Why is it so Hard to Build a Diagnostic Business?

	A	B	C	D	E	F	G	H	I	J	K	L	M	N	O	P	Q	R	S	T	U	V	W	X	Y	Z	AA	AB
1		1997	1998	1999	2000	2001	2002	2003	2004	2005	2006	2007	2008	2009	2010	2011	2012	2013	2014	2015	2016	2017	2018	2019	2020	2021	2022	2023

2	Revenue	0	0	0	0	51	897	2,901	4,935	4,250	4,750	1,798	-867	4,758	5,344	4,163	4,144	4,144	1,798	39,437	99,376	265,989	454,462	876,293	1,491,391	1,767,087	2,084,279	2,499,766
3	Lab Service / Screening Revenue	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1,504	39,437	99,376	265,989	454,462	810,120	815,100	1,062,300	1,424,700	1,864,700
4	Cost of Goods	0	0	0	0	0	9	22	487	566	809	49	1	20	24	24	0	0	4,325	24,501	45,195	78,305	116,644	216,717	354,324	458,757	574,394	654,248
5	GM																		-141%	38%	55%	71%	74%	75%	76%	74%	72%	74%
6	R&D	1,222	2,849	3,689	5,332	13,335	19,989	17,084	10,901	7,956	6,735	4,887	2,034	4,213	9,023	21,968	42,131	27,678	28,669	33,914	33,473	42,099	67,285	139,694	554,052	385,646	393,418	425,882
7	SG&A	814	1,170	1,560	4,814	9,078	9,701	13,515	12,244	10,736	10,702	8,532	6,469	9,775	8,123	10,994	14,655	23,227	69,343	140,090	189,724	262,912	427,464	737,629	1,071,312	1,663,151	1,583,315	1,620,294
8	S&M	0	0	0	0	2,211	4,172	7,363	5,697	5,239	3,792	991	0	226	1,793	2,857	4,755	9,578	38,908	82,140	112,826	153,924	249,448	385,176	589,919	861,889	846,011	727,090
9	Loss	-1,883	-3,578	-4,964	-11,883	-23,485	-29,883	-28,340	-18,523	-14,520	-12,915	-11,959	-9,741	-9,128	-11,556	-28,675	-52,421	-46,514	-100,048	-157,803	-167,211	-114,397	-175,149	-213,090	-823,605	-595,625	-623,506	-204,149
10
11	Operating Cash Flow	-1,776	-3,034	-4,608	-7,991	-15,837	-11,917	-13,870	-20,911	-15,982	-12,154	-8,767	-7,904	-12,640	-13,478	-27,464	-44,155	-40,282	-81,458	-134,017	-130,066	-71,724	-69,325	-115,655	136,482	-102,236	-223,559	156,119
12	ICF - Property & Equip	-340	-355	-292	-763	-2,615	-1,335	-2,560	-287	-227	-149	-78	-4	-462	-626	-2,115	-681	-8,748	-11,991	-20,084	-14,851	-48,480	-150,093	-172,654	-65,078	-135,766	-214,462	-124,190
13	FCF - Common Stock Sale	30	8	0	18	50,558	0	0	43,305	0	0	0	0	8,062	82,327	27,215	57,755	73,296	238,580	174,140	144,242	253,388	0	0	861,701	0	0	0
14	FCF - Pref Stock Sale	121	10,538	0	31,723	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
15	FCF - Genzyme deal				0	0	0	0	0	0	0	0	0	22,650	1,896	0	0	0	0	0	0	0	0	0	0	0	0	0
16	FCF - Convertible Note Issuance																					0	896,430	729,477	1,125,547	0	0	0
17	FCF - Settling Convertible Notes																							-493,356	-150,054	0	0	0
18
19	Cash + Marketable Securities	1,792	8,826	3,553	26,570	56,843	43,846	27,806	50,280	34,119	21,075	12,587	4,937	24,328	95,415	93,361	108,121	133,259	282,756	306,879	311,100	424,715	1,124,182	323,655	1,839,987	1,030,476	632,057	777,644
20			S-1			2002 10-K	2003 10-K		2005 10-K	2006 10-K		2008 10-K		2010 10-K		2012 10-K		2014 10-K		2016 10-K		2018 10-K		2020 10-K		2022 10-K		2024 10-K
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