aspartyl Aminopeptidase (PFM18AAP). (Class of assay: confirmatory) [Related PubChem assays: 2170 (Confirmation screen (PFM18AAP inhibitors).), 1855 (Summary AID.)]
8	CHEMBL1836386	1.426	LIM domain kinase 1	CHEMBL3836	8	Bioorg. Med. Chem. Lett., (2011) 21:19:5992	39	Homo sapiens	IC50	='	3200	nM	CHEMBL1839797	B	Inhibition of LIMK1 using cofilin-2 as substrate after 60 mins by Kinase-Glo assay
9	CHEMBL125928	1.388	Human immunodeficiency virus type 1 reverse transcriptase	CHEMBL247	9	J. Med. Chem., (1998) 41:20:3793	30	Human immunodeficiency virus 1	IC50	='	230	nM	CHEMBL799144	B	Inhibition of HIV-1 reverse transcriptase (P236L)
10	CHEMBL107167	1.369	Dihydrofolate reductase	CHEMBL2902	9	J. Med. Chem., (1993) 36:21:3103	table 2	Lactobacillus casei	IC50	='	2000	nM	CHEMBL884365	B	Tested for inhibitory activity against dihydrofolate reductase in Lactobacillus casei
11	CHEMBL1095649	1.358	Phosphodiesterase 4	CHEMBL2093863	5	Bioorg. Med. Chem., (2010) 18:10:3506	10e	Homo sapiens	IC50	='	385	nM	CHEMBL1106451	B	Inhibition of PDE4 in human U937 cells after 30 mins by electrochemiluminescence based immunoassay
12	CHEMBL510249	1.356	Fructose-1,6-bisphosphatase	CHEMBL3975	9	J. Med. Chem., (2009) 52:9:2880	4.9	Homo sapiens	IC50	='	1800	nM	CHEMBL981259	B	Inhibition of human liver FBPase expressed in Escherichia coli by spectrophotometry
13	CHEMBL3701444	1.354	Tyrosine-protein kinase SYK	CHEMBL2599	9	Unspecified	164	Homo sapiens	IC50	='	38	nM	CHEMBL3705362	B	BindingDB_Patents: Mobility-Shift kinase assay. Compounds of the examples provided herein were assessed for their ability to inhibit Syk kinase by utilizing Caliper Life Sciences' proprietary LabChip technology. The off-chip incubation mobility-shift kinase assay uses a microfluidic chip to measure the conversion of a fluorescent peptide substrate to a phosphorylated product. The reaction mixture, from a microtiter plate well, is introduced through a capillary sipper onto the chip, where the nonphosphorylated substrate and phosphorylated product are separated by electrophoresis and detected via laser induced fluorescence. The signature of the fluorescence signal over time reveals the extent of the reaction. The phosphorylated product migrates through the chip faster than the non-phosphorylated substrate, and signals from the two forms of the peptide appear as distinct peaks.
14	CHEMBL571385	1.336	Carbonic anhydrase IX	CHEMBL3594	9	Bioorg. Med. Chem., (2009) 17:20:7093	2a	Homo sapiens	Ki	='	6.1	nM	CHEMBL1046494	B	Inhibition of human recombinant CA9 catalytic domain expressed in Sf9 cells by stopped flow CO2 hydration assay
15	CHEMBL571385	1.336	Carbonic anhydrase XII	CHEMBL3242	9	Bioorg. Med. Chem., (2009) 17:20:7093	2a	Homo sapiens	Ki	='	7.3	nM	CHEMBL1046495	B	Inhibition of human recombinant CA12 catalytic domain expressed in Sf9 cells by stopped flow CO2 hydration assay
16	CHEMBL571385	1.336	PROBABLE TRANSMEMBRANE CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE)	CHEMBL5767	9	Bioorg. Med. Chem. Lett., (2009) 19:17:4929	5a	Mycobacterium tuberculosis	Ki	='	9230	nM	CHEMBL1048176	B	Inhibition of Mycobacterium tuberculosis recombinant carbonic anhydrase Rv3273 by stopped flow CO2 hydration assay
17	CHEMBL571385	1.336	Uncharacterized protein Rv1284/MT1322	CHEMBL5631	9	Bioorg. Med. Chem. Lett., (2009) 19:17:4929	5a	Mycobacterium tuberculosis	Ki	='	8970	nM	CHEMBL1048175	B	Inhibition of Mycobacterium tuberculosis recombinant carbonic anhydrase Rv1284 by stopped flow CO2 hydration assay
18	CHEMBL3608876	1.324	Carbonic anhydrase I	CHEMBL261	9	Unspecified	9e	Homo sapiens	Ki	='	289	nM	CHEMBL3610377	B	Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration method
19	CHEMBL1339149	1.32	Mannose-6-phosphate isomerase	CHEMBL2758	9	Unspecified	SID24834029	Homo sapiens	IC50	='	5250.1	nM	CHEMBL1614255	B	PUBCHEM_BIOASSAY: HTS identification of compounds inhibiting phosphomannose isomerase (PMI) via a fluorescence intensity assay. (Class of assay: confirmatory) [Related pubchem assays: 1220 ]
20	CHEMBL1339149	1.32	Phosphoethanolamine/phosphocholine phosphatase	CHEMBL6113	9	Unspecified	SID56373499	Homo sapiens	IC50	='	495	nM	CHEMBL1738189	B	PUBCHEM_BIOASSAY: SAR assay for compounds that inhibit PHOSPHO1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1545, AID1565, AID1574]
21	CHEMBL3403322	1.317	Intestinal alkaline phosphatase	CHEMBL5695	9	Bioorg. Med. Chem., (2015) 23:10:2435	2d	Bos taurus	IC50	='	9750	nM	CHEMBL3404592	B	Inhibition of calf intestinal alkaline phosphatase using CDP-star chemiluminescent substrate assessed as change in luminescence by spectrophotometric method
22	CHEMBL2414439	1.31	Carbonic anhydrase VII	CHEMBL2326	9	Bioorg. Med. Chem., (2013) 21:17:5168	4	Homo sapiens	Ki	='	3.5	nM	CHEMBL2415806	B	Inhibition of human cytosolic carbonic anhydrase 7 preincubated for 15 mins by stopped flow CO2 hydration assay
23	CHEMBL2011909	1.31	Serine/threonine-protein kinase TBK1	CHEMBL5408	8	Bioorg. Med. Chem. Lett., (2012) 22:5:2063	2g	Homo sapiens	IC50	='	9550	nM	CHEMBL2013355	B	Inhibition of recombinant TBK1 using 5FAM-AhxKRRAL(ps)VASLPGL as substrate by microfluidic mobility shift assay
24	CHEMBL3110226	1.308	CDK2/Cyclin A	CHEMBL3038469	7	J. Med. Chem., (2014) 57:1:56	44	Homo sapiens	IC50	='	8700	nM	CHEMBL3111100	B	Inhibition of CDK2/Cyclin A (unknown origin)
25	CHEMBL2059908	1.307	PI3-kinase p110-alpha subunit	CHEMBL4005	9	Bioorg. Med. Chem. Lett., (2012) 22:14:4546	3, CZC19463	Homo sapiens	IC50	='	10000	nM	CHEMBL2062043	B	Inhibition of PI3Kalpha in human HL60 cell lysate by kinobead assay
26	CHEMBL2059908	1.307	PI3-kinase p110-beta subunit	CHEMBL3145	9	Bioorg. Med. Chem. Lett., (2012) 22:14:4546	3, CZC19463	Homo sapiens	IC50	='	2511.89	nM	CHEMBL2062044	B	Inhibition of PI3Kbeta in human HL60 cell lysate by kinobead assay
27	CHEMBL2059908	1.307	PI3-kinase p110-delta subunit	CHEMBL3130	9	Bioorg. Med. Chem. Lett., (2012) 22:16:5257	33	Homo sapiens	IC50	='	6309.57	nM	CHEMBL2065219	B	Inhibition of PI3Kdelta by high throughput chemoproteomics binding assay
28	CHEMBL3681011	1.303	Serine/threonine-protein kinase ILK-1	CHEMBL5247	9	Unspecified	Table 1, cpd 27	Homo sapiens	IC50	='	1900	nM	CHEMBL3734121	B	Inhibition of full-length recombinant human GST-tagged ILK1 expressed in baculovirus infected insect Hi5 cells using CKRRRLASLR-amide as substrate after 15 mins by scintillation counting analysis in presence of [gamma-32P]-ATP
29	CHEMBL3612649	1.301	Serine/threonine-protein kinase TNNI3K	CHEMBL5260	9	J. Med. Chem., (2015) 58:18:7431	9	Homo sapiens	IC50	='	8000	nM	CHEMBL3615799	B	Displacement of 5-({[2-({[3-({4-[(5-hydroxy-2-methylphenyl)amino]-2-pyrimidinyl}amino)phenyl]carbonyl}amino)-ethyl]amino}carbonyl)-2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid from His6-MBP-TEV-full length human TNNI3K expressed in Baculovirus expression system after 60 mins by fluorescence polarization assay
30	CHEMBL2011842	1.292	Heat shock protein HSP 90-beta	CHEMBL4303	9	Bioorg. Med. Chem. Lett., (2012) 22:7:2550	2	Homo sapiens	IC50	='	9974	nM	CHEMBL2016162	B	Inhibition of HSP90-mediated Her2 degradation in human AU565 cells after 24 hrs by ELISA
31	CHEMBL1478592	1.289	Branched-chain-amino-acid aminotransferase, mitochondrial	CHEMBL3616354	9	J. Med. Chem., (2016) 59:6:2452	18	Homo sapiens	IC50	='	7943.28	nM	CHEMBL3795165	B	Inhibition of human BCATm incubated for 10 mins by Amplex red- based fluorescence analysis
32	CHEMBL383603	1.285	Tyrosine-protein kinase TIE-2	CHEMBL4128	8	J. Mol. Graph. Model., (2007) 26:1:236	73	Homo sapiens	IC50	='	1479.11	nM	CHEMBL1243605	B	Inhibition of Tie2
33	CHEMBL321769	1.282	Adenosine A1 receptor	CHEMBL226	8	J. Med. Chem., (2004) 47:12:3019	43	Homo sapiens	Ki	='	2200	nM	CHEMBL643493	B	Binding affinity against adenosine A1 receptor in human cortical membranes using [3H]CHA as radioligand
34	CHEMBL321769	1.282	Adenosine A2a receptor	CHEMBL251	8	J. Med. Chem., (2004) 47:12:3019	43	Homo sapiens	Ki	='	3400	nM	CHEMBL642332	B	Binding affinity against adenosine A2 receptor in human striatal membranes using [3H]CGS-21680 as radioligand
35	CHEMBL1083064	1.273	Acetylcholinesterase	CHEMBL220	8	Eur. J. Med. Chem., (2010) 45:3:1167	22	Homo sapiens	IC50	='	350	nM	CHEMBL1119333	B	Inhibition of AChE
36	CHEMBL3600699	1.272	PI4-kinase alpha subunit	CHEMBL3667	9	Bioorg. Med. Chem. Lett., (2015) 25:16:3189	18	Homo sapiens	IC50	='	398.11	nM	CHEMBL3603389	B	Inhibition of N-terminal FLAG-tagged human full length recombinant PI4K3alpha using D-myo-phosphatidylinositol substrate and ATP incubated for 45 mins by ADP-Glo kinase Assay
37	CHEMBL3600699	1.272	PI4-kinase beta subunit	CHEMBL3268	9	Bioorg. Med. Chem. Lett., (2015) 25:16:3189	18	Homo sapiens	IC50	='	3981.07	nM	CHEMBL3603390	B	Inhibition of N-terminal GST-tagged human full length recombinant PI4K3beta expressed in Sf9 cells using D-myo-phosphatidylinositol substrate and ATP incubated for 45 mins by ADP-Glo kinase Assay
38	CHEMBL407113	1.266	Glycogen synthase kinase-3 alpha	CHEMBL2850	8	Bioorg. Med. Chem. Lett., (2003) 13:18:3059	16	Homo sapiens	IC50	='	481	nM	CHEMBL686309	B	Inhibitory concentration against glycogen synthase kinase-3 alpha
39	CHEMBL407113	1.266	Glycogen synthase kinase-3 beta	CHEMBL262	8	J. Med. Chem., (2008) 51:7:2062	137	Homo sapiens	IC50	='	481	nM	CHEMBL930273	B	Inhibition of recombinant GSK3-beta
40	CHEMBL3612661	1.266	Serine/threonine-protein kinase B-raf	CHEMBL5145	9	J. Med. Chem., (2015) 58:18:7431	21	Homo sapiens	IC50	='	63	nM	CHEMBL3615800	B	Inhibition of His6-tagged full length BRAF V600E mutant (2 to 766 residues) (unknown origin) expressed in Baculovirus expression system by BRAMA method
41	CHEMBL2087526	1.265	MAP kinase p38 delta	CHEMBL2939	8	Bioorg. Med. Chem. Lett., (2012) 22:10:3431	31	Homo sapiens	IC50	='	3.1	nM	CHEMBL2092446	B	Inhibition of p38alpha
42	CHEMBL3415054	1.26	Adenosine A3 receptor	CHEMBL256	9	Unspecified	33	Homo sapiens	Ki	='	110	nM	CHEMBL3418856	B	Displacement of [125I]AB-MECA from human adenosine A3 receptor expressed in CHO cell membranes incubated for 120 mins by scintillation counting method
43	CHEMBL57333	1.258	Thymidylate synthase	CHEMBL1952	9	J. Med. Chem., (1991) 34:7:1925	3	Homo sapiens	Ki	='	2200	nM	CHEMBL817302	B	Inhibition of human Thymidylate synthase (Ki)
44	CHEMBL569193	1.256	Histone deacetylase 6	CHEMBL1865	8	J. Med. Chem., (2009) 52:21:6782	6h	Homo sapiens	IC50	='	70	nM	CHEMBL1042267	B	Inhibition of HDAC6
45	CHEMBL363389	1.255	Vascular endothelial growth factor receptor 2	CHEMBL279	9	Bioorg. Med. Chem. Lett., (2005) 15:9:2203	7b	Homo sapiens	IC50	='	180	nM	CHEMBL829593	B	Inhibitory concentration against human vascular endothelial growth factor receptor 2
46	CHEMBL526101	1.25	MAP kinase p38 alpha	CHEMBL260	8	Bioorg. Med. Chem. Lett., (2008) 18:19:5285	16a	Homo sapiens	Ki	='	1100	nM	CHEMBL997720	B	Displacement of fluorescent ATP competitive ligand from p38alpha
47	CHEMBL3360731	1.248	Monoamine oxidase B	CHEMBL2039	9	Bioorg. Med. Chem. Lett., (2015) 25:3:642	2	Homo sapiens	IC50	='	6	nM	CHEMBL3377807	B	Inhibition of human recombinant MAOB expressed in BTI-TN-5B1-4 cells using p-tyramine substrate assessed as reduction in H2O2 production
48	CHEMBL2070915	1.248	Phosphodiesterase 8B	CHEMBL4408	9	Bioorg. Med. Chem. Lett., (2012) 22:17:5721	SI,63	Homo sapiens	IC50	='	551	nM	CHEMBL2073616	B	Inhibition of PDE8B expressed in Sf9 insect cells
49	CHEMBL3668079	1.248	Serine/threonine-protein kinase/endoribonuclease IRE1	CHEMBL1163101	9	Unspecified	64	Homo sapiens	IC50	<	100	nM	CHEMBL3705669	B	BindingDB_Patents: Inhibition Assay. A fusion protein comprising glutathione S transferase (GST) and human IRE-1alpha (GST-IRE-1alpha) obtained from a 500 ml baculovirus-infected insect cell culture can be used to measure IRE-1alpha activity in vitro. Five ul of a reaction mixture comprising IX reaction buffer (5x reaction buffer is 100 mM Hepes pH 7.5, 250 mM KOAc, 2.5 mM MgCl2), 3 mM DTT, and 0.4% polyethylene glycol water is added to each well of 384 well plates. Twenty-five nanoliters of a 1 mM test compound solution are added to test wells. Three ul of a 128 ng/ml IRE-1alpha preparation are added to each test well and to positive control wells (final concentration 5.82 ng/well). Negative control wells contain only reaction mixture and test compound.After spinning the plates at 1200 rpm for 30 seconds, 3 ul of an IRE-1alpha human mini-XBP-1 mRNA stem-loop substrate 5'-CAGUCCGCAGCACUG-3' (SEQ ID NO:1), labeled with the fluorescent dye Cy5 at the 5' end and Black Hole Quencher 2.
50	CHEMBL1836722	1.247	Mitogen-activated protein kinase kinase kinase 8	CHEMBL4899	8	Bioorg. Med. Chem. Lett., (2011) 21:19:5952	15	Homo sapiens	IC50	='	7100	nM	CHEMBL1838148	B	Inhibition of TPL2
51	CHEMBL578168	1.246	Pteridine reductase 1	CHEMBL6194	9	J. Med. Chem., (2010) 53:1:221	12	Leishmania major	Ki	='	4200	nM	CHEMBL1037349	B	Inhibition of Leishmania major recombinant PTR1
52	CHEMBL3680043	1.244	Hepatocyte growth factor receptor	CHEMBL3717	9	Unspecified	57	Homo sapiens	IC50	='	37	nM	CHEMBL3705632	B	BindingDB_Patents: Tyrosine Kinase Activity Assay. Tyrosine kinase activity assay (NADH Read-Out)using human c-Met protein (Invitrogen, Carlsbad, Calif., USA). The amount of phosphorylated substrate is evaluated by measurement of the decrease of NADH fluorescence.
53	CHEMBL59263	1.24	GABA-A receptor; anion channel	CHEMBL1907607	5	Bioorg. Med. Chem. Lett., (1997) 7:15:2003	25	Rattus norvegicus	Ki	='	8	nM	CHEMBL652454	B	Displacement of [3H]flunitrazepine binding from GABA-A central benzodiazepine receptor of rat cerebral cortical membrane
54	CHEMBL1834444	1.238	Acyl-CoA desaturase 1	CHEMBL5424	9	Bioorg. Med. Chem. Lett., (2011) 21:19:5692	2e	Rattus norvegicus	IC50	='	56	nM	CHEMBL1839319	B	Inhibition of rat SCD1 in rat liver microsome
55	CHEMBL187219	1.236	Estrogen receptor alpha	CHEMBL206	9	J. Med. Chem., (2004) 47:21:5021	56	Homo sapiens	IC50	='	24	nM	CHEMBL829540	B	Inhibitory concentration against human ER alpha expressed in Escherichia coli was determined using [3H]17-beta-estradiol as radio ligand
56	CHEMBL187219	1.236	Estrogen receptor beta	CHEMBL242	9	J. Med. Chem., (2004) 47:21:5021	56	Homo sapiens	IC50	='	20	nM	CHEMBL829091	B	Inhibitory concentration against human ER beta expressed in Escherichia coli was determined using [3H]17-beta-estradiol as radio ligand
57	CHEMBL1330033	1.236	Heat shock protein HSP 90-alpha	CHEMBL3880	9	Unspecified	SID14721757	Homo sapiens	IC50	='	9385	nM	CHEMBL1614478	B	PUBCHEM_BIOASSAY: Luminescence-based dose response biochemical high throughput screening assay for inhibitors of the Heat Shock Protein 90 (HSP90). (Class of assay: confirmatory) [Related pubchem assays: 1831 (Summary AID.), 1846 (Confirmation screen.), 1789 (Primary screen.)]
58	CHEMBL189977	1.234	Tyrosine kinase non-receptor protein 2	CHEMBL4599	8	Bioorg. Med. Chem. Lett., (2012) 22:19:6212	1	Homo sapiens	Ki	='	1000	nM	CHEMBL2090700	B	Inhibition of ACK1
59	CHEMBL2205766	1.233	Adaptor-associated kinase	CHEMBL3830	8	Bioorg. Med. Chem. Lett., (2012) 22:14:4613	14, CZC24758	Homo sapiens	IC50	='	5888.44	nM	CHEMBL2216361	B	Inhibition of AAK1
60	CHEMBL2205766	1.233	Casein kinase I alpha	CHEMBL2793	8	Bioorg. Med. Chem. Lett., (2012) 22:14:4613	14, CZC24758	Homo sapiens	IC50	='	9120.11	nM	CHEMBL2211482	B	Inhibition of CSNK1A1
61	CHEMBL2205766	1.233	Casein kinase I gamma 1	CHEMBL2426	8	Bioorg. Med. Chem. Lett., (2012) 22:14:4613	14, CZC24758	Homo sapiens	IC50	='	9549.93	nM	CHEMBL2211485	B	Inhibition of CSNK1G1
62	CHEMBL2205766	1.233	Phosphatidylinositol-5-phosphate 4-kinase type-2 gamma	CHEMBL1770034	8	Bioorg. Med. Chem. Lett., (2012) 22:14:4613	14, CZC24758	Homo sapiens	IC50	='	1071.52	nM	CHEMBL2211988	B	Inhibition of PIP4K2C
63	CHEMBL2205766	1.233	Serine/threonine-protein kinase PAK 4	CHEMBL4482	8	Bioorg. Med. Chem. Lett., (2012) 22:14:4613	14, CZC24758	Homo sapiens	IC50	='	9332.54	nM	CHEMBL2211976	B	Inhibition of PAK4
64	CHEMBL2205766	1.233	Tyrosine-protein kinase JAK1	CHEMBL2835	8	Bioorg. Med. Chem. Lett., (2012) 22:14:4613	14, CZC24758	Homo sapiens	IC50	='	4365.16	nM	CHEMBL2211513	B	Inhibition of JAK1
65	CHEMBL3401364	1.232	Fibroblast growth factor receptor 1	CHEMBL3650	9	Bioorg. Med. Chem. Lett., (2015) 25:7:1556	C6	Homo sapiens	IC50	='	4840	nM	CHEMBL3404248	B	Inhibition of FGFR1 (unknown origin) after 90 mins by TR-FRET assay
66	CHEMBL3401364	1.232	Fibroblast growth factor receptor 2	CHEMBL4142	9	Bioorg. Med. Chem. Lett., (2015) 25:7:1556	C6	Homo sapiens	IC50	='	9130	nM	CHEMBL3404249	B	Inhibition of FGFR2 (unknown origin) after 90 mins by TR-FRET assay
67	CHEMBL233807	1.231	Metabotropic glutamate receptor 5	CHEMBL2564	9	Bioorg. Med. Chem. Lett., (2007) 17:16:4415	37	Rattus norvegicus	IC50	='	1090	nM	CHEMBL898093	B	Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assay
68	CHEMBL462579	1.213	MAP kinase-activated protein kinase 2	CHEMBL2208	9	Bioorg. Med. Chem. Lett., (2008) 18:23:6142	3	Homo sapiens	IC50	='	1230	nM	CHEMBL955774	B	Inhibition of human MK2
69	CHEMBL136974	1.213	Neuropeptide Y receptor type 5	CHEMBL4561	8	J. Med. Chem., (2000) 43:22:4288	89e	Homo sapiens	IC50	<	0.1	nM	CHEMBL857689	B	Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]PYY binding assay
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