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Neuro / dementia laboratory codes
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CMS CLFS — October 1, 2026 | 24 biomarker and dementia-specific codes
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CodeFull code descriptionPLA test / manufacturer or laboratoryCLFS price ($)PAMA prelim median ($)Reporting TINsOridinalRatio
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0035UNeurology (prion disease), cerebrospinal fluid, detection of prion protein by quaking-induced conformational conversion, qualitativeRT-QuIC prion detection — National Prion Disease Pathology Surveillance Center$540.99$432.79MASKED TIN10.8
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0206UNeurology (alzheimer disease); cell aggregation using morphometric imaging and protein kinase c-epsilon (pkce) concentration in response to amylospheroid treatment by elisa, cultured skin fibroblasts, each reported as positive or negative for alzheimer diseaseDISCERN — NeuroDiagnostics, Inc. (dba Synaps Dx)$2,215.40$2,171.09MASKED TIN21.0
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0207UNeurology (alzheimer disease); quantitative imaging of phosphorylated erk1 and erk2 in response to bradykinin treatment by in situ immunofluorescence, using cultured skin fibroblasts, reported as a probability index for alzheimer disease (list separately in addition to code for primary procedure)DISCERN (AD Index component) — NeuroDiagnostics, Inc. (dba Synaps Dx)$511.20$500.98MASKED TIN31.0
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0289UNeurology (alzheimer disease), mrna, gene expression profiling by rna sequencing of 24 genes, whole blood, algorithm reported as predictive risk scoreMindX Blood Test / MindX One — Memory/Alzheimer’s; MindX Sciences Laboratory / MindX Sciences, Inc.$760.00EMPTY4x
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0358UNeurology (mild cognitive impairment), analysis of b-amyloid 1-42 and 1-40, chemiluminescence enzyme immunoassay, cerebral spinal fluid, reported as positive, likely positive, or negativeLumipulse G β-Amyloid Ratio (1-42/1-40) Test — Fujirebio Diagnostics, Inc.$260.50$260.40MASKED TIN51.0
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0393UNeurology (eg, parkinson disease, dementia with lewy bodies), cerebrospinal fluid (csf), detection of misfolded -synuclein protein by seed amplification assay, qualitativeSAAmplify-αSYN (formerly SYNTap) Biomarker Test — Amprion Clinical Laboratory$540.99$540.99MASKED TIN61.0
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0412UBeta amyloid, ab42/40 ratio, immunoprecipitation with quantitation by liquid chromatography with tandem mass spectrometry (lc-ms/ms) and qualitative apoe isoform-specific proteotyping, plasma combined with age, algorithm reported as presence or absence of brain amyloid pathologyPrecivityAD blood test — C2N Diagnostics, LLC$750.00$735.30MASKED TIN71.0
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0443UNeurofilament light chain (nfl), ultra-sensitive immunoassay, serum or cerebrospinal fluidNeurofilament Light Chain (NfL) — Neuromuscular Clinical Laboratory, Washington University in St. Louis School of Medicine$116.23$205.88MASKED TIN81.8
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0445UB-amyloid (abeta42) and phospho tau (181p) (ptau181), electrochemiluminescent immunoassay (eclia), cerebral spinal fluid, ratio reported as positive or negative for amyloid pathologyElecsys Phospho-Tau (181P) CSF / β-Amyloid (1-42) CSF II Ratio — Roche Diagnostics Operations, Inc.$260.50EMPTY9x
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0459UB-amyloid (abeta42) and total tau (ttau), electrochemiluminescent immunoassay (eclia), cerebral spinal fluid, ratio reported as positive or negative for amyloid pathologyElecsys Total-Tau CSF / β-Amyloid (1-42) CSF II Ratio — Roche Diagnostics Operations, Inc.$260.50EMPTY10x
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0479UTau, phosphorylated, ptau217ALZpath pTau217 — Neurocode USA, Inc. (Quanterix/ALZpath assay)$17.27$18.13MASKED TIN111.0
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0503UNeurology (alzheimer disease), beta amyloid (ab40, ab42, ab42/40 ratio) and tau-protein (ptau217, np-tau217, ptau217/nptau217 ratio), blood, immunoprecipitation with quantitation by liquid chromatography with tandem mass spectrometry (lc-ms/ms), algorithm score reported as likelihood of positive or negative for amyloid plaquesPrecivityAD2 — C2N Diagnostics, LLC$750.00$735.0011121.0
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0547UNeurofilament light chain (nfl), chemiluminescent enzyme immunoassay, plasma, quantitativeNeurofilament Light Blood Test — Neurocode USA, Inc.; Fujirebio Diagnostics, Inc.$116.23EMPTY13x
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0548UGlial fibrillary acidic protein (gfap), chemiluminescent enzyme immunoassay, using plasmaGlial Fibrillary Acidic Protein Blood Test — Neurocode USA, Inc.; Fujirebio Diagnostics, Inc.$116.23EMPTY14x
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0568UNeurology (dementia), beta amyloid (ab40, ab42, ab42/40 ratio), tau-protein phosphorylated at residue (eg, ptau217), neurofilament light chain (nfl), and glial fibrillary acidic protein (gfap), by ultra-high sensitivity molecule array detection, plasma, algorithm reported as positive, intermediate, or negative for alzheimer pathologyLucentAD Complete — Quanterix Corporation$897.00EMPTY15x
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0584UNeurology (prion disease), cerebrospinal fluid, detection of prion protein by quakinginduced conformational conversion, qualitativeRT-QuIC Prion, CSF — Mayo Clinic Laboratories$540.99EMPTY16x
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0596UNeurology (alzheimer disease), plasma, 3 distinct isoform-specific peptides (apoe2, apoe3, and apoe4) by liquid chromatography with tandem mass spectrometry (lcms/ms), reported as an apoe prototypePrecivity–ApoE — C2N Diagnostics, LLC$0.00EMPTY17x
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0616UNeurology (dementia), dna methylation analysis of more than 30,000 sites, whole blood, algorithm reported as positive or negative riskTruD MDS Alzheimer’s & MCI — TruDiagnostic, Inc.$0.00EMPTY18x
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0649UNeurology (alzheimer disease), dna, targeted next-generation sequencing (ngs) of ad-1 and ad-2 target regions, whole blood, prognostic algorithmic analysis, reported as categorization of cognitive statusMAP-AD — ADmit Therapeutics S.L.$0.00EMPTY19x
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82233Beta-amyloid; 1-40 (abeta 40)$128.92$175.0057201.4
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82234Beta-amyloid; 1-42 (abeta 42)$128.92$175.0072211.4
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83884Neurofilament light chain (nfl)$116.23$210.0058221.8
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84393Tau, phosphorylated (eg, ptau 181, ptau 217), each$128.92$210.00101231.6
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84394Tau, total (ttau)$128.92$159.1829241.2
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Price noteA $0.00 listed rate usually indicates a code under current-year gapfill, or a code so new that it has not yet gone through the summer pricing meeting.
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Zero rates are reproduced from the supplied CLFS file; $0.00 should not be read as an established zero-dollar payment amount.
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ScopeIncludes tau, beta-amyloid, NfL, GFAP, dementia-specific assays, and multi-marker / algorithmic PLA tests. Broad genetic-code matches are on the related sheet.
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