T32_List_2022.xlsx

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1	https://reporter.nih.gov/search/xto1uKdA2UO-m4K3imNocg/projects?shared=true
2	This is a listing of NIDA T32 Institutional Training Programs.
3	Project Title	Project Number	Contact PI / Project Leader	Department	Organization Name	Organization City	Organization State	Organization Type	Supports Predoc Trainees (Slots)	Supports Postdoc Trainees (Slots)	Project Abstract
4	Biomedical Research Training in Drug Abuse	5T32DA007261-30	AGRAWAL, ARPANA	PSYCHIATRY	WASHINGTON UNIVERSITY	SAINT LOUIS	MO	SCHOOLS OF MEDICINE	0	6	Project Summary The purpose of this application is to request a further five years of support for an Institutional National Research Service Award (years 26-30) which we have held for 25 years to support multidisciplinary, interdepartmental post-doctoral training focused on the neurobiology of substance abuse with a strong emphasis on neuroimaging, molecular and familial genetics, pharmacoepidemiology, behavior, neural circuits, and pharmacology. We request support for six postdoctoral fellows, as we have had for the past five years – filling all slots consistently. The fellowship will usually last two years for PhDs and often three for MDs due to their lack of research training in pursuit of their medical degrees. Fellows with a wide variety of backgrounds will be recruited including: Psychology, Psychiatry, Genetics, Medicine, Anthropology, Sociology, Biology, Neuropharmacology and Neuroscience. The primary research training experience is the apprenticeship model – conduct of supervised research under the tutelage of one or more preceptors who are well established researchers, and experienced mentors. The trainee's work is usually focused on a single but broad ranging research project developed jointly by the preceptor and trainee. Mentored research takes up approximately 70%-80% of the trainee's effort. The remainder of the training program is made up of lectures, seminars, reading courses, individual tutorials and, when appropriate, formal didactic course work available in our graduate and medical school. Tutorials in neurobiology and genetics are tailored for trainees with specific interests that may or may not fall into their major area of focus. To arrange these tutorials, the program coordinator and preceptor identify areas of specific interest and set up the tutorial for the trainees with one of our preceptors or tutors who best meets the training objective. The main research interests of the five Departments involved in this grant (Psychiatry [as the central, administrative department], Anesthesiology, Psychological & Brain Sciences, Neurology and Genetics) are broad yet all have a heavy focus on neurobiology in its broadest context and/or pain and pain management (i.e., anesthesiology). These Departments as a whole offer more than 30 hours of relevant seminars per week dealing with the subject matter of this grant and are open to any of our interested postdoctoral fellows, although to be sure we cannot envision any circumstances that would encourage attendance at all, or most, of these seminars. Some careful selection must be made to ensure that trainees focus on their main research and career objective, mentored research. None-the-less, it is reassuring to have that much ancillary training available to amplify or to broaden the perspectives of our trainees.
5	Training in the Science of Co-Occurring Disorders	5T32DA037202-08	BUDNEY, ALAN JEFFREY	PSYCHIATRY	DARTMOUTH COLLEGE	HANOVER	NH	SCHOOLS OF MEDICINE	3	4	This renewal application proposes a plan to sustain and enhance a unique training program in an emerging area of trans-disciplinary research, co-occurring substance use and other psychiatric and medical disorders (COD). The need for this scientific focus is vital given that COD are more the norm than the exception among those with addictive disorders. The philosophy of this program charges that to effectively impact the problems of addiction and other common psychiatric and health disorders, one must be fully aware of their co-existence, etiologies, phenomenology, and clinical manifestations. Our evolving program leverages unique resources and opportunities available at Dartmouth. Five diverse research groups (Center for Technology and Behavioral Health, Department of Psychological and Brain Sciences, Norris Cotton Cancer Control Research Program, the Department of Psychiatry’s Addiction Research Program, and the Program of Experimental and Molecular Medicine-Neuroscience) provide COD-focused opportunities in behavioral and neurobiological mechanisms, behavioral and pharmacological treatment development, technology-assisted innovations in assessment and treatment delivery, implementation science, and health services and policy. Training faculty include MD and PhD investigators with strong histories of training young scientists and outstanding records of extramural funding to support their research programs. Currently our T32 faculty have 24 NIH-, 3 NSF-, and 1 PCORI- funded projects. During the first 4 years of this program (the initial cycle of funding), our training slots have remained at capacity with high quality trainees, and we have now trained or are in the process of training 4 predoctoral and 7 postdoctoral T-32 funded trainees and two other trainees who participated in our program but were funded by other sources. These trainees have authored 75 peer-reviewed publications related to their training activities and were first author on 45% of these. Our trainees have presented their research at many national and local scientific conferences, and all but two have completed capstone projects in a secondary area of interest with an alternative mentor. All the trainees who have or are about to complete the program continue in research intensive positions or have continued in the next step of research training towards becoming independent research scientists. Our evaluation process has yielded highly positive feedback, and also resulted in planned enhancements to our training program. This renewal application proposes to maintain an active census of 3 predoctoral and 4 postdoctoral trainees. We have developed a revised a recruitment plan that takes advantage of new Dartmouth initiatives to address our continued difficulty attracting and enrolling underrepresented minorities to the program. Overall, the first cycle of T32 funding has resulted in the successful development and implementation of a vigorous training program that is effectively preparing young scientists to engage in collaborative and transdisciplinary research that embraces and addresses the co- existence of addiction and other psychiatric and health disorders.
6	Predoctoral Training in Addiction Science	5T32DA007244-32	CARELLI, REGINA M	PSYCHOLOGY	UNIV OF NORTH CAROLINA CHAPEL HILL	CHAPEL HILL	NC	SCHOOLS OF ARTS AND SCIENCES	7	0	Program Summary/Abstract The present proposal is a continuation of an interdisciplinary, predoctoral training program in research on substance use disorders (SUDs) currently in its 29th year as a NIDA-supported training grant. The objective continues to be the preparation of individuals for careers that require broad knowledge and research expertise in addiction science, with emphasis on the abuse of drugs and alcohol (alone or in combination), consistent with the Collaborative Research on Addiction at NIH (CRAN). Only predoctoral trainees with an established interest in pursuing research related to SUDs are selected from a substantial pool of competitive applicants at the University of North Carolina, Chapel Hill (UNC-CH). The environment at UNC-CH provides optimal resources for training in addiction science, including rapidly advancing 21st century methodologies. First, the training program includes a core of faculty mentors whose research and teaching activities provide a broad spectrum of research training opportunities. These include research programs focusing on motivated behaviors, opioid and cytokine neurobiology, astrocytes in SUDs, the neuropharmacology and neurobiological effects of abused substances, investigations of the immune system and of HIV/AIDS and drug abuse, behavioral genetics of drug abuse and vulnerability and impulsivity. The inclusion of mentors from the Clinical Psychology program and from UNC’s Obstetrics & Gynecology Department brings research opportunities in translational areas that will enrich the trainees’ knowledge in substance abuse treatment. Research laboratories are located within the Psychology and Neuroscience Department, the Psychiatry Department, the Neuroscience Center and the Center for Alcohol Studies. Second, all trainees receive formal training in basic neural and behavioral sciences and statistics. More focused training related to addiction science takes place through several interdepartmental courses and seminars and extensive laboratory research. Third, the program offers many opportunities for professional development through a yearlong Seminar in Addiction Science which trainees take part in every year as they progress through the program. The Seminar in Addiction Science provides a) training in grant writing, b) practice in making research presentations, c) numerous presentations by outside scientists in addiction science and d) introduction of a range of career options. Fourth, the trainees regularly present their research at national meetings and receive training in teaching skills. Finally, UNC-CH is committed to maintaining ethical conduct in research and instruction on this topic is integrated from a variety of sources and takes place over the course of the entire training period. Over the last 15 years, 43 trainees have received their PhD (average time to degree: 5.5 yrs.) and the program has successfully trained several individuals from underrepresented groups. Upon completion of the program, trainees have established careers within addiction science, in both academic and research-intensive settings.
7	T32 Translational Addiction Research Fellowship Program	5T32DA028874-11	CHILDRESS, ANNA ROSE	PSYCHIATRY	UNIVERSITY OF PENNSYLVANIA	PHILADELPHIA	PA	SCHOOLS OF MEDICINE	4	4	Addictions and the associated public health problems of HIV transmission, crime and violence, exact a severe toll on our nation, costing billions annually in health care, lost productivity, and incarceration. As there have been rapid advances in neuroscience and genetics in the past two decades, we need to speed the "forward" translation of this knowledge into more effective clinical treatments for the addictions. Conversely, for addiction treatments with some known efficacy, we can now apply new neuroscience and genetic tools in "backward- translation" -- e.g., finding why a treatment works well for some individuals, yet not at all for others. To help meet the need for skilled translational researchers, this application proposes continuation of a successful (17 total trainees; 13 in the current funding period) NIDA T32 Translational Addiction Research Fellowship at the University of Pennsylvania. The (pre- and postdoctoral) training program make explicit a long-standing translational tradition at Penn, integrating clinical and basic research strengths to create trainees, whether clinical or preclinical, Ph.D.s or M.D.s, who will accelerate addiction science in the next decade. The emphasis on translation is reflected at each level of the program - through the Co-PIs (clinical and basic, Drs. Childress and Pierce), the internal and external advisory board members, the formal didactics, the "dual" (clinical - preclinical) mentoring, and in the trainees' mentored research projects. The translational emphasis of the program is driven by the recognition that addictions are complex disorders, multi-determined by interaction of genetic vulnerabilities, exposure to drug, and a host of modulating (e.g., early trauma ,stress, cultural norms) influences. Trainees are thus offered state-of-the-art knowledge about these interacting determinants through a didactic series specific to the program, and through mentored projects that may range from molecular and genetic studies, to brain systems (neuroscience and neuroimaging), to clinical treatment trials, and drug policy. This wide range of choices is enabled by the long history of excellence in addiction research at the University, reflected in the several academic research Centers (Penn Center for Studies on Addiction; Translational Research Laboratories/CNB; Center for AIDS Research; Center for Integrated Nicotine Research (CIRNA), the Treatment Research Institute, and collaborative laboratories offering skilled, successful mentors to the Fellowship. Mentored research also takes place within several affiliated treatment settings (VA, Presby-Penn, community methadone clinics, and mobile HIV Prevention units), critical for translating new research findings into the "real world”.
8	Training in Advanced Data Analytics to End Drug-Related Harms (TADA)	5T32DA050552-02	COOPER, HANNAH L	PUBLIC HEALTH & PREV MEDICINE	EMORY UNIVERSITY	ATLANTA	GA	SCHOOLS OF PUBLIC HEALTH	5	0	Abstract: Collins and Riley, Directors of NIH and of NIH’s Office of Behavioral and Social Science Research, have described the 21st century data revolution as potentially “transformative” for social and behavioral science (SBS) research. Evolutionary leaps in technology have generated vast arrays of novel sources of Big Data: in 2018, for example, 500 million microblogs were tweeted daily, and 2.48 billion users engaged with Facebook. The data revolution has also catalyzed massive growth in administrative data, as governments and other entities digitize their data (e.g., the CDC has data on billions of prescriptions dispensed in the US). Constella- tions of tweets, posts, and administrative data provide “transformative” opportunities for SBS researchers to swiftly identify threats to health; characterize-more comprehensively than ever before, and often in real time- the conditions in which people thrive, suffer, and die; and develop novel interventions. Nowhere are such transformations more direly needed than to address a 21st century crisis: substance use disorders (SUD). In 2017, HHS declared the opioid crisis a national emergency, as 11.4 million people misused opioid analgesics, and overdoses killed >70,000 people, contributing to a drop in US life expectancy. We are, though, failing to prepare the next generation of SBS researchers to engage these transforma- tive tools. A scan of syllabi from departments of behavioral and social science in 10 top public health schools reveals that required methods courses culminate with multilevel and structural equation models, decades-old methods ill-equipped to leverage emerging data to catalyze transformative approaches to end SUD epidemics. Supported by 45 Emory faculty from 11 departments, the proposed training program (TADA) will prepare a diverse cadre of 21st century SBS researchers to develop transformative approaches to end the SUD crisis. TADA will prepare trainees to ethically, critically, and seamlessly integrate advanced data science methods into the SBS research lifecycle for SUD. Trainees will learn to: (1) Conduct theoretically-informed studies of distributions and ecologies of SUD-related harms using advanced data science methods; (2) Conduct theoretically-informed studies motivating and assessing policies and programmatic interventions that may affect SUD-related harms and services; (3) Disseminate findings to multiple stakeholder communities to strengthen efforts to end SUD-related harms; (4) Critically apply principles of the ethical and responsible conduct of research. TADA will engage trainees in a comprehensive mentoring program; a 2-semester course and lab consisting of 5 “modules,” each of which pairs a specific SBS theory with an advanced data science method; journal clubs; dissertation workshops; $5000 dissertation grants; and research rotations at Emory, the CDC, and the Georgia DPH. We are seeking 5 funded slots across two cohorts, each with 2 years of funding, for pre-doctoral students in 4 programs (Behavioral Science, Health Policy, Sociology’s Health Track, and Clinical Psychology). TADA will extend its reach beyond funded trainees via a TADA Certificate program.
9	UF Substance Abuse Training Center in Public Health	5T32DA035167-08	COTTLER, LINDA B.	PUBLIC HEALTH & PREV MEDICINE	UNIVERSITY OF FLORIDA	GAINESVILLE	FL	SCHOOLS OF PUBLIC HEALTH	5	3	Abstract The mentors of the University of Florida (UF) NIDA T32 Substance Abuse Training Center in Public Health are eager to submit the renewal for five additional years of funding to train diverse pre and postdocs for careers in drug use, addiction, and consequences of addiction with a population science and public health lens. Situated in the Department of Epidemiology in two Colleges of the six in the UF Health Science Center, its 19 faculty mentors/preceptors (from 10 departments in 6 colleges) base their model on five premises: reduce health disparities, fill a significant need for training, develop authentic partnerships, utilize a mentoring mosaic approach and value social justice and high ethical standards. Their collaborations with each other have been significant (7 per faculty). Directed by Linda Cottler and Co-Directed by Sara Jo Nixon, this T32 renewal is justified by: a) increased drug use in Florida, especially opioids and cocaine; b) a significant shortage of public health scientists in the drug abuse field; c) UF’s strong academic and research environment as a top 10 University in the third most populous state; d) the underrepresentation of NIDA and other NIH T32 training programs in the Southeast US region; e) a strong and enthusiastic group of mentors who have an excellent track record to train substance abuse researchers; and f) the commitment of UF. Since 2014, with 4 predoc and 2 postdoc slots awarded, our T32 has trained 9 predocs (4 minority/disability) and 5 postdocs (3 minority); this year both postdocs are minority scholars and 3 of 4 predocs are diverse for an overall diversity rate of 83%. The predoc publication record is 5.9 per person with 2 years of training; the postdoc publication rate in the same timeframe is 5.3 per person. No slots have gone unfilled. Going forward, the UF T32 is requesting 5 pre and 3 postdoc slots. A number of valuable approaches are encouraged for career growth of both the mentor and mentees; robust centers and institutes contribute to this growth. While this T32 has made excellent progress since 2014, there are additional goals to achieve. More than ever, public health researchers, especially epidemiologists, need to work together with scientists from other disciplines to develop best practices for addiction research through all translational stages. Thus, the T32 renewal will: i. provide trainees with an apprenticeship style education to master skills to critically evaluate data, conduct multiple aspects of addiction research and become successful investigators who contribute to the field; ii. be a beacon, model program, with a high return on investment as evaluated through outcomes that matter, and iii. train individuals to understand, apply and maintain the highest ethical standards in their science and scholarship and be socially responsible investigators. We at UF are ready to train the next cohort and facilitate trainees’ contributions to the science of addiction medicine using all of the newest tools.
10	Neural and Pharmacological Mechanisms of Abused Drugs	5T32DA007287-25	CUNNINGHAM, KATHRYN A.	PHARMACOLOGY	UNIVERSITY OF TEXAS MED BR GALVESTON	GALVESTON	TX	SCHOOLS OF MEDICINE	3	3	ABSTRACT Substance use disorders constitute a major, high-impact health problem.This competitive renewal of the training grant Neural and Pharmacological Mechanisms of Abused Drugs (T32 DA 07287) at the University of Texas Medical Branch (UTMB) proposes to address the large gap between the problem of addiction and efficacious solutions by mentoring the next generation of scientists prepared and committed to the search for answers. The overarching goal of the Training Program is to provide nascent scientists with the knowledge base, technical expertise and professional skills needed to advance knowledge in the addictions and to move these advances toward new therapeutics. The 23 faculty mentors/co-mentors have a wealth of training and career development successes, extensive collaborative networks and expertise in translational addiction research conducted with modern technologies. Our objectives are to provide exemplary training in translational research in the neural bases for drug abuse and addiction, drug discovery and medications development, and the medical consequences of drug abuse and addiction. Strategies to achieve these objectives include providing well-funded, state-of-the-art research opportunities and facilities,effective mentoring and monitoring plans, challenging curricula and supportive interactive programs (e.g., short-term clinical rotations, journal clubs, workgroups, seminars), and first-rate program activities that develop the professional skills needed for advancement towards an independent career. The culmination of our efforts is the success of our trainees as complete, contemporary scientists equipped with the tools to advance the mechanistic understanding of addiction and move these advances toward new therapeutic approaches to its treatment.
11	Transdisciplinary Training in Addictions Research	5T32DA015035-19	CUNNINGHAM-WILLIAMS, RENEE M	SOCIAL SCIENCES	WASHINGTON UNIVERSITY	SAINT LOUIS	MO	SCHOOLS OF SOCIAL WELFARE/WORK	3	2	Project Summary / Abstract The George Warren Brown School of Social Work at Washington University seeks an additional five years (years 16-20) of support for a predoctoral and postdoctoral research training program, funded since 2002 focusing on services to, treatment of, clinical correlates of and policies affecting minority, underserved populations and those particularly vulnerable to substance use disorders and co-occurring and comorbid conditions. Maximizing an effective transdisciplinary collaboration between the Brown School and the School of Medicine, the Transdisciplinary Training in Addictions Research (TranSTAR) Program provides a stimulating and collaborative research training environment to produce exceptionally well-trained addictions researchers. TranSTAR faculty are particularly well-suited for addressing challenging addiction research issues such as polydrug users, non-treatment seeking, incarcerated populations, or those with mental health/health comorbidities, and URM and other populations disproportionately impacted by social issues such as poverty, racism and discrimination, housing and educational inequality. TranSTAR holds a superlative training record, with 100% of its 10 past predoctoral trainees currently in addictions research, 40% tenured, 53% with external funding during and 90% subsequent to training. Postdoctoral trainees are similarly accomplished: with 100% of past trainees in addictions research, 37% tenured, and 50% with external or university funding. With a highly diverse training faculty, led by two faculty from social work/public health and psychiatry, TranSTAR has demonstrated success in recruiting and retaining women and URM scholars; current predoctoral trainees are 100% women and 67% URM; diversity of postdoctoral trainees overall is similarly excellent (50% women, 50% URM). TranSTAR leverages successes and “lessons learned” with on-going monitoring and evaluation to ensure that trainees (three pre- and two postdocs/year) have the necessary knowledge and skills to: (1) conceptualize meaningful research questions with practical service and policy implications; (2) execute rigorous, cutting-edge projects; (3) develop competitive grant applications; and (4) translate and disseminate results with potential for high impact. TranSTAR provides:(a) transdisciplinary and specialized addictions coursework and seminars taught by leading faculty in social work, public health, psychiatry, statistics, and the social sciences; (b) structured mentoring, advising, and “hands-on” experience on addictions research projects for postdoctoral trainees over two years of training and for predoctoral trainees across three years of mentored research; (c) proposal critique review sessions; (d) predoctoral teaching assistantships in Master-level courses in addiction, comorbid conditions, statistics, and research methodology; (e) professional development sessions on presentation skills, effective communication of research findings, and “soft-skills” related to networking and effective collaborative team science; and (f) on-going, multi-faceted responsible conduct of research training.
12	Integrative Training in the Neurobiology of Addictive Behaviors	5T32DA043469-05	DE WIT, HARRIET	PSYCHIATRY	UNIVERSITY OF CHICAGO	CHICAGO	IL	SCHOOLS OF MEDICINE	3	4	PROJECT SUMMARY/ABSTRACT The Integrative Training in the Neurobiology of Addictive Behaviors Program at The University of Chicago offers training for both pre- and postdoctoral trainees in drug abuse-related research. We have an outstanding panel of core faculty trainers, who are productive researchers, with successful training credentials of both pre- and postdoctoral trainees. Their expertise and therefore their training areas, range from molecular biology, electrophysiology, pharmacology and animal models of drug addiction, to the social, behavioral and psychopharmacological aspects of human drug use, including etiology, treatment and drug policy. Our goal is to prepare the next generation of scientists to investigate the etiology, prevention and treatment of drug abuse with integrative approaches. We propose a program for 3 predoctoral and 4 postdoctoral trainees. Trainees will be supported by the Training Program for 1-3 years. Trainees obtain specialized intensive training in their `home' laboratories, but they are also exposed to the full breadth of addictions research outside their own area, from molecular to policy. In addition to their doctoral program requirements, predoctoral trainees will participate in a bi-weekly training grant seminar and a didactic course providing a broad overview of addiction (history, epidemiology, pharmacology, treatment and policy). Trainees will also participate in 20-hour rotation experiences in laboratories conducting addictions research distinct from their own expertise. The organizational structure will include an Executive Committee making overall training decisions, a Selection Subcommittee to ensure a good flow and balance of trainees, a Program and Review Subcommittee to monitor trainees' progress through the program, and an External Advisory Committee to provide expert outside consultation. The University of Chicago provides a unique environment with both a long history of interdisciplinary collaboration and recently a significant commitment to neuroscience research. This provides a rich intellectual context for trainees in drug abuse related research. To ensure that there is substantial interaction among the trainees, and between trainees and trainers, we will schedule bi-weekly meetings consisting of journal club presentations, seminars by invited speakers, and didactic classes. We will devote resources to recruiting underrepresented minorities and we will provide comprehensive training in ethical conduct of research.
13	Training in the pharmacology of abused drugs	2T32DA007027-46	DEWEY, WILLIAM L.	PHARMACOLOGY	VIRGINIA COMMONWEALTH UNIVERSITY	RICHMOND	VA	SCHOOLS OF MEDICINE	10	3	Project Summary During the current funding period, this program has continued its outstanding record of educating scholars as independent investigators and leaders in drug-abuse research. Since the submission of our last competitive application in 2015, competition for support from this program has been robust, and all slots have been filled. Twenty-five pre-doctoral and 14 post-doctoral trainees have received support from the grant, these trainees have published 149 papers, and 10 pre-doctoral and 5 post-doctoral trainees have earned individual NIH fellowships. Looking forward, we are poised to continue this record of success. We have recruited 2 new drug-abuse faculty in pharmacology as well as 5 new faculty members with relevant skills and interests from other departments. Moreover, recognizing the many strengths of the Department of Pharmacology and Toxicology, the dean has authorized the recruitment of up to 10 additional well- established faculty to join our team of 22 drug-abuse faculty. Additionally, a large increase in the number of clinical faculty in recent years justifies our request to increase the number of both pre and post-doctoral trainees by 2. Further support for this requested increase comes from the fact that there are more than 90 research grants from NIDA at this institution, and this is the only institutional training grant. Our preceptors provide trainees with “cutting edge” expertise in molecular, cellular, behavioral, clinical, and translational research. The program continues to emphasize pharmacology, but it has truly developed into a university- wide program open to trainees from all schools and incorporating multiple disciplines. The broad academic scope of the program is accomplished through rigorous core courses and a wide variety of advanced electives, a high level of collaboration among mentors to include reciprocal service on thesis committees, and multiple excellent seminar series. Additional initiatives are proposed to increase the diversity of the trainees and enhance mentor training. These academic opportunities complement a research infrastructure supported by a NIDA P30 grant that provides for the development of genetically altered animals, sophisticated bioanalytical technology, and expertise in advanced gastrointestinal and neuropharmacology research methodologies. Academic and research training is further supplemented by guidance on teaching, professional development for a career in drug-abuse science, and all aspects of becoming a productive, independent researcher. Our goal is to build on the program’s established record of success by continuing to provide a rigorous and supportive atmosphere for training leading scholars in the drug-abuse field for the future.
14	Integrated Care for Addiction, HIV and HCV Research and Education (ICAHRE)	5T32DA041898-05	DRAINONI, MARI-LYNN	PUBLIC HEALTH & PREV MEDICINE	BOSTON UNIVERSITY MEDICAL CAMPUS	BOSTON	MA	SCHOOLS OF PUBLIC HEALTH	11	0	Project Summary/Abstract The proposed T32 program objectives are to: 1) provide rigorous interdisciplinary pre- doctoral and post-doctoral training in health services research related to addiction and HIV or addiction and HIV/HCV co-infection; 2) mentor trainees to conduct studies that involve the development, testing and implementation of strategies to improve HIV testing, linkage, and adherence to care, and use integrated approaches to service delivery related to substance use and co-occurring HIV and HCV; and 3) prepare trainees to disseminate research findings and translate them into practice and policy. Addiction, HIV and HCV commonly co-occur and require integration of care. To address the need for health services researchers focused on the co-occurrence of addiction, HIV, and HIV/HCV co- infection, we propose the Integrated Care for Addiction, HIV and HCV Research and Education (ICAHRE) training program within the PhD and MS programs in Health Services Research (HSR) at the Boston University School of Public Health (BUSPH), in partnership with the Boston University School of Medicine (BUSM) and Boston Medical Center (BMC), New England’s largest safety net hospital. The program will provide training both to pre-doctoral trainees in the PhD program, and to post-doctoral trainees (physician investigators) in the MS program who have a strong research interest in addiction and HIV and/or HCV, thus addressing the need to train a variety of clinical researchers for work in this understudied area. The formal training period will encompass the coursework phase of the trainee’s degree program, and include research seminars, research rotations, mentored research leading to the degree, and both didactic and experiential training in the communication of science. Our focus on implementation and organization science and the translation of research into practice, and our model of mentoring teams with a Primary Research Mentor, a Research Methods Mentor,and a matching Clinical Implementation Mentor for trainees are among this proposal’s innovations. Collectively, our training faculty brings substantial knowledge in addiction, HIV, HCV and different approaches to HSR, including using both qualitative and quantitative methods.
15	Training Program on HIV and Substance Use in the Criminal Justice System	5T32DA037801-08	EL-BASSEL, NABILA	OTHER HEALTH PROFESSIONS	COLUMBIA UNIV NEW YORK MORNINGSIDE	NEW YORK	NY	SCHOOLS OF SOCIAL WELFARE/WORK	4	4	PROJECT SUMMARY This T32 training program was established in 2014 to train the next generation of pre- and post- doctoral scholars in the prevention, treatment, and care of HIV and substance use among individuals in the criminal justice (CJ) system. The training program is a partnership between the Columbia University School of Social Work (SSW) and the Mailman School of Public Health (MSPH), with strong support from longstanding partnerships with a number of research centers, schools, and departments at Columbia University Medical Center. We propose to renew the program by continuing its unique position as the only NIDA-funded T32 program jointly run out of a school of social work and school of public health as well as the successful administration and activities; the renewal also proposes to focus on two key significant themes for the nation and the field: (1) the opioid epidemic; and (2) implementation science. The training program provides: (1) interdisciplinary research instruction and training for pre-doctoral students and post- doctoral fellows on the intersecting issues of substance use (particularly opioid use disorders and overdose), HIV, and implementation research with the CJ system and CJ-involved populations; and (2) hands-on, mentored experience conducting independent research in the study implementation of evidence-based HIV and/or substance use prevention, treatment, and care for criminal justice-involved populations. This program is designed to strengthen the pool of researchers by increasing the diversity of academic backgrounds—e.g., social work, public health, medicine, sociology, political science, anthropology—and those from underrepresented populations—e.g., underrepresented minorities (URM), people with disabilities, individuals from disadvantaged backgrounds. Participating faculty are leaders in HIV, substance/opioid use, implementation science, and criminal justice fields, with strong track records of support from NIH. They are also well-qualified to provide training, as evidenced by their strong records of mentorship of pre- and post-doctoral early career scholars. The program supports 4 pre-doctoral students and 4 post-doctoral trainees per year at capacity (a total of 6-8 pre-doctoral trainees and 8-10 post- doctoral trainees in the renewal period). Thus, the program will add a substantial number of highly qualified new scholars to the field focusing on HIV, substance use, opioid use disorders and overdose, and implementation science among criminal justice-involved populations. Dr. Nabila El-Bassel and Dr. Lisa Metsch will continue to serve successfully as PIs/Co-Directors for the proposed training program, which provides an opportunity for two noted and distinguished scientists to collaborate and lead this initiative. They each contribute over 25 years of experience in the fields of HIV, substance/opioid use disorder treatment and overdose prevention, implementation science, and criminal justice.
16	Behavioral Sciences Training in Drug Abuse Research	5T32DA007233-38	FALKIN, GREGORY P	NONE	NEW YORK UNIVERSITY	NEW YORK	NY	SCHOOLS OF NURSING	8	6	Since its inception in 1984, the Behavioral Science Training in Drug Abuse Research program (BST) has become one of the nation's largest and oldest NRSA programs specializing in training behavioral scientists for careers in drug abuse research and related issues, especially HIV/AIDS. BST has trained 218 predoctoral and postdoctoral trainees—nearly half of them racial/ethnic minorities. This application requests authorization to maintain the current number of positions—7 postdoctoral and 9 predoctoral trainees—during each of years 36 to 40. BST is housed in the Rory Meyers College of Nursing at New York University. It collaborates with the Center for Drug Use and HIV/HCV Research (CDUHR), NIDA's largest and oldest P30 center focusing on drug use and infectious diseases (also housed at Myers), and National Development and Research Institutes, Inc., a freestanding research institute that specializes in drug abuse research. The Principal Investigator, Dr. Gregory Falkin has managed the BST program for 34 years; he works closely with Dr. George De Leon, the program's Co-Director and Scientific Advisor, in all aspects of training and program operations. The BST core faculty comprises 42 CDUHR affiliate investigators who currently manage nearly 100 grants—about half are funded by NIDA—providing ample opportunity for trainees to be mentored by leading experts on a wide range of NIDA research studies. The BST mission is to prepare behavioral scientists, especially racial/ethnic minorities, for careers in drug abuse research. The program aims to accomplish this by: (1) recruiting and appointing promising behavioral scientists, at least one third of whom are minorities; (2) providing advanced training in substance abuse research and theory, research methods and practices, and the responsible conduct of research; and (3) mentoring and advising trainees on their careers as well as their research and NIH grant submissions. Distinguishing features of the BST program that combined make it a truly unique T32, are that (a) trainees comprise a diverse group—they come from a wide range of behavioral disciplines and ethnic/racial backgrounds; (b) the core faculty includes 42 leading experts on drug abuse who manage dozens of NIDA-funded grants; (c) predocs are enrolled at various universities, not just NYU; (d) the trainees receive highly intensive training that involves classroom learning (they meet as a group all day every Monday in a variety of BST seminars and workshops, which are supplemented by CDUHR trainings) and hands-on research experience on projects of their own design and NIDA studies—they have the flexibility to choose the projects they work on—and postdocs write grant applications; and (e) all fellows receive considerable mentorship from multiple mentors, including the Program Directors, core BST faculty, and other faculty (e.g., thesis committee members). BST's long-standing success is evident in the significant contributions of its fellows who have distinguished themselves through research and publications, which number over 1,500, and their success as independently funded NIH investigators—they have obtained about 100 NIH grants.
17	NIDA Training Program in Neuroscience	5T32DA007281-25	FLAGEL, SHELLY BETH	PSYCHOLOGY	UNIVERSITY OF MICHIGAN AT ANN ARBOR	ANN ARBOR	MI	SCHOOLS OF ARTS AND SCIENCES	5	0	DESCRIPTION (provided by applicant): This application is a request for continuing support for a predoctoral NIDA Training Program in Neuroscience, which was founded at The University of Michigan (UM) in 1995. The major goal of this Program is to recruit and develop student interest in research related to the neurobiology of substance abuse, and to provide the necessary infrastructure for trainees to pursue these interests as they work towards their doctoral degree in the field of neuroscience. To be eligible for support by the NIDA Training Program students must first gain admittance to an existing UM graduate program in the biological, biomedical or natural sciences, such as the interdepartmental Neuroscience Graduate Program or the Biopsychology Program. Students nominated for support by the NIDA Training Program in Neuroscience are selected on the basis of two criteria: 1) academic qualifications and references (i.e. academic excellence), and 2) the relevance of their program of study and research interests to the NIDA mission. After admission to the NIDA Training Program in Neuroscience, students pursue a program of study in the neurosciences, including a required course on the neuropsychopharmacology of substance abuse and an accompanying seminar series involving the NIDA Training Program faculty. The NIDA Training Program in Neuroscience consists of 18 affiliated faculty, all of whom conduct research related to the biological basis of substance abuse. Most of the faculty is either a principal or co-investigator o a NIDA-funded research grant. The core faculty members have changed since the prior funding cycle, with 7 new faculty replacing those who are no longer conducting relevant research at the University of Michigan. Most of these new faculty members are considered junior investigators; thus, there is a plan in place for more senior faculty to serve as co-mentors for any trainees that join a junior faculty's lab. In addition, the faculty affiliated with this training grant is assistd by over 120 Neuroscience Graduate Program faculty who are also involved in many aspects of the training. The training grant is used primarily to foster interest in students to do research rotatins in a laboratory that studies the neurobiology of substance abuse, and to ultimately choose one of these labs for their dissertation work. In addition, we hope to maintain their interest in substance abuse research throughout their dissertation work with journal clubs, seminar series and social events that will be open to all current and previous trainees supported by this training grant. The NIDA Training Program in Neuroscience is administered by a Director and a Co-Director, and now includes a Director of Student Development in order to enhance the experience of the trainees.
18	NIDA Training Program in Neuroscience-Administrative Supplement	3T32DA007281-25S1	FLAGEL, SHELLY BETH	PSYCHOLOGY	UNIVERSITY OF MICHIGAN AT ANN ARBOR	ANN ARBOR	MI	SCHOOLS OF ARTS AND SCIENCES	1	0	Project Summary (as submitted in 2015 for current funded project) This application is a request for continuing support for a predoctoral NIDA Training Program in Neuroscience, which was founded at The University of Michigan (UM) in 1995. The major goal of this Program is to recruit and develop student interest in research related to the neurobiology of substance abuse, and to provide the necessary infrastructure for trainees to pursue these interests as they work towards their doctoral degree in the field of neuroscience. To be eligible for support by the NIDA Training Program students must first gain admittance to an existing UM graduate program in the biological, biomedical or natural sciences, such as the interdepartmental Neuroscience Graduate Program or the Biopsychology Program. Students nominated for support by the NIDA Training Program in Neuroscience are selected on the basis of two criteria: 1) academic qualifications and references (i.e. academic excellence), and 2) the relevance of their program of study and research interests to the NIDA mission. After admission to the NIDA Training Program in Neuroscience, students pursue a program of study in the neurosciences, including a required course on the neuropsychopharmacology of substance abuse and an accompanying seminar series involving the NIDA Training Program faculty. The NIDA Training Program in Neuroscience consists of 18 affiliated faculty, all of whom conduct research related to the biological basis of substance abuse. Most of the faculty are either a principal or co-investigator on a NIDA-funded research grant. The core faculty members have changed since the prior funding cycle, with 7 new faculty replacing those who are no longer conducting relevant research at the University of Michigan. Most of these new faculty members are considered junior investigators; thus, there is a plan in place for more senior faculty to serve as co-mentors for any trainees that join a junior faculty’s lab. In addition, the faculty affiliated with this training grant are assisted by over 120 Neuroscience Graduate Program faculty who are also involved in many aspects of the training. The training grant is used primarily to foster interest in students to do research rotations in a laboratory that studies the neurobiology of substance abuse, and to ultimately choose one of these labs for their dissertation work. In addition, we hope to maintain their interest in substance abuse research throughout their dissertation work with journal clubs, seminar series and social events that will be open to all current and previous trainees supported by this training grant. The NIDA Training Program in Neuroscience is administered by a Director and a Co-Director, and now includes a Director of Student Development in order to enhance the experience of the trainees
19	HIV and Other Infectious Consequences of Substance Abuse	5T32DA013911-20	FLANIGAN, TIMOTHY P	Unavailable	MIRIAM HOSPITAL	PROVIDENCE	RI	Independent Hospitals	0	3	PROJECT SUMMARY This is the third competitive renewal for T32DA013911 (“HIV and Other Infectious Consequences of Substance Abuse”) and seeks funding for Years 2017-2022. The program will now be led by dual PIs: Dr. Timothy P. Flanigan (the PI for the past 15 years), who will direct mentoring and training, and Dr. Josiah D. Rich, who will direct research project development. This training grant focuses on applied clinical and substance use research in Rhode Island and beyond. Rhode Island has among the highest rates of substance use in the nation and ranks 6th in the country for overdose rates. Our substance use training program emerged from the Brown University-affiliated Miriam Hospital Immunology Center, the largest HIV care center in Southern New England, where approximately 60% of the patients engage in substance use (alcohol, cocaine, opiate, methamphetamines, and poly-substance abuse). Our program's strengths are our interdisciplinary collaborations to reduce the infectious disease consequences of substance use, including HIV, hepatitis B and C, sexually transmitted infections, and TB. This training program brings together core expertise from the Division of Infectious Diseases, the Providence-Boston Center for AIDS Research (CFAR), the Centers for Behavioral and Preventive Medicine, the Brown University Center for Statistical Studies, and the Brown University School of Public Health. This interdisciplinary training program focuses on HIV prevention and treatment, including innovative PrEP programs, and correctional health, with a primary focus on reducing the infectious consequences of substance use as well as overdose. Our mentors have strong track records in applied clinical, substance use, translational science, correctional health research, and community-engaged scholarship.
20	Postdoctoral Training in Drug Abuse Research: Behavior & Neurobiology	2T32DA031115-11	FRANCE, CHARLES P	PHARMACOLOGY	UNIVERSITY OF TEXAS HLTH SCIENCE CENTER	SAN ANTONIO	TX	SCHOOLS OF MEDICINE	0	6	ABSTRACT This application responds to PA-20-142 and is the second competing continuation of a postdoctoral training program entitled “Training in drug abuse research: behavior and neurobiology” at the University of Texas Health Science Center at San Antonio (UTHSCSA). This Program has become an integral component of the recently launched Addiction Research, Treatment & Training Center of Excellence, the umbrella organization for a large variety of activities related to substance use disorder (SUD) on campus and extending into the San Antonio community. During the current period of support, all 6 training positions were filled with fellows selected from a pool of highly qualified applications. Since 2016, a total of 14 trainees have been or are currently supported by the Program, including 11 women (78%); 4 of the trainees (28%) are underrepresented minorities. Among 10 fellows that completed training, 8 are in academic positions. During the current period of support, trainees published 40 manuscripts (28 as first author), submitted 11 grant applications, and made 111 presentations at scientific meetings. Increasingly trainees are participating in community outreach activities, advocating for SUD research, education, and treatment. This Program sponsors numerous career development activities, many of which are attended by students and fellows, in addition to trainees in this Program. The well- funded research programs of the 18 Regular and 3 Junior faculty mentors span cell signaling to neurochemistry, preclinical behavioral pharmacology, and human clinical trials. The Program enjoys outstanding financial and other support from UTHSCSA (e.g., 10% salary for the Director), including an Office of Postdoctoral Affairs that offers many programs on career development, grant writing, and teaching, among others. Program Leadership includes a Director, Associate Director, Coordinator, and an Internal Advisory Committee. An External Advisory Committee evaluates the Program as part of an annual Advisory Committee Meeting in San Antonio; the details and operation of the Program as well as the training experience of fellows have improved as a result of recommendations by the Advisory Committees. The training environment at UTHSCSA is outstanding and includes excellent seminars, grand rounds, journal clubs (including the Addiction Journal Club hosted by this Program), formal training in rigor and reproducibility, formal training in the responsible conduct of research, and an annual international SUD meeting entitled Behavior, Biology & Chemistry: Translational Research in Addiction. This competing continuation requests 5 additional years of support for 6 positions in this highly successful, vibrant Program that is contributing to the NIDA mission of recruiting and training the next generation of SUD researchers.
21	Training in Complex Systems and Data Science Approaches Applied to the Neurobiology of Drug Use	5T32DA043593-04	GARAVAN, HUGH P.	PSYCHIATRY	UNIVERSITY OF VERMONT & ST AGRIC COLLEGE	BURLINGTON	VT	SCHOOLS OF MEDICINE	2	2	The purpose of this program is to train pre- and post-doctoral scholars in the application of complex systems and data science approaches to the neurobiology of substance abuse, with the dual strategies of: (1) training candidates with expertise in data science, applied mathematics, computer science, and complex systems to apply their skills to the neuroscience of addiction; and (2) training candidates pursuing addiction research from neuroscience, psychiatry, psychology and genetics in the theory and application of Big Data methods, including network analysis, machine learning algorithms, and Bayesian statistical models. Trainees will be paired across disciplines, and academic stages, for research collaboration and reciprocal tutoring to facilitate the development of proficiency in each trainee's new field. Each trainee will also be dual mentored, their secondary mentor being their partner's primary. Over its five-year duration, the program will provide three years of funding for each of five pairs of pre- and post-doctoral researchers, with an initial cohort of four (two pairs), and additional pairs entering in each of the middle three years. The core curriculum will incorporate: (1) the established complex systems and data science graduate certificate at the University of Vermont; (2) course work in neuroscience, psychology and addiction, including classes focused on developing human subjects research skills; as well as (3) specialized courses designed to directly and effectively bridge the gap between the core disciplines. Trainees will also attend a biweekly journal club and monthly seminar, led by senior participants in the program, to further support the acquisition of multidisciplinary research skills. The overarching aim of the program is to produce researchers poised to apply state-of-the-art analytic tools to understand the neurobiology of drug abuse. The focus will be characterizing the neural substrates of addiction and other comorbid psychopathologies, always with an eye toward clinical application. Recent increases in the quantity and quality of large-sample, multi-modal datasets that address the neural, genetic and environmental substrates of addiction make this a propitious time for such a training program. Researchers at UVM are ideally suited to provide this training as there exist close links between addiction research, cognitive neuroscience, complex systems and data science, and the mentoring faculty have access to exceptional datasets that are ideal for interrogation with Big Data methods. Armed with coherent domain knowledge and practiced with advanced methods for complex systems, trainees will develop analysis pipelines that: (1) incorporate sophisticated aggregation of longitudinal and multi-modal datasets, including various neuroimaging modalities, genetic information, survey and clinical data; (2) harness the power of supercomputing and modern machine learning algorithms to step beyond linear and univariate effects; and (3) address questions of immediate clinical importance to substance abuse that can inform the determination of risk factors, treatment and intervention strategy, and policy decisions.
22	Pre-Doctoral Training in Interdisciplinary Neuroscience	5T32DA018926-17	GOLDING, NACE L	NEUROSCIENCES	UNIVERSITY OF TEXAS, AUSTIN	AUSTIN	TX	SCHOOLS OF ARTS AND SCIENCES	6	0	PROJECT SUMMARY/ABSTRACT This proposal requests continued funding of an established Neuroscience Graduate Training Program in the Institute for Neuroscience (INS) at the University of Texas at Austin (UT-Austin). This program is becoming a nationally-recognized center of excellence in neuroscience training with the creation of a new Department of Neuroscience, construction of the new Dell Medical School with Clay Johnston, a neuroscientist, as the inaugural Dean, and recruitment of outstanding Faculty. Faculty have appointments in Neuroscience, Neurology, Psychology, Psychiatry, Pharmacy, Computer Science, Biomedical Engineering, Mechanical Engineering, Communication Sciences and Disorders, Molecular Bioscience, and Integrative Biology, and resolutely participate in 8 prestigious centers that are part of the INS, including the Center for Learning and Memory, Center for Perceptual Systems, Institute for Cellular and Molecular Biology, Waggoner Center for Alcohol and Addiction Research, Dell Pediatric Research Institute, Behavioral Neuroscience, Imaging Research Center, and Computational Visualization Center. The program has particular strengths in the neuroscience of perceptual systems, learning and memory, and addiction research, and Faculty provide excellent training across levels of inquiry from molecules to biochemistry, structure, physiology, behavior, neuroethology, and evolution with advanced computation and theory at all levels. This breadth provides graduate students with extensive options for training in cross-disciplinary research, and the training Faculty have substantial funding to foster their research. We propose predoctoral funding for 4 new trainees and 4 second-year trainees (totaling 8 per year). The training program requirements include: a Boot Camp, laboratory research rotations, seminar presentations, 2 principles of neuroscience courses, a science/ethics course detailing responsible scientific conduct, a course in experimental design and statistics, and 4 electives including a neuroscience of disease course. They also participate in at least 1 specialized journal club related to their project. Students join a research lab by the summer of year 1, and complete coursework and qualifying exams, including oral defense of a review paper at the beginning of year 2. Our recruitment strategies have become even more successful as reflected in the quality and diversity of the applicants. The broad interdisciplinary training uniquely prepares our trainees for research success in neuroscience, which is crucial for advancements in the etiology, pathophysiology, and treatment of brain diseases. Furthermore, the founding of the Dell Medical School on the UT-Austin campus will greatly facilitate our translational neuroscience research.
23	Research training in drug abuse prevention: closing the research-practice gap	2T32DA039772-06	GONZALES, NANCY A.	PSYCHOLOGY	ARIZONA STATE UNIVERSITY-TEMPE CAMPUS	TEMPE	AZ	SCHOOLS OF ARTS AND SCIENCES	3	3	Abstract Despite clear and convincing evidence for the efficacy of preventive interventions in preventing substance use and abuse (SU/A), the public health impact of these programs has been limited by inadequate uptake in community settings. This application seeks to train 3 pre-doctoral and 3 post-doctoral fellows annually to conduct research that reduces the gap between real-world practice and evidence-based preventive interventions targeting SU/A. The proposed background is a renewal of our current NIDA-funded T32 (currently in Year 5) and builds on a lengthy and successful 33-year history of T32 training that has been funded by NIMH from 1987-2014 and NIDA from 2014-present. Our training program is informed by the translational research cycle and Chambers and Proctor's recommendations on training for early career Dissemination & Implementation (D&I) researchers. The training is housed at ASU's REACH Institute, and participating units include the Arizona State University (ASU) Department of Psychology and School for Social and Family Dynamics. The interdisciplinary training faculty will be drawn from these units, as well as existing collaborators from College of Health Solutions, W.P. Carey Colleges of Business, Edson College of Nursing and Health Innovation, Fulton Schools of Engineering, Hugh Downs School of Human Communications, School of Criminology and Social Justice, and the School of Social Work. Training faculty conduct numerous NIH-funded projects in which collaborative research teams design, implement, and evaluate theory-based preventive interventions in natural service delivery settings and study the implementation science questions related to successful program uptake. Training faculty have unique strengths in SU/A prevention, D&I, culture and health disparities, and research methodology (particularly quantitative methods). The program is guided by an External Training Faculty of national experts in implementation science and a Community Advisory Board composed of decision leaders from service delivery settings (schools, courts, health care, and mental health care settings), with whom we partner on community-based research projects. Training consists of mentored research apprenticeships, an ongoing training seminar (including training in ethics and career development), required courses in SU/A and D&I, and other relevant experiences based on Individualized Training Plans that will be co-created with mentors. Through this tailored combination of coursework and research apprenticeships, trainees acquire skills in designing interventions for implementation, models of cultural adaptation, technology-based interventions, community-based participatory research, implementation theory and design, organizational characteristics, and economic analysis. The research contributions of our trainees will increase the adoption of evidence-based interventions in real world practice, helping to realize their public health impact at the population level.
24	Substance Abuse Epidemiology Training Program (SAETP) at Columbia University	5T32DA031099-10	HASIN, DEBORAH S	PUBLIC HEALTH & PREV MEDICINE	COLUMBIA UNIVERSITY HEALTH SCIENCES	NEW YORK	NY	SCHOOLS OF PUBLIC HEALTH	4	4	Substance use and substance use disorders (SUD), with their associated disability, comorbidity and mortality, constitute major public health problems. Combatting these problems requires cutting-edge public health research conducted by scientists of the highest caliber. The Substance Abuse Epidemiology Training Program (SAETP) at Columbia University Medical Center (CUMC) was established in 2012 to train talented young scientists to become the next generation of leaders in substance abuse epidemiology. Thus far, SAETP has been very successful, competitively attracting fellows who are productive and successful during and after their training. Completed SAETP and SAETP-affiliated fellows have attained prestigious research positions in academic medical center settings. We now propose a 5-year renewal cycle for SAETP. CUMC offers a rich array of research and training resources for SAETP, based in the Department of Epidemiology, Mailman School of Public Health, in collaboration with the Department of Psychiatry. SAETP has a cells-to-society perspective on substance abuse epidemiology, offering training at multiple levels of causation ranging from molecular to large-scale social forces. With its specialized training for substance abuse epidemiology careers, SAETP is unique at CUMC. Dr. Deborah Hasin, SAETP director, is an internationally recognized substance abuse epidemiologist with extensive successful mentoring experience. She will continue to direct SAETP in its next cycle. The disciplines of the 23 other internationally recognized SAETP faculty members include epidemiology, psychology, medicine, sociology, biostatistics, neuroscience and genetics, making for an interdisciplinary program. SAETP faculty have outstanding records in publishing, funding, and mentoring productive and successful trainees. At any given time in the renewal, SAETP will be training 4 pre-doctoral fellows (for training periods of 3-5 years each), and 4 post-doctoral fellows (for training periods of 2-3 years each). Fellows will be selected based on interest in and commitment to substance abuse epidemiology, experience, and prior accomplishments. Recruitment efforts to enroll under-represented minority trainees have been successful, with 25% of SAETP fellows from such groups to date; we will continue these recruitment efforts. SAETP will provide broad, intensive training in substance abuse epidemiology and related areas; depth in one or more areas of specialization; methodological and conceptual skills, including formulation of key research questions and testable hypotheses, and how to design and conduct high-quality substance abuse epidemiology studies. Fellows will receive mentoring and co-mentoring, and participate in many training components, e.g., a weekly substance abuse epidemiology faculty-fellow seminar; academic courses; field placements. Training will enable fellows to publish papers, hone their presentation skills in seminars and conferences, learn to write grant proposals; become knowledgeable about the responsible conduct of research, and enhance collaboration and leadership skills.
25	Training in Research on Addictions in Interdisciplinary NeuroAIDS (TRAIN)	2T32DA031098-11A1	HEATON, ROBERT KERNACHAN	PSYCHIATRY	UNIVERSITY OF CALIFORNIA, SAN DIEGO	LA JOLLA	CA	SCHOOLS OF MEDICINE	4	3	PROJECT SUMMARY/ABSTRACT Interdisciplinary clinical research on the combined effects of substance abuse and HIV disease on the central nervous system (CNS) is of considerable public health importance. Despite this, few laboratories address this critical topic and the current training program is the only one dedicated to preparing the next generation of investigators to conduct this research. In this proposed second renewal of our NRSA T32 training grant, “Training in Research on Addictions in Interdisciplinary NeuroAIDS (TRAIN),” we aim to accelerate our contribution to the field. We will continue to recruit talented and diverse pre- and post- doctoral trainees whose academic development will be furthered by an accomplished multidisciplinary team of mentors and the extensive academic resources at UC San Diego. TRAIN has been highly successful in the current funding period–since 2016, the 8 trainees produced 55 research manuscripts (22 first-authored), 88 conference presentations, and 6 book chapters, as well as 2 extramural NIH-funded grants (1 under review, impact score=21, 2nd percentile), 3 supplements to NIH-funded grants, and 2 intramural pilot grants. In this second renewal, we plan to enhance our training grant by augmenting faculty expertise, didactics, and training in new methodologies to support our new complementary theme of the complex biological mechanisms underlying the CNS consequences of HIV and substance use. Factors of particular focus include the microbiome and gut brain-axis, systemic and CNS inflammation, neuroimmunology, and biomarkers. This focus will augment TRAIN continuity themes of neurobehavioral functioning (e.g., frontal systems behaviors, decision-making, memory) and health-related everyday functioning (e.g., treatment adherence, vocational outcomes). Given our previous success and the growing demands of the field, we propose to increase our steady state number of trainees to four pre- and three post-doctoral trainees. Our students and fellows will be actively engaged in individualized career development plans, such as applied research training, didactics, and targeted clinical experiences. TRAIN faculty, all with strong training interests and robust histories of collaborative research, consists of 25 primary mentors across multiple academic levels and disciplines, with considerable expertise across the aforementioned scientific themes. We also have made organizational enhancements (e.g., addition of internal TRAIN committees) to further ensure continued progress towards the accomplishment of trainee goals. TRAIN is led by R. Heaton, Co- Directors I. Grant and D. Moore (new to this role), and Associate Directors J. Iudicello and E. Morgan; this team will oversee all training, scientific, and administrative aspects of the program. TRAIN will be housed at the HNRP-CMCR within the Department of Psychiatry, which is a resource-rich research and training environment in substance abuse and neuroHIV research. Our central goal remains unchanged: to train, mentor, and guide the next generation of researchers on combined CNS effects of HIV and substance use.
26	Behavioral Pharmacology of Human Drug Use Disorders	2T32DA007242-31	HIGGINS, STEPHEN T	PSYCHIATRY	UNIVERSITY OF VERMONT & ST AGRIC COLLEGE	BURLINGTON	VT	SCHOOLS OF MEDICINE	3	3	PROJECT SUMMARY The purpose of this application is to continue the University of Vermont’s highly successful 30-year T32 training program in the human behavioral pharmacology of drug use disorders. During the past 15 years, we trained 16 predoctoral and 22 postdoctoral fellows. Among those 38 fellows, all but two remain involved in research-related careers. Twenty-five have completed the training phase of their careers. Among those 25, 14 (58%) have primary university faculty/research-institute positions, six (24%) have been principal investigators (PI) on one or more NIH research awards, seven (28%) are employed by government agencies, two (8%) work in industry, and collectively they have more than 500 peer-reviewed publications on addiction. In addition to being a productive training program, the training our fellows receive in human behavioral pharmacology fills a unique niche in addiction research. Our fellows learn to identify basic behavioral and pharmacological processes underpinning addiction and to translate that knowledge into effective clinical interventions and policy. We propose to continue our emphasis on human behavioral pharmacology in the next funding period, continuing our expansion into tobacco regulatory science and the impact of addictive behavior on health outcomes. Since the last T32 renewal, we renewed our U54 Tobacco Centers of Regulatory Science (TCORS) and P20 Center of Biomedical Research Excellence (COBRE) awards in behavior and health, and obtained a new UD9 Center Award in Rural Addiction. These Centers add value to our training program via access to additional seminars, guest lectures, interactions with additional fellows and guests, and new research and career opportunities. Indeed, three of our T32 fellows have taken research scientist positions with FDA’s division on tobacco regulation. We propose to continue supporting four predoctoral and four postdoctoral training slots with this T32 award. The eight members of the proposed training faculty consist of seven PhDs and one MD. These faculty members are PIs on three NIH/HRSA center grants, five R01s, two R33/34s, two R21s, and one private- foundation award creating a rich range of training opportunities in addiction research. All faculty and fellows are located at a single, on-campus site composed of 8000 sq. ft of newly renovated space. Fellows are selected based on scholastic excellence and commitment to a career in addiction research. Predoctoral fellows are enrolled in the Department of Psychological Science PhD programs in experimental or clinical psychology where they complete required coursework including those developed for this training program, and complete master’s and doctoral theses. Postdoctoral fellows primarily focus on conducting and supervising independent research, with additional opportunities to further their education via coursework. Each fellow has a primary mentor from the training faculty. Fellows attend weekly seminars in addiction research and ethics. Additionally, they present their research at two or more national scientific meetings annually. The training period is generally 4-5 years for predoctoral and 2-3 years for postdoctoral fellows. The overarching goal of the proposed training program is to continue developing productive, independent, state-of-the-art addiction researchers.
27	The Neurobiology of Drug Abuse	5T32DA041349-05	JONES, SARA RAULERSON	PHYSIOLOGY	WAKE FOREST UNIVERSITY HEALTH SCIENCES	WINSTON-SALEM	NC	SCHOOLS OF MEDICINE	4	0	NEUROBIOLOGY OF DRUG ABUSE TRAINING PROGRAM SUMMARY One of the keys to understanding the actions of drugs of abuse is a systematic study of the neurobiological basis of drug abuse. Such studies must involve multi-disciplinary approaches to examine the effects of drugs of abuse at several different levels of brain function. This is the goal of the current application, the Neurobiology of Drug Abuse Training Program, which proposes to continue a successful tradition of NIDA training at Wake Forest School of Medicine (WFSM). This program requests funding to train four predoctoral students in a multi-disciplinary program in the neurobiology of drug abuse. The program consists of 15 faculty members at WFSM, with research interests including molecular biology, receptor pharmacology, brain imaging techniques in humans and non-human primates, electrophysiology, and behavioral analysis of drug self- administration. The research of the faculty is supported by a significant number of federally-funded grants related to the field of substance abuse. A central focus of research for the training program is the NIDA-funded Center for the Neurobiology of Addiction Treatment, which offers highly integrated collaborative research projects among a number of faculty. The program is organized around three principal areas of research: Molecular/Cellular Neurobiology, Neurobiological Systems, and Behavioral Neurobiology. The training program offers a specific course in drug abuse related to each of these three areas. Predoctoral students have a choice of two different Ph.D. degree tracks: Integrated Physiology/Pharmacology and Neuroscience. Although these programs have their own individual requirements, specific drug abuse-related topics are integrated into the standard programs. The training program offers specific seminars and journal clubs for trainees. The program also contains specialized components dealing with grant writing, rigor and transparency in research, and ethics in scientific research. Recruitment of students will be aided by the fact that the field of neuroscience is one of the fastest growing disciplines in the biological sciences. In addition, recruitment of applicants from under- represented minorities will be a high priority, including a bridge program with North Carolina Central University. In summary, the Neurobiology of Drug Abuse Training Program not only offers students outstanding opportunities for education and research in the neurobiology of drug abuse, but is also a valuable resource for the field of drug abuse by providing trained young investigators capable of independent scientific careers.
28	Training Program in Substance Use Disorders	1T32DA053558-01	KENNY, PAUL J.	NEUROSCIENCES	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	NEW YORK	NY	SCHOOLS OF MEDICINE	1	1	SUMMARY The Training Program in Substance Use Disorders at the Icahn School of Medicine at Mount Sinai (ISMMS) will offer late-stage predoctoral (PhD) students and early-stage postdoctoral fellows an integrated program of training in substance use disorders (SUDs) research that leverages the exceptional expertise in cellular, molecular and behavioral neuroscience, translational neuroscience, neurology, psychiatry, genomic science and pharmacological sciences at ISMMS. The overarching goal of the program is to provide rigorous, broad- based, individualized, and multidisciplinary training with enhanced opportunities for mentoring, collaboration, and career development designed to prepare the next generation of independent investigators in SUDs research. At the heart of this new Training Program will be a superb training faculty representing remarkable diversity in basic and clinically relevant topics; from synaptic plasticity and chromatin remodeling; cognitive, social, and emotional disorders; disorders of mood, motivation, and anxiety; addiction; human neuropsychology; and cognitive neuroscience – all relevant to SUDs. The Training Program comprises inter- related components: academic coursework, laboratory training, non-curricular training activities (seminars, retreats, etc.), testing/evaluation, teaching opportunities, mentoring, and career development activities. The diverse research environment at ISMMS will provide for laboratory opportunities in core areas of strength, including in translational neuroscience, computational neuroscience, neuropsychiatric genomics, neuroimaging, epigenetics, and synaptic and behavioral plasticity, and the study of diverse model systems. The Training Program includes more than a dozen initiatives that have been newly created or adapted from existing programs to support training in SUDs, which emphasize multidisciplinary collaborations, and the promotion of exceptional rigor and creativity. Pre- and post-doctoral trainees will participate in required and optional training activities to ensure strong grounding in basic neuroscience and opportunities to learn from and with peers and faculty from across ISMMS, including those in the Graduate School of Biomedical Sciences, the medical school, interdisciplinary Centers and Institutes, and the Friedman Brain Institute. Creating a structured culture of mentoring across the career continuum of participants is a hallmark feature of the Training Program. Formal and informal advising and mentoring will be integrated into training across roles and levels, including mentoring opportunities for training faculty and sponsors (preceptors). Integrating predoctoral and postdoctoral training through formal mechanisms will provide greater continuity in the overall training experience, enhanced opportunities for collaboration among trainees interested in pursuing careers in SUDs research, and will benefit the neuroscience research effort at ISMMS. The Training Program in Substance Use Disorders will prepare the most promising trainees for productive, independent careers in SUD research at all levels – from preclinical genetics, cellular and molecular mechanisms of the disorders, to clinical research and interventions.
29	Translational Training in Addiction	5T32DA022981-13	KILTS, CLINTON D	PSYCHIATRY	UNIV OF ARKANSAS FOR MED SCIS	LITTLE ROCK	AR	SCHOOLS OF MEDICINE	3	4	PROJECT SUMMARY/ABSTRACT This proposal seeks competitive renewal (years 11-15) of the UAMS NIDA T32 training program “Translational Training in Addiction”. Spanning five academic departments and three Colleges, the program provides multi- level, cross-disciplinary, team science training that spans the full translational research gamut from molecular to population-based approaches to solutions to curb or halt drug addiction. With program priorities of training innovation, diversity, connectivity and outcomes, this renewal request seeks to further the development of a program of training excellence that is dynamic and evolving in response to the rapidly changing societal, legislative, research, clinical and community responses to addiction. Quantitative and qualitative data support the claim of program excellence for the current funding cycle. A program evaluation plan is based on progress towards seven training objectives including (1) foster a shared knowledge of the broad societal and health impacts of drug use disorders and of the diversity of engaged scientific disciplines, (2) provide an individualized path to diverse addiction impact career areas and maximize post-training outcomes, (3) foster diversity as a strength for maximizing program impact, (4) provide career building environments emphasizing interdisciplinary, team science, translational research, (5) innovate advances in training approaches to research ethics, professional development, and program connectivity, (6) evaluate both bibliometric and translational science benefit outcomes of the program, and (7) foster the engagement of physicians and other clinicians in the career building processes of the program. Program administration, connectivity and oversight would remain the roles of the program Director, co-Associate Directors, Governance and Steering Committees, and external evaluators/advisers. Continued support is requested for three levels of trainees involving three predoctoral students, four postdoctoral fellows, and four annual M2 summer addiction research interns, complemented by institutional support of one annual PGY3 psychiatry resident, to foster the addiction translational science training objective of the program. Program-wide courses, faculty-facilitated seminar and presentation series, professional development lectures and workshops, and elective mentored research training emphasis/impact areas would support translational research training opportunities across the full spectrum of T0 to T4 translational science. Mechanisms of trainee and program evaluation focus on both scientific bibliometric and translational human health and society benefit indicators of program impact. Significant institutional commitment and resources support the accrued value and continued success of the training program. A continued trainee-led program of community outreach would support a program goal of bringing addiction science and impact into the community. The UAMS T32 training program has established a cross-discipline network of connectivity between addiction researchers and clinicians that were previously unlinked to contribute to the building of a translational science workforce.
30	Comorbidity: Substance Use Disorders and Other Psychiatric Conditions	5T32DA037183-08	KUSHNER, MATT G	PSYCHIATRY	UNIVERSITY OF MINNESOTA	MINNEAPOLIS	MN	SCHOOLS OF MEDICINE	0	4	Abstract Introduction: This is a renewal application for T32 institutional training grant application – Comorbidity: Substance Use Disorders and Other Psychiatric Conditions (NIDA DA037183) -- following the completion of its first five-year funding cycle. Among the current portfolio of NIDA funded training grants, only one program other than ours (Dartmouth) has comorbidity as a primary focus. This is striking given co-occurrence prevalence of Substance Use Disorders (SUD) with other psychiatric conditions and health conditions (e.g. diabetes), and the extent to which either SUD or the comorbid disorder can go under- or untreated in conventional treatment settings. The goals, elements and resources of the renewal program retains critical and effective elements of the initial funding period while incorporating important lessons learned. Long term goals: The proposed program will develop a cadre of scientists with research expertise in comorbidity mechanisms, antecedents and correlates, diagnostics, and psychosocial and pharmacological interventions. Component objectives are to provide each trainee with a working knowledge of comorbidity research including: (a) translational science from Early Phase Clinical Trials to Community Based Participatory Research perspectives; (b) effective research strategies for comorbid conditions across populations and ethnic and cultural groups (e.g. American Indian, Hmong, Somali). Accomplishing programmatic features will capitalize on (a) the spectrum of faculty expertise providing mentoring across multiple areas, and (b) integration across training programs and departments. Key Elements: (1) Involvement of scientists and clinicians with diverse expertise and a core internal advisory group. Primary sites (4 postdoctoral trainees, 2 yrs each) are the Departments of Psychiatry and Psychology (UMN Twin Cities) and Family Medicine and Biobehavioral Health (UMN Duluth); (2) Recruitment, including under represented group outreach, of rigorously screened PhD and MD candidates with SUD and comorbidity as primary career focus; (3) Training with an interdisciplinary mentoring team (primary & 2 secondary mentors) with complementary expertise; (4) Formal training plans with clear milestones including trainee development of an NIH application initiated in Year 1; (5) Active research, seminars, didactic course work, workshops, and development of management, ethics, and regulatory expertise; (6) Dynamic program administration entailing monitoring with enhancements and problem resolution along with continued contact with trainees after completion and; (7) Annually convened external advisory group. Resources: Mentor funding sources include NIH Institutes, NSF, Minnesota Medical Foundation, and pharmaceutical industry. Key Personnel and Primary Mentors are directors of clinics, centers, or departments with significant resources.
31	Research Fellowship in Substance Abuse Disorder	5T32DA007294-29	LEVIN, FRANCES RUDNICK	PSYCHIATRY	COLUMBIA UNIVERSITY HEALTH SCIENCES	NEW YORK	NY	SCHOOLS OF MEDICINE	0	6	Substance use disorders are a significant public health problem. There is a need for clinician-scientists to be trained to design and conduct clinical trials that translate the latest findings in basic neurobiology and pharmacology of substance use into clinical practice and the development of new treatments. For over two decades The Division on Substance Use Disorders of the Columbia University Department of Psychiatry and the New York State Psychiatric Institute has provided such training to a large cohort of clinical investigators. The purpose of this renewal application is to continue our postdoctoral program focused on training primarily physicians and psychologists for research careers in substance use disorders. The main objective of this program, now in its 24th year of continuous funding, remains to provide both the research skills and clinical expertise necessary to design and carry out independent translational research on the etiology and treatment of substance use disorders. Most of our trainees are encouraged to submit a K award, and about half of our trainees do so while the remainder continues work in affiliation with academic or research institutions. Both outcomes promote our goal of providing research skills and developing future leaders in clinical and treatment research on substance use and related disorders and academic medicine more broadly. Fellows are offered 2 years of training, while a third year may be offered to fellows making excellent progress but needing more time to develop their K awards or other other research proposals. In this competing application we are requesting 5 additional years of funding for 6 postdoctoral fellows to be enrolled in the program each year. We have developed a successful approach to training that includes: 1) Didactic introduction to clinical research in substance-related and addictive disorders that incorporates a comprehensive overview of the substance abuse field, an introduction and advanced course in statistics, weekly journal clubs and methodology seminars, and a formal course and ongoing instruction on the ethical and appropriate scientific conduct of clinical research; 2) Research apprenticeship where each fellow works as a junior collaborator under the close supervision of a senior investigator who serves as a preceptor and mentor; 3) Clinical experience in the major modalities used to treat substance use disorders; and 4) Development of teaching skills where each fellow is provided opportunities to provide lectures/seminars to medical students, psychiatric and other medical housestaff and at journal clubs and scientific meetings. The traditional foci of training remain clinical trials and human behavioral pharmacology. Further, over the past 5 years we have recruited new faculty in order to expand research opportunities for trainees across the translational spectrum and into new frontiers of treatment development. New directions include animal models to human translational work, development of new technologies for diagnostic and therapeutic purposes, health policy, implementation, and services research, adolescent/young adult substance use and neuroimaging.
32	UCLA Training Program in the Translational Neuroscience of Drug Abuse (TNDA)	5T32DA024635-14	LONDON, EDYTHE D	NONE	UNIVERSITY OF CALIFORNIA LOS ANGELES	LOS ANGELES	CA	SCHOOLS OF MEDICINE	4	2	PROJECT SUMMARY/ABSTRACT This proposal seeks support for a pre- and postdoctoral training program in the Translational Neuroscience of Drug Addiction (TNDA) at UCLA (5-year competitive renewal, requesting positions for four predoctoral and three postdoctoral fellows). Four participating programs/departments host TNDA trainees: Brain Research Inst. (administering the Neuroscience Interdepartmental PhD program), Dept. Psychology, Dept. Molecular & Medical Pharmacology, Semel Institute of Neuroscience and Human Behavior, the first three offering doctoral training programs. TNDA has five aims: 1) to recruit and enroll highly qualified candidates who are interested in and committed to translational research in drug addiction (including vigorously recruiting from underrepresented populations); 2) to provide hands-on experience at all stages of addiction research, including evidence-based hypothesis formation, experimental design, data acquisition and analyses, and preparing findings for oral and written presentation; 3) ; to ensure that trainees develop expertise in a specific research area and supporting technology, while providing opportunities for trainees to acquire the breadth of knowledge needed to conduct translational research in drug addiction; 4) to provide the resources, opportunities, and training that will enable trainees to use preliminary data in generating novel hypotheses and specific aims for NIH grant proposals, laying the groundwork for success in securing funding to pursue independent research; and 5) to provide career guidance so that trainees can successfully identify and secure professional positions allowing them to use the skills and knowledge obtained from TNDA. Accordingly, TNDA provides comprehensive interdisciplinary training through formal education and supervised research. Methodological issues and techniques are emphasized, and rigorous education in the ethics of conducting scientific research is provided. The participating mentors have active research programs at all levels of analysis ─ from cell and molecular biology and integrative study in animal models to brain imaging and cognitive neuroscience in humans. TNDA trainees have a primary project in a specific mentor's laboratory, but gain exposure to other areas of research through laboratory rotations, common core training, as well as by formal and informal interaction among TNDA faculty and leadership, including organized professional and social events for TNDA trainees. The Program Director and participating faculty have excellent records in research and past mentorship and strive to provide trainees with the knowledge needed to plan and conduct integrative, translational studies.
33	Training in genetic and neurobehavioral mechanisms of addiction	5T32DA050560-02	LUCIANA, MONICA	PSYCHOLOGY	UNIVERSITY OF MINNESOTA	MINNEAPOLIS	MN	SCHOOLS OF ARTS AND SCIENCES	2	3	Project Summary Substance use disorders are increasingly described as highly heritable and brain-based. Preclinical work has established that deviations in subcortical and frontal networks are associated with progression from experimentation to use to compulsive drug-seeking, to cycles of abstinence and relapse. Current models emphasize the importance of genetic vulnerabilities to intermediate phenotypes that predispose to substance use and dependence, including neural mechanisms of behavioral disinhibition, reward valuation, negative reinforcement, and negative affect that exacerbates withdrawal/craving. These models also emphasize how such mechanisms might be differentially impacted as a function of neurodevelopment. These various mechanisms, their neural correlates and genetic underpinnings, are increasingly being investigated in the context of large consortium efforts using novel technologies such as the ABCD study, various arms of the Human Connectome Project, TOPMed, AllofUS, and the UK Biobank, to name a few. However, today’s students are not necessarily prepared to leverage these resources to advance the field. We propose a mixed predoctoral/postdoctoral training program, with a central focus on neurobehavioral measures (e.g., neuroimaging), genetically informative designs, and cutting edge quantitative methods to uncover and characterize neurobehavioral mechanisms in the development of addiction. The University of Minnesota is a leader in the investigation of behavioral and molecular genetics of addiction, neurobehavioral mechanisms of substance abuse and its development through the use of preclinical, pharmacological, and neuroimaging techniques, and in quantitative modeling. Led by co-PDs Luciana and Vrieze and with the goal of producing the next generation of scientific/academic leaders, the proposed training program will train six predoctoral and three postdoctoral students each year in quantitative methods and the genetics and/or neurobehavioral mechanisms of addiction. A diverse group of trainees will be selected using stringent criteria from the pool of graduate students (predoctoral) as well as nationally (postdoctoral). The University of Minnesota’s Department of Psychology will lead this effort, with the support of an interdisciplinary team of 19 mentors in addition to the PDs. Each trainee will be funded for a two-year period, will be co-mentored by scientists with topical as well as quantitative expertise, and will pursue a combination of didactic training, lab- based experiences, workshops, seminars focused on professional development, and training in research ethics. For each trainee, individualized development plans will be developed and reviewed by a Steering Committee with articulated milestones related to training in specific research methods and the dissemination of findings. Accordingly, the proposed program will uniquely advance addiction science through its emphasis on computational/quantitative modeling of genetic and neurobehavioral factors relevant to addiction.
34	Training in Drug Abuse and Brain Imaging	5T32DA015036-20	LUKAS, SCOTT E	Unavailable	MCLEAN HOSPITAL	BELMONT	MA	Independent Hospitals	0	4	LUKAS, SE Training in Drug Abuse and Imaging T32 DA015036-15 This is a proposal to continue with years 16-20 of a postdoctoral training program in brain imaging and drug and alcohol abuse. We have at our disposal a variety of brain imaging tools that have yielded valuable insights into reward systems and addiction. The need for such a dedicated program is driven by the emergence of new and innovative techniques to view both the anatomical and functional aspects of the brain under a variety of conditions related to drug and alcohol abuse such as: acute intoxicating effects, tracking cue-induced craving, measuring cognitive effects, detecting persistent neurological and cognitive defects, monitoring withdrawal, sleep disturbances, medication compliance, tracking treatment progress and medication development. Because the nature and spectrum of the disciplines involved in imaging are complex, a new breed of scientists with backgrounds in imaging technology, multimodal analyses, neuroscience, pharmacology, addiction medicine and treatment are needed to more fully explore the neurobiological bases of drug abuse and fill the anticipated needs in the United States—our Training Program has been filling this void. Over the past 14 years we have successfully directed an integrated, multidisciplinary Drug Abuse and Brain Imaging Training Program that is supported by the McLean Hospital/Harvard Medical School and the Martinos Center for Biomedical Imaging at the MGH. Our program emphasizes both clinical and translational research directives that have solid foundations in magnetic resonance [imaging, functional and spectroscopy], EEG, PET and most recently Near Infrared Spectroscopy (NIRS). The infrastructure of the training program is built around two Siemens 3T clinical scanners (a TIM Trio and a Prisma), a Varian 4T clinical scanner, a 9.4T small bore animal magnet, both low and high density EEG/ERP and an Imagent NIRS system. Both animal and clinical PET is available at our MGH site. Our mentors are well funded by NIDA, NIAAA and NIMH and as such offer a unique breadth of research opportunities for our trainees. Our postdoctoral training program is structured to provide the trainees, over the course of 2 or 3 years, with the basics of imaging techniques, followed by placement in one of four distinct research tracks supporting each trainee's specific career goals: 1) Technology and Instrumentation; 2) Basic-Clinical; 3) Clinical-Treatment; and 4) Translational. In collaboration with the Martinos Center, we offer training in concurrent PET/MRI. The combination of didactic training in brain imaging and psychopharmacology with practical applications in a variety of highly successful research laboratories provides our trainees with the skills to utilize a broad range of brain imaging techniques as they embark on the next decade of research on how drugs and alcohol affect the brain.
35	Interdisciplinary Research Training in Pain and/or Substance Use Disorders	5T32DA035165-09	MACKEY, SEAN C	ANESTHESIOLOGY	STANFORD UNIVERSITY	STANFORD	CA	SCHOOLS OF MEDICINE	0	8	Project Summary/Abstract: This competing application seeks an additional five years (Years 6-10) of support for a post-doctoral research training program in pain and substance use disorders. The magnitude of these two problems in the US is astounding. More than 100 million Americans have pain that persists for weeks to years and over 20 million meet diagnostic criteria for an alcohol/drug use disorder. According to the National Academy of Medicine’s (NAM) report, Relieving Pain in America and the Surgeon General’s report Facing Addiction, these problems cost society almost $1 trillion annually. Contemporary neurobiologic, psychological, and epidemiologic research as well as the tragic experience of the opioid addiction epidemic show a clear intersection of pain and SUDs. Two of the NAM committee’s recommendations for improving research at a national level are (1) increase support for interdisciplinary research in pain, and (2) increase the training of pain researchers. Similarly, NIDA’s strategic goals and the Surgeon General’s report call for the multidisciplinary training of scientists to address the complexities of SUD research. In this proposal, we describe a collaborative, postdoctoral (PhD, MD/PhD and MD), interdisciplinary training program that will produce scientists with rigorous grounding in pain and SUD research. The accomplished faculty are all committed to interdisciplinary collaboration and mentorship across their substantive areas of expertise, which range from cells-to-society. The training program includes both required and elective coursework, mentored research experiences, an individual integrated research project, seminars, and exposure to professional development skills, including grant proposal and manuscript writing. The training program housed in the Division of Pain Medicine, Department of Anesthesiology, Stanford University School of Medicine, is intended to develop postdoctoral trainees’ skills, so that they will become independent investigators in the fields of pain, SUD and their intersection. The training program will be led by Dr. Sean Mackey, in collaboration with a steering committee comprising senior scientist/mentors. They will oversee the training, scientific, and administrative aspects of the program, including a rigorous process of internal and external evaluation. In summary, this training program will bring together a talented group of post-doctoral trainees, an accomplished team of interdisciplinary mentors, an effective administrative structure, and a world- class research environment at Stanford University. The combination of talent and environment will launch the next generation of researchers who will advance our scientific knowledge and practice of pain and substance use disorders.
36	INTEGRATIVE PREDOCTORAL TRAINING IN DRUG ABUSE RESEARCH AT INDIANA UNIVERSITY	5T32DA024628-12	MACKIE, KENNETH P.	PSYCHOLOGY	INDIANA UNIVERSITY BLOOMINGTON	BLOOMINGTON	IN	SCHOOLS OF ARTS AND SCIENCES	4	0	This proposal requests support for the second renewal of a highly successful, integrative pre-doctoral training program in the neuroscience of drug abuse at Indiana University Bloomington. Despite substantial advances in understanding drug addiction within specific levels of analysis (e.g., behavioral, clinical, and molecular), the problem of drug abuse will not be solved by focusing on a single level of analysis. If the next generation of researchers is to make meaningful progress, they must be well-rounded scientists with an appreciation that drug abuse is a multi-faceted problem, while possessing the flexibility to respond to and incorporate rapidly evolving technologies that will enable them to understand mechanisms and develop treatments for drug abuse. To prepare trainees for success in the next decade and beyond, our program emphasizes a team-driven, inter- disciplinary approach based on the translational model. Our program is successful because it brings together 12 core faculty members who are committed to integrative training and have a long history of collaboration on questions integral to drug abuse research. They include senior and junior investigators, molecular neurobiologists, cognitive neuroscientists, epidemiologists, and clinical scientists. They come from several departments in the College of Arts and Sciences and the School of Public Health, and all have joint appointments in the campus-wide Program in Neuroscience. Working together in state-of-the-art facilities, this group has access to a pool of highly talented trainees motivated to pursue careers in drug abuse research. Our training program develops trainees by emphasizing three key components: integrative course work, translational research training, and professional skills development. Course work covers basic neuro- and psychopharmacology, provides an integrative view of biobehavioral processes in substance use disorders, and brings a translational perspective to theoretical and empirical knowledge. Research is guided by a mentor in molecular, systems, cognitive, or clinical neuroscience closely integrated with a co-mentor representing a complimentary level of analysis. This integrative approach is reinforced through discussion groups, attendance at colloquia, and participation at national meetings. Instruction in ethical scientific behavior includes formal course work and campus workshops as well as specialized instruction led by a core faculty member who has many years of experience leading seminars on ethical issues unique to substance use research. Trainees also learn to develop skills in grant writing, manuscript preparation, teaching, and community outreach and organize an annual program retreat with outside experts in drug abuse. In short, our program relies on a combination of course work and research training aimed at integrating and translating bench and bedside approaches to produce scientists well prepared for productive and transformative careers in drug abuse research.
37	Prevention and Methodology Training	2T32DA017629-16	MAGGS, JENNIFER L	MISCELLANEOUS	PENNSYLVANIA STATE UNIVERSITY-UNIV PARK	UNIVERSITY PARK	PA	SCH ALLIED HEALTH PROFESSIONS	7	3	PROJECT SUMMARY/ABSTRACT Since 2005 the Prevention and Methodology Training Program (PAMT) T32 has met a critical need in the training of drug abuse prevention scientists by nurturing scientists focused on integrating prevention science and highly innovative methodology. The objective of PAMT, which is unique to NIDA’s portfolio, is to produce scientists who lead the application of cutting-edge methods to emerging critical research needs in the prevention of substance use and addiction. We do this in the context of Penn State’s long-standing dual commitment to innovation in data collection, design, and statistical analysis methods and to impactful research on the etiology and prevention of substance use and addiction across the life span. Building on PAMT’s long- term success training 83 prevention scientists to date, we propose to enhance this successful pre- and post- doctoral training program with (1) increased depth in formal training opportunities related to our core competency domains: substance use, prevention science, and innovative methods; (2) strategic initiatives to build diversity in mentors, trainees, and training; and (3) expanded disciplinary integration by leveraging Penn State’s deep investment in its new Consortium to Combat Substance Abuse. PAMT is administered through the Edna Bennett Pierce Prevention Research Center. Drs. Jennifer Maggs and Stephanie Lanza, Program Directors, and Dr. Rina Eiden, Associate Training Director, lead the program as distinguished substance use researchers with expertise in prevention science and innovative methods. To achieve trainees’ individualized training goals, the program offers (1) interdisciplinary instruction on substance use, prevention science, and innovative methods; (2) mentored experiential training in all aspects of research; (3) training in professional skills and the responsible conduct of research; (4) proseminars including workshops on methods, health equity, cultural competence, and goal tracking; (5) a biennial visit to NIH; and (6) formal training in NIH grant-writing, leading to many successful F31, R03, and K99 grant submissions. An Expert Advisory Committee will meet annually to provide feedback and guidance related to training and diversity goals. Faculty mentors are leaders in substance use, prevention science, and innovative methods, with strong track records of NIH support and mentorship of early career scholars. Forty-five faculty mentors span disciplines such as human development and family studies, biobehavioral health, sociology/criminology, psychology, and engineering. Our trainees work toward novel solutions to mounting challenges related to substance use. The proposed renewal supports 7 pre- and 3 post-doctoral trainees per year, with strong institutional support for an additional 3 pre- and 1 post- doctoral trainees per year. Together, this represents 25 pre- and 10 post-doctoral trainees in the 2021-2026 renewal period. PAMT trainees are engaged in cutting-edge work that rigorously integrates new methods into prevention research, providing a seamless, holistic approach to understanding and preventing drug abuse. The scientists we train will be at the forefront of this critical area for many years to come.
38	NIDA Epidemiology Training Program	5T32DA007292-29	MAHER, BRION S	OTHER HEALTH PROFESSIONS	JOHNS HOPKINS UNIVERSITY	BALTIMORE	MD	SCHOOLS OF PUBLIC HEALTH	8	7	Substance use disorders remain among the leading causes of disability and premature death in the world, with rates remaining stubbornly high. Training with a rigorous methodological basis and a breadth of course work and research experiences is necessary to develop the next generation of scientists able to lead efforts to reduce the public health burden of substance use disorders. Accordingly, this renewal application seeks to extend the pre- and post-doctoral Drug Dependence Epidemiology Training Program, one of NIDA’s oldest continuously funded training grants now entering its 25th year in the Department of Mental Health at the Johns Hopkins Bloomberg School of Public Health. The goal of this training program is to produce the next generation of substance use epidemiologists who can address this need by: conducting research that will advance our understanding of the environmental and biological components of the etiology and natural history of substance use; developing, implementing, and evaluating interventions to prevent and control substance use; and critically examining substance abuse services, treatment and trends to improve substance abuse outcomes including HIV-related risk. We will train substance use epidemiologists who are able to tackle these challenges by emphasizing four focal areas in this iteration: (1) social and environmental factors; (2) genetic and biological factors; (3) treatment and services; (4) emerging trends. This training program will capitalize on the interdisciplinary resources at Johns Hopkins University to provide trainees with the skills and experiences needed to lead multi-disciplinary research that takes advantage of these emerging opportunities and promotes overall health and well being of communities. Trainees will achieve this through a rigorous program of coursework, research apprenticeships, and integrative activities that provide a solid foundation in the core proficiencies of substance use epidemiology. The program will include 7 predoctoral students and 7 postdoctoral fellows who are supported by an experienced group of 12 Core Faculty and 36 Affiliate Faculty. The trainees will be prepared to assume leadership positions in academia carrying out substance use epidemiology and HIV research typically as faculty in Schools of Public Health or Medicine, in government formulating research priorities and substance abuse policy at the local, state, national, and international levels, in private industry conducting applied research for pharmaceutical companies, and in non- profit agencies or non- governmental organizations advocating for those with substance use disorders.
39	Neuroimaging Sciences Training Program	5T32DA022975-13	MASON, GRAEME F.	RADIATION-DIAGNOSTIC/ONCOLOGY	YALE UNIVERSITY	NEW HAVEN	CT	SCHOOLS OF MEDICINE	0	5	NISTP: NEUROIMAGING SCIENCES TRAINING PROGRAM This institutional grant requests funds for five postdoctoral positions for interdisciplinary training and research in neuroimaging. Two general classes of neuroimaging will be emphasized: radiotracer and nuclear magnetic resonance. The specific imaging methods are described by the following acronyms: PET (positron emission tomography, MRI (magnetic resonance imaging), including fMRI (functional magnetic resonance imaging) and DTI (diffusion tensor imaging), and MRS (magnetic resonance spectroscopy). These imaging methodologies offer real promise for the expanded clinical utility of neuroimaging in the diagnosis, treatment, and understanding of the pathophysiology of substance abuse and dependence. However, these new methodologies typically derive from complex, multidisciplinary sciences, which thereby create a challenging information barrier to their further development and application in medical practice. The purposes of the proposed program are the following: - Provide formal course training to postdoctoral fellows, with an emphasis on imaging and clinical research methodology, and instruction in their underlying multidisciplinary sciences. - Provide mentored training for fellows to apply these new methods to the interdisciplinary advance of our understanding of the function of the brain in health, substance abuse, and other psychiatric diseases. - Provide an integrated research experience for the fellows both in imaging applications and in methodology. All postdoctoral fellows will be expected to complete at least one research project with an applications mentor and one with a methodology mentor during their training period. The integration of training in methodology and imaging applications will be enhanced by the organization of this program as two interactive tracks of approximately equal size: Methodology and Application. We expect that the majority of postdoctoral fellows in the Methodology track will have Ph.D. degrees, and those in the Application track, primarily M.D. degrees or Ph.D. in neurosciences or behavioral sciences. Each fellow will have a primary and secondary faculty mentor to represent the two tracks.
40	Drug Abuse Training Program	5T32DA007288-30	MCGINTY, JACQUELINE F.	NEUROSCIENCES	MEDICAL UNIVERSITY OF SOUTH CAROLINA	CHARLESTON	SC	SCHOOLS OF MEDICINE	4	7	PROJECT SUMMARY /ABSTRACT The long term goal of the training program is to equip our predoctoral students and postdoctoral fellows with the knowledge base and research skills to compete successfully in the world of substance use disorder (SUD) research. For the past 24 years, the Drug Abuse Training Program at the Medical University of South Carolina (MUSC) has trained predoctoral and postdoctoral scholars who are cognizant of multiple preclinical and clinical dimensions of the SUD problem. The objectives of the training program are to (1) integrate a diverse group of trainees into various funded addiction-related research programs with appropriate mentors, (2) provide general knowledge about SUDs and related treatment research, (3) expose trainees to appropriate role models, (4) expose students to issues related to scientific ethics; rigor, transparency and reproducibility; and diversity issues, (5) teach trainees communication skills, (6) teach trainees how to prepare a research grant application and transition to individual fellowships, (7) help each fellow gain an appreciation of both clinical and basic science research, and (8) assist trainees in their professional development. There has been tremendous growth and development of neuroscience faculty who conduct preclinical and clinical SUD research in NIH- funded centers at MUSC within the past decade. Concomitant with this growth has been an explosion in training program applicants who are eager to learn from this highly interactive faculty. Thus, support to continue this training program at the level of 8 postdoctoral (2 in level 0, 3 each in levels 1 and 2) and 4 predoctoral trainees per year for 5 years is requested. There are four major areas of preclinical and clinical research opportunities: neurobiology of drug relapse; sex and gender differences in vulnerability to SUDs; stress and substance use disorders; and neurobiology and treatment of nicotine dependence. Since the main sites of research training are in very close proximity to one another, there is coordination of educational (courses, seminars, journal clubs) and research (preclinical and clinical) opportunities. Coupled to the environment is a comprehensive training package incorporating didactic material, clinical experiences, and research experience that provides an ideal training opportunity that is evaluated on an annual basis. Recruitment and selection of trainees is accomplished by the Program Directors and internal Steering Committee members. Augmented recruitment and retention of underrepresented individuals is accomplished in partnership with the College of Graduate Studies and Postdoctoral Affairs Office at MUSC. Eligible mentors are those with actively funded substance abuse-related research projects; matching of trainees with mentors is by mutual consent. An External Advisory Board is consulted annually for evaluation and recommendations for program improvement. The NIDA training program at MUSC has been very successful in placing our trainees in highly-productive postdoctoral and faculty-level positions through which they continue to contribute to SUD research and treatment.
41	Neuroscience Training in Drug Abuse Research	5T32DA007234-35	MERMELSTEIN, PAUL G	NEUROSCIENCES	UNIVERSITY OF MINNESOTA	MINNEAPOLIS	MN	SCHOOLS OF MEDICINE	6	3	PROJECT SUMMARY/ABSTRACT Overview: For 30 years, this institutional training program at the University of Minnesota has focused on the preparation of graduate students and postdoctoral fellows for research and study in the field of drug addiction. The faculty mentors are all members of the University interdepartmental Graduate Program of Neuroscience. The 13 current trainers span four departments within the Academic Health Center. Our trainers' research programs are strongly supported by extramural funds. Each shares the common interest in understanding the changes that occur to the nervous system with drug abuse. Objective: The proposed program is to support six predoctoral trainees and three postdoctoral fellows: the same number of trainees supported by the current funding period. The vast majority of predoctoral trainees are students in the interdepartmental Graduate Program of Neuroscience. This program has been ranked as one of the top three graduate programs within the entire University. Exceptional graduate students in departmental graduate programs (e.g. Pharmacology) that minor in Neuroscience are also eligible. Graduate students become eligible for support at the end of their first year, once they select a faculty mentor who is part of the training program. For postdoctoral fellows, a strong publication history and previous training in addiction research are the most important criteria for selection to the training grant. Of the eligible postdoctoral fellows working in the laboratories of our trainers, only the top third are selected. Rationale and Design: The motivation for this training program is for all trainees to experience the breadth of topics, scientific approaches, and methodologies taken to study drug addiction. Additionally, research programs across investigators are highly collaborative. This enrichment is intended to maximize the trainees' potentials for rewarding careers in scientific thought and research. Active classroom activities and journal clubs, along with a seminar series and a program retreat reinforce the cohesive community. Additionally, the University's committed support to the neurosciences (over 100 million dollars in just the last five years) is unequalled at the institution. While breadth is important, each trainee has his/her own individual development plan. Trainees work with both their mentor as well as additional trainers to further their specific career goals. This is true for postdoctoral fellows as well, where both the PI as well as additional trainers monitor progress. Notably, the graduate students and postdoctoral fellows are not the only ones receiving preparation. Our trainers undergo additional instruction, to ensure they are better mentors beyond just laboratory advisors, which ensures an optimal environment for training.
42	Genetic and Environmental Influences on Addiction	5T32DA039080-05	MILNER, TERESA A	NEUROSCIENCES	WEILL MEDICAL COLL OF CORNELL UNIV	NEW YORK	NY	SCHOOLS OF MEDICINE	3	0	Abstract: Understanding how genetic and environmental factors impact drug use and abuse may be critical for addiction prevention and diagnosis, as well as the development of novel effective addiction therapeutics. This application plans to provide 3 predoctoral training slots (for ~2 yrs, starting in the 2nd yr) in the Weill Cornell Graduate School (WCGS) Neuroscience and Pharmacology Programs aimed at understanding the impact of genes and environment on drug addiction. A unique feature of this training plan is the diversity of faculty expertise in both genetic (e.g. sex, single nucleotide polymorphisms, gene splice variants, dendritic/axonal translation, and epigenetics) and environmental (maternal environment, developmental stage, and stress) factors that are essential for the emergence of addictive disease. Our faculty is also noteworthy for the breadth of the approaches they bring to addiction science; we have expertise in studying how several major abused drugs (i.e. opiates, cocaine, and other psychostimulants) impact neuronal function from the expression and behavior of single molecules to the performance of complex functional systems that regulate the behavior of rodents and humans. In addition to our talented faculty, this training grant will take advantage of the WCGS outstanding research environment, educational resources, and recruiting activities, particularly our history of attracting and training under-represented minorities as basic and clinical scientists. Particular strengths of the training grant include: 1) the experience of the Director and Co-Director in mentoring, teaching and drug abuse research; 2) the broad scope of multidisciplinary research training provided by the faculty; 3) extensive collaborations and co-mentoring between the faculty; and 4) the strong emphasis on “bench-to- bedside” translational research. Training grant faculty will be divided into three groups: 1) Major Sponsors: graduate student thesis mentors with NIDA mission supported research programs; 2) Training Sponsors: individuals with extensive experience in drug abuse research who will work closely with Major Sponsors and their trainees; and 3) Minor Sponsors: individuals with NIDA- mission interests who will collaborate with Major Sponsors and their trainees. Resource Cores comprised of training grant faculty from all three groups will be established to provide a platform for students to incorporate approaches from multiple laboratories into their PhD thesis work. Beyond the laboratory, a new course entitled “Addiction and Society” developed by a group of graduate students in consultation with faculty, as well as a Drug Abuse focused retreat and WCGS developed programs in grant-preparation, will provide students with important training experiences in teaching, grantsmanship, and networking that will be essential for their career development. These courses together with the existing coursework and curricula, symposia and lectures, as well as each students individual training plan, will provide a solid foundation for the development of independent basic and clinical scientists in drug abuse research.
43	Training in PharmacoNeuroImmune Substance Abuse Research	5T32DA007097-40	MOLITOR, THOMAS WILLIAM	INTERNAL MEDICINE/MEDICINE	UNIVERSITY OF MINNESOTA	MINNEAPOLIS	MN	SCHOOLS OF MEDICINE	9	3	7. Project Summary/Abstract This is a renewal application for an interdisciplinary Drug Abuse Research Training Program titled “Training in PharmacoNeuroimmunology (PNI) Substance Abuse Research” (T32 DA007097-34). The PNI Training Program <z.umn.edu/pni> meets a well-recognized need to train biomedical scientists at the pre- and postdoctoral levels in an interdisciplinary and translational field that focuses on the interactions of drugs of abuse with the nervous and immune systems, and integrates our understanding of these physiological interactions with their behavioral counterparts. A critical component of the training program considers the role of drugs of abuse as co-factors in HIV/AIDS, specifically relating to NeuroAIDS. The program has trained 48 predoctoral and 35 postdoctoral (83 total) in the past 15 years. These individuals hold influential positions in academia, government, and industry. Our 39 primary faculty preceptors are a talented group of laboratory based and clinical scientists working at these intersections of disciplines. Our well-funded faculty preceptors have extensive experience as mentors and are committed to training predoctoral students and postdoctoral fellows in this interdisciplinary setting. To fulfill our training mission with our available resources, we are requesting funding for 10 predoctoral and 5 postdoctoral slots. All of the elements of a successful training program are in place and are functioning efficiently and effectively: a formal curricula, including the two core courses in Neuro-immune Interactions and Neuropsychopharmacology and two colloquium in Substance Abuse at the Bedside and HIV/AIDS: Pathogenesis, Treatment, and Prevention. Additional critical training activities include a bimonthly seminar series, a research-in-progress symposium, and a yearly retreat. The new expanded PNI training components in this application include: a) adding 13 new faculty as preceptors; b) developing online learning modules for use by program trainees and undergraduate students participating in the linked summer research program for students of diversity; c) developing a unique research rigor training component; and d) developing a training experience for postdoctoral fellows focused on nonacademic positions. The PNI training program is further enhanced by the University of Minnesota strong initiative to highlight translational research, (Center for Translational Research) and the designation of Addiction as one major research priority by the AHC, University of Minnesota evidenced by the establishment of Minnesota Center for Addiction Neuroscience MNCAN. The emphasized commitment to addiction research as a priority, and the long standing history of research funding to investigators by NIDA provide additional evidence of a rich environment for the training of pre and postdoctoral research fellows in substance abuse research.
44	Training Program in Adolescent Substance Use Disorders and Co-Occurring Mental and Behavioral Disorders	5T32DA043449-03	PELHAM, WILLIAM E	PSYCHOLOGY	FLORIDA INTERNATIONAL UNIVERSITY	MIAMI	FL	SCHOOLS OF ARTS AND SCIENCES	3	3	Project Summary It is well documented that adolescents that abuse drugs, including those who meet criteria for a Substance Use Disorder (SUD), frequently suffer from at least one other mental health or behavioral disorder (Kaminer, 2013). Among youth with a SUD, it is common for at least one mental or behavioral disorder to co-occur (National Institute on Drug Abuse, 2014). The nature of the substance abuse and SUD-co-occurring disorder association is complex. One model points to the role of adolescent drug use as a contributor to an elevated risk of a mental or behavioral problem. Another major conceptual model is that childhood-onset mental disorders precede drug use, and that drug use also complicates the trajectory of the mental disorder. In this light, these early-onset internalizing or externalizing problems contribute to psychological, social and other contextual functional triggers to use substances. No training program in NIDA’s current portfolio has adolescent SUD and co-occurring behavioral/mental health disorders as a primary focus. The proposed T32 training program will include a diverse range of research faculty with considerable expertise in mentoring, administration, and research in adolescent substance abuse, SUD and related mental health disorders. Training will focus on the mentors’ research that address etiology, prevention, intervention and treatment. The program, which will accommodate cohorts of three predoctoral trainees (during years 3-5 of their graduate program) and cohorts of three postdoctoral trainees (for 2 years each), will train a total of 15 predoctoral and postdoctoral fellows over the five-year period. The training will be characterized by rigorous program leadership, rich and varied training experiences and resources, administration, oversight and continuous monitoring from the Training Steering Committee, updating of trainee resources, and the annual convening of an External Advisory Committee. Trainees and a Primary Mentor, with additional assistance from an Affiliated Faculty, will develop a personalized training roadmap via an Individual Development Plan (IDP). The IDP will provide the trainee guidelines as to advance research knowledge and skills pertaining to at least one of these four content domains: (1) developmental psychopathology, (2) preventive interventions and dissemination, (3) treatment and dissemination, and (4) health services practices and implementation. In sum, the proposed T32 training program at FIU includes all the essential ingredients for successful training across the spectrum of research activities associated with adolescent SUD and co-occurring disorders, and the program will serve as a national example of a training ground for young investigators in this field.
45	Research Training Fellowship in Substance Abuse	2T32DA007238-31	PETRAKIS, ISMENE L.	PSYCHIATRY	YALE UNIVERSITY	NEW HAVEN	CT	SCHOOLS OF MEDICINE	0	3	Project Summary/Abstract This is the competitive renewal of a T32 training program, the Research Training Fellowship in Substance Abuse Program (RTFSA-P), which has been in existence since 1988. Despite recent advances in understanding the neurobiology of addiction, there is a persistent gap in the application of knowledge gained from basic science studies to clinical practice in the field of addiction. A new generation of behavioral, psychopharmacology, neuroimaging, molecular genetics and molecular neuroscience studies has broad clinical implications and these studies bring the potential to bridge the gap between basic and clinical research. Despite the quality of the available science, actual progress in bridging this gap depends also upon the availability of appropriately trained young scientists. The purpose of the RTFSA-P is to meet this need by providing post-doctoral training for a total of 4 physicians or PhDs interested in careers in translational or intervention research in the field of addiction. The proposed RTFSA-P is a two-year program in the Division of Addictions (DA), Department of Psychiatry, Yale School of Medicine, and will afford post-doctoral trainees the opportunity to devote virtually full-time effort, during the initial phase of their careers, to developing the skills and experience needed to become independent researchers in the field of clinical or translational research in substance use disorders. The DA is an ongoing, stable addiction research program that now encompasses over 123 major funded projects including 4 Centers covering a broad scope of topics and research methodologies. This facilitates research that moves rapidly and in both directions from preclinical projects (“bench”) to clinical studies (“bedside” and “community”). Applicants will be MDs or PhD post-doctoral candidates trained in specialties that include psychiatry, internal medicine, clinical psychology, or neuroscience. Candidates will be selected by an admission committee based on their potential for excellence in the field of translational or intervention research in addictions. The RTFSA-P program includes (1) individualized research preceptorship, (2) successful completion of a translational-research project, (3) a core curriculum, which includes seminars on addiction clinical research and treatment, biostatistics and research design, the responsible conduct of scientific research and grant writing skills and (4) individualized participation in seminars of interest in the Department, Medical School and University. The training facilities include the major institutions affiliated with Yale School of Medicine, Department of Psychiatry. At the conclusion of training, applicants will be well suited for independent careers in translational or intervention research in the field of addiction.
46	Training in Molecular Pharmacology of Abused Drugs	5T32DA007278-28	PHILLIPS, PAUL E. M.	PSYCHIATRY	UNIVERSITY OF WASHINGTON	SEATTLE	WA	SCHOOLS OF MEDICINE	4	4	Project Summary The University of Washington training program in the Molecular Pharmacology of Abused Drugs is designed to provide a cohesive training environment for five predoctoral and five postdoctoral fellows per year, interested in the molecular, cellular and behavioral pharmacological aspects of opioid, cannabinoid, and psychostimulant drug action, and their abuse. The program emphasizes training in research skills along with career development professional skills and responsible conduct of research-ethical skills. Faculty mentors provide training in a broad range of research approaches including molecular pharmacology, electrophysiology, neurochemistry, neuroinflammation, mouse genetics, viral-based gene expression, optogenetics, chemogenetics and behavioral pharmacology. In addition to the general, ongoing training typical at this vibrant institution, trainees in this program experience a coordinated series of events specifically designed for their benefit including invited speaker seminar sessions featuring internationally respected drug abuse researchers; monthly research progress meetings featuring local experts in abused drug research; weekly journal clubs on the current literature of opioid, cannabinoid and psychostimulant research; frequent opportunities for the trainees to enhance their presentation skills; courses organized for them on the 'Molecular Basis of Addiction' and 'Addiction: Mechanisms, Treatment, Prevention'; and career development seminars designed to strengthen their scientific and professional foundations. Faculty mentors are highly collaborative, and trainees benefit from a strongly interactive, multidisciplinary research program. The training program will continue to be a catalyst for research collaborations among the participating labs, for technology transfer between labs, and for newly funded collaborative NIDA- research grants. The trainees are drawn from an outstanding pool of candidates recruited to the participating graduate programs in Pharmacology and Neuroscience and to the well-respected laboratories as post-doctoral fellows. We have an active outreach program designed to encourage participation of underrepresented minorities and fellows from disadvantaged backgrounds. We actively train our students and fellows in responsible conduct of research and ethical treatment of animal subjects. The program is proud of its 25-year history of success in training fellows who have gone on to very successful scientific careers.
47	Substance Abuse Intervention Outcome Research Training	5T32DA016184-19	ROHSENOW, DAMARIS J.	PUBLIC HEALTH & PREV MEDICINE	BROWN UNIVERSITY	PROVIDENCE	RI	SCHOOLS OF PUBLIC HEALTH	0	4	Project Summary The aim of our multidisciplinary program is to train post-doctoral biomedical, behavioral, health care and other public health scientists to conduct substance abuse intervention research. An overarching goal is to enhance the scientific reasoning skills needed to advance treatment research in drug abuse. From our perspective such research will benefit from interventions guided by sophisticated and fully-developed theory using a multidisciplinary framework that includes the biological, psychological, social, cultural, and policy context in which interventions occur. While other institutional training programs may address intervention research, this is the primary mission for this program. Distinctive features of our training program are: that it is interdisciplinary; that it embraces no single ideology or theory concerning the nature of dysfunctions related to drug abuse; that it provides training in early intervention and treatment along a continuum; and that it provides trainees with highly individualized opportunities to develop competitive grant applications and by doing so, contribute to the knowledge base of substance-related dysfunction and treatment. The training experience is structured to provide individualized research experience and training, complemented by a core academic curriculum to which 20% of fellows' training time is allocated. Four distinct areas are covered in the curriculum: (1) statistics/research methodology; (2) grantsmanship; (3) ethical issues in research; and (4) a two-year series of formal courses covering the etiology and treatment of substance abuse from varying disciplinary perspectives. We also subscribe to a research apprenticeship model under the guidance of the research mentor. Each fellow's individual research training experience emerges from an individualized development plan (“training plan”) developed by the fellow, agreed to by his/her mentors, and reviewed and approved by the Training Committee. The program has a primary emphasis on training in innovative treatment development and clinical trials research with a secondary emphasis on the translation of clinical research into services research. Our research in behavioral economics, neuroscience, and behavioral genetics expands our focus of translational research from basic to clinical. An additional area of emerging prominence in our training program is tobacco regulatory science. The expected training program duration is two years but on occasion we offer 3rd years of training, for example for fellows with less extensive training in research methods; fellows who are cross-training, e.g. training in Behavioral Genetics for a clinical psychologist; or for fellows in each cohort who need more time to accomplish their goals of becoming independent investigators. The program accepts on average two new fellows per year. At any given time there are likely to be four fellows in residence.
48	Multidisciplinary Training in Substance Abuse Research	5T32DA045734-03	ROY, SABITA	SURGERY	UNIVERSITY OF MIAMI SCHOOL OF MEDICINE	CORAL GABLES	FL	SCHOOLS OF MEDICINE	2	2	Project Summary This is a resubmission of a T32 training grant from the University of Miami, Miller school of Medicine aimed at training pre- and post-doctoral trainees in drug abuse research. Our program's goal is to train both basic scientists and clinicians to better understand the basic science concepts underlying substance abuse and to translate the findings made “at the bench” to inform clinical practices at the “bedside”. With the alarming increase in the abuse of prescription opioids it is imperative to understand the mechanisms underlying drug abuse at a multidisciplinary level to improve evidence-based and formulate effective treatments for patients with addictive disorders. Our overall goal is to provide trainees with professional skills to pursue productive academic careers in drug abuse research. Primary objectives of this program include: 1) provide trainees with either a rigorous laboratory research experience or patient- or population-oriented research experience in substance abuse research by linking promising candidates with outstanding mentors who are meticulously selected based on scientific qualifications and experience in drug abuse training; 2) to provide trainees with essential research skills and information regarding career development in substance abuse research through structured course work, lectures and seminars, which emphasizes training in ethics and scientific integrity academic "survival skills," specific research tools and exposure to diverse research methodologies; 3) to enhance and teach skills in mentorship to junior faculty through active co-mentoring of trainees with senior faculty with a formal training program. This program will include outstanding mentors who, in addition to success in their focused areas of research, are committed to teaching broad research skills, such as performing scholarly reviews of the literature; formulating hypotheses and study design; developing essential skills in statistics, oral and written presentation of scientific findings and grant writing; understanding issues and defining potential problems of scientific integrity and ethics. The program leadership will further ensure close monitoring of trainee progress. Our team of experienced mentors with active, external peer-reviewed funding are committed to the highest quality research experience, providing state of art training in substance abuse research. The proposed program incorporates a comprehensive training plan in the responsible conduct of research and promotes diversity by recruiting and retaining women, and minority candidates. The University of Miami offers a dynamic, stimulating and collegial learning environment for this training mechanism.
49	Research Training in Drug Abuse Behavior	5T32DA035200-24	RUSH, CRAIG R	PSYCHOLOGY	UNIVERSITY OF KENTUCKY	LEXINGTON	KY	SCHOOLS OF MEDICINE	3	3	ABSTRACT/SUMMARY This continuation application proposes to support 3 pre-doctoral and 3 post-doctoral trainees with a faculty of 20 drawn from six academic and research units of the University of Kentucky. The rich environment provides opportunities for translational and multidisciplinary bio-behavioral research training in facilities such as the: 1) Center on Drug and Alcohol Research/Straus Research Building; 2) Center for Drug and Alcohol Research Translation; 3) Center for Clinical and Translational Science; 4) Laboratory of Human Behavioral Pharmacology; and 5) Residential Research Facility. During the most recent five-year funding period, we trained 10 pre-doctoral students and 8 post-doctoral fellows. These trainees have authored 237 publications and presented 336 papers at local, national or international conferences. Seventeen of these trainees remain involved in research or academics. Additional pre-doctoral trainees (N=2) and post-doctoral fellows (N=3) will be added during the final year of the current funding period to keep all 6 training slots filled. Individuals from under-represented racial and ethnic groups filled 27 percent of the available training slots. The program is designed to prepare trainees to assume translational and multidisciplinary research responsibilities in academic and other scientific organizations concerned with substance-use disorders (SUDs). Pre-doctoral trainees concentrate in translational and interdisciplinary aspects of SUDs as part of a doctoral program in a behavioral science discipline (e.g., psychology, sociology). Post-doctoral fellows have a doctorate in a behavioral science discipline and are preparing for a research role in SUDs, or they are health professionals seeking translational and interdisciplinary training in a behavioral orientation in SUDs research. Basic elements of the program include: (1) training in the basic building blocks of research (e.g., experimental design, data analysis) and independent research competence; (2) a translational and interdisciplinary orientation taking students beyond their basic discipline and providing exposure to key theoretical concepts and methodological issues of the related behavioral sciences along with a bio-behavioral conceptualization; (3) professional development to support a career in SUDs research; (4) exploration of SUDs topics from a medical-behavioral perspective through courses offered by training faculty; and (5) opportunities for research around relevant questions in SUDs constituting a dissertation project for pre-doctoral trainees. The post- doctoral program is individually tailored to the objectives of the fellows and builds on their previous knowledge and experience, while drawing on these core elements. The need for a translational and interdisciplinary program such as the one proposed is greater today than ever before and fills a unique niche in substance abuse research.
50	Substance Use Disorders Treatment/Services Research Training Program	5T32DA007250-28	SORENSEN, JAMES L	PSYCHIATRY	UNIVERSITY OF CALIFORNIA, SAN FRANCISCO	SAN FRANCISCO	CA	SCHOOLS OF MEDICINE	0	5	PROJECT SUMMARY / ABSTRACT This UCSF postdoctoral training program, entering its 24th year, develops substance use disorders (SUD) treatment and services researchers. The training focuses on four areas: a) clinical trials of behavioral, pharmacological and psychosocial interventions, in both practice-based and community settings; b) services research, including organizational change, in health care systems; c) psychosocial and biological factors that interact with treatments, including genetics and neuroimaging; and d) treatment and services research in complex, comorbid populations. Trainees are admitted for two years with possibility of a third year. The exceptional trainee may enter for a one-year training program. To date the program has successfully trained 60 doctoral level psychologists, physicians, public health, and policy professionals for academic and research careers. The program's graduates have embarked on fruitful careers to improve SUD treatment through scientific study. In the most recent funding cycle the program focused on linking with mental health disciplines, conducted rigorous program evaluation, extended its emphasis on technology, and enhanced its strength in HIV health care and prevention. During the next five years we focus on technology; evolving opportunities through health care reform; health care for underserved populations such as youth and sexual and racial/ethnic minorities; and SUD and HIV prevention and care. The program is based in an environment with outstanding and highly relevant resources, including linkages with diverse clinical sites and a variety of academic centers and activities that supplement the training experience. The program is led by the Director and 4 Site Directors, an Executive Committee of Investigators, and has guidance from a Scientific and Training Advisory Committee. Core faculty members have backgrounds including psychology, psychiatry, biostatistics, nursing, public health, and epidemiology. These faculty have strong histories of mentorship, extensive experience in obtaining extramural funding, and ongoing research productivity in SUD treatment and services research. New faculty members have joined the program, bringing important lines of inquiry, research settings, and methods. The result is a scientifically productive environment that allows trainees to draw on multiple perspectives in designing and completing treatment and services research. The expectation is that program graduates will conduct independent, methodologically rigorous and clinically relevant SUD treatment and services research, contributing to the knowledge base in the field.
51	Research Training - Genetics of Substance Abuse	5T32DA017637-18	STITZEL, JERRY A	GENETICS	UNIVERSITY OF COLORADO	Boulder	CO	GRADUATE SCHOOLS	4	2	PROJECT SUMMARY This proposal seeks continued support, via an institutional training grant, for a training program for pre and postdoctoral fellows who will pursue research careers that focus on genetic influences on substance abuse. The faculty, from the Institute for Behavioral Genetics (IBG) and collaborating units, is distinguished and active in research, and IBG scientists have actively pursued studies of genetic influences on substance abuse for over 50 years. Major substance abuse-related research projects are in progress in both human and animal behavior genetics. The application of biometrical, statistical, and quantitative genetic techniques, together with bioinformatics, genome-wide analyses and next generation sequencing, and epigenetics, is providing real advances in knowledge. Neuro-chemical, -pharmacological, -physiological, and molecular genetic studies, are providing an understanding of gene function related to behavior. Since our last application, we have added a major commitment to functional and structural brain imaging as a research tool and have expanded our faculty and training program accordingly. Our research and training include the use of large scale collaborative studies that are amassing DNA repositories and rich phenotypic data sets available for studies of substance abuse. These include the Adolescent Brain Cognitive Development (ABCD) study, for which our training faculty are PIs of the twin study component, the NIDA Genetics Consortium, the Psychiatric Genetics Consortium, the UK Biobank, and GSCAN, a genome wide study of over 1 million cases. IBG facilities are available for gene function and expression studies, and behavioral, biochemical, and neurophysiological studies, and we are actively pursuing animal model studies of the functional implications of SNPs robustly associated with drug phenotypes in the human population. To reflect the expanded need for training, particularly for genetics expertise applied in the context of ABCD, brain imaging, translational research, and `big data' studies, funds are requested to support 6 pre-doctoral and 3 postdoctoral trainees. Trainees will typically be supported for up to 3 years. Pre-doctoral trainees receive doctorate degrees from a cooperating academic unit and certification in behavior genetics. Academic requirements in the training program include training in behavior genetics, quantitative and biometrical genetics, theoretical and computer-based statistics, molecular genetics, neuroscience, bioinformatics and genomics, mandatory training in the responsible conduct of research, and courses on behavioral, brain imaging, and clinical phenotypes. Additional requirements vary according to the degree granting academic unit. Research is an integral part of training. Postdoctoral trainees also pursue a formalized program that emphasizes individual research as well as competence in molecular and quantitative behavior genetics. Other activities in preparation for research careers in substance abuse include: supervision of students and/or technicians, hosting of seminar speakers and conference organization, guest lecturing, a weekly journal club, grant writing, and the development of individual professional plans.
52	Human Behavioral Pharmacology of Substance Abuse	2T32DA007209-41	STRAIN, ERIC C.	PSYCHIATRY	JOHNS HOPKINS UNIVERSITY	BALTIMORE	MD	SCHOOLS OF MEDICINE	0	8	PROJECT SUMMARY Substance use disorders occur at the interface of behavior and pharmacology. This is a proposal to renew an ongoing and successful postdoctoral clinical research training program on the human behavioral pharmacology of substance abuse, for its 41st thru 45th years. Nine training positions are proposed, all at the postdoctoral level. Training duration is two to three years. The goal is to produce experts in various aspects of substance abuse, psychopharmacology, and treatment who go on to succeed as independent clinical researchers, scientists, academicians, and administrators in drug abuse and related fields. The program has a long and successful history, with many distinguished graduates. The program will provide training and experience in translational experimental clinical trials research methods, extending from the human laboratory to the clinic. Training consists primarily of conducting supervised clinical research in collaboration with training faculty and analyzing and publishing the results, conclusions and implications of that research. Trainees attend and report at major scientific meetings and participate in an organized program of educational seminars designed to provide both breadth and depth to their knowledge and skills relevant to drug abuse and clinical research. The training program site is a multifaceted drug abuse clinical research program -- the Behavioral Pharmacology Research Unit -- plus other affiliated drug abuse treatment and research programs, primarily on the same campus, but extending more broadly into the community as well. Research training is provided in the following areas: clinical pharmacology of drugs of abuse; medications development research; the cognitive neuroscience and behavioral toxicity of drugs of abuse; abuse liability assessment; pharmacological treatment of drug abuse; behavioral treatment of drug abuse, especially incentive-based strategies; integration of behavioral and pharmacological treatments; psychiatric and medical comorbidity; behavioral and neuropsychiatric assessment; HIV risk behavior assessment; promotion of engagement and adherence; and clinical trials research methods and trials management. Training includes a broad range of abused drug classes – opioids, cocaine, prescription medications, cannabis, club drugs/psychedelics, alcohol, tobacco/nicotine, and caffeine.
53	Training Program in Substance Use, HIV and Related Infections	5T32DA023356-15	STRATHDEE, STEFFANIE A.	FAMILY MEDICINE	UNIVERSITY OF CALIFORNIA, SAN DIEGO	LA JOLLA	CA	SCHOOLS OF MEDICINE	4	4	Renewed funding is requested to continue a T32 training program to train the next generation of prevention scientists with expertise in HIV and related co-morbidities among substance users. Our program builds upon three joint doctoral programs in public health, clinical psychology and a new PhD in Interdisciplinary Research on Substance Use offered in partnership between the University of California San Diego (UCSD) School of Medicine and the San Diego State University (SDSU) Graduate Schools of Public Health and Social Work. Our objectives are: 1) To provide opportunities for interdisciplinary research training experiences for pre-doctoral students and postdoctoral fellows in epidemiology, health behavior and psychology who wish to focus on prevention research at the intersection of substance use and HIV or other infectious diseases (e.g. viral hepatitis, TB, STIs) or comorbidities; 2) To offer students hands-on experience in the study of HIV and related comorbidities in international settings which bear the greatest burden of injection drug use, HIV and related infections; 3) To recruit and train researchers from diverse academic backgrounds and under-represented minority populations (URM) with the tools needed to become independent researchers with state-of-the-art skills to address high priority challenges in HIV prevention research among substance users; and 4) To train individuals in the responsible conduct of research with human subjects, especially in international and cross- cultural settings. During the past 4 years, our program supported 31 trainees (12 predoctoral and 19 postdoctoral fellows; 12 (39%) were URM). Of completed trainees (8 predocs and 16 postdocs), all but 1 predoc and 1 postdoc are still active in the field. Time to matriculation for predocs averaged 4.1 years. Three completed predocs are Assistant Professors, 2 are postdocs funded by other NIDA T32s, and two are in applied positions that include research. Seven K01s were newly awarded to postdocs with 3 more pending NGAs; half of these were URM. Our 31 predocs and postdocs published 82 and 141 manuscripts, respectively, almost half of which were first authored. We request support for 4 predoctoral and 4 postdoctoral trainees, who will be mentored from a pool of 25 Preceptors. Depending on their level of training, mentees complete courses in substance use and infectious diseases, instruction in responsible conduct of research, quarterly cultural sensitivity training workshops, seminars on scientific rigor, presentations on 'Work In Progress', and new seminars (e.g., Writing Circle). Our active research projects in nearby Mexico (6 R01s) and several other international settings offer the opportunity for unique, hands-on international training experiences and a robust infrastructure for trainees to develop into independent investigators.
54	Research Training Program in Substance Abuse Prevention	5T32DA019426-17	TEBES, JACOB K	PSYCHIATRY	YALE UNIVERSITY	NEW HAVEN	CT	SCHOOLS OF MEDICINE	0	6	Project Summary/Abstract This renewal application requests continued support for the Postdoctoral Research Training Program in Substance Abuse Prevention at Yale University. The host site for the program will continue to be the Division of Prevention and Community Research in the Yale Department of Psychiatry, along with two primary partner sites in Psychiatry: the Division of Addictions and the Yale Stress Center. In addition, the program will continue to draw on faculty in three other Yale sites: Women's Health Research at Yale, the Yale School of Public Health, and the Yale Child Study Center. Faculty have a strong track record of scholarship in substance abuse prevention and longstanding collaborations as researchers and mentors. This application builds on the success of our current training program originally funded by NIDA in 2005 and renewed in 2010 and 2015. Our request for renewal funding is based on the continuing demand for advanced training in rigorous, interdisciplinary, community-based translational research focused on substance abuse prevention. The program trains six postdoctoral fellows across two years: 1) to understand drug abuse and addiction and related behaviors within an ecological framework that emphasizes relevant developmental, family, social, cultural, and neurobiological contexts; 2) to enhance knowledge in pre-intervention, implementation, and dissemination research; 3) to learn state-of-the-art data analytic methods that incorporate rigorous field and laboratory research methods, including mixed method designs; 4) to gain experience in interdisciplinary research through collaborations with scientists working in interdisciplinary teams across departments, centers, and programs; and 5) to increase knowledge about the translation of research into real-world contexts in order to impact prevention practice and policy, and ultimately, public health. These program objectives are reinforced in mentored relationships with two scientific advisors, didactic seminars, and individually-tailored experiences based on each fellow’s Individual Development Plan. The training aligns with NIDA research objectives and cross-cutting priorities. Over the past 14 years, the program has enrolled 38 fellows, who have virtually gone on to careers as prevention scientists. More than three-quarters are faculty in academic settings, and others are employed as prevention scientists in interdisciplinary research organizations. The program has also been successful in training fellows from diverse backgrounds; 26% identify as an underrepresented racial/ethnic minority and 13% identify as other racial/ethnic minorities.
55	Postdoctoral Training in the Biology of Drug Abuse	5T32DA007268-30	TRAYNOR, JOHN R.	PHARMACOLOGY	UNIVERSITY OF MICHIGAN AT ANN ARBOR	ANN ARBOR	MI	SCHOOLS OF MEDICINE	0	6	Abstract The overall purpose of this training grant is to provide postdoctoral training to young basic scientists and physicians in the area of neurobiology of substance abuse, with a focus on the mode of action of psychostimulant and opiate drugs at the genetic, molecular, circuit and behavioral levels. Our objective is to provide an exciting and innovative environment with world class facilities and faculty to develop the next generation of scientists working in drug abuse. Training will take place in the multidisciplinary setting at the University of Michigan. The faculty members are all NIDA grantees (or co-Investigators) and have expertise in the neurobiology of substance abuse, with particular emphasis on the area of opioid and psychostimulant drugs. The focus of the proposal is the training of postdoctoral fellows in state-of-the-art approaches for studying mechanisms underlying abuse of psychoactive drugs. This includes studying the genetic, developmental and environmental factors that lead to vulnerability to substance abuse; the mode of action of drugs of abuse at the molecular, cellular, anatomical and behavioral levels; and the long-term consequences of psychoactive drugs on the brain, as mediated through mechanisms of neural plasticity; and the development of medications, and prevention strategies. The working assumption is that the functional and structural brain remodeling associated with chronic drug use lies at the basis of tolerance, sensitization, physical dependence, and psychological addiction to these drugs. The drug abuse research community at the University of Michigan is of high quality and has a long history in the field. Beyond their individual strengths, the training faculty members have long-standing collaborative scientific and training relationships with each other. These historical strengths have recently been further enhanced with a number of initiatives at the University of Michigan, designed to facilitate life science research in general, and neuroscience research in particular. They include state-of-the- art tools for mouse and rat genetics, genomics, proteomics, and informatics. Thus, our postdoctoral fellows will profit from a highly sophisticated, yet supportive, research and training environment.
56	Training Program: Drugs of Abuse & Related Neuropeptides	5T32DA007237-32	UNTERWALD, ELLEN M	PHARMACOLOGY	TEMPLE UNIV OF THE COMMONWEALTH	PHILADELPHIA	PA	SCHOOLS OF MEDICINE	6	4	Project Summary/Abstract The Drugs of Abuse Training Program prepares predoctoral students and postdoctoral fellows for successful independent careers in the field of substance abuse research. This program has been the cornerstone of interdisciplinary basic science training in addiction, drugs of abuse, and HIV/AIDS at Temple University since 1988. This application is requesting continuation of the program at the current level of support, 6 predoctoral students and 4 postdoctoral fellows. The Drugs of Abuse Training Program is administered through the Center for Substance Abuse Research (CSAR) at the Lewis Katz School of Medicine. CSAR brings together faculty from multiple disciplines who share a common interest in researching topics related to the neurobiology of addiction, pharmacology of drugs of abuse, and the intersection of drugs of abuse with immune function including HIV/AIDS. This common goal creates a rich, highly collaborative environment for trainees who’s research often extends beyond a single laboratory. The Drugs of Abuse Training Program is supported by a cadre of dedicated faculty mentors who are devoted to the education and training of the next generation of scientists. These faculty are highly successful researchers as evidenced by their excellent extramural research funding and strong publication records. The program provides rigorous training in scientific methods, experiment design, data analysis, and research ethics. It includes didactic instruction through a set of core courses and seminars focusing on the pharmacology of drugs of abuse, neurobiology of addiction, and neuroimmunology. Excellence in scientific communication is achieved through coursework and practical opportunities for written and oral presentations. Participation in seminars, meetings with visiting scientists, journal club, scientific retreats, annual self-assessments and faculty evaluations of progress results in trainees who are exceedingly well-prepared for the next step in their scientific careers. The program promotes the highest level of scientific integrity and ethics, along with personal and public accountability in the conduct of science. The Drugs of Abuse Training Program at Temple University has been effective in recruiting outstanding trainees including individuals from diverse backgrounds and has a near perfect record of retention. Trainees complete the program with excellent credentials and go on to successful careers in academia, industry, government and other science- related employment, thus fulfilling the NIH directive to improve human health. The Drugs of Abuse Training Program is a critical resource for supporting students and postdoctoral fellows and advancing the field of substance abuse research.
57	Biological Bases of Drug-Seeking Behavior	5T32DA007262-29	WILLIAMS, JOHN T	OTHER BASIC SCIENCES	OREGON HEALTH & SCIENCE UNIVERSITY	PORTLAND	OR	SCHOOLS OF MEDICINE	5	4	Project Summary / Abstract This program for pre- and post-doctoral training supports the training of specialists who are able to conduct preclinical research at levels ranging from the molecular to the cognitive/clinical on the biological mechanisms underlying the development, maintenance, and elimination of drug-seeking behavior. Twenty-three members of the graduate faculty of the Oregon Health & Science University (OHSU) serve as preceptors for postdoctoral research fellows and for Ph.D. students matriculating into basic science graduate programs in behavioral neuroscience, neuroscience, physiology and pharmacology, or biochemistry. Major research areas represent four levels. Some faculty members work primarily at the cellular/molecular level, using molecular biological, cell biological, and electron microscopic techniques. Other faculty work principally at the level of physiological, biochemical and pharmacological systems, using receptor binding, autoradiography, in vivo microdialysis and voltammetry, and electrophysiological techniques, and some work primarily in behavioral pharmacology and pharmacogenetics, using behavioral testing, intravenous drug self-administration, quantitative genetics and genetic mapping, as well as computer modelling techniques. Finally, some faculty work with human subjects, using cognitive testing and a variety of imaging techniques. Areas of extensive existing faculty collaboration include: studies of dopaminergic systems, ranging from molecular biology to behavior; extensive studies of genetic determinants of drug responses, at all levels from molecular to statistical gene mapping; and the study of learned and unlearned determinants of responses to drugs, particularly their rewarding effects and drug self- administration. Sensitivity, tolerance, and dependence/withdrawal phenomena for all major classes of drugs of abuse are under active investigation. Training includes firm curricular grounding in the basic sciences, specific pharmacological training in abused drugs, and extensive and continuous participation in research. Trainees also receive extensive instruction in the responsible conduct of research through interactive seminars that cover ethical considerations in all aspects of science. OHSU and this training program have put considerable efforts into recruiting and retaining trainees from diverse backgrounds. These efforts have resulted in a significantly more diverse pool of graduate students and postdoctoral fellows receiving training in the biological basis of drug-seeking behavior.
58	Training Program in Substance Use and Use Disorders	5T32DA050558-02	WOOD, MARCELO ANDRES	OTHER BASIC SCIENCES	UNIVERSITY OF CALIFORNIA-IRVINE	IRVINE	CA	SCHOOLS OF ARTS AND SCIENCES	4	0	Drug abuse and addiction represent major health issues both in the United States and worldwide. In the United States alone costs related to loss of work, crime, and health care exceed $700 billion a year. The field of addiction spans numerous disciplines including, but not limited to, medicine, psychiatry, neurobiology, pharmacology, public health, and law, illustrating the impact that drugs of abuse and addiction have on the human condition. We are currently experiencing an amazing growth of technologies yielding new insights into the biological effects of drugs of abuse and mechanisms for the development of dependence and addiction. At UC Irvine, the community of faculty and researchers studying the neurobiology of addiction is rapidly growing with support from the UC Irvine Center for Addiction Neuroscience (ICAN), a new NIDA P50 Center of Excellence called the Impact of Cannabinoids Across Lifespan (ICAL), and a new center focused on the medical and legislative challenges of legalized marijuana (Center for the Study of Cannabis). The goal of the proposed Training Program in Substance Use and Use Disorders is to train the next generation of innovative researchers in the field of addiction neuroscience by leveraging the exceptional strength in neuroscience at UCI, and the new centers focused on addiction research, to provide an educational and research experience that will position trainees as new leaders in the field. The training program is focused on predoctoral students and will provide the following: 1) a modern and interdisciplinary neurobiology of addiction course; 2) two courses related to cannabinoids and the endocannabinoid system that dovetail with the P50 ICAL research endeavors; 3) an annual addiction neuroscience symposium; 4) a training program annual retreat; 5) a scientific writing course; 6) a public speaking course provided by Activate to Captivate; 7) an addiction research seminar series; 8) a journal club; 9) instruction in methods for enhancing reproducibility; and 10) conference presentations. This will be the first training program on campus that is specifically focused on drugs of abuse and addiction. Together, the new centers focused on addiction bring together scientists and clinicians from over a dozen departments and four schools to address the grand challenges in this field, to train and educate the next generation of investigators and clinicians, and to disseminate important information to the public.
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