Why is it so Hard to Build a Diagnostic Business?

	A	B	C	D	E	F	G
1		Pop (conf. by Colonoscopy)	Cologuard+		FIT
2			Positive	Negative	Positive	Negative
3	Colorectal Cancer	98	92	6	66	32
4	Advanced Precancerous Lesions	2144	931	1213	500	1644
5	non-advanced + negatives	17934	1689	16245	937	16997
6	Total	20176	2712	17464	1503	18673
7	Negative on Colonoscopy	7510	498	7012	303	7207
8	Positive on Colonoscopy	12666	2214	10452	1200	11466
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10			Cologuard+		FIT
11			Positive	Negative	Positive	Negative
12	Colorectal Cancer		92	6	66	32
13	Not Colorectal Cancer		2620	17458	1437	18641
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15	Colorectal Cancer OR Lesion		1023	1219	566	1676
16	Not Cancer/Lesion		1689	16245	937	16997
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18			Cologuard+		FIT		Prevalence
19			Sensitivity	Specificity	Sensitivity	Specificity	Prevalence
20		Cancer	93.9%	87.0%	67.3%	92.8%	0.49%
21		Cancer OR Lesion	45.6%	90.6%	25.2%	94.8%	11.11%
22		Something on Colonoscopy	17.5%	93.4%	9.5%	96.0%	62.8%
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