ABCDEFGHIJKLMNOPQRSTUVWXYZAAABACADAEAFAGAHAIAJAKALAM
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First AuthorMM/YYYYOutcome
1. Study Participation (Risk of Selection Bias)
2. Study Attrition (Risk of Attrition Bias)
3. Prognostic Factor Measurement (Risk of Measurement Bias)
4. Outcome Measurement (Risk of Measurement Bias)
5. Study Confounding (Risk of Bias from confounding factors)
6. Statistical Analysis and Reporting (Risk of Statistical analysis bias)
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Source population is adequately described for key characteristicsSampling frame and recruitment are adequately describedInclusion and exclusion criteria are adequately describedThere is adequate participation in the study by eligible individualsThe baseline study sample is adequately described for key characteristicsRisk of selection bias judgement (High/ Moderate/ Low)Response rate is adequate and is > 80%Attempts to collect information on participants who dropped out of the study are describedReasons for loss to follow up are describedNo important differences between key characteristics + outcomes in participants who completed the study and those who did notRisk of Attrition bias judgement (High/ Moderate/ Low)A clear definition or description of the prognostic factors is providedMethod of prognostic factor measurement is adequately valid + reliable to limit misclassification biasThe prognostic factors measured are blinded for outcome measureContinuous variables are reported or appropriate cut-offs are usedThe method and setting of measurement of PF is the same for all study participantsMore than 80% of the study sample has completed data for PF variableAppropriate methods of imputation are used for missing ‘PF’ dataRisk of PF measurement bias judgement (High/ Moderate/ Low)A clear definition of the Outcome is providedThe method of outcome measurement used in valid and reliable to limit misclassification biasThe method and setting of outcome measurement is the same for all study participantsRisk of outcome measurement bias judgement (High/ Moderate/ Low)All important confounders are measuredClear definitions of the important confounders measured are providedThe method and setting of confounding measurement are the same for all study participantsImportant potential confounders are accounted for in the study designImportant potential confounders are accounted for in the analysisRisk of confounding bias judgement (High/ Moderate/ Low)There is sufficient presentation of data to assess the adequacy of the analysisThe strategy for model building is appropriate and is based on a conceptual framework or modelThe selected statistical model is adequate for the design of the studyThere is a description of the association of the prognostic factor + outcome, including info re. statistical significanceContinuous variables are reported or cut-off points are usedThere is no selective reporting of resultsRisk of statistical analysis bias judgement (High/ Moderate/ Low)
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AbumayyalehMar-21mortalityYesYesPartialYesYesLowYesYesYesYesLowYesYesYesYesYesNoNoModerateYesYesYesLowNoYesYesNoPartialModerateYesNoYesYesYesYesModerate
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Ahlstrom01/2021mortalityYesYesYesYesYesLowYesYesYesYesLowYesYesYesYesYesNoyesLowYesYesYesLowYesYesYesYesNoModerateYesYesYesYesYesYesLow
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Al- salameh11/2020ICU admissionYesYesYesYesYesLowYesYesYesYesLowYesYesYesYesYesYesNoLowYesYesYesLowYesPartiallyYesNoYesModerateYesYesYesYesYesYesLow
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Al- salameh11/2020mortalityYesYesYesYesYesLowYesYesYesYesLowYesYesYesYesYesYesNoLowYesYesYesLowYesPartiallyYesNoYesModerateYesYesYesYesYesYesLow
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Al- salameh11/2020mechanical ventilationYesYesYesYesYesLowYesYesYesYesLowYesYesYesYesYesYesNoLowYesYesYesLowYesPartiallyYesNoNoHighYesYesYesYesYesYesLow
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Al-sabah10/2020ICU admissionYesYesYesYesYesLowYesYesYesYesLowYesYesYesYesYesNoNoModerateYesYesYesLowYesYesYesNoNoModerateYesYesYesYesYesYesLow
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Alkhatib08/2020ICU admissionYesYesYesNoYesModerateYesYesYesYesLowNoPartiallyYesYesYesYesNoModerateYesYesYesLowYesNoYesNoYesModerateNoYesNoYesNoNoHigh
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Anderson07/2021mortality (patients requiring intubation)NoYesNoUnsureNoHighYesYesYesYesLowYesYesYesYesYesYesYesLowYesYesYesLowYesYesYesNoYesLowNoYesYesNoYesNoHigh
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Andrea Giacomelli 08/ 2020Mortality yesyespartial yesyeslowyesyes yesyeslowyesyesnoyesyesyesyeslowyesyesyeslownoyesyesno no high yesno yesnoyesyesmoderate
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Ankeet S. BhattJan-21mortalityYesYesYesYesYesLowYesnoYesYesmodnoyesunsureUnsureyesYesYesmodyesYesYesLowYespartialYesNoYesLowYesYesYesYesYesNolow
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Apea01/2021mortalityYesYesYesYesYesLowYesYesYesYesLowYesYesYesYesYesYesYesLowYesYesYesLowYesYesYesNoNoModerateYesYesYesYesYesYesLow
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Arcelia Guerson2020MortalityPartialNoYesYesYesModerateYesYesYesYesLowYesYesNoYesYesYesYesLowYesYesYesLowNoNoYesYesYesModerateYesYesYesYesYesNoModerate
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Argenziano05/2020mortalityYesYesYesYesYesLowYesYesYesYesLowYesYesYesYesYesYesNoModerateYesYesYesLowYesPartiallyYesNoNoHighYesYesYesYesYesYesLow
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Argenziano05/2020mechanical ventilationYesYesYesYesYesLowYesYesYesYesLowYesYesYesYesYesYesNoModerateYesYesYesLowYesPartiallyYesNoNoHighYesYesYesYesYesYesLow
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Ashuin Kammar-García 05/2020Mortalityyesyespartialyesnomoderateunsureunsureunsureunsurehighnonoyesnounsureunsureunsurehighnoyesyesmoderateyespartialyesyespartialmoderateyesnonoyesyesunsurehigh
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Ashuin Kammar-García 05/2020ICU Admissionyesyespartialyesnomoderateunsureunsureunsureunsurehighnonoyesnounsureunsureunsurehighyesyesyeslowyespartialyesyespartialmoderateyesnonoyesyesunsurehigh
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Ashuin Kammar-García 05/2020Mechanical ventilationyesyespartialyesnomoderateunsureunsureunsureunsurehighnonoyesnounsureunsureunsurehighyesyesyeslowyespartialyesyespartialmoderateyesnonoyesyesunsurehigh
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Ashuin Kammar-García 05/2020Pneumoniayesyespartialyesnomoderateunsureunsureunsureunsurehighnonoyesnounsureunsureunsurehighnonoyeshighyespartialyesyespartialmoderateyesnonoyesyesunsurehigh
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Ashuin Kammar-García 05/2020Hospitalizationyesyespartialyesnomoderateunsureunsurenounsurehighnonoyesnounsureunsureunsurehighyesyesyeslowyespartialyesyespartialmoderateyesnonoyesyesunsurehigh
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AwadFeb-21ICU admission (Entire cohort)YesYesYesYesYesLowYesYesYesYesLowYesNoYesYesNoYesYesModerateYesYesYesLowNoPartialYesNoNoHighYesYesYesYesNoYesLow
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AwadFeb-21mechanical ventilation(Entire cohort)YesYesYesYesYesLowYesYesYesYesLowYesNoYesYesNoYesYesModerateYesYesYesLowNoPartialYesNoNoHighYesYesYesYesNoYesLow
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AwadFeb-21ICU admission (patients with mild to moderate symptoms)YesYesYesYesNoLowYesYesYesYesLowYesNoYesYesNoYesYesModerateYesYesYesLowNoPartialYesNoNoHighNoYesYesYesNoNoModerate
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AwadFeb-21mechanical ventilation(patients with mild to moderate symptoms)YesYesYesYesNoLowYesYesYesYesLowYesNoYesYesNoYesYesModerateYesYesYesLowNoPartialYesNoNoHighNoYesYesYesNoNoModerate
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AwadFeb-21ICU admission (patients with severe symptoms)YesYesYesYesNoLowYesYesYesYesLowYesNoYesYesNoYesYesModerateYesYesYesLowNoPartialYesNoNoHighNoYesYesYesNoNoModerate
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AwadFeb-21mechanical ventilation(patients with severe symptoms)YesYesYesYesNoLowYesYesYesYesLowYesNoYesYesNoYesYesModerateYesYesYesLowNoPartialYesNoNoHighNoYesYesYesNoNoModerate
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Baronio12/2020ICU admissionYesYesYesNoYesModerateYesYesYesYesLowYesYesYesYesYesYesYesLowYesYesYesLowNoYesYesNoPartiallyModerateYesYesYesYesYesYesLow
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Baronio12/2020mortality (Entire cohort)YesYesYesNoYesModerateYesYesYesYesLowYesYesYesYesYesYesYesLowYesYesYesLowNoYesYesNoPartiallyModerateYesYesYesYesYesYesLow
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Baronio12/2020mortality (ICU admitted patients)YesYesNoNoyesModerateYesYesYesYesLowYesYesYesYesYesYesYesLowYesYesYesLowYesYesYesNoPartiallyModerateYesYesYesYesYesYesLow
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Bartoletti11/2020Severe COVID-19 (Derivation cohort)YesYesYesYesYesLowYesYesYesYesLowYesYesYesYesYesYesNoLowYesYesYesLowYesYesYesYesYesLowYesYesYesYesYesYesLow
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Bartoletti11/2020Severe COVID-19 (validation cohort)YesYesYesYesYesLowYesYesYesYesLowYesYesYesYesYesYesNoLowYesYesYesLowYesYesYesYesYesLowYesYesYesYesYesYesLow
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Bella- Chavolla05/2020mortalityYesYesNoYesYesLowYesYesYesYesLowNoYesYesNoYesYesYesModerateYesYesYesLowYesYesYesNoYesLowYesYesYesYesPartiallyYesLow
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Bella- Chavolla05/2020ICU admissionYesYesNoYesYesLowYesYesYesYesLowNoYesYesNoYesYesYesModerateYesYesYesLowYesYesYesNoYesLowYesYesYesYesPartiallyYesLow
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Bella- Chavolla05/2020mechanical ventilationYesYesNoYesYesLowYesYesYesYesLowNoYesYesNoYesYesYesModerateYesYesYesLowYesYesYesNoYesLowYesYesYesYesPartiallyYesLow
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Bella- Chavolla05/2020hospitalizationYesYesNoYesYesLowYesYesYesYesLowNoYesYesNoYesYesYesModerateYesYesYesLowYesYesYesNoYesLowYesYesYesYesPartiallyYesLow
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BelliniMar-21hospitalization (Entire cohort)YesYesPartialYesYesLowYesYesYesYesLowYesYesYesYesYesNoNoModerateYesYesYesLowYesYesYesNoPartialLowNoYesYesYesYesNoModerate
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BelliniMar-21hospitalization (patients <70 years old)YesYesNoUnclearNoModerateYesYesYesYesLowYesYesYesYesYesNoNoModerateYesYesYesLowYesYesYesNoPartialLowNoYesYesYesYesNoModerate
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BelliniMar-21hospitalization (patients >70 years old)YesYesNoUnclearNoModerateYesYesYesYesLowYesYesYesYesYesNoNoModerateYesYesYesLowYesYesYesNoPartialLowNoYesYesYesYesNoModerate
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BennettApr-21mortality (Entire cohort)YesYesNoYesYesLowYesYesYesYesLowYesYesYesYesYesNoNoModerateYesYesYesLowYesYesYesNoYesLowYesYesYesYesYesYesLow
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BennettApr-21hospitalization (Entire cohort)YesYesNoYesYesLowYesYesYesYesLowYesYesYesYesYesNoNoModerateYesYesYesLowYesYesYesNoYesLowYesYesYesYesYesYesLow
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BennettApr-21ICU admission (hospitalized patients)YesYesNoYesYesLowYesYesYesYesLowYesYesYesYesYesNoNoModerateYesYesYesLowYesYesYesNoYesLowYesYesYesYesYesYesLow
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BennettApr-21mortality (hospitalized patients)YesYesNoYesYesLowYesYesYesYesLowYesYesYesYesYesNoNoModerateYesYesYesLowYesYesYesNoYesLowYesYesYesYesYesYesLow
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Bertrand Cariou ; May-20tracheal intubation and/or death
within 7 days of admission
YESYESYESYESYESLOWYESYESNONOMODNONOUNSUREYESYESYESUNSUREMODYESNONOMODYESYESYESYESYESLOWYESYESYESYESYESYESLOW
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Bertrand Cariou ; May-20mortalityYESYESYESYESYESLOWYESYESNONOMODNONOUNSUREYESYESYESUNSUREMODYESNONOMODYESYESYESYESYESLOWYESnonoYESYESYESmod
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BonifaziMar-21mortalityYesYesPartialNoPartialModerateYesYesYesYesLowYesYesYesYesYesNoNoModerateYesYesYesLowPartialNoYesNoPartialModerateYesYesYesYesYesYesLow
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BonifaziMar-21mechanical ventilationYesYesPartialNoPartialModerateYesYesYesYesLowYesYesYesYesYesNoNoModerateYesYesYesLowPartialNoYesNoPartialModerateYesYesYesYesYesYesLow
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Busetto Aug-20mortalityyesyespartialyesyeslowyesnonoyeslowyesyesyesyesyesyesyeslowyesyesyeslowyespartialyespartialpartiallowyesyesyesyespartialunsuremod
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cai.h 44228severe COVIDyesyesnoyesyeslowyesnononoohighyesyesyesnoyesyesunsurelowyesyesyeslownonoyesyesyeslowyesyesyesyesnoyeslow
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Cao 44317pneumoniayesyesyesyesyeslowyesnonoyesmodyesyesunclearnoyesyesunsurelowyesyesyeslownonoyesyesyeslowyesyesyesyesnoyeslow
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Cavallaro12/2020mortalityyesyesyesyesnomoderateyesnonounclearmoderateyesnounclearyesyesyesnolowyesyesyeslowyesyesyesyespartiallowyesyesyesyesyesyeslow
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Cavallaro12/2020ICU admissionyesyesyesyesnomoderateyesnonounclearmoderateyesnounclearyesyesyesnolowyesyesyeslowyesyesyesyespartiallowyesyesyesyesyesyeslow
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Cedano 44197mortalityyesyesyesyesyeslowyesnonoyesmodyesyesunclearnoyesyesunsurelowyesyesyeslownonoyesunsureyesmodyesyesyesyesnoyeslow
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Chand 07/2020mortalityyesyesyespartialpartialmoderateyesyesnoyeslowyesnounclearyesyesyesnomoderateyesyesyeslowyesyesyesyesyeslowyesyesyesyesyesunclearlow
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Charlotte Kaeuffer12/2020Mortalityyesyesyesyesyeslowyesnoyesunsuremoderateyesyespartialyesunsureyesyeslowyesyesyeslowyesnoyesnonohighyesyesyesyesyesyeslow
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Charlotte Kaeuffer12/2020Severe Covidyesyesyesyesyeslowyesnoyesunsuremoderateyesyespartialyesunsureyesyeslowyesyesyeslowyesnoyesnonohighyesyesyesyesyesyeslow
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Chris 44105 mechanical
ventilation
yesyesyesyesyeslowyesnonoyesmodyesyesunclearnoyesyesunsurelowyesyesyeslownonoyesyesyeslowyesyesyesyesnoyeslow
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Christopher M Petrilli, + 05/200.25hospitalizationyesyesyesyesyeslowyesyesyesyeslowyesyesyesyesyesyesyeslowyesyesyeslowyesyesyesyesyeslowyesyesyesyesyesyeslow
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Chua nrmortalityyesnonononohighyesnononohighyesyesunclearnoyesyesyeslowyesyesyeslownonoyesnounsuremodyesyesyesnonoyeslow
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ContibutorsDec-20Severe COVIDnoyespartialyesyeslowyesnoYesunclearmoderateyesyesunclearyesyesyesYeslowyesnounclearmoderateYesYesYesyesYesLowyesyesyesyesyesyeslow
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ContibutorsDec-20Severe COVIDnoyespartialyesyeslowyesnoYesunclearmoderateyesyesunclearyesyesyesYeslowyesyesyeslowYesYesYesyesYesLowyesyesyesyesyesyeslow
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Coss-Rovirosa 44136mechanical ventilationyesyesyesyesyeslowyesnononnomodyesyesyesnoyesyesunsurelowyesyesyeslownonoyesyesyeslowyesyesyesyesnoyeslow
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Cummins 44317Hospitalisationsyesyesyesyesyeslowyesnonoyesmodyesyesyesnoyesyesunsurelowyesyesyeslownonoyesyesunsuremodyesyesyesyesnoyeslow
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Cummins 44317ICU admissionyesyesyesyesyeslowyesnonoyesmodyesyesyesnoyesyesunsurelowyesyesyeslownonoyesyesyeslowyesyesyesyesnoyeslow
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Cummins 44317mortalityyesyesyesyesyeslowyesnonoyesmodyesyesyesnoyesyesunsurelowyesyesyeslownonoyesyesyeslowyesyesyesyesnoyeslow
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Czernichow11/2020mortalityyesyesyesyesyeslowyesnonoyesmoderateyesyesunclearyesyesnoyesmoderateyesyesyeslowyesyesyesyesyeslowyesyesyesyesyesyeslow
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Deng09/2020severe COVIDyesyesyesnoyesmoderateyesnonounclearmoderateyespartialunclearyesyesyesnolowyesnounclearlowunclearnoyesunclearunclearhighpartialunclearyesnoyesunclearhigh
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Dennison03.2021Mechanical Ventilationyesyesyesyesnoacceptableyesnoyesunclearacceptableyespartialunclearyesnounclearnohighnounclearyesacceptablenoyesyesnonohighnoyesyesyesyesnoacceptable
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Dennison03/2021Mortalityyesyesyesyesnoacceptableyesnoyesunclearacceptableyespartialunclearyesnounclearnohighyesyesyeslownoyesyesnonohighnoyesyesyesyesnoacceptable
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Denova-Gutiérrez 08/2020severe COVIDyesyesyesyesyeslowyesnonono moderatenonounclearNAnoyesnohighyesnonomoderateyesyesnoyesnomoderateyesyesyesyesyesyeslow
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Doriane Calmes, Jan-21mortalityyesyesoartialyesyesmodyesnononohighnonounsurenoyesyespartialhighyesyesyeslowyesyesyesyesyeslowyesyesyesyesyesyeslow
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Doriane Calmes, jan/2021Jan-21icu admissionyesyespartialyesyesmpdyesnonoNohighnonounsurenoyesyespartialhighyesyesyeslowyesyesyesyesyeslowyesyesyesyesyesyeslow
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Eastment2021Hospitalizationyesyesyesnoyesmoderateyesnoyesunclearmoderateyespartialunclearyesyesyesnolowyesyesyeslowyesyesyesyesyeslowyesyesyesyesyesyeslow
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Eastment2021ICU admissionyesyesyesnoyesmoderateyesnoyesunclearmoderateyespartialunclearyesyesyesnolowyesyesyeslowyesyesyesyesyeslowyesyesyesyesyesyeslow
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Eastment2021Mechanical Ventilationyesyesyesnoyesmoderateyesnoyesunclearmoderateyespartialunclearyesyesyesnolowyesyesyeslowyesyesyesyesyeslowyesyesyesyesyesyeslow
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Eastment2021mortalityyesyesyesnoyesmoderateyesnoyesunclearmoderateyespartialunclearyesyesyesnolowyesyesyeslowyesyesyesyesyeslowyesyesyesyesyesyeslow
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Ebinger07/2020Hospitalizationyesyesnonoyesmoderateyesnonoyeslownounclearunclearyesunclearyesyeshighyesyesnomoderateyesyesnoyesyeslowyesyesyesyesyesyeslow
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Ebinger07/2020ICU admissionyesyesnonoyesmoderateyesnonoyeslownounclearunclearyesunclearyesyeshighyespartialnomoderateyesyesnoyesyeslowyesyesyesyesyesyeslow
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Ebinger07/2020Mechanical Ventilationyesyesnonoyesmoderateyesnonoyeslownounclearunclearyesunclearyesyeshighyespartialnomoderateyesyesnoyesyeslowyesyesyesyesyesyeslow
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Ebinger07/2020severe COVIDyesyesnonoyesmoderateyesnonoyeslownounclearunclearyesunclearyesyeshighyespartialnomoderateyesyesnoyesyeslowyesyesyesyesyesyeslow
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Eboni G. Price-Haywood + 05/20hospitalizationyesyesyesyesyeslowyesyesyesyeslowyesyesyesyesyesyesyeslowyesyesyeslowyesyesyesyesyeslowyesyesyesyesyesyeslow
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Eboni G. Price-Haywood + 05/21mortalityyesyesyesyesnomodERATEyesyesyesyeslowyesyesyesyesyesyesyeslowyesyesyeslowyesyesyesyesyeslowyesyesyesyesyesyeslow
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Eboni G. Price-Haywood + 05/22icu durationyesyesyesyesnomodERATEyesyesyesyeslowyesyesyesyesyesyesyeslownoyesyesmoderateyesyesyesyesyeslowyesyesyesyesyesyeslow
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Elliot 02/2021Mortalityyesyesnoyesyeslowyesnonounclearacceptableyesyesunclearyesunclearyesunclearacceptableyesyesyeslowyesyesyesyesyeslowyesyesyesyesyesyeslow
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Escalera06/2020mortalitynoyesnononohighyesnonoyesacceptablenonounclearyesunclearyesnohighyesyesyeslownoyesunclearnounclearhighnoyesunsureyesyesnohigh
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Eugene MerzonApr-21HospitalizationyesyesyesyesyesLowyesyesyesyesLowyesunclearunclearyesunclearnounclearHighyesyesyesLowyesyesyesyesyesLowyesyesyesyesyesunclearLow
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Eyal Klang08/2020Mortalityyesyesyesyesyeslowyesnonounsurehighyesyesunsureyesunsureyesnolowyesyesyeslowyesyesyesyesyeslowyesyesyesyesyesyeslow
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Eyal Klang08/2020Mechanical ventilationyesyesyesyesyeslowyesnonounsurehighyesyesunsureyesunsureyesnolownoyesyeslowyesyesyesyesyeslowyesyesyesyesyesyeslow
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Farrell11/2020mortalityyesyesyesnoyesmoderateyesnoyesunclearmoderateyesyesunclearyesyesyesnolowyesyesyeslownoyesyesnonohighyesyesyesyesyesunclearlow
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Farrell11/2020ICU admissionyesyesyesnoyesmoderateyesnoyesunclearmoderateyesyesunclearyesyesyesnolowyesyesyeslownoyesyesnonohighyesyesyesyesyesunclearlow
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Feng Gao 07/ 2020Sever COVIDyesyespartialyesnomoderateyesyes yesyesLowyesyesUnsureyesyesyesyesLowyesyesyeslowNoNoyesPartial partial High partialnoyespartial yesnoHigh
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Filardo 11/2020mortalityyesyesyespartialyeslowyesnoyesunclearmoderateyesyesunclearyesyesyesunclearlowyesyesyeslowyesyesyesyesyeslowyesyesyesyesyesnomoderate
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Forest02/2021Mortalityyesyesyesyespartiallowyesnoyesunclearaccpetableyesyesunclearyesyesyesunclearacceptableyesyesyeslowyesyesyesyesyeslowpartialyesyespartialyesyeslow
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Gang Li 09/2020Mortalityyesyespartialyesyeslowyesunsureyesyeslowyesyesunsurenoyesunsureyeshighyesyesyeslowyesyesyesyesyeslowpartialyesyesyesyesnomoderate
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Gang Li 09/2020ICU Admissionyesyespartialyesyeslowyesunsureyesyeslowyesyesunsurenoyesunsureyeshighyesyesyeslowyesyesyesyesyeslowpartialyesyesyesyesnomoderate
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Gao21-AprHospitalizationNoYesPartialYesNoModerateYesYesYesYesLowYesYesYesYesYesYesNot ApplicableLowYesYesYesLowYesYesYesYesYesLowYesYesYesYesYesYesLow
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Gao21-AprICU admissionNoYesPartialYesNoModerateYesYesYesYesLowYesYesYesYesYesYesNot ApplicableLowYesYesYesLowYesYesYesYesYesLowYesYesYesYesYesYesLow
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Gao21-AprMortalityNoYesPartialYesNoModerateYesYesYesYesLowYesYesYesYesYesYesNot ApplicableLowYesYesYesLowYesYesYesYesYesLowYesYesYesYesYesYesLow
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Garcia Moreno05/2021Mortalityunsureunsureunsureunsureunsureunsureunsureunsureunsureunsureunsureunsureunsureunsureunsureunsureunsureunsureunsureunsureunsureunsureunsureunsureunsureunsureunsureunsureunsureunsureunsureunsureunsureunsureunsureunsure
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Garcia Olivares2020Mortalityunsureunsureunsureunsureunsureunsureunsureunsureunsureunsureunsureunsureunsureunsureunsureunsureunsureunsureunsureunsureunsureunsureunsureunsureunsureunsureunsureunsureunsureunsureunsureunsureunsureunsureunsureunsure