Selective Activation Of Members Of The Signal Transducers And Activators Of Transcription Family In Prostate Carcinoma

doi: 10.1016/s0022-5347(05)65249-4

Fernando De Miguel

Jennifer Rubin Grandis

Stat3 enhances the growth of LNCaP human prostate cancer cells in intact and castrated male nude mice

Fernando De Miguel

Mutations in the helix 3 region of the androgen receptor abrogate ARA70 promotion of 17beta-estradiol-induced androgen receptor transactivation

doi: 10.1074/jbc.m202824200

Journal of Biological Chemistry

Activation of mitogen-activated protein kinase pathway by the antiandrogen hydroxyflutamide in androgen receptor-negative prostate cancer cells

Edward M Messing

Interleukin-4 enhances prostate-specific antigen expression by activation of the androgen receptor and Akt pathway

Interleukin-6 promotes androgen-independent growth in LNCaP human prostate cancer cells

Clinical cancer research : an official journal of the American Association for Cancer Research

Fernando De Miguel

Interruption of nuclear factor kappaB signaling by the androgen receptor facilitates 12-O-tetradecanoylphorbolacetate-induced apoptosis in androgen-sensitive prostate cancer LNCaP cells

Kuang-Hsiang Chuang

LeRoy A Hanchett

Cytochrome P450 genes are differentially expressed in female and male hepatocyte retinoid X receptor alpha-deficient mice

Kuang-Hsiang Chuang

Chawnshang Chang

Interleukin-6 protects LNCaP cells from apoptosis induced by androgen deprivation through the Stat3 pathway

Candace S. Johnson

Functional domain and motif analyses of androgen receptor coregulator ARA70 and its differential expression in prostate cancer

Journal of Biological Chemistry

Androgen Receptor Regulates Expression of Skeletal Muscle–Specific Proteins and Muscle Cell Types

Kuang-Hsiang Chuang

LeRoy A. Hanchett

Hong-Chiang Chang

Stat3 activation of NF-{kappa}B p100 processing involves CBP/p300-mediated acetylation

doi: 10.1073/pnas.0509808103

Proceedings of the National Academy of Sciences

Nagalakshmi Nadiminty

Promotion of bladder cancer development and progression by androgen receptor signals

JNCI Journal of the National Cancer Institute

Hiroshi Miyamoto

Yoshinobu Kubota

Edward M Messing

ASC-J9 ameliorates spinal and bulbar muscular atrophy phenotype via degradation of androgen receptor

Hiroshi Miyamoto

Interleukin-4 activates androgen receptor through CBP/p300

Nagalakshmi Nadiminty

Susceptibility to autoimmunity and B cell resistance to apoptosis in mice lacking androgen receptor in B cells

Molecular Endocrinology

Kuang-Hsiang Chuang

Hong-Chiang Chang

Targeting the Unique Methylation Pattern of Androgen Receptor (AR) Promoter in Prostate Stem/Progenitor Cells with 5-Aza-2′-deoxycytidine (5-AZA) Leads to Suppressed Prostate Tumorigenesis

doi: 10.1074/jbc.m112.395574

Journal of Biological Chemistry

Chiung-Kuei Huang

Suppressed prostate epithelial development with impaired branching morphogenesis in mice lacking stromal fibromuscular androgen receptor

Molecular Endocrinology

Shinichi Yamashita

Differential androgen deprivation therapies with anti-androgens casodex/bicalutamide or MDV3100/Enzalutamide versus anti-androgen receptor ASC-J9(R) Lead to promotion versus suppression of prostate cancer metastasis

doi: 10.1074/jbc.m113.477216

Journal of Biological Chemistry

Suppression of androgen receptor enhances the self-renewal of mesenchymal stem cells through elevated expression of EGFR

doi: 10.1016/j.bbamcr.2013.01.007

Biochimica et Biophysica Acta

Chiung-Kuei Huang

Loss of androgen receptor promotes adipogenesis but suppresses osteogenesis in bone marrow stromal cells

doi: 10.1016/j.scr.2013.06.001

Chiung-Kuei Huang

New therapy targeting differential androgen receptor signaling in prostate cancer stem/progenitor vs. non-stem/progenitor cells

Journal of Molecular Cell Biology

Shinichi Yamashita

Chiung-Kuei Huang

Chawnshang Chang

IL-6 signaling contributes to cisplatin resistance in non-small cell lung cancer via the up-regulation of anti-apoptotic and DNA repair associated molecules

doi: 10.18632/oncotarget.4753

IL-6 signaling promotes DNA repair and prevents apoptosis in CD133+ stem-like cells of lung cancer after radiation

doi: 10.1186/s13014-015-0534-1

TR4 nuclear receptor promotes prostate cancer metastasis via upregulation of CCL2/CCR2 signaling

International Journal of Cancer

Infiltrated pre-adipocytes increase prostate cancer metastasis via modulation of the miR-301a/androgen receptor (AR)/TGF-β1/Smad/MMP9 signals

doi: 10.18632/oncotarget.3619

Hong-Chiang Chang

John J. Krolewski

Infiltrating neutrophils promote renal cell carcinoma (RCC) proliferation via modulating androgen receptor (AR) → c-Myc signals

doi: 10.1016/j.canlet.2015.07.027

Luke Sien-Shih Chang

Targeting TR4 nuclear receptor suppresses prostate cancer invasion via reduction of infiltrating macrophages with alteration of the TIMP-1/MMP2/MMP9 signals

doi: 10.1186/s12943-014-0281-1

Androgen receptor (AR) suppresses miRNA-145 to promote renal cell carcinoma (RCC) progression independent of VHL status

doi: 10.18632/oncotarget.4522

Infiltrating T cells promote prostate cancer metastasis via modulation of FGF11→miRNA-541→androgen receptor (AR)→MMP9 signaling

doi: 10.1016/j.molonc.2014.07.013

Hong-Chiang Chang

A FASN-TGF-β1-FASN regulatory loop contributes to high EMT/metastatic potential of cisplatin-resistant non-small cell lung cancer

doi: 10.18632/oncotarget.10837

Kuang-Hsiang Chuang

IL-6 promotes growth and epithelial-mesenchymal transition of CD133+ cells of non-small cell lung cancer

doi: 10.18632/oncotarget.6570

Recruited mast cells in the tumor microenvironment enhance bladder cancer metastasis via modulation of ERβ/CCL2/CCR2 EMT/MMP9 signals

doi: 10.18632/oncotarget.5467

Chawnshang Chang

Radiation alters PD-L1/NKG2D ligand levels in lung cancer cells and leads to immune escape from NK cell cytotoxicity via IL-6-MEK/Erk signaling pathway

doi: 10.18632/oncotarget.19193

Simultaneous targeting of ATM and Mcl-1 increases cisplatin sensitivity of cisplatin-resistant non-small cell lung cancer

doi: 10.1080/15384047.2017.1345391

Cancer Biology & Therapy

Enhancing NK cell-mediated cytotoxicity to cisplatin-resistant lung cancer cells via MEK/Erk signaling inhibition

doi: 10.1038/s41598-017-08483-z

Neuroendocrine differentiation contributes to radioresistance development and metastatic potential increase in non-small cell lung cancer

doi: 10.1016/j.bbamcr.2018.09.005

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Increased infiltration of macrophages to radioresistant lung cancer cells contributes to the development of the additional resistance of tumor cells to the cytotoxic effects of NK cells

International Journal of Oncology

In vitro -induced M2 type macrophages induces the resistance of prostate cancer cells to cytotoxic action of NK cells

doi: 10.1016/j.yexcr.2018.01.041

Experimental Cell Research

Adipocytes affect castration‐resistant prostate cancer cells to develop the resistance to cytotoxic action of NK cells with alterations of PD‐L1/NKG2D ligand levels in tumor cells

FASN-TGF-β1-PD-L1 axis contributes to the development of resistance to NK cell cytotoxicity of cisplatin-resistant lung cancer cells

doi: 10.1016/j.bbalip.2017.12.012

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

Inhibition of IL-6-JAK/Stat3 signaling in castration-resistant prostate cancer cells enhances the NK cell-mediated cytotoxicity via alteration of PD-L1/NKG2D ligand levels

doi: 10.1002/1878-0261.12135

Radiation-induced glucocorticoid receptor promotes CD44+ prostate cancer stem cell growth through activation of SGK1-Wnt/β-catenin signaling

doi: 10.1007/s00109-019-01807-8

Journal of Molecular Medicine

Glucocorticoid receptor upregulation increases radioresistance and triggers androgen independence of prostate cancer

IL-6 signaling contributes to radioresistance of prostate cancer through key DNA repair-associated molecules ATM, ATR, and BRCA 1/2

doi: 10.1007/s00432-019-02917-z

Journal of Cancer Research and Clinical Oncology