ABCDEFGHIJKLMNOPQRSTUVWXYZ
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L99A binders
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These compounds are known to bind to T4 lysozme L99A:
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namesmileszinciddTM (cels)kd (µM)pdbrefs
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(2-thienylthio)acetoneCC(=O)CSc1cccs1ZINC0000001562171.1Su et al., 2001
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1-ethyl-2-hydro-1,2-azaborineCCN1BC=CC=C1ZINC0001980320793HH5Liu et al., 2009
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1-ethyl-2-methylcyclopenteneCCC1=C(C)CCC1ZINC0000025754371.2Su et al., 2001
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1-methylpyrroleCn1cccc1ZINC0000016924462.25442OU0Mobley et al., 2007
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1-phenyl-1-propyneCC#Cc1ccccc1ZINC0000018458413Morton et al., 1995
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1,2-benzenedithiolSc1ccccc1SZINC0000003885652.5n.a.Mobley et al., 2007
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1,2-benzisoxazolec1noc2ccccc12ZINC0000045211870.4Morton et al., 1995
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1,2-dichlorobenzeneClc1ccccc1ClZINC0000003885062.9202OTYMobley et al., 2007
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1,2-dihydro-1,2-azaborineB1C=CC=CN1ZINC0001980320721973HH3Lee et al., 2016Liu et al., 2009
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2-(methylthio)thiopheneCSc1cccs1ZINC0000001609283.3Su et al., 2001
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2-ethoxyphenolCCOc1ccccc1OZINC0000004047471.22RB1Graves et al., 2008
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2-ethylfuranCCc1ccco1ZINC0000020377261.9Morton et al., 1995
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2-ethyltolueneCCc1ccccc1CZINC0000015987171.1505.1Morton et al., 1995
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2-iodopropaneCC(C)IZINC0000020128141.1Morton et al., 1995
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2-iodotolueneCc1ccccc1IZINC0000016728461.9Morton et al., 1995
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2-methylbenzofuranCc1cc2ccccc2o1ZINC0000020133441.1Morton et al., 1995
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2,3-benzofuranc2cc1ccccc1o2ZINC0000015918143112.4182LMorton et al., 1995
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2,6-difluorobenzylbromideFc1cccc(F)c1CBrZINC0000022425871.62RB0Graves et al., 2008
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3-ethyltolueneCCc1cccc(C)c1ZINC0000016995601.1198Morton et al., 1995
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3-iodotolueneCc1cccc(c1)IZINC0000016728472Morton et al., 1995
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3-methylbenzylazideCc1cccc(CN=[N+]=[N-])c1ZINC0000154431261.52RB2Graves et al., 2008
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3-phenyl-1-propanethiolSCCCc1ccccc1ZINC0000051389754.5Morton et al., 1995
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3-phenyl-1-propanolOCCCc1ccccc1ZINC0000017478391Morton et al., 1995
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4-(methylthio)nitrobenzeneCSc1ccc([N+](=O)[O-])cc1ZINC0000001633561.32RAZGraves et al., 2008
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4-ethyltolueneCCc1ccc(C)cc1ZINC0000016995611.7120Morton et al., 1995
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4-iodotolueneCc1ccc(I)cc1ZINC0000010037501.3Morton et al., 1995
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6-methyl-1,5,heptadieneC=CCCC=C(C)CZINC0000025633752.8n.a.Graves et al., 2008
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allyl ethyl sulfideCCSCC=CZINC0000021664761.9Morton et al., 1995
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allyl n-propyletherCCCOCC=CZINC0000016017991.6Morton et al., 1995
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allyl sulfideC=CCSCC=CZINC0000015310831.9Morton et al., 1995
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anisoleCOc1ccccc1ZINC0000008971311.4Morton et al., 1995
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b-et-1,2-azaborineCCB1C=CC=CN1ZINC0005849047401725JWSLee et al., 2016
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benzenec1ccccc1ZINC0000009675325.985 , 175 4W52, 3HH4, 181LLee et al., 2016Merski et al., 2014Liu et al., 2009Eriksson et al., 1992
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benzyl mercaptanSCc1ccccc1ZINC0000038736472.1Morton et al., 1995
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beta-chlorophenetoleClCCOc1ccccc1ZINC0000015878156.52RAYGraves et al., 2008
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bromoethaneCCBrZINC0000139509132.4Morton et al., 1995
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cis-3-hexenyl formateCC/C=C\CCOC=OZINC0000144387011.5n.a.Graves et al., 2008
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cyclohexeneC1CCC=CC1ZINC0000139509111Morton et al., 1995
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diethyl disulfideCCSSCCZINC0000016482643.5Morton et al., 1995
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diisopropyl disulfideCC(C)SSC(C)CZINC0000016740780.7Morton et al., 1995
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dipropyl disulfideCCCSSCCCZINC0000015310842Morton et al., 1995
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ethylbenzeneCCc1ccccc1ZINC00000096827085 , 68 4W54, 3HH6Lee et al., 2016Merski et al., 2014Liu et al., 2009Morton et al., 1995
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fluorobenzeneFc1ccccc1ZINC0000009677595.9Morton et al., 1995
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hexafluorobenzeneFc1c(c(c(c(c1F)F)F)F)FZINC0000015837431.5Morton et al., 1995
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indeneC1C=Cc2ccccc21ZINC0000016998881.2193.4183LMorton et al., 1995
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indolec2cc1ccccc1[nH]2ZINC0000145169841.7289.9185LMorton et al., 1995
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iodobenzeneIc1ccccc1ZINC0000016998782.6Morton et al., 1995
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iodoethaneCCIZINC0000139509141.6Morton et al., 1995
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isobutylbenzeneCC(C)Cc1ccccc1ZINC0000016153272.919.3184LMorton et al., 1995
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m-xyleneCc1cccc(c1)CZINC0000009682811.8363.6Morton et al., 1995
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methylcyclohexaneCC1CCCCC1ZINC0000016999641.1Morton et al., 1995
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n-butylbenzeneCCCCc1ccccc1ZINC0000015867561.4144W57,186LMerski et al., 2014Morton et al., 1995
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n-hexylbenzeneCCCCCCc1ccccc1ZINC0000017608230.54W59Merski et al., 2014Morton et al., 1995
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n-methylanilineCNc1ccccc1ZINC00000090134313502OTZMobley et al., 2007
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n-pentylbenzeneCCCCCc1ccccc1ZINC0000016994444W58Merski et al., 2014Morton et al., 1995
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n-propylbenzeneCCCc1ccccc1ZINC0000017478376.2184W55Merski et al., 2014Morton et al., 1995
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naphthalenec2ccc1ccccc1c2ZINC0000009675221Morton et al., 1995
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nitrobenzeneO=[N+]([O-])c1ccccc1 ZINC0000008964260.7Morton et al., 1995
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o-xyleneCc1ccccc1CZINC0000009682822.9469.6188LMorton et al., 1995
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p-xyleneCc1ccc(cc1)CZINC0000009682542.4421.9187LMorton et al., 1995
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phenylacetyleneC#Cc1ccccc1ZINC0000016806390.7Morton et al., 1995
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sec-butylbenzeneCCC(C)c1ccccc1ZINC0000020410001.34W56Merski et al., 2014Morton et al., 1995
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styreneC=Cc1ccccc1ZINC0000009682692Morton et al., 1995
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thianaphthenec2cc1ccccc1s2ZINC0000016791611.5Morton et al., 1995
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thioanisoleCSc1ccccc1ZINC0000016887631.4Morton et al., 1995
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thiophene-2-thiolSc1cccs1ZINC0000021691562.1Su et al., 2001
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thiophenolSc1ccccc1ZINC0000018671274.5Su et al., 2001
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tolueneCc1ccccc1ZINC0000009675344.41024W53Merski et al., 2014Morton et al., 1995
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L99A non-binders
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We have NOT been able to detect binding of these compounds to T4 lysozyme L99A at high concentrations, and we consider them non-binders.
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namesmileszinciddTM (cels)kdpdbref
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thieno[2,3-c]pyridinec1cc2ccncc2s1ZINC966806-0.4Mobley et al., 2007
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trichloromethaneClC(Cl)ClZINC8214524Morton et al., 1995
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methanolCON.A.Morton et al., 1995
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2-bromoethan-1-olOCCBrZINC4978447Morton et al., 1995
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2-iodoethan-1-olOCCIZINC13951488Morton et al., 1995
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ethanolCCOZINC12358605Morton et al., 1995
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methanesulfinylmethaneCS(C)=OZINC5224188Morton et al., 1995
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propan-1-olCCCOZINC895969Morton et al., 1995
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furanO1C=CC=C1ZINC2041074Morton et al., 1995
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2-methylpropaneCC(C)CZINC8214586Morton et al., 1995
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pyridineC1=CC=NC=C1ZINC895354Morton et al., 1995
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1,1-diethylureaCCN(CC)C(N)=OZINC409175Morton et al., 1995
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1-azido-2,3,4,5,6-pentafluorobenzene
FC1=C(F)C(F)=C(N=[N+]=[N-])C(F)=C1F
ZINC13950912Morton et al., 1995
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pentafluoroanilineNC1=C(F)C(F)=C(F)C(F)=C1FZINC2022414Morton et al., 1995
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2-azido-1,3-difluorobenzeneFC1=CC=CC(F)=C1N=[N+]=[N-]ZINC35854893Morton et al., 1995
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1,2-diiodobenzeneIC1=C(I)C=CC=C1ZINC6827585Morton et al., 1995
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1,4-diiodobenzeneIC1=CC=C(I)C=C1ZINC6827587Morton et al., 1995
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phenolOC1=CC=CC=C1ZINC5133329Morton et al., 1995
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anilineNC1=CC=CC=C1ZINC17886255Morton et al., 1995
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2,5-dimethylfuranCC1=CC=C(C)O1ZINC1693339Morton et al., 1995